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Entry version 127 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

CKLF-like MARVEL transmembrane domain-containing protein 1

Gene

CMTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZ96

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.64.5.5, the plasmolipin (plasmolipin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 1
Alternative name(s):
Chemokine-like factor superfamily member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMTM1
Synonyms:CKLFSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000089505.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19172, CMTM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607884, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ96

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113540

Open Targets

More...
OpenTargetsi
ENSG00000089505

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38811

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZ96, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CMTM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34921810

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001860971 – 169CKLF-like MARVEL transmembrane domain-containing protein 1Add BLAST169

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZ96

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ96

PeptideAtlas

More...
PeptideAtlasi
Q8IZ96

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ96

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71290 [Q8IZ96-1]
71291 [Q8IZ96-10]
71292 [Q8IZ96-11]
71293 [Q8IZ96-12]
71294 [Q8IZ96-13]
71295 [Q8IZ96-14]
71296 [Q8IZ96-15]
71297 [Q8IZ96-16]
71298 [Q8IZ96-17]
71299 [Q8IZ96-2]
71300 [Q8IZ96-3]
71301 [Q8IZ96-4]
71302 [Q8IZ96-5]
71303 [Q8IZ96-6]
71304 [Q8IZ96-7]
71305 [Q8IZ96-8]
71306 [Q8IZ96-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ96

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ96

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089505, Expressed in right testis and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ96, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ96, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000089505, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125251, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ96, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8IZ96

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368814

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZ96, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 135MARVELPROSITE-ProRule annotationAdd BLAST119

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4788, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_108546_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ96

Identification of Orthologs from Complete Genome Data

More...
OMAi
TILEACI

Database of Orthologous Groups

More...
OrthoDBi
1224540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ96

TreeFam database of animal gene trees

More...
TreeFami
TF338711

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008253, Marvel

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51225, MARVEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (17+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 17 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 17 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZ96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPEHAKPES SEAPSGNLKQ PETAAALSLI LGALACFIIT QANESFITIT
60 70 80 90 100
SLEICIVVFF ILIYVLTLHH LLTYLHWPLL DLTNSIITAV FLSVVAILAM
110 120 130 140 150
QEKKRRHLLY VGGSLCLTAV IVCCIDAFVV TTKMRTNLKR FLGVEVERKL
160
SPAKDAYPET GPDAPQRPA
Length:169
Mass (Da):18,576
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72F3C2E26D738E76
GO
Isoform 1a (identifier: Q8IZ96-2) [UniParc]FASTAAdd to basket
Also known as: 17

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR

Show »
Length:149
Mass (Da):16,656
Checksum:i49B9A541A50808A4
GO
Isoform 1b (identifier: Q8IZ96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR
     115-169: Missing.

Show »
Length:94
Mass (Da):10,640
Checksum:i191F4C3E3CAC7D90
GO
Isoform 2 (identifier: Q8IZ96-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: S → R
     115-169: Missing.

Show »
Length:114
Mass (Da):12,629
Checksum:iF50DA17544F24B18
GO
Isoform 3 (identifier: Q8IZ96-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-33: SLILGA → ASSGSV
     34-80: Missing.

Show »
Length:122
Mass (Da):13,037
Checksum:i3F2C56CEBC3F3146
GO
Isoform 4 (identifier: Q8IZ96-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.

Show »
Length:116
Mass (Da):12,549
Checksum:iF641CD1FB1E06E98
GO
Isoform 5 (identifier: Q8IZ96-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     114-114: S → R
     115-169: Missing.

Show »
Length:61
Mass (Da):6,602
Checksum:iFD45F64EAC5105D7
GO
Isoform 6 (identifier: Q8IZ96-8) [UniParc]FASTAAdd to basket
Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     28-92: SLILGALACF...TNSIITAVFL → ASSGSVVSSV...TVSLQLCSFQ
     93-169: Missing.

Show »
Length:92
Mass (Da):9,389
Checksum:i73AF83CE10165410
GO
Isoform 8 (identifier: Q8IZ96-9) [UniParc]FASTAAdd to basket
Also known as: 9

The sequence of this isoform differs from the canonical sequence as follows:
     81-91: DLTNSIITAVF → NAEYRKQTKQI
     92-169: Missing.

Show »
Length:91
Mass (Da):10,194
Checksum:i7124F06BA1F1E5A1
GO
Isoform 10 (identifier: Q8IZ96-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-65: SLILGALACF...IVVFFILIYV → ASSGSVVSSV...TGPDAPQRPA
     66-169: Missing.

Show »
Length:65
Mass (Da):6,669
Checksum:iFEC634E7970EA7DB
GO
Isoform 11 (identifier: Q8IZ96-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-33: SLILGA → EAYNSK
     34-169: Missing.

Show »
Length:33
Mass (Da):3,499
Checksum:i0AA27266266CA05B
GO
Isoform 12 (identifier: Q8IZ96-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-65: Missing.
     77-77: W → R
     81-103: DLTNSIITAVFLSVVAILAMQEK → AAELSLSHRMPSTGSRQSKYEQL
     104-169: Missing.

Show »
Length:45
Mass (Da):5,208
Checksum:iC680DB671BC002BB
GO
Isoform 13 (identifier: Q8IZ96-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-38: SLILGALACFI → EADKANMSNFN
     39-169: Missing.

Show »
Length:38
Mass (Da):4,028
Checksum:i60F335FBCEADCA15
GO
Isoform 14 (identifier: Q8IZ96-14) [UniParc]FASTAAdd to basket
Also known as: 15

The sequence of this isoform differs from the canonical sequence as follows:
     28-32: SLILG → LCSFQ
     33-169: Missing.

Show »
Length:32
Mass (Da):3,385
Checksum:i511FE8C500905B46
GO
Isoform 16 (identifier: Q8IZ96-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: S → R
     29-169: Missing.

Show »
Length:28
Mass (Da):2,962
Checksum:i43B05B463D202C28
GO
Isoform 19 (identifier: Q8IZ96-16) [UniParc]FASTAAdd to basket
Also known as: 20,21,22,23

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MDPEHAKPESSEAPSGNLKQPETAAA → MLKILR
     81-91: DLTNSIITAVF → NAEYRKQTKQI
     92-169: Missing.

Show »
Length:71
Mass (Da):8,274
Checksum:i8F60080E17B7AC10
GO
Isoform 24 (identifier: Q8IZ96-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: A → ALASSGSVVS...SPTGMLKILR

Show »
Length:286
Mass (Da):31,068
Checksum:i72C6D584CB10DEEC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PAX0E9PAX0_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIL3E9PIL3_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM1
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEC2H0YEC2_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTE4A0A0A0MTE4_HUMAN
CKLF-like MARVEL transmembrane doma...
CMTM1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05303910S → T. Corresponds to variant dbSNP:rs16956746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0082291 – 26MDPEH…ETAAA → MLKILR in isoform 1a, isoform 1b and isoform 19. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_0082308 – 65Missing in isoform 12. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_04357926A → ALASSGSVVSSVPKAQRNIS AKTAPRKHPAVSIRSAQSAA AARPQGSEGTAPSRKATTRP PPKPTLPPPTPSAHTESKLL NEMAIKERVEGRAKVPYKFR DSLKRFSFSPTGMLKILR in isoform 24. 1 Publication1
Alternative sequenceiVSP_00823828 – 92SLILG…TAVFL → ASSGSVVSSVPKAQRNISAK TAPRKHPAVSIRSAQSAAAA RPQGSEGTAPSRILPTVSLQ LCSFQ in isoform 6. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_00823728 – 80Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_00823628 – 65SLILG…ILIYV → ASSGSVVSSVPKAQRNISAK TAPRKHPETGPDAPQRPA in isoform 10. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_00823528 – 38SLILGALACFI → EADKANMSNFN in isoform 13. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_00823328 – 33SLILGA → EAYNSK in isoform 11. 1 Publication6
Alternative sequenceiVSP_00823428 – 33SLILGA → ASSGSV in isoform 3. 1 Publication6
Alternative sequenceiVSP_00823228 – 32SLILG → LCSFQ in isoform 14. 1 Publication5
Alternative sequenceiVSP_00823128S → R in isoform 16. 1 Publication1
Alternative sequenceiVSP_00823929 – 169Missing in isoform 16. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_00824033 – 169Missing in isoform 14. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_00824134 – 169Missing in isoform 11. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_00824234 – 80Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_00824339 – 169Missing in isoform 13. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_00824466 – 169Missing in isoform 10. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_00824577W → R in isoform 12. 1 Publication1
Alternative sequenceiVSP_00824681 – 103DLTNS…AMQEK → AAELSLSHRMPSTGSRQSKY EQL in isoform 12. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_00824781 – 91DLTNSIITAVF → NAEYRKQTKQI in isoform 8 and isoform 19. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_00824892 – 169Missing in isoform 8 and isoform 19. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_00824993 – 169Missing in isoform 6. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_008250104 – 169Missing in isoform 12. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_008251114S → R in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_008252115 – 169Missing in isoform 1b, isoform 2 and isoform 5. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF278576 mRNA Translation: AAK73015.1
AF278577 mRNA Translation: AAK73016.1
AY174118 mRNA Translation: AAN73227.1
AY174119 mRNA Translation: AAN73228.1
AY174120 mRNA Translation: AAN73229.1
AY174121 mRNA Translation: AAN73230.1
AY174122 mRNA Translation: AAN73231.1
AY174123 mRNA Translation: AAN73232.1
AY174124 mRNA Translation: AAN73233.1
AY174125 mRNA Translation: AAN73234.1
AY174126 mRNA Translation: AAN73235.1
AY174127 mRNA Translation: AAN73236.1
AY174128 mRNA Translation: AAN73237.1
AY174129 mRNA Translation: AAN73238.1
AY174130 mRNA Translation: AAN73239.1
AY174131 mRNA Translation: AAN73240.1
AY174132 mRNA Translation: AAN73241.1
AY174133 mRNA Translation: AAN73242.1
AY174134 mRNA Translation: AAN73243.1
AY174135 mRNA Translation: AAN73244.1
AY174136 mRNA Translation: AAN73245.1
AY174137 mRNA Translation: AAN73246.1
AY174138 mRNA Translation: AAN73247.1
DQ309766 mRNA Translation: ABC33727.2
AC010542 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83023.1
BC057852 mRNA Translation: AAH57852.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10810.1 [Q8IZ96-5]
CCDS10811.1 [Q8IZ96-6]
CCDS10812.2 [Q8IZ96-17]
CCDS45503.1 [Q8IZ96-1]
CCDS54019.1 [Q8IZ96-4]
CCDS54020.1 [Q8IZ96-7]
CCDS54021.1 [Q8IZ96-15]

NCBI Reference Sequences

More...
RefSeqi
NP_443725.3, NM_052999.3 [Q8IZ96-17]
NP_851785.2, NM_181268.2
NP_851786.1, NM_181269.2 [Q8IZ96-1]
NP_851787.1, NM_181270.2 [Q8IZ96-4]
NP_851788.1, NM_181271.2 [Q8IZ96-5]
NP_851789.1, NM_181272.2 [Q8IZ96-6]
NP_851800.1, NM_181283.2 [Q8IZ96-7]
NP_851813.1, NM_181296.2 [Q8IZ96-15]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332695; ENSP00000331428; ENSG00000089505 [Q8IZ96-5]
ENST00000333001; ENSP00000331494; ENSG00000089505 [Q8IZ96-9]
ENST00000336328; ENSP00000337119; ENSG00000089505 [Q8IZ96-6]
ENST00000379500; ENSP00000368814; ENSG00000089505 [Q8IZ96-17]
ENST00000457188; ENSP00000405729; ENSG00000089505 [Q8IZ96-1]
ENST00000528324; ENSP00000432398; ENSG00000089505 [Q8IZ96-4]
ENST00000528484; ENSP00000437079; ENSG00000089505 [Q8IZ96-13]
ENST00000529386; ENSP00000431303; ENSG00000089505 [Q8IZ96-13]
ENST00000531885; ENSP00000432687; ENSG00000089505 [Q8IZ96-7]
ENST00000533078; ENSP00000432387; ENSG00000089505 [Q8IZ96-14]
ENST00000533666; ENSP00000435020; ENSG00000089505 [Q8IZ96-15]
ENST00000533915; ENSP00000435755; ENSG00000089505 [Q8IZ96-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113540

UCSC genome browser

More...
UCSCi
uc002epa.5, human [Q8IZ96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278576 mRNA Translation: AAK73015.1
AF278577 mRNA Translation: AAK73016.1
AY174118 mRNA Translation: AAN73227.1
AY174119 mRNA Translation: AAN73228.1
AY174120 mRNA Translation: AAN73229.1
AY174121 mRNA Translation: AAN73230.1
AY174122 mRNA Translation: AAN73231.1
AY174123 mRNA Translation: AAN73232.1
AY174124 mRNA Translation: AAN73233.1
AY174125 mRNA Translation: AAN73234.1
AY174126 mRNA Translation: AAN73235.1
AY174127 mRNA Translation: AAN73236.1
AY174128 mRNA Translation: AAN73237.1
AY174129 mRNA Translation: AAN73238.1
AY174130 mRNA Translation: AAN73239.1
AY174131 mRNA Translation: AAN73240.1
AY174132 mRNA Translation: AAN73241.1
AY174133 mRNA Translation: AAN73242.1
AY174134 mRNA Translation: AAN73243.1
AY174135 mRNA Translation: AAN73244.1
AY174136 mRNA Translation: AAN73245.1
AY174137 mRNA Translation: AAN73246.1
AY174138 mRNA Translation: AAN73247.1
DQ309766 mRNA Translation: ABC33727.2
AC010542 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83023.1
BC057852 mRNA Translation: AAH57852.2
CCDSiCCDS10810.1 [Q8IZ96-5]
CCDS10811.1 [Q8IZ96-6]
CCDS10812.2 [Q8IZ96-17]
CCDS45503.1 [Q8IZ96-1]
CCDS54019.1 [Q8IZ96-4]
CCDS54020.1 [Q8IZ96-7]
CCDS54021.1 [Q8IZ96-15]
RefSeqiNP_443725.3, NM_052999.3 [Q8IZ96-17]
NP_851785.2, NM_181268.2
NP_851786.1, NM_181269.2 [Q8IZ96-1]
NP_851787.1, NM_181270.2 [Q8IZ96-4]
NP_851788.1, NM_181271.2 [Q8IZ96-5]
NP_851789.1, NM_181272.2 [Q8IZ96-6]
NP_851800.1, NM_181283.2 [Q8IZ96-7]
NP_851813.1, NM_181296.2 [Q8IZ96-15]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125251, 2 interactors
IntActiQ8IZ96, 1 interactor
MINTiQ8IZ96
STRINGi9606.ENSP00000368814

Protein family/group databases

TCDBi1.A.64.5.5, the plasmolipin (plasmolipin) family

PTM databases

iPTMnetiQ8IZ96
PhosphoSitePlusiQ8IZ96

Polymorphism and mutation databases

BioMutaiCMTM1
DMDMi34921810

Proteomic databases

MassIVEiQ8IZ96
PaxDbiQ8IZ96
PeptideAtlasiQ8IZ96
PRIDEiQ8IZ96
ProteomicsDBi71290 [Q8IZ96-1]
71291 [Q8IZ96-10]
71292 [Q8IZ96-11]
71293 [Q8IZ96-12]
71294 [Q8IZ96-13]
71295 [Q8IZ96-14]
71296 [Q8IZ96-15]
71297 [Q8IZ96-16]
71298 [Q8IZ96-17]
71299 [Q8IZ96-2]
71300 [Q8IZ96-3]
71301 [Q8IZ96-4]
71302 [Q8IZ96-5]
71303 [Q8IZ96-6]
71304 [Q8IZ96-7]
71305 [Q8IZ96-8]
71306 [Q8IZ96-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2985, 110 antibodies

Genome annotation databases

EnsembliENST00000332695; ENSP00000331428; ENSG00000089505 [Q8IZ96-5]
ENST00000333001; ENSP00000331494; ENSG00000089505 [Q8IZ96-9]
ENST00000336328; ENSP00000337119; ENSG00000089505 [Q8IZ96-6]
ENST00000379500; ENSP00000368814; ENSG00000089505 [Q8IZ96-17]
ENST00000457188; ENSP00000405729; ENSG00000089505 [Q8IZ96-1]
ENST00000528324; ENSP00000432398; ENSG00000089505 [Q8IZ96-4]
ENST00000528484; ENSP00000437079; ENSG00000089505 [Q8IZ96-13]
ENST00000529386; ENSP00000431303; ENSG00000089505 [Q8IZ96-13]
ENST00000531885; ENSP00000432687; ENSG00000089505 [Q8IZ96-7]
ENST00000533078; ENSP00000432387; ENSG00000089505 [Q8IZ96-14]
ENST00000533666; ENSP00000435020; ENSG00000089505 [Q8IZ96-15]
ENST00000533915; ENSP00000435755; ENSG00000089505 [Q8IZ96-9]
GeneIDi113540
KEGGihsa:113540
UCSCiuc002epa.5, human [Q8IZ96-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113540
DisGeNETi113540
EuPathDBiHostDB:ENSG00000089505.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CMTM1
HGNCiHGNC:19172, CMTM1
HPAiENSG00000089505, Tissue enriched (testis)
MIMi607884, gene
neXtProtiNX_Q8IZ96
OpenTargetsiENSG00000089505
PharmGKBiPA38811

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4788, Eukaryota
GeneTreeiENSGT00940000163203
HOGENOMiCLU_108546_5_0_1
InParanoidiQ8IZ96
OMAiTILEACI
OrthoDBi1224540at2759
PhylomeDBiQ8IZ96
TreeFamiTF338711

Enzyme and pathway databases

PathwayCommonsiQ8IZ96

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
113540, 4 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CMTM1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113540
PharosiQ8IZ96, Tbio

Protein Ontology

More...
PROi
PR:Q8IZ96
RNActiQ8IZ96, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089505, Expressed in right testis and 119 other tissues
ExpressionAtlasiQ8IZ96, baseline and differential
GenevisibleiQ8IZ96, HS

Family and domain databases

InterProiView protein in InterPro
IPR008253, Marvel
PROSITEiView protein in PROSITE
PS51225, MARVEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKLF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ96
Secondary accession number(s): Q2PPY5
, Q6PEV5, Q8IU76, Q8IU83, Q8IU86, Q8IU93, Q8IZ87, Q8IZ88, Q8IZ89, Q8IZ90, Q8IZ91, Q8IZ92, Q8IZ93, Q8IZ94, Q8IZ95, Q96JC2, Q96JC3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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