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Entry version 151 (31 Jul 2019)
Sequence version 2 (02 Nov 2010)
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Protein

Chondroitin sulfate synthase 2

Gene

CHPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication, Co2+1 PublicationNote: Highest activities are measured with Mn2+. Can also utilize Co2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi617Divalent metal cationSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS13103-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.175 2681
2.4.1.226 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022870 Chondroitin sulfate biosynthesis

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT31 Glycosyltransferase Family 31
GT7 Glycosyltransferase Family 7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate synthase 2 (EC:2.4.1.175, EC:2.4.1.226)
Alternative name(s):
Chondroitin glucuronyltransferase 2
Chondroitin-polymerizing factor
Short name:
ChPF
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
N-acetylgalactosaminyltransferase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHPF
Synonyms:CSS2
ORF Names:UNQ651/PRO1281
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24291 CHPF

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610405 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ52

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini35 – 775LumenalSequence analysisAdd BLAST741

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79586

Open Targets

More...
OpenTargetsi
ENSG00000123989

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382245

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CHPF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895601 – 775Chondroitin sulfate synthase 2Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IZ52

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZ52

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IZ52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ52

PeptideAtlas

More...
PeptideAtlasi
Q8IZ52

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ52

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71279 [Q8IZ52-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IZ52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123989 Expressed in 194 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IZ52 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IZ52 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035123

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds CHSY1. Isoform 1, isoform 2 and isoform 3 interact with PRKN.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PRKNO602605EBI-9029620,EBI-716346

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122729, 16 interactors

Protein interaction database and analysis system

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IntActi
Q8IZ52, 14 interactors

Molecular INTeraction database

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MINTi
Q8IZ52

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000243776

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IZ52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi515 – 571Ala-richAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3708 Eukaryota
ENOG410XWZJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037934

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ52

KEGG Orthology (KO)

More...
KOi
K00747

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFLENCR

Database of Orthologous Groups

More...
OrthoDBi
758579at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ52

TreeFam database of animal gene trees

More...
TreeFami
TF318303

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008428 Chond_GalNAc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05679 CHGN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZ52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRASLLLSVL RPAGPVAVGI SLGFTLSLLS VTWVEEPCGP GPPQPGDSEL
60 70 80 90 100
PPRGNTNAAR RPNSVQPGAE REKPGAGEGA GENWEPRVLP YHPAQPGQAA
110 120 130 140 150
KKAVRTRYIS TELGIRQRLL VAVLTSQTTL PTLGVAVNRT LGHRLERVVF
160 170 180 190 200
LTGARGRRAP PGMAVVTLGE ERPIGHLHLA LRHLLEQHGD DFDWFFLVPD
210 220 230 240 250
TTYTEAHGLA RLTGHLSLAS AAHLYLGRPQ DFIGGEPTPG RYCHGGFGVL
260 270 280 290 300
LSRMLLQQLR PHLEGCRNDI VSARPDEWLG RCILDATGVG CTGDHEGVHY
310 320 330 340 350
SHLELSPGEP VQEGDPHFRS ALTAHPVRDP VHMYQLHKAF ARAELERTYQ
360 370 380 390 400
EIQELQWEIQ NTSHLAVDGD QAAAWPVGIP APSRPASRFE VLRWDYFTEQ
410 420 430 440 450
HAFSCADGSP RCPLRGADRA DVADVLGTAL EELNRRYHPA LRLQKQQLVN
460 470 480 490 500
GYRRFDPARG MEYTLDLQLE ALTPQGGRRP LTRRVQLLRP LSRVEILPVP
510 520 530 540 550
YVTEASRLTV LLPLAAAERD LAPGFLEAFA TAALEPGDAA AALTLLLLYE
560 570 580 590 600
PRQAQRVAHA DVFAPVKAHV AELERRFPGA RVPWLSVQTA APSPLRLMDL
610 620 630 640 650
LSKKHPLDTL FLLAGPDTVL TPDFLNRCRM HAISGWQAFF PMHFQAFHPA
660 670 680 690 700
VAPPQGPGPP ELGRDTGRFD RQAASEACFY NSDYVAARGR LAAASEQEEE
710 720 730 740 750
LLESLDVYEL FLHFSSLHVL RAVEPALLQR YRAQTCSARL SEDLYHRCLQ
760 770
SVLEGLGSRT QLAMLLFEQE QGNST
Length:775
Mass (Da):85,467
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94EDDB2481C97B70
GO
Isoform 2 (identifier: Q8IZ52-2) [UniParc]FASTAAdd to basket
Also known as: Klokin1

The sequence of this isoform differs from the canonical sequence as follows:
     1-460: Missing.

Show »
Length:315
Mass (Da):34,955
Checksum:iF31E832CBAF52F64
GO
Isoform 3 (identifier: Q8IZ52-4) [UniParc]FASTAAdd to basket
Also known as: ChPF(D996)

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:613
Mass (Da):68,341
Checksum:iF921806F335177C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W6H2F8W6H2_HUMAN
Hexosyltransferase
CHPF
298Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti650A → G in AAQ88769 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047394371Q → R Most frequent polymorphism. 7 PublicationsCorresponds to variant dbSNP:rs6436155Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534331 – 460Missing in isoform 2. 1 PublicationAdd BLAST460
Alternative sequenceiVSP_0534341 – 162Missing in isoform 3. 1 PublicationAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB095813 mRNA Translation: BAC78393.1
AB086063 mRNA Translation: BAC81536.1
AY358403 mRNA Translation: AAQ88769.1
AK026331 mRNA Translation: BAB15449.1
AK302124 mRNA Translation: BAG63502.1
AC009955 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70768.1
BC008878 mRNA Translation: AAH08878.2
BC021223 mRNA Translation: AAH21223.2
BC023531 mRNA Translation: AAH23531.1
AL136814 mRNA Translation: CAB66748.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2443.1 [Q8IZ52-1]
CCDS56169.1 [Q8IZ52-4]

NCBI Reference Sequences

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RefSeqi
NP_001182660.1, NM_001195731.1
NP_078812.2, NM_024536.5 [Q8IZ52-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000243776; ENSP00000243776; ENSG00000123989 [Q8IZ52-1]
ENST00000535926; ENSP00000445571; ENSG00000123989 [Q8IZ52-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79586

UCSC genome browser

More...
UCSCi
uc002vmc.5 human [Q8IZ52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095813 mRNA Translation: BAC78393.1
AB086063 mRNA Translation: BAC81536.1
AY358403 mRNA Translation: AAQ88769.1
AK026331 mRNA Translation: BAB15449.1
AK302124 mRNA Translation: BAG63502.1
AC009955 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70768.1
BC008878 mRNA Translation: AAH08878.2
BC021223 mRNA Translation: AAH21223.2
BC023531 mRNA Translation: AAH23531.1
AL136814 mRNA Translation: CAB66748.2
CCDSiCCDS2443.1 [Q8IZ52-1]
CCDS56169.1 [Q8IZ52-4]
RefSeqiNP_001182660.1, NM_001195731.1
NP_078812.2, NM_024536.5 [Q8IZ52-1]

3D structure databases

SMRiQ8IZ52
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122729, 16 interactors
IntActiQ8IZ52, 14 interactors
MINTiQ8IZ52
STRINGi9606.ENSP00000243776

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31
GT7 Glycosyltransferase Family 7

PTM databases

iPTMnetiQ8IZ52
PhosphoSitePlusiQ8IZ52

Polymorphism and mutation databases

BioMutaiCHPF
DMDMi311033361

Proteomic databases

EPDiQ8IZ52
jPOSTiQ8IZ52
MaxQBiQ8IZ52
PaxDbiQ8IZ52
PeptideAtlasiQ8IZ52
PRIDEiQ8IZ52
ProteomicsDBi71279 [Q8IZ52-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
79586
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243776; ENSP00000243776; ENSG00000123989 [Q8IZ52-1]
ENST00000535926; ENSP00000445571; ENSG00000123989 [Q8IZ52-4]
GeneIDi79586
KEGGihsa:79586
UCSCiuc002vmc.5 human [Q8IZ52-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79586
DisGeNETi79586

GeneCards: human genes, protein and diseases

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GeneCardsi
CHPF
HGNCiHGNC:24291 CHPF
HPAiHPA035123
MIMi610405 gene
neXtProtiNX_Q8IZ52
OpenTargetsiENSG00000123989
PharmGKBiPA162382245

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3708 Eukaryota
ENOG410XWZJ LUCA
GeneTreeiENSGT00950000182646
HOGENOMiHOG000037934
InParanoidiQ8IZ52
KOiK00747
OMAiPFLENCR
OrthoDBi758579at2759
PhylomeDBiQ8IZ52
TreeFamiTF318303

Enzyme and pathway databases

BioCyciMetaCyc:HS13103-MONOMER
BRENDAi2.4.1.175 2681
2.4.1.226 2681
ReactomeiR-HSA-2022870 Chondroitin sulfate biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHPF human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CHPF

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79586

Protein Ontology

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PROi
PR:Q8IZ52

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123989 Expressed in 194 organ(s), highest expression level in right testis
ExpressionAtlasiQ8IZ52 baseline and differential
GenevisibleiQ8IZ52 HS

Family and domain databases

InterProiView protein in InterPro
IPR008428 Chond_GalNAc
PfamiView protein in Pfam
PF05679 CHGN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHSS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ52
Secondary accession number(s): B4DXU0
, Q6UXD6, Q7L4G1, Q9H0F8, Q9H618
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 2, 2010
Last modified: July 31, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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