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Entry version 112 (18 Sep 2019)
Sequence version 1 (01 Mar 2003)
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Protein

ELMO domain-containing protein 2

Gene

ELMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processAntiviral defense

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ELMO domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELMOD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28111 ELMOD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610196 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
255520

Open Targets

More...
OpenTargetsi
ENSG00000179387

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134984145

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ELMOD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728441

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002250171 – 293ELMO domain-containing protein 2Add BLAST293

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZ81

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZ81

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZ81

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZ81

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ81

PeptideAtlas

More...
PeptideAtlasi
Q8IZ81

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ81

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71286

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ81

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IZ81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179387 Expressed in 209 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ81 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ81 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047600

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129109, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ81, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8IZ81

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326342

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZ81

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 282ELMOPROSITE-ProRule annotationAdd BLAST157

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2998 Eukaryota
ENOG410XRXC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007810

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ81

KEGG Orthology (KO)

More...
KOi
K23538

Identification of Orthologs from Complete Genome Data

More...
OMAi
LSHSNHP

Database of Orthologous Groups

More...
OrthoDBi
1282549at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ81

TreeFam database of animal gene trees

More...
TreeFami
TF323472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006816 ELMO_dom
IPR030724 ELMOD2

The PANTHER Classification System

More...
PANTHERi
PTHR12771:SF47 PTHR12771:SF47, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04727 ELMO_CED12, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51335 ELMO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IZ81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS
60 70 80 90 100
LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL
110 120 130 140 150
QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK
160 170 180 190 200
QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL
210 220 230 240 250
GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY
260 270 280 290
EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV
Length:293
Mass (Da):34,961
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i339CD216FC46ADD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBS5D6RBS5_HUMAN
ELMO domain-containing protein 2
ELMOD2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHX2D6RHX2_HUMAN
ELMO domain-containing protein 2
ELMOD2
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY58V9GY58_HUMAN
ELMO domain-containing protein 2
ELMOD2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJB5D6RJB5_HUMAN
ELMO domain-containing protein 2
ELMOD2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK312800 mRNA Translation: BAG35659.1
CH471056 Genomic DNA Translation: EAX05096.1
CH471056 Genomic DNA Translation: EAX05097.1
BC015168 mRNA Translation: AAH15168.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3752.1

NCBI Reference Sequences

More...
RefSeqi
NP_714913.1, NM_153702.3
XP_005262943.1, XM_005262886.2
XP_011530121.1, XM_011531819.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323570; ENSP00000326342; ENSG00000179387

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
255520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:255520

UCSC genome browser

More...
UCSCi
uc003iik.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312800 mRNA Translation: BAG35659.1
CH471056 Genomic DNA Translation: EAX05096.1
CH471056 Genomic DNA Translation: EAX05097.1
BC015168 mRNA Translation: AAH15168.2
CCDSiCCDS3752.1
RefSeqiNP_714913.1, NM_153702.3
XP_005262943.1, XM_005262886.2
XP_011530121.1, XM_011531819.2

3D structure databases

SMRiQ8IZ81
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129109, 3 interactors
IntActiQ8IZ81, 3 interactors
MINTiQ8IZ81
STRINGi9606.ENSP00000326342

PTM databases

iPTMnetiQ8IZ81
PhosphoSitePlusiQ8IZ81
SwissPalmiQ8IZ81

Polymorphism and mutation databases

BioMutaiELMOD2
DMDMi74728441

Proteomic databases

EPDiQ8IZ81
jPOSTiQ8IZ81
MassIVEiQ8IZ81
MaxQBiQ8IZ81
PaxDbiQ8IZ81
PeptideAtlasiQ8IZ81
PRIDEiQ8IZ81
ProteomicsDBi71286

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323570; ENSP00000326342; ENSG00000179387
GeneIDi255520
KEGGihsa:255520
UCSCiuc003iik.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
255520
DisGeNETi255520

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ELMOD2
HGNCiHGNC:28111 ELMOD2
HPAiHPA047600
MIMi610196 gene
neXtProtiNX_Q8IZ81
OpenTargetsiENSG00000179387
PharmGKBiPA134984145

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2998 Eukaryota
ENOG410XRXC LUCA
GeneTreeiENSGT00940000156589
HOGENOMiHOG000007810
InParanoidiQ8IZ81
KOiK23538
OMAiLSHSNHP
OrthoDBi1282549at2759
PhylomeDBiQ8IZ81
TreeFamiTF323472

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ELMOD2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
255520

Pharos

More...
Pharosi
Q8IZ81

Protein Ontology

More...
PROi
PR:Q8IZ81

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179387 Expressed in 209 organ(s), highest expression level in heart
ExpressionAtlasiQ8IZ81 baseline and differential
GenevisibleiQ8IZ81 HS

Family and domain databases

InterProiView protein in InterPro
IPR006816 ELMO_dom
IPR030724 ELMOD2
PANTHERiPTHR12771:SF47 PTHR12771:SF47, 1 hit
PfamiView protein in Pfam
PF04727 ELMO_CED12, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELMD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ81
Secondary accession number(s): B2R712, D3DNZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: September 18, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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