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Protein

Neurensin-1

Gene

NRSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).By similarity1 Publication

GO - Biological processi

Protein family/group databases

TCDBi9.B.189.1.1 the vesicular membrane neurensin (neurensin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-1
Alternative name(s):
Neuro-p24
Vesicular membrane protein of 24 kDa
Short name:
Vesicular membrane protein p24
Gene namesi
Name:NRSN1Imported
Synonyms:VMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000152954.11
HGNCiHGNC:17881 NRSN1
MIMi616630 gene
neXtProtiNX_Q8IZ57

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140767
OpenTargetsiENSG00000152954
PharmGKBiPA38254

Polymorphism and mutation databases

BioMutaiNRSN1
DMDMi74750784

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705831 – 195Neurensin-1Add BLAST195

Proteomic databases

PaxDbiQ8IZ57
PeptideAtlasiQ8IZ57
PRIDEiQ8IZ57
ProteomicsDBi71280

PTM databases

PhosphoSitePlusiQ8IZ57

Expressioni

Tissue specificityi

Expressed in brain. Not detectable in other tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000152954 Expressed in 103 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_NRSN1
ExpressionAtlasiQ8IZ57 baseline and differential
GenevisibleiQ8IZ57 HS

Organism-specific databases

HPAiHPA061006

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10264528,EBI-743099

Protein-protein interaction databases

BioGridi126698, 1 interactor
IntActiQ8IZ57, 7 interactors
STRINGi9606.ENSP00000367752

Structurei

3D structure databases

ProteinModelPortaliQ8IZ57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJHW Eukaryota
ENOG4111HTK LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG053471
InParanoidiQ8IZ57
OMAiTEGGYQR
OrthoDBiEOG091G0K9J
PhylomeDBiQ8IZ57
TreeFamiTF332090

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029698 Nrsn1
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF6 PTHR14796:SF6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IZ57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSCSNVCGS RQAQAAAEGG YQRYGVRSYL HQFYEDCTAS IWEYEDDFQI
60 70 80 90 100
QRSPNRWSSV FWKVGLISGT VFVILGLTVL AVGFLVPPKI EAFGEADFVV
110 120 130 140 150
VDTHAVQFNS ALDMYKLAGA VLFCIGGTSM AGCLLMSVFV KSYSKEEKFL
160 170 180 190
QQKFKERIAD IKAHTQPVTK APGPGETKIP VTLSRVQNVQ PLLAT
Length:195
Mass (Da):21,475
Last modified:March 1, 2003 - v1
Checksum:iBFADD774F04279D6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VTS0Q5VTS0_HUMAN
Neurensin-1
NRSN1
172Annotation score:
Q5VTS2Q5VTS2_HUMAN
Neurensin-1
NRSN1
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138V → A in AAL14639 (PubMed:12463420).Curated1
Sequence conflicti161I → T in BAC04748 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02981641I → V. Corresponds to variant dbSNP:rs17299946Ensembl.1
Natural variantiVAR_053737104H → Y. Corresponds to variant dbSNP:rs11544636Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418980 mRNA Translation: AAL14639.1
AK096290 mRNA Translation: BAC04748.1
AK314373 mRNA Translation: BAG37001.1
FO393410 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55439.1
BC023514 mRNA Translation: AAH23514.1
CCDSiCCDS4549.1
RefSeqiNP_542454.3, NM_080723.4
UniGeneiHs.726270

Genome annotation databases

EnsembliENST00000378478; ENSP00000367739; ENSG00000152954
ENST00000378491; ENSP00000367752; ENSG00000152954
GeneIDi140767
KEGGihsa:140767
UCSCiuc010jpq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418980 mRNA Translation: AAL14639.1
AK096290 mRNA Translation: BAC04748.1
AK314373 mRNA Translation: BAG37001.1
FO393410 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55439.1
BC023514 mRNA Translation: AAH23514.1
CCDSiCCDS4549.1
RefSeqiNP_542454.3, NM_080723.4
UniGeneiHs.726270

3D structure databases

ProteinModelPortaliQ8IZ57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126698, 1 interactor
IntActiQ8IZ57, 7 interactors
STRINGi9606.ENSP00000367752

Protein family/group databases

TCDBi9.B.189.1.1 the vesicular membrane neurensin (neurensin) family

PTM databases

PhosphoSitePlusiQ8IZ57

Polymorphism and mutation databases

BioMutaiNRSN1
DMDMi74750784

Proteomic databases

PaxDbiQ8IZ57
PeptideAtlasiQ8IZ57
PRIDEiQ8IZ57
ProteomicsDBi71280

Protocols and materials databases

DNASUi140767
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378478; ENSP00000367739; ENSG00000152954
ENST00000378491; ENSP00000367752; ENSG00000152954
GeneIDi140767
KEGGihsa:140767
UCSCiuc010jpq.1 human

Organism-specific databases

CTDi140767
DisGeNETi140767
EuPathDBiHostDB:ENSG00000152954.11
GeneCardsiNRSN1
HGNCiHGNC:17881 NRSN1
HPAiHPA061006
MIMi616630 gene
neXtProtiNX_Q8IZ57
OpenTargetsiENSG00000152954
PharmGKBiPA38254
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJHW Eukaryota
ENOG4111HTK LUCA
GeneTreeiENSGT00530000063877
HOGENOMiHOG000231873
HOVERGENiHBG053471
InParanoidiQ8IZ57
OMAiTEGGYQR
OrthoDBiEOG091G0K9J
PhylomeDBiQ8IZ57
TreeFamiTF332090

Miscellaneous databases

GeneWikiiNRSN1
GenomeRNAii140767
PROiPR:Q8IZ57
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152954 Expressed in 103 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_NRSN1
ExpressionAtlasiQ8IZ57 baseline and differential
GenevisibleiQ8IZ57 HS

Family and domain databases

InterProiView protein in InterPro
IPR024883 Neurensin
IPR029698 Nrsn1
PANTHERiPTHR14796 PTHR14796, 1 hit
PTHR14796:SF6 PTHR14796:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ57
Secondary accession number(s): B2RAV4, Q8N8R6, Q96P21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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