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Protein

tRNA (uracil-5-)-methyltransferase homolog A

Gene

TRMT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in nucleic acid metabolism and/or modifications.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei411S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei461S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei510S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei538NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (uracil-5-)-methyltransferase homolog A (EC:2.1.1.-)
Alternative name(s):
HpaII tiny fragments locus 9c protein
Gene namesi
Name:TRMT2A
Synonyms:HTF9C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099899.14
HGNCiHGNC:24974 TRMT2A
MIMi611151 gene
neXtProtiNX_Q8IZ69

Pathology & Biotechi

Organism-specific databases

DisGeNETi27037
OpenTargetsiENSG00000099899
PharmGKBiPA164726751

Polymorphism and mutation databases

BioMutaiTRMT2A
DMDMi51316479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816141 – 625tRNA (uracil-5-)-methyltransferase homolog AAdd BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei378PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZ69
MaxQBiQ8IZ69
PaxDbiQ8IZ69
PeptideAtlasiQ8IZ69
PRIDEiQ8IZ69
ProteomicsDBi71283
71284 [Q8IZ69-2]

PTM databases

iPTMnetiQ8IZ69
PhosphoSitePlusiQ8IZ69

Expressioni

Gene expression databases

BgeeiENSG00000099899
CleanExiHS_TRMT2A
ExpressionAtlasiQ8IZ69 baseline and differential
GenevisibleiQ8IZ69 HS

Organism-specific databases

HPAiHPA001077

Interactioni

Protein-protein interaction databases

BioGridi117968, 60 interactors
IntActiQ8IZ69, 30 interactors
MINTiQ8IZ69
STRINGi9606.ENSP00000252136

Structurei

3D structure databases

ProteinModelPortaliQ8IZ69
SMRiQ8IZ69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 146RRMPROSITE-ProRule annotationAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 209Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi153 – 156Poly-Arg4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2187 Eukaryota
COG2265 LUCA
GeneTreeiENSGT00530000063723
HOGENOMiHOG000232103
HOVERGENiHBG052043
InParanoidiQ8IZ69
KOiK15332
PhylomeDBiQ8IZ69
TreeFamiTF314569

Family and domain databases

CDDicd12439 RRM_TRMT2A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR029063 SAM-dependent_MTases
IPR034262 TRMT2A_RRM
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS51687 SAM_MT_RNA_M5U, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZ69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA
60 70 80 90 100
TGPGPQPGLY SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP
110 120 130 140 150
HKTKLFGQPP CAFVTFRSAA ERDKALRVLH GALWKGRPLS VRLARPKADP
160 170 180 190 200
MARRRRQEGE SEPPVTRVAD VVTPLWTVPY AEQLERKQLE CEQVLQKLAK
210 220 230 240 250
EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR NKCEFLVGVG
260 270 280 290 300
VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP
310 320 330 340 350
YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA
360 370 380 390 400
QHFTAGPGRA SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL
410 420 430 440 450
TFRISPHAFF QVNTPAAEVL YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL
460 470 480 490 500
ARKVKRVIGV ELCPEAVEDA RVNAQDNELS NVEFHCGRAE DLVPTLVSRL
510 520 530 540 550
ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP RAAMGNFVDL
560 570 580 590 600
CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP
610 620
HSPPAQPTPG PPDNTLQETG TFPSS
Length:625
Mass (Da):68,726
Last modified:March 1, 2004 - v2
Checksum:i2D310E521D846E06
GO
Isoform 2 (identifier: Q8IZ69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-562: LCRAPSNRVKGIP → APLFPPQPLQSPI
     563-625: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):61,979
Checksum:iF0D87D27746DE1DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti498S → G in BAB71349 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033721602S → R. Corresponds to variant dbSNP:rs447017Ensembl.1
Natural variantiVAR_035482604P → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011322550 – 562LCRAP…VKGIP → APLFPPQPLQSPI in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_011323563 – 625Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456354 mRNA Translation: CAG30240.1
AK025106 mRNA Translation: BAB15067.1
AK057029 mRNA Translation: BAB71349.1
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02996.1
CH471176 Genomic DNA Translation: EAX02997.1
BC013352 mRNA Translation: AAH13352.2
BC017184 mRNA Translation: AAH17184.2
BC108251 mRNA Translation: AAI08252.1
CCDSiCCDS13774.1 [Q8IZ69-1]
CCDS58793.1 [Q8IZ69-2]
RefSeqiNP_001244923.1, NM_001257994.1 [Q8IZ69-2]
NP_073564.3, NM_022727.5 [Q8IZ69-1]
NP_892029.2, NM_182984.4 [Q8IZ69-1]
UniGeneiHs.713579

Genome annotation databases

EnsembliENST00000252136; ENSP00000252136; ENSG00000099899 [Q8IZ69-1]
ENST00000403707; ENSP00000385807; ENSG00000099899 [Q8IZ69-1]
ENST00000404751; ENSP00000384968; ENSG00000099899 [Q8IZ69-2]
GeneIDi27037
KEGGihsa:27037
UCSCiuc002zrk.3 human [Q8IZ69-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRM2A_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ69
Secondary accession number(s): D3DX25
, Q32P57, Q96ME6, Q9H732
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2004
Last modified: July 18, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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