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Protein

Aldehyde dehydrogenase family 16 member A1

Gene

ALDH16A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 16 member A1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161618.9
HGNCiHGNC:28114 ALDH16A1
MIMi613358 gene
neXtProtiNX_Q8IZ83

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi126133
OpenTargetsiENSG00000161618
PharmGKBiPA134903503

Polymorphism and mutation databases

BioMutaiALDH16A1
DMDMi269849532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129861 – 802Aldehyde dehydrogenase family 16 member A1Add BLAST802

Proteomic databases

EPDiQ8IZ83
MaxQBiQ8IZ83
PaxDbiQ8IZ83
PeptideAtlasiQ8IZ83
PRIDEiQ8IZ83
ProteomicsDBi71287
71288 [Q8IZ83-2]
71289 [Q8IZ83-3]

PTM databases

iPTMnetiQ8IZ83
PhosphoSitePlusiQ8IZ83

Expressioni

Gene expression databases

BgeeiENSG00000161618 Expressed in 163 organ(s), highest expression level in spleen
CleanExiHS_ALDH16A1
ExpressionAtlasiQ8IZ83 baseline and differential
GenevisibleiQ8IZ83 HS

Organism-specific databases

HPAiHPA059488

Interactioni

Subunit structurei

Interacts with SPG21.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DERAQ9Y3154EBI-1044483,EBI-1048152

Protein-protein interaction databases

BioGridi125959, 22 interactors
IntActiQ8IZ83, 12 interactors
STRINGi9606.ENSP00000293350

Structurei

3D structure databases

ProteinModelPortaliQ8IZ83
SMRiQ8IZ83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00910000144187
HOGENOMiHOG000112558
HOVERGENiHBG069396
InParanoidiQ8IZ83
OMAiVPESHAC
OrthoDBiEOG091G01XG
PhylomeDBiQ8IZ83
TreeFamiTF329461

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 3 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR011408 Aldehyde_DH
IPR015590 Aldehyde_DH_dom
PANTHERiPTHR11699:SF98 PTHR11699:SF98, 2 hits
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF036490 Aldedh_dupl, 1 hit
SUPFAMiSSF53720 SSF53720, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8IZ83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK
60 70 80 90 100
PEHRNSVPCQ DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV
110 120 130 140 150
RAQHLTRLAE VIQKHQRLLW TLESLVTGRA VREVRDGDVQ LAQQLLHYHA
160 170 180 190 200
IQASTQEEAL AGWEPMGVIG LILPPTFSFL EMMWRICPAL AVGCTVVALV
210 220 230 240 250
PPASPAPLLL AQLAGELGPF PGILNVLSGP ASLVPILASQ PGIRKVAFCG
260 270 280 290 300
APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS
310 320 330 340 350
DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC
360 370 380 390 400
DLVQRFVREA QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP
410 420 430 440 450
WPVVVASPFR TAKEALLVAN GTPRGGSASV WSERLGQALE LGYGLQVGTV
460 470 480 490 500
WINAHGLRDP SVPTGGCKES GCSWHGGPDG LYEYLRPSGT PARLSCLSKN
510 520 530 540 550
LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG ARSSRPIRDS
560 570 580 590 600
SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE
610 620 630 640 650
RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL
660 670 680 690 700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP
710 720 730 740 750
LLALEVCQDM ATVFPAGLAN VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG
760 770 780 790 800
SQFVEWASAG NLKPVWASRG CPRAWDQEAE GAGPELGLRV ARTKALWLPM

GD
Length:802
Mass (Da):85,127
Last modified:November 24, 2009 - v2
Checksum:i2820628CD0EF5823
GO
Isoform 2 (identifier: Q8IZ83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-308: EGRALRRSLA...WSDRGPGGLR → VPSGQGSWRN...WRWGRSRCCC
     309-802: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):33,128
Checksum:i7D022E99C1ACAAA7
GO
Isoform 3 (identifier: Q8IZ83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-304: Missing.

Note: No experimental confirmation available.
Show »
Length:751
Mass (Da):79,918
Checksum:iAFE26F607346D768
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4B6F5H4B6_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
639Annotation score:
M0QY06M0QY06_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
163Annotation score:
M0QYY1M0QYY1_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
103Annotation score:

Sequence cautioni

The sequence AAH35641 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84962 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037638110E → K. Corresponds to variant dbSNP:rs3745312Ensembl.1
Natural variantiVAR_037639227L → V2 PublicationsCorresponds to variant dbSNP:rs1320303Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029982254 – 308EGRAL…PGGLR → VPSGQGSWRNAAGGRKAPPA AELGGVPRKGVPFDGAWRES VRSWAWRWGRSRCCC in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_043280254 – 304Missing in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_029983309 – 802Missing in isoform 2. 1 PublicationAdd BLAST494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074136 mRNA Translation: BAB84962.1 Sequence problems.
AK297101 mRNA Translation: BAG59613.1
AC010619 Genomic DNA No translation available.
BC014895 mRNA Translation: AAH14895.2
BC035641 mRNA Translation: AAH35641.1 Different initiation.
BC042142 mRNA Translation: AAH42142.1
CCDSiCCDS12766.1 [Q8IZ83-1]
CCDS46141.1 [Q8IZ83-3]
RefSeqiNP_001138868.1, NM_001145396.1 [Q8IZ83-3]
NP_699160.2, NM_153329.3 [Q8IZ83-1]
UniGeneiHs.719998

Genome annotation databases

EnsembliENST00000293350; ENSP00000293350; ENSG00000161618 [Q8IZ83-1]
ENST00000455361; ENSP00000410142; ENSG00000161618 [Q8IZ83-3]
GeneIDi126133
KEGGihsa:126133
UCSCiuc002pnt.4 human [Q8IZ83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiA16A1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ83
Secondary accession number(s): B4DLQ1
, C9JBH6, Q86YF0, Q8IYL4, Q8TEI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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