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Protein

Histone H1oo

Gene

H1FOO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).By similarity

GO - Molecular functioni

  • double-stranded DNA binding Source: GO_Central
  • nucleosomal DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1oo
Alternative name(s):
Oocyte-specific histone H1
Oocyte-specific linker histone H1
Short name:
osH1
Gene namesi
Name:H1FOO
Synonyms:H1OO, OSH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178804.7
HGNCiHGNC:18463 H1FOO
neXtProtiNX_Q8IZA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958422

Polymorphism and mutation databases

BioMutaiH1FOO
DMDMi74762503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434121 – 346Histone H1ooAdd BLAST346

Proteomic databases

EPDiQ8IZA3
PaxDbiQ8IZA3
PeptideAtlasiQ8IZA3
PRIDEiQ8IZA3
ProteomicsDBi71310
71311 [Q8IZA3-2]

PTM databases

iPTMnetiQ8IZA3
PhosphoSitePlusiQ8IZA3

Expressioni

Tissue specificityi

Oocyte-specific.1 Publication

Gene expression databases

BgeeiENSG00000178804 Expressed in 31 organ(s), highest expression level in oocyte
CleanExiHS_H1FOO
GenevisibleiQ8IZA3 HS

Organism-specific databases

HPAiHPA037992

Interactioni

Protein-protein interaction databases

BioGridi126315, 50 interactors
STRINGi9606.ENSP00000319799

Structurei

3D structure databases

ProteinModelPortaliQ8IZA3
SMRiQ8IZA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 129H15PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi164 – 179Nuclear localization signalSequence analysisAdd BLAST16

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00900000141023
HOGENOMiHOG000112841
HOVERGENiHBG096668
InParanoidiQ8IZA3
OMAiKEDPPNV
OrthoDBiEOG091G0LIU
PhylomeDBiQ8IZA3
TreeFamiTF333386

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZA3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGSVTSDI SPSSTSTAGS SRSPESEKPG PSHGGVPPGG PSHSSLPVGR
60 70 80 90 100
RHPPVLRMVL EALQAGEQRR GTSVAAIKLY ILHKYPTVDV LRFKYLLKQA
110 120 130 140 150
LATGMRRGLL ARPLNSKARG ATGSFKLVPK HKKKIQPRKM APATAPRRAG
160 170 180 190 200
EAKGKGPKKP SEAKEDPPNV GKVKKAAKRP AKVQKPPPKP GAATEKARKQ
210 220 230 240 250
GGAAKDTRAQ SGEARKVPPK PDKAMRAPSS AGGLSRKAKA KGSRSSQGDA
260 270 280 290 300
EAYRKTKAES KSSKPTASKV KNGAASPTKK KVVAKAKAPK AGQGPNTKAA
310 320 330 340
APAKGSGSKV VPAHLSRKTE APKGPRKAGL PIKASSSKVS SQRAEA
Length:346
Mass (Da):35,813
Last modified:March 1, 2003 - v1
Checksum:i666964009BE6F4AC
GO
Isoform 2 (identifier: Q8IZA3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.

Show »
Length:207
Mass (Da):21,010
Checksum:iF70644D8CCD87E9B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061208296N → S. Corresponds to variant dbSNP:rs59415528Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0345921 – 139Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158091 mRNA Translation: AAN46899.1
CH471052 Genomic DNA Translation: EAW79242.1
CH471052 Genomic DNA Translation: EAW79243.1
BC047943 mRNA Translation: AAH47943.1
CCDSiCCDS3064.1 [Q8IZA3-1]
CCDS77815.1 [Q8IZA3-2]
RefSeqiNP_001295191.1, NM_001308262.1 [Q8IZA3-2]
NP_722575.1, NM_153833.2 [Q8IZA3-1]
XP_016861222.1, XM_017005733.1 [Q8IZA3-2]
UniGeneiHs.97358

Genome annotation databases

EnsembliENST00000324382; ENSP00000319799; ENSG00000178804 [Q8IZA3-1]
ENST00000503977; ENSP00000422964; ENSG00000178804 [Q8IZA3-2]
GeneIDi132243
KEGGihsa:132243
UCSCiuc003emu.3 human [Q8IZA3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158091 mRNA Translation: AAN46899.1
CH471052 Genomic DNA Translation: EAW79242.1
CH471052 Genomic DNA Translation: EAW79243.1
BC047943 mRNA Translation: AAH47943.1
CCDSiCCDS3064.1 [Q8IZA3-1]
CCDS77815.1 [Q8IZA3-2]
RefSeqiNP_001295191.1, NM_001308262.1 [Q8IZA3-2]
NP_722575.1, NM_153833.2 [Q8IZA3-1]
XP_016861222.1, XM_017005733.1 [Q8IZA3-2]
UniGeneiHs.97358

3D structure databases

ProteinModelPortaliQ8IZA3
SMRiQ8IZA3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126315, 50 interactors
STRINGi9606.ENSP00000319799

PTM databases

iPTMnetiQ8IZA3
PhosphoSitePlusiQ8IZA3

Polymorphism and mutation databases

BioMutaiH1FOO
DMDMi74762503

Proteomic databases

EPDiQ8IZA3
PaxDbiQ8IZA3
PeptideAtlasiQ8IZA3
PRIDEiQ8IZA3
ProteomicsDBi71310
71311 [Q8IZA3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324382; ENSP00000319799; ENSG00000178804 [Q8IZA3-1]
ENST00000503977; ENSP00000422964; ENSG00000178804 [Q8IZA3-2]
GeneIDi132243
KEGGihsa:132243
UCSCiuc003emu.3 human [Q8IZA3-1]

Organism-specific databases

CTDi132243
EuPathDBiHostDB:ENSG00000178804.7
GeneCardsiH1FOO
HGNCiHGNC:18463 H1FOO
HPAiHPA037992
neXtProtiNX_Q8IZA3
PharmGKBiPA134958422
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00900000141023
HOGENOMiHOG000112841
HOVERGENiHBG096668
InParanoidiQ8IZA3
OMAiKEDPPNV
OrthoDBiEOG091G0LIU
PhylomeDBiQ8IZA3
TreeFamiTF333386

Miscellaneous databases

GeneWikiiH1FOO
GenomeRNAii132243
PROiPR:Q8IZA3

Gene expression databases

BgeeiENSG00000178804 Expressed in 31 organ(s), highest expression level in oocyte
CleanExiHS_H1FOO
GenevisibleiQ8IZA3 HS

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH1FOO_HUMAN
AccessioniPrimary (citable) accession number: Q8IZA3
Secondary accession number(s): Q86WT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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