Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 152 (11 Dec 2019)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rhotekin-2

Gene

RTKN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in lymphopoiesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhotekin-2
Alternative name(s):
Pleckstrin homology domain-containing family K member 1
Short name:
PH domain-containing family K member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTKN2
Synonyms:PLEKHK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182010.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19364 RTKN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618450 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZC4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
219790

Open Targets

More...
OpenTargetsi
ENSG00000182010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402276

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZC4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RTKN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750788

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003093261 – 609Rhotekin-2Add BLAST609

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZC4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZC4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZC4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZC4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZC4

PeptideAtlas

More...
PeptideAtlasi
Q8IZC4

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZC4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71313 [Q8IZC4-1]
71314 [Q8IZC4-2]
71315 [Q8IZC4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in cells resistant to 25-hydroxy cholesterol (25-OHC). Down-regulated in lymphocytes activated by treatment with phytohemagglutinin (PHA).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182010 Expressed in 99 organ(s), highest expression level in visceral pleura

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZC4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZC4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037946
HPA038446

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128576, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZC4, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8IZC4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362894

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZC4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZC4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 81REM-1PROSITE-ProRule annotationAdd BLAST77
Domaini286 – 393PHPROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili56 – 91Sequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIHF Eukaryota
ENOG410ZX8Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZC4

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIMAYTL

Database of Orthologous Groups

More...
OrthoDBi
497196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZC4

TreeFam database of animal gene trees

More...
TreeFami
TF331476

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012966 AHD
IPR011072 HR1_rho-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR030469 RTKN2

The PANTHER Classification System

More...
PANTHERi
PTHR21538:SF21 PTHR21538:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08174 Anillin, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00742 Hr1, 1 hit
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS51860 REM_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGPSLRGPA LRLAGLPTQQ DCNIQEKIDL EIRMREGIWK LLSLSTQKDQ
60 70 80 90 100
VLHAVKNLMV CNARLMAYTS ELQKLEEQIA NQTGRCDVKF ESKERTACKG
110 120 130 140 150
KIAISDIRIP LMWKDSDHFS NKERSRRYAI FCLFKMGANV FDTDVVNVDK
160 170 180 190 200
TITDICFENV TIFNEAGPDF QIKVEVYSCC TEESSITNTP KKLAKKLKTS
210 220 230 240 250
ISKATGKKIS SVLQEEDDEM CLLLSSAVFG VKYNLLAHTT LTLESAEDSF
260 270 280 290 300
KTHNLSINGN EESSFWLPLY GNMCCRLVAQ PACMAEDAFA GFLNQQQMVE
310 320 330 340 350
GLISWRRLYC VLRGGKLYCF YSPEEIEAKV EPALVVPINK ETRIRAMDKD
360 370 380 390 400
AKKRIHNFSV INPVPGQAIT QIFAVDNRED LQKWMEAFWQ HFFDLSQWKH
410 420 430 440 450
CCEELMKIEI MSPRKPPLFL TKEATSVYHD MSIDSPMKLE SLTDIIQKKI
460 470 480 490 500
EETNGQFLIG QHEESLPPPW ATLFDGNHQM VIQKKVLYPA SEPLHDEKGK
510 520 530 540 550
KRQAPLPPSD KLPFSLKSQS NTDQLVKDNW GKTSVSQTSS LDTKLSTLMH
560 570 580 590 600
HLQKPMAAPR KLLPARRNRL SDGEHTDTKT NFEAKPVPAP RQKSIKDILD

PRSWLQAQV
Length:609
Mass (Da):69,304
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i928E5F197EBBDBE4
GO
Isoform 2 (identifier: Q8IZC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-340: K → KSLVLFEDSLEGIQLAISQSFK
     486-506: VLYPASEPLHDEKGKKRQAPL → NNSNQLHNLQKLPATSKFLFT
     507-609: Missing.

Show »
Length:527
Mass (Da):60,083
Checksum:i4C007BE107D3B519
GO
Isoform 3 (identifier: Q8IZC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: F → L
     164-609: Missing.

Show »
Length:163
Mass (Da):18,655
Checksum:iD3A8CC8BFA920BC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVY4Q5SVY4_HUMAN
Rhotekin-2
RTKN2
308Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04837 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC048002 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050516101K → T. Corresponds to variant dbSNP:rs3765004Ensembl.1
Natural variantiVAR_050517462H → R2 PublicationsCorresponds to variant dbSNP:rs3125734Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029135163F → L in isoform 3. 1 Publication1
Alternative sequenceiVSP_029136164 – 609Missing in isoform 3. 1 PublicationAdd BLAST446
Alternative sequenceiVSP_029137340K → KSLVLFEDSLEGIQLAISQS FK in isoform 2. 1 Publication1
Alternative sequenceiVSP_029138486 – 506VLYPA…RQAPL → NNSNQLHNLQKLPATSKFLF T in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_029139507 – 609Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY150309 mRNA Translation: AAN71738.1
AC024597 Genomic DNA No translation available.
AL607150 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54232.1
BC025765 mRNA Translation: AAH25765.1
BC048002 mRNA No translation available.
BC141821 mRNA Translation: AAI41822.1
BC142725 mRNA Translation: AAI42726.1
AK096671 mRNA Translation: BAC04837.1 Different initiation.
CR749217 mRNA Translation: CAH18074.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7263.1 [Q8IZC4-1]
CCDS73140.1 [Q8IZC4-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001269870.1, NM_001282941.1 [Q8IZC4-3]
NP_660350.2, NM_145307.3 [Q8IZC4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373789; ENSP00000362894; ENSG00000182010 [Q8IZC4-1]
ENST00000395260; ENSP00000378678; ENSG00000182010 [Q8IZC4-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:219790

UCSC genome browser

More...
UCSCi
uc001jlw.5 human [Q8IZC4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150309 mRNA Translation: AAN71738.1
AC024597 Genomic DNA No translation available.
AL607150 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54232.1
BC025765 mRNA Translation: AAH25765.1
BC048002 mRNA No translation available.
BC141821 mRNA Translation: AAI41822.1
BC142725 mRNA Translation: AAI42726.1
AK096671 mRNA Translation: BAC04837.1 Different initiation.
CR749217 mRNA Translation: CAH18074.1
CCDSiCCDS7263.1 [Q8IZC4-1]
CCDS73140.1 [Q8IZC4-3]
RefSeqiNP_001269870.1, NM_001282941.1 [Q8IZC4-3]
NP_660350.2, NM_145307.3 [Q8IZC4-1]

3D structure databases

SMRiQ8IZC4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128576, 6 interactors
IntActiQ8IZC4, 6 interactors
MINTiQ8IZC4
STRINGi9606.ENSP00000362894

PTM databases

iPTMnetiQ8IZC4
PhosphoSitePlusiQ8IZC4

Polymorphism and mutation databases

BioMutaiRTKN2
DMDMi74750788

Proteomic databases

EPDiQ8IZC4
jPOSTiQ8IZC4
MassIVEiQ8IZC4
MaxQBiQ8IZC4
PaxDbiQ8IZC4
PeptideAtlasiQ8IZC4
PRIDEiQ8IZC4
ProteomicsDBi71313 [Q8IZC4-1]
71314 [Q8IZC4-2]
71315 [Q8IZC4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
219790

Genome annotation databases

EnsembliENST00000373789; ENSP00000362894; ENSG00000182010 [Q8IZC4-1]
ENST00000395260; ENSP00000378678; ENSG00000182010 [Q8IZC4-3]
GeneIDi219790
KEGGihsa:219790
UCSCiuc001jlw.5 human [Q8IZC4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
219790
DisGeNETi219790
EuPathDBiHostDB:ENSG00000182010.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RTKN2
HGNCiHGNC:19364 RTKN2
HPAiHPA037946
HPA038446
MIMi618450 gene
neXtProtiNX_Q8IZC4
OpenTargetsiENSG00000182010
PharmGKBiPA162402276

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIHF Eukaryota
ENOG410ZX8Y LUCA
GeneTreeiENSGT00940000157470
HOGENOMiHOG000015094
InParanoidiQ8IZC4
OMAiRIMAYTL
OrthoDBi497196at2759
PhylomeDBiQ8IZC4
TreeFamiTF331476

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RTKN2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
219790
PharosiQ8IZC4 Tbio

Protein Ontology

More...
PROi
PR:Q8IZC4
RNActiQ8IZC4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182010 Expressed in 99 organ(s), highest expression level in visceral pleura
ExpressionAtlasiQ8IZC4 baseline and differential
GenevisibleiQ8IZC4 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966 AHD
IPR011072 HR1_rho-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR030469 RTKN2
PANTHERiPTHR21538:SF21 PTHR21538:SF21, 1 hit
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00742 Hr1, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS51860 REM_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTKN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZC4
Secondary accession number(s): Q3ZCR1
, Q68DZ6, Q8N8K1, Q8TAV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: December 11, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again