UniProtKB - Q8IZ41 (RASEF_HUMAN)

BLAST

>sp|Q8IZ41|RASEF_HUMAN Ras and EF-hand domain-containing protein OS=Homo sapiens OX=9606 GN=RASEF PE=1 SV=1
MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG
AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG
PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ
STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE
TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL
QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL
ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP
LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV
PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK
AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ
ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD
TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI
TNLTGTNSKKSPQMKNCCNG

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History
Entry version 151 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Ras and EF-hand domain-containing protein

Gene

RASEF

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds predominantly GDP, and also GTP.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	21 – 32	1Add BLAST	12
Calcium bindingⁱ	55 – 66	2Add BLAST	12
Nucleotide bindingⁱ	548 – 555	GTPCurated	8
Nucleotide bindingⁱ	596 – 600	GTPCurated	5
Nucleotide bindingⁱ	654 – 657	GTPBy similarity	4

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
GDP binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17448446
GTPase activity Source: InterPro
GTP binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22399288
identical protein binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17448446

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein homooligomerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17448446

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Ligand

Calcium, GTP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras and EF-hand domain-containing protein Alternative name(s): Ras-related protein Rab-45
Gene namesⁱ	Name:RASEF Synonyms:RAB45
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165105.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26464 RASEF
MIMⁱ	611344 gene
neXtProtⁱ	NX_Q8IZ41

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	555	S → N: Impairs nucleotide binding and perinuclear localization. 1 Publication		1
Mutagenesisⁱ	600	Q → L: Favors GTP association. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	158158
Open Targets More...OpenTargetsⁱ	ENSG00000165105
PharmGKBⁱ	PA134867201

Polymorphism and mutation databases

DMDMⁱ	74750780

DMDMⁱ

74750780

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000299577	1 – 740	Ras and EF-hand domain-containing proteinAdd BLAST		740

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	377	PhosphoserineBy similarity		1
Modified residueⁱ	383	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IZ41
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZ41
PaxDbⁱ	Q8IZ41
PeptideAtlas More...PeptideAtlasⁱ	Q8IZ41
PRIDEⁱ	Q8IZ41
ProteomicsDBⁱ	71277 71278 [Q8IZ41-2]
TopDownProteomicsⁱ	Q8IZ41-2 [Q8IZ41-2]

PTM databases

iPTMnetⁱ	Q8IZ41
PhosphoSitePlusⁱ	Q8IZ41

Expressionⁱ

Tissue specificityⁱ

Down-regulated in cutaneous melanoma cells but not in breast cancer cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000165105 Expressed in 131 organ(s), highest expression level in pancreas
CleanExⁱ	HS_RASEF
Genevisibleⁱ	Q8IZ41 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021431

HPAⁱ

HPA021431

Interactionⁱ

Subunit structureⁱ

Homodimer.2 Publications

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17448446

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127651, 19 interactors
STRINGⁱ	9606.ENSP00000365630

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 20	Combined sources	17
Beta strandⁱ	25 – 29	Combined sources	5
Helixⁱ	30 – 39	Combined sources	10
Helixⁱ	44 – 54	Combined sources	11
Beta strandⁱ	59 – 62	Combined sources	4
Helixⁱ	64 – 67	Combined sources	4
Helixⁱ	69 – 73	Combined sources	5
Beta strandⁱ	542 – 549	Combined sources	8
Helixⁱ	554 – 563	Combined sources	10
Beta strandⁱ	579 – 585	Combined sources	7
Beta strandⁱ	588 – 596	Combined sources	9
Helixⁱ	604 – 613	Combined sources	10
Beta strandⁱ	615 – 622	Combined sources	8
Helixⁱ	626 – 630	Combined sources	5
Helixⁱ	632 – 642	Combined sources	11
Beta strandⁱ	649 – 654	Combined sources	6
Helixⁱ	656 – 658	Combined sources	3
Helixⁱ	659 – 664	Combined sources	6
Helixⁱ	672 – 682	Combined sources	11
Beta strandⁱ	685 – 688	Combined sources	4
Turnⁱ	691 – 693	Combined sources	3
Helixⁱ	697 – 708	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IZ41
SMRⁱ	Q8IZ41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8IZ41

EvolutionaryTraceⁱ

Q8IZ41

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 42	EF-hand 1PROSITE-ProRule annotationAdd BLAST		35
Domainⁱ	42 – 77	EF-hand 2PROSITE-ProRule annotationAdd BLAST		36

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	175 – 356	Sequence analysisAdd BLAST		182

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0078 Eukaryota ENOG410XPUI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139330
HOGENOMⁱ	HOG000008699
HOVERGENⁱ	HBG057757
InParanoidⁱ	Q8IZ41
KEGG Orthology (KO) More...KOⁱ	K17199
OMAⁱ	IRDEETY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CBJ
PhylomeDBⁱ	Q8IZ41
TreeFamⁱ	TF313106

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF00071 Ras, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS51419 RAB, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8IZ41-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEADGDGEEL ARLRSVFAAC DANRSGRLER EEFRALCTEL RVRPADAEAV 
        60         70         80         90        100
FQRLDADRDG AITFQEFARG FLGSLRGGRR RDWGPLDPAP AVSEAGPETH 
       110        120        130        140        150
DSEEDEGDED AAAALATSCG PASPGRAWQD FQARLGDEAK FIPREEQVST 
       160        170        180        190        200
LYQNINLVEP RLIQPYEHVI KNFIREIRLQ STEMENLAIA VKRAQDKAAM 
       210        220        230        240        250
QLSELEEEMD QRIQAAEHKT RKDEKRKAEE ALSDLRRQYE TEVGDLQVTI 
       260        270        280        290        300
KKLRKLEEQS KRVSQKEDVA ALKKQIYDLS MENQKVKKDL LEAQTNIAFL 
       310        320        330        340        350
QSELDALKSD YADQSLNTER DLEIIRAYTE DRNSLERQIE ILQTANRKLH 
       360        370        380        390        400
DSNDGLRSAL ENSYSKFNRS LHINNISPGN TISRSSPKFI GHSPQPLGYD 
       410        420        430        440        450
RSSRSSYVDE DCDSLALCDP LQRTNCEVDS LPESCFDSGL STLRDPNEYD 
       460        470        480        490        500
SEVEYKHQRG FQRSHGVQES FGGDASDTDV PDIRDEETFG LEDVASVLDW 
       510        520        530        540        550
KPQGSVSEGS IVSSSRKPIS ALSPQTDLVD DNAKSFSSQK AYKIVLAGDA 
       560        570        580        590        600
AVGKSSFLMR LCKNEFRENI SATLGVDFQM KTLIVDGERT VLQLWDTAGQ 
       610        620        630        640        650
ERFRSIAKSY FRKADGVLLL YDVTCEKSFL NIREWVDMIE DAAHETVPIM 
       660        670        680        690        700
LVGNKADIRD TAATEGQKCV PGHFGEKLAM TYGALFCETS AKDGSNIVEA 
       710        720        730        740
VLHLAREVKK RTDKDDSRSI TNLTGTNSKK SPQMKNCCNG

Length:740

Mass (Da):82,879

Last modified:March 1, 2003 - v1

Checksum:ⁱ89AFCF4C159760F0

Isoform 2 (identifier: Q8IZ41-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
145-189: EEQVSTLYQN...QSTEMENLAI → FGYTISKPAF...IEEGGAKMAE
190-740: Missing.

« Hide

        10         20         30         40         50
MEADGDGEEL ARLRSVFAAC DANRSGRLER EEFRALCTEL RVRPADAEAV 
        60         70         80         90        100
FQRLDADRDG AITFQEFARG FLGSLRGGRR RDWGPLDPAP AVSEAGPETH 
       110        120        130        140        150
DSEEDEGDED AAAALATSCG PASPGRAWQD FQARLGDEAK FIPRFGYTIS 
       160        170        180 
KPAFVFVRHL ITLCALSWAK KEGRETLWTI EEGGAKMAE

Note: No experimental confirmation available.

Show »

Length:189

Mass (Da):20,736

Checksum:ⁱ472825570664F33D

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034858	262	R → C1 PublicationCorresponds to variant dbSNP:rs4146960Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_027766	145 – 189	EEQVS…ENLAI → FGYTISKPAFVFVRHLITLC ALSWAKKEGRETLWTIEEGG AKMAE in isoform 2. 1 PublicationAdd BLAST		45
Alternative sequenceⁱVSP_027767	190 – 740	Missing in isoform 2. 1 PublicationAdd BLAST		551

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056176 mRNA No translation available. AL499602 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62643.1 BC023566 mRNA Translation: AAH23566.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6662.1 [Q8IZ41-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_689786.2, NM_152573.3 [Q8IZ41-1]
UniGeneⁱ	Hs.129136 Hs.677846

Genome annotation databases

Ensemblⁱ	ENST00000340717; ENSP00000345651; ENSG00000165105 [Q8IZ41-2] ENST00000376447; ENSP00000365630; ENSG00000165105 [Q8IZ41-1]
GeneIDⁱ	158158
KEGGⁱ	hsa:158158
UCSC genome browser More...UCSCⁱ	uc004amo.2 human [Q8IZ41-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8IZ41	Uncharacterized protein		MACNE		743	UniRef90_Q8IZ41
cDNA FLJ75033, highly similar to Homo sapiens RAS and EF-hand domain containing (RASEF), mRNA		HUMAN		740
RAS and EF-hand domain containing		PANTR		740
Ras-related protein Rab-45		MACMU		740
Uncharacterized protein		COLAP		740
+24
Q8IZ41-2	RAS and EF-hand domain containing		PANTR		174	UniRef90_Q8IZ41-2
Uncharacterized protein		PANPA		174
RAS and EF-hand domain containing		GORGO		174
Uncharacterized protein		RHIRO		173
Uncharacterized protein		RHIBE		173
+3

Protein	Similar proteins		Species	Score	Length	Source
Q8IZ41	Ras and EF-hand domain-containing protein		XENTR		722	UniRef50_Q8IZ41
Uncharacterized protein		MACNE		743
RAS and EF-hand domain containing		GORGO		740
Uncharacterized protein		RHIBE		740
Uncharacterized protein		PAPAN		740
+167
Q8IZ41-2	RAS and EF-hand domain containing		PANTR		174	UniRef50_Q8IZ41-2
Uncharacterized protein		PANPA		174
RAS and EF-hand domain containing		GORGO		174
Uncharacterized protein		RHIBE		173
Uncharacterized protein		RHIRO		173
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056176 mRNA No translation available. AL499602 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62643.1 BC023566 mRNA Translation: AAH23566.1
CCDSⁱ	CCDS6662.1 [Q8IZ41-1]
RefSeqⁱ	NP_689786.2, NM_152573.3 [Q8IZ41-1]
UniGeneⁱ	Hs.129136 Hs.677846

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2P5S	X-ray	2.15	A/B	533-712	[»]
	2PMY	X-ray	2.30	A/B	3-75	[»]
ProteinModelPortalⁱ	Q8IZ41
SMRⁱ	Q8IZ41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127651, 19 interactors
STRINGⁱ	9606.ENSP00000365630

PTM databases

iPTMnetⁱ	Q8IZ41
PhosphoSitePlusⁱ	Q8IZ41

Polymorphism and mutation databases

DMDMⁱ	74750780

DMDMⁱ

74750780

Proteomic databases

EPDⁱ	Q8IZ41
MaxQBⁱ	Q8IZ41
PaxDbⁱ	Q8IZ41
PeptideAtlasⁱ	Q8IZ41
PRIDEⁱ	Q8IZ41
ProteomicsDBⁱ	71277 71278 [Q8IZ41-2]
TopDownProteomicsⁱ	Q8IZ41-2 [Q8IZ41-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340717; ENSP00000345651; ENSG00000165105 [Q8IZ41-2] ENST00000376447; ENSP00000365630; ENSG00000165105 [Q8IZ41-1]
GeneIDⁱ	158158
KEGGⁱ	hsa:158158
UCSCⁱ	uc004amo.2 human [Q8IZ41-1]

Organism-specific databases

CTDⁱ	158158
DisGeNETⁱ	158158
EuPathDBⁱ	HostDB:ENSG00000165105.9
GeneCardsⁱ	RASEF
HGNCⁱ	HGNC:26464 RASEF
HPAⁱ	HPA021431
MIMⁱ	611344 gene
neXtProtⁱ	NX_Q8IZ41
OpenTargetsⁱ	ENSG00000165105
PharmGKBⁱ	PA134867201
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0078 Eukaryota ENOG410XPUI LUCA
GeneTreeⁱ	ENSGT00890000139330
HOGENOMⁱ	HOG000008699
HOVERGENⁱ	HBG057757
InParanoidⁱ	Q8IZ41
KOⁱ	K17199
OMAⁱ	IRDEETY
OrthoDBⁱ	EOG091G0CBJ
PhylomeDBⁱ	Q8IZ41
TreeFamⁱ	TF313106

Miscellaneous databases

ChiTaRSⁱ	RASEF human
EvolutionaryTraceⁱ	Q8IZ41
GenomeRNAiⁱ	158158
Protein Ontology More...PROⁱ	PR:Q8IZ41
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165105 Expressed in 131 organ(s), highest expression level in pancreas
CleanExⁱ	HS_RASEF
Genevisibleⁱ	Q8IZ41 HS

Family and domain databases

CDDⁱ	cd00051 EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF00071 Ras, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 2 hits PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RASEF_HUMAN
Accessionⁱ	Q8IZ41Primary (citable) accession number: Q8IZ41 Secondary accession number(s): A6NC29, Q96N04
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q8IZ41 (RASEF_HUMAN)

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Ras and EF-hand domain-containing protein

RASEF

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ