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Entry version 107 (10 Feb 2021)
Sequence version 2 (13 Jun 2012)
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Protein

Proline-rich protein 22

Gene

PRR22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZ63

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRR22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28354, PRR22

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ63

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000212123.3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000212123

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394215

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZ63, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRR22

Domain mapping of disease mutations (DMDM)

More...
DMDMi
391358151

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321651 – 422Proline-rich protein 22Add BLAST422

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZ63

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IZ63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ63

PeptideAtlas

More...
PeptideAtlasi
Q8IZ63

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ63

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71281

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000212123, Expressed in right testis and 107 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ63, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ63, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000212123, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127854, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ63, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000407653

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZ63, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZ63

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 248Pro-richAdd BLAST145

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SI56, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016128

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053707_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ63

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFNFKAL

Database of Orthologous Groups

More...
OrthoDBi
1583493at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ63

TreeFam database of animal gene trees

More...
TreeFami
TF350682

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031535, PRR22

The PANTHER Classification System

More...
PANTHERi
PTHR37871, PTHR37871, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15776, PRR22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IZ63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHPKPFCAP AAPQEGFSPQ SLEGAEVLGN QPAPTCAEPP PAMGSLNLYH
60 70 80 90 100
PPDPEKEVFP APPAGFQMAP CGCFFDPRIY RIEWTTPDLG QSALYKLAAS
110 120 130 140 150
SGGPAGVPSA PGSYLLEPQP YLKAPGLPPY PHYQQAPGGP QFLLPYFPPE
160 170 180 190 200
GPGPEALGFV GDAGPAAFVE LPLPPLEEGP APLPPPPPKE NKPPPVLITL
210 220 230 240 250
PAEPTLPPDA YSHLQGHLGH FPGPEPLAFP VKELQGSGAR PGVPLYPPGL
260 270 280 290 300
SELKVAEVKE GALLGAGKAK APKTARALAL PDKVLLEDAM KLFDCLPGAS
310 320 330 340 350
EPEGTLCEVP GPALPDSSGG NSADDIRSLC LPEELLSFDY SVPEILDTVS
360 370 380 390 400
NVDYFFNFKA LDEEQPPHPG PPATNTPAPI LSGKRKASTA KKGKPGRKAR
410 420
QPAGPASATP PGPREDLGAT PH
Length:422
Mass (Da):43,980
Last modified:June 13, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48169A0A2ABC7F85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJN8K7EJN8_HUMAN
Proline-rich protein 22
PRR22
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08985 differs from that shown. Probable cloning artifact.Curated
The sequence AAH23278 differs from that shown. Probable cloning artifact.Curated
The sequence EAW69147 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120P → L in BQ082540 (PubMed:15146197).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042962118P → L. Corresponds to variant dbSNP:rs3745640Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011499 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69147.1 Sequence problems.
BC008985 mRNA Translation: AAH08985.1 Sequence problems.
BC023278 mRNA Translation: AAH23278.1 Sequence problems.
CN370733 mRNA No translation available.
BQ082540 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45933.1

NCBI Reference Sequences

More...
RefSeqi
NP_001127788.1, NM_001134316.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000419421; ENSP00000407653; ENSG00000212123

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
163154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163154

UCSC genome browser

More...
UCSCi
uc010xiv.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011499 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69147.1 Sequence problems.
BC008985 mRNA Translation: AAH08985.1 Sequence problems.
BC023278 mRNA Translation: AAH23278.1 Sequence problems.
CN370733 mRNA No translation available.
BQ082540 mRNA No translation available.
CCDSiCCDS45933.1
RefSeqiNP_001127788.1, NM_001134316.1

3D structure databases

SMRiQ8IZ63
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127854, 26 interactors
IntActiQ8IZ63, 4 interactors
STRINGi9606.ENSP00000407653

PTM databases

PhosphoSitePlusiQ8IZ63

Genetic variation databases

BioMutaiPRR22
DMDMi391358151

Proteomic databases

jPOSTiQ8IZ63
MassIVEiQ8IZ63
PaxDbiQ8IZ63
PeptideAtlasiQ8IZ63
PRIDEiQ8IZ63
ProteomicsDBi71281

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49704, 49 antibodies

The DNASU plasmid repository

More...
DNASUi
163154

Genome annotation databases

EnsembliENST00000419421; ENSP00000407653; ENSG00000212123
GeneIDi163154
KEGGihsa:163154
UCSCiuc010xiv.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
163154

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRR22
HGNCiHGNC:28354, PRR22
HPAiENSG00000212123, Tissue enriched (testis)
neXtProtiNX_Q8IZ63
OpenTargetsiENSG00000212123
PharmGKBiPA165394215
VEuPathDBiHostDB:ENSG00000212123.3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SI56, Eukaryota
GeneTreeiENSGT00390000016128
HOGENOMiCLU_053707_0_0_1
InParanoidiQ8IZ63
OMAiFFNFKAL
OrthoDBi1583493at2759
PhylomeDBiQ8IZ63
TreeFamiTF350682

Enzyme and pathway databases

PathwayCommonsiQ8IZ63

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
163154, 28 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
163154
PharosiQ8IZ63, Tdark

Protein Ontology

More...
PROi
PR:Q8IZ63
RNActiQ8IZ63, protein

Gene expression databases

BgeeiENSG00000212123, Expressed in right testis and 107 other tissues
ExpressionAtlasiQ8IZ63, baseline and differential
GenevisibleiQ8IZ63, HS

Family and domain databases

InterProiView protein in InterPro
IPR031535, PRR22
PANTHERiPTHR37871, PTHR37871, 1 hit
PfamiView protein in Pfam
PF15776, PRR22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRR22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ63
Secondary accession number(s): E9PB31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 13, 2012
Last modified: February 10, 2021
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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