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Protein

Aldehyde dehydrogenase family 16 member A1

Gene

ALDH16A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldehyde dehydrogenase family 16 member A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000161618.9

Human Gene Nomenclature Database

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HGNCi
HGNC:28114 ALDH16A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613358 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ83

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
126133

Open Targets

More...
OpenTargetsi
ENSG00000161618

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134903503

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALDH16A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849532

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129861 – 802Aldehyde dehydrogenase family 16 member A1Add BLAST802

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IZ83

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZ83

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ83

PeptideAtlas

More...
PeptideAtlasi
Q8IZ83

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ83

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71287
71288 [Q8IZ83-2]
71289 [Q8IZ83-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ83

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161618 Expressed in 163 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

More...
CleanExi
HS_ALDH16A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ83 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ83 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059488

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SPG21.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DERAQ9Y3154EBI-1044483,EBI-1048152

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125959, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ83, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000293350

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IZ83

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZ83

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2450 Eukaryota
COG1012 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112558

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069396

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ83

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDYGPAP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01XG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ83

TreeFam database of animal gene trees

More...
TreeFami
TF329461

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR011408 Aldehyde_DH
IPR015590 Aldehyde_DH_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11699:SF98 PTHR11699:SF98, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171 Aldedh, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036490 Aldedh_dupl, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53720 SSF53720, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZ83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK
60 70 80 90 100
PEHRNSVPCQ DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV
110 120 130 140 150
RAQHLTRLAE VIQKHQRLLW TLESLVTGRA VREVRDGDVQ LAQQLLHYHA
160 170 180 190 200
IQASTQEEAL AGWEPMGVIG LILPPTFSFL EMMWRICPAL AVGCTVVALV
210 220 230 240 250
PPASPAPLLL AQLAGELGPF PGILNVLSGP ASLVPILASQ PGIRKVAFCG
260 270 280 290 300
APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS
310 320 330 340 350
DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC
360 370 380 390 400
DLVQRFVREA QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP
410 420 430 440 450
WPVVVASPFR TAKEALLVAN GTPRGGSASV WSERLGQALE LGYGLQVGTV
460 470 480 490 500
WINAHGLRDP SVPTGGCKES GCSWHGGPDG LYEYLRPSGT PARLSCLSKN
510 520 530 540 550
LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG ARSSRPIRDS
560 570 580 590 600
SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE
610 620 630 640 650
RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL
660 670 680 690 700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP
710 720 730 740 750
LLALEVCQDM ATVFPAGLAN VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG
760 770 780 790 800
SQFVEWASAG NLKPVWASRG CPRAWDQEAE GAGPELGLRV ARTKALWLPM

GD
Length:802
Mass (Da):85,127
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2820628CD0EF5823
GO
Isoform 2 (identifier: Q8IZ83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-308: EGRALRRSLA...WSDRGPGGLR → VPSGQGSWRN...WRWGRSRCCC
     309-802: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):33,128
Checksum:i7D022E99C1ACAAA7
GO
Isoform 3 (identifier: Q8IZ83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-304: Missing.

Note: No experimental confirmation available.
Show »
Length:751
Mass (Da):79,918
Checksum:iAFE26F607346D768
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H4B6F5H4B6_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY06M0QY06_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYY1M0QYY1_HUMAN
Aldehyde dehydrogenase family 16 me...
ALDH16A1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35641 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84962 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037638110E → K. Corresponds to variant dbSNP:rs3745312Ensembl.1
Natural variantiVAR_037639227L → V2 PublicationsCorresponds to variant dbSNP:rs1320303Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029982254 – 308EGRAL…PGGLR → VPSGQGSWRNAAGGRKAPPA AELGGVPRKGVPFDGAWRES VRSWAWRWGRSRCCC in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_043280254 – 304Missing in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_029983309 – 802Missing in isoform 2. 1 PublicationAdd BLAST494

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074136 mRNA Translation: BAB84962.1 Sequence problems.
AK297101 mRNA Translation: BAG59613.1
AC010619 Genomic DNA No translation available.
BC014895 mRNA Translation: AAH14895.2
BC035641 mRNA Translation: AAH35641.1 Different initiation.
BC042142 mRNA Translation: AAH42142.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12766.1 [Q8IZ83-1]
CCDS46141.1 [Q8IZ83-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001138868.1, NM_001145396.1 [Q8IZ83-3]
NP_699160.2, NM_153329.3 [Q8IZ83-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.719998

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293350; ENSP00000293350; ENSG00000161618 [Q8IZ83-1]
ENST00000455361; ENSP00000410142; ENSG00000161618 [Q8IZ83-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
126133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126133

UCSC genome browser

More...
UCSCi
uc002pnt.4 human [Q8IZ83-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074136 mRNA Translation: BAB84962.1 Sequence problems.
AK297101 mRNA Translation: BAG59613.1
AC010619 Genomic DNA No translation available.
BC014895 mRNA Translation: AAH14895.2
BC035641 mRNA Translation: AAH35641.1 Different initiation.
BC042142 mRNA Translation: AAH42142.1
CCDSiCCDS12766.1 [Q8IZ83-1]
CCDS46141.1 [Q8IZ83-3]
RefSeqiNP_001138868.1, NM_001145396.1 [Q8IZ83-3]
NP_699160.2, NM_153329.3 [Q8IZ83-1]
UniGeneiHs.719998

3D structure databases

ProteinModelPortaliQ8IZ83
SMRiQ8IZ83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125959, 22 interactors
IntActiQ8IZ83, 12 interactors
STRINGi9606.ENSP00000293350

PTM databases

iPTMnetiQ8IZ83
PhosphoSitePlusiQ8IZ83

Polymorphism and mutation databases

BioMutaiALDH16A1
DMDMi269849532

Proteomic databases

EPDiQ8IZ83
MaxQBiQ8IZ83
PaxDbiQ8IZ83
PeptideAtlasiQ8IZ83
PRIDEiQ8IZ83
ProteomicsDBi71287
71288 [Q8IZ83-2]
71289 [Q8IZ83-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293350; ENSP00000293350; ENSG00000161618 [Q8IZ83-1]
ENST00000455361; ENSP00000410142; ENSG00000161618 [Q8IZ83-3]
GeneIDi126133
KEGGihsa:126133
UCSCiuc002pnt.4 human [Q8IZ83-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126133
DisGeNETi126133
EuPathDBiHostDB:ENSG00000161618.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ALDH16A1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202728
HGNCiHGNC:28114 ALDH16A1
HPAiHPA059488
MIMi613358 gene
neXtProtiNX_Q8IZ83
OpenTargetsiENSG00000161618
PharmGKBiPA134903503

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00940000161135
HOGENOMiHOG000112558
HOVERGENiHBG069396
InParanoidiQ8IZ83
OMAiMDYGPAP
OrthoDBiEOG091G01XG
PhylomeDBiQ8IZ83
TreeFamiTF329461

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ALDH16A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126133

Protein Ontology

More...
PROi
PR:Q8IZ83

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161618 Expressed in 163 organ(s), highest expression level in spleen
CleanExiHS_ALDH16A1
ExpressionAtlasiQ8IZ83 baseline and differential
GenevisibleiQ8IZ83 HS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR011408 Aldehyde_DH
IPR015590 Aldehyde_DH_dom
PANTHERiPTHR11699:SF98 PTHR11699:SF98, 2 hits
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF036490 Aldedh_dupl, 1 hit
SUPFAMiSSF53720 SSF53720, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA16A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ83
Secondary accession number(s): B4DLQ1
, C9JBH6, Q86YF0, Q8IYL4, Q8TEI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: December 5, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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