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Protein

tRNA (uracil-5-)-methyltransferase homolog A

Gene

TRMT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in nucleic acid metabolism and/or modifications.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei411S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei461S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei510S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei538NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (uracil-5-)-methyltransferase homolog A (EC:2.1.1.-)
Alternative name(s):
HpaII tiny fragments locus 9c protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT2A
Synonyms:HTF9C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000099899.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24974 TRMT2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611151 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ69

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27037

Open Targets

More...
OpenTargetsi
ENSG00000099899

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164726751

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRMT2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816141 – 625tRNA (uracil-5-)-methyltransferase homolog AAdd BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei378PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IZ69

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZ69

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZ69

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ69

PeptideAtlas

More...
PeptideAtlasi
Q8IZ69

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ69

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71283
71284 [Q8IZ69-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099899 Expressed in 174 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRMT2A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ69 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ69 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001077

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117968, 60 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ69, 31 interactors

Molecular INTeraction database

More...
MINTi
Q8IZ69

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252136

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IZ69

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IZ69

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 146RRMPROSITE-ProRule annotationAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili180 – 209Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi153 – 156Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2187 Eukaryota
COG2265 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063723

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232103

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052043

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IZ69

KEGG Orthology (KO)

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KOi
K15332

Database of Orthologous Groups

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OrthoDBi
248059at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ69

TreeFam database of animal gene trees

More...
TreeFami
TF314569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12439 RRM_TRMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR029063 SAM-dependent_MTases
IPR034262 TRMT2A_RRM
IPR010280 U5_MeTrfase_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11061 PTHR11061, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53335 SSF53335, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS51687 SAM_MT_RNA_M5U, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZ69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA
60 70 80 90 100
TGPGPQPGLY SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP
110 120 130 140 150
HKTKLFGQPP CAFVTFRSAA ERDKALRVLH GALWKGRPLS VRLARPKADP
160 170 180 190 200
MARRRRQEGE SEPPVTRVAD VVTPLWTVPY AEQLERKQLE CEQVLQKLAK
210 220 230 240 250
EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR NKCEFLVGVG
260 270 280 290 300
VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP
310 320 330 340 350
YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA
360 370 380 390 400
QHFTAGPGRA SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL
410 420 430 440 450
TFRISPHAFF QVNTPAAEVL YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL
460 470 480 490 500
ARKVKRVIGV ELCPEAVEDA RVNAQDNELS NVEFHCGRAE DLVPTLVSRL
510 520 530 540 550
ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP RAAMGNFVDL
560 570 580 590 600
CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP
610 620
HSPPAQPTPG PPDNTLQETG TFPSS
Length:625
Mass (Da):68,726
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D310E521D846E06
GO
Isoform 2 (identifier: Q8IZ69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-562: LCRAPSNRVKGIP → APLFPPQPLQSPI
     563-625: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):61,979
Checksum:iF0D87D27746DE1DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2W7F2Z2W7_HUMAN
tRNA (uracil-5-)-methyltransferase ...
TRMT2A
643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C100H7C100_HUMAN
tRNA (uracil-5-)-methyltransferase ...
TRMT2A
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K041C9K041_HUMAN
tRNA (uracil-5-)-methyltransferase ...
TRMT2A
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZZ4H7BZZ4_HUMAN
tRNA (uracil-5-)-methyltransferase ...
TRMT2A
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498S → G in BAB71349 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033721602S → R. Corresponds to variant dbSNP:rs447017Ensembl.1
Natural variantiVAR_035482604P → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011322550 – 562LCRAP…VKGIP → APLFPPQPLQSPI in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_011323563 – 625Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456354 mRNA Translation: CAG30240.1
AK025106 mRNA Translation: BAB15067.1
AK057029 mRNA Translation: BAB71349.1
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02996.1
CH471176 Genomic DNA Translation: EAX02997.1
BC013352 mRNA Translation: AAH13352.2
BC017184 mRNA Translation: AAH17184.2
BC108251 mRNA Translation: AAI08252.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13774.1 [Q8IZ69-1]
CCDS58793.1 [Q8IZ69-2]

NCBI Reference Sequences

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RefSeqi
NP_001244923.1, NM_001257994.1 [Q8IZ69-2]
NP_073564.3, NM_022727.5 [Q8IZ69-1]
NP_892029.2, NM_182984.4 [Q8IZ69-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.713579

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252136; ENSP00000252136; ENSG00000099899 [Q8IZ69-1]
ENST00000403707; ENSP00000385807; ENSG00000099899 [Q8IZ69-1]
ENST00000404751; ENSP00000384968; ENSG00000099899 [Q8IZ69-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27037

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27037

UCSC genome browser

More...
UCSCi
uc002zrk.3 human [Q8IZ69-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456354 mRNA Translation: CAG30240.1
AK025106 mRNA Translation: BAB15067.1
AK057029 mRNA Translation: BAB71349.1
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02996.1
CH471176 Genomic DNA Translation: EAX02997.1
BC013352 mRNA Translation: AAH13352.2
BC017184 mRNA Translation: AAH17184.2
BC108251 mRNA Translation: AAI08252.1
CCDSiCCDS13774.1 [Q8IZ69-1]
CCDS58793.1 [Q8IZ69-2]
RefSeqiNP_001244923.1, NM_001257994.1 [Q8IZ69-2]
NP_073564.3, NM_022727.5 [Q8IZ69-1]
NP_892029.2, NM_182984.4 [Q8IZ69-1]
UniGeneiHs.713579

3D structure databases

ProteinModelPortaliQ8IZ69
SMRiQ8IZ69
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117968, 60 interactors
IntActiQ8IZ69, 31 interactors
MINTiQ8IZ69
STRINGi9606.ENSP00000252136

PTM databases

iPTMnetiQ8IZ69
PhosphoSitePlusiQ8IZ69

Polymorphism and mutation databases

BioMutaiTRMT2A
DMDMi51316479

Proteomic databases

EPDiQ8IZ69
jPOSTiQ8IZ69
MaxQBiQ8IZ69
PaxDbiQ8IZ69
PeptideAtlasiQ8IZ69
PRIDEiQ8IZ69
ProteomicsDBi71283
71284 [Q8IZ69-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27037
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252136; ENSP00000252136; ENSG00000099899 [Q8IZ69-1]
ENST00000403707; ENSP00000385807; ENSG00000099899 [Q8IZ69-1]
ENST00000404751; ENSP00000384968; ENSG00000099899 [Q8IZ69-2]
GeneIDi27037
KEGGihsa:27037
UCSCiuc002zrk.3 human [Q8IZ69-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27037
DisGeNETi27037
EuPathDBiHostDB:ENSG00000099899.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TRMT2A
HGNCiHGNC:24974 TRMT2A
HPAiHPA001077
MIMi611151 gene
neXtProtiNX_Q8IZ69
OpenTargetsiENSG00000099899
PharmGKBiPA164726751

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2187 Eukaryota
COG2265 LUCA
GeneTreeiENSGT00530000063723
HOGENOMiHOG000232103
HOVERGENiHBG052043
InParanoidiQ8IZ69
KOiK15332
OrthoDBi248059at2759
PhylomeDBiQ8IZ69
TreeFamiTF314569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRMT2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27037

Protein Ontology

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PROi
PR:Q8IZ69

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000099899 Expressed in 174 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_TRMT2A
ExpressionAtlasiQ8IZ69 baseline and differential
GenevisibleiQ8IZ69 HS

Family and domain databases

CDDicd12439 RRM_TRMT2A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR029063 SAM-dependent_MTases
IPR034262 TRMT2A_RRM
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS51687 SAM_MT_RNA_M5U, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRM2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ69
Secondary accession number(s): D3DX25
, Q32P57, Q96ME6, Q9H732
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2004
Last modified: January 16, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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