UniProtKB - Q8IZ41 (RASEF_HUMAN)
Protein
Ras and EF-hand domain-containing protein
Gene
RASEF
Organism
Homo sapiens (Human)
Status
Functioni
Binds predominantly GDP, and also GTP.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 21 – 32 | 1Add BLAST | 12 | |
Calcium bindingi | 55 – 66 | 2Add BLAST | 12 | |
Nucleotide bindingi | 548 – 555 | GTPCurated | 8 | |
Nucleotide bindingi | 596 – 600 | GTPCurated | 5 | |
Nucleotide bindingi | 654 – 657 | GTPBy similarity | 4 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- GDP binding Source: UniProtKB
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB
- identical protein binding Source: UniProtKB
Keywordsi
Ligand | Calcium, GTP-binding, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IZ41 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras and EF-hand domain-containing proteinAlternative name(s): Ras-related protein Rab-45 |
Gene namesi | Name:RASEF Synonyms:RAB45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165105.9 |
HGNCi | HGNC:26464, RASEF |
MIMi | 611344, gene |
neXtProti | NX_Q8IZ41 |
Subcellular locationi
Other locations
- perinuclear region 1 Publication
Cytosol
- cytosol Source: UniProtKB
Other locations
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 555 | S → N: Impairs nucleotide binding and perinuclear localization. 1 Publication | 1 | |
Mutagenesisi | 600 | Q → L: Favors GTP association. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 158158 |
OpenTargetsi | ENSG00000165105 |
PharmGKBi | PA134867201 |
Miscellaneous databases
Pharosi | Q8IZ41, Tbio |
Polymorphism and mutation databases
BioMutai | RASEF |
DMDMi | 74750780 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299577 | 1 – 740 | Ras and EF-hand domain-containing proteinAdd BLAST | 740 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 377 | PhosphoserineBy similarity | 1 | |
Modified residuei | 383 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IZ41 |
jPOSTi | Q8IZ41 |
MassIVEi | Q8IZ41 |
MaxQBi | Q8IZ41 |
PaxDbi | Q8IZ41 |
PeptideAtlasi | Q8IZ41 |
PRIDEi | Q8IZ41 |
ProteomicsDBi | 71277 [Q8IZ41-1] 71278 [Q8IZ41-2] |
TopDownProteomicsi | Q8IZ41-2 [Q8IZ41-2] |
PTM databases
iPTMneti | Q8IZ41 |
PhosphoSitePlusi | Q8IZ41 |
Expressioni
Tissue specificityi
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.1 Publication
Gene expression databases
Bgeei | ENSG00000165105, Expressed in pancreas and 148 other tissues |
Genevisiblei | Q8IZ41, HS |
Organism-specific databases
HPAi | ENSG00000165105, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsGO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 127651, 20 interactors |
IntActi | Q8IZ41, 3 interactors |
STRINGi | 9606.ENSP00000365630 |
Miscellaneous databases
RNActi | Q8IZ41, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IZ41 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IZ41 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 42 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 42 – 77 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 175 – 356 | Sequence analysisAdd BLAST | 182 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0078, Eukaryota |
GeneTreei | ENSGT00940000159488 |
HOGENOMi | CLU_023178_1_0_1 |
InParanoidi | Q8IZ41 |
OMAi | PKFTGHS |
OrthoDBi | 1184845at2759 |
PhylomeDBi | Q8IZ41 |
TreeFami | TF313106 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS51419, RAB, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IZ41-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEADGDGEEL ARLRSVFAAC DANRSGRLER EEFRALCTEL RVRPADAEAV
60 70 80 90 100
FQRLDADRDG AITFQEFARG FLGSLRGGRR RDWGPLDPAP AVSEAGPETH
110 120 130 140 150
DSEEDEGDED AAAALATSCG PASPGRAWQD FQARLGDEAK FIPREEQVST
160 170 180 190 200
LYQNINLVEP RLIQPYEHVI KNFIREIRLQ STEMENLAIA VKRAQDKAAM
210 220 230 240 250
QLSELEEEMD QRIQAAEHKT RKDEKRKAEE ALSDLRRQYE TEVGDLQVTI
260 270 280 290 300
KKLRKLEEQS KRVSQKEDVA ALKKQIYDLS MENQKVKKDL LEAQTNIAFL
310 320 330 340 350
QSELDALKSD YADQSLNTER DLEIIRAYTE DRNSLERQIE ILQTANRKLH
360 370 380 390 400
DSNDGLRSAL ENSYSKFNRS LHINNISPGN TISRSSPKFI GHSPQPLGYD
410 420 430 440 450
RSSRSSYVDE DCDSLALCDP LQRTNCEVDS LPESCFDSGL STLRDPNEYD
460 470 480 490 500
SEVEYKHQRG FQRSHGVQES FGGDASDTDV PDIRDEETFG LEDVASVLDW
510 520 530 540 550
KPQGSVSEGS IVSSSRKPIS ALSPQTDLVD DNAKSFSSQK AYKIVLAGDA
560 570 580 590 600
AVGKSSFLMR LCKNEFRENI SATLGVDFQM KTLIVDGERT VLQLWDTAGQ
610 620 630 640 650
ERFRSIAKSY FRKADGVLLL YDVTCEKSFL NIREWVDMIE DAAHETVPIM
660 670 680 690 700
LVGNKADIRD TAATEGQKCV PGHFGEKLAM TYGALFCETS AKDGSNIVEA
710 720 730 740
VLHLAREVKK RTDKDDSRSI TNLTGTNSKK SPQMKNCCNG
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034858 | 262 | R → C1 PublicationCorresponds to variant dbSNP:rs4146960Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027766 | 145 – 189 | EEQVS…ENLAI → FGYTISKPAFVFVRHLITLC ALSWAKKEGRETLWTIEEGG AKMAE in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_027767 | 190 – 740 | Missing in isoform 2. 1 PublicationAdd BLAST | 551 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056176 mRNA No translation available. AL499602 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62643.1 BC023566 mRNA Translation: AAH23566.1 |
CCDSi | CCDS6662.1 [Q8IZ41-1] |
RefSeqi | NP_689786.2, NM_152573.3 [Q8IZ41-1] |
Genome annotation databases
Ensembli | ENST00000340717; ENSP00000345651; ENSG00000165105 [Q8IZ41-2] ENST00000376447; ENSP00000365630; ENSG00000165105 [Q8IZ41-1] |
GeneIDi | 158158 |
KEGGi | hsa:158158 |
UCSCi | uc004amo.2, human [Q8IZ41-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056176 mRNA No translation available. AL499602 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62643.1 BC023566 mRNA Translation: AAH23566.1 |
CCDSi | CCDS6662.1 [Q8IZ41-1] |
RefSeqi | NP_689786.2, NM_152573.3 [Q8IZ41-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2P5S | X-ray | 2.15 | A/B | 533-712 | [»] | |
2PMY | X-ray | 2.30 | A/B | 3-75 | [»] | |
SMRi | Q8IZ41 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127651, 20 interactors |
IntActi | Q8IZ41, 3 interactors |
STRINGi | 9606.ENSP00000365630 |
PTM databases
iPTMneti | Q8IZ41 |
PhosphoSitePlusi | Q8IZ41 |
Polymorphism and mutation databases
BioMutai | RASEF |
DMDMi | 74750780 |
Proteomic databases
EPDi | Q8IZ41 |
jPOSTi | Q8IZ41 |
MassIVEi | Q8IZ41 |
MaxQBi | Q8IZ41 |
PaxDbi | Q8IZ41 |
PeptideAtlasi | Q8IZ41 |
PRIDEi | Q8IZ41 |
ProteomicsDBi | 71277 [Q8IZ41-1] 71278 [Q8IZ41-2] |
TopDownProteomicsi | Q8IZ41-2 [Q8IZ41-2] |
Protocols and materials databases
Antibodypediai | 13004, 94 antibodies |
Genome annotation databases
Ensembli | ENST00000340717; ENSP00000345651; ENSG00000165105 [Q8IZ41-2] ENST00000376447; ENSP00000365630; ENSG00000165105 [Q8IZ41-1] |
GeneIDi | 158158 |
KEGGi | hsa:158158 |
UCSCi | uc004amo.2, human [Q8IZ41-1] |
Organism-specific databases
CTDi | 158158 |
DisGeNETi | 158158 |
EuPathDBi | HostDB:ENSG00000165105.9 |
GeneCardsi | RASEF |
HGNCi | HGNC:26464, RASEF |
HPAi | ENSG00000165105, Low tissue specificity |
MIMi | 611344, gene |
neXtProti | NX_Q8IZ41 |
OpenTargetsi | ENSG00000165105 |
PharmGKBi | PA134867201 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0078, Eukaryota |
GeneTreei | ENSGT00940000159488 |
HOGENOMi | CLU_023178_1_0_1 |
InParanoidi | Q8IZ41 |
OMAi | PKFTGHS |
OrthoDBi | 1184845at2759 |
PhylomeDBi | Q8IZ41 |
TreeFami | TF313106 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZ41 |
Miscellaneous databases
BioGRID-ORCSi | 158158, 3 hits in 844 CRISPR screens |
ChiTaRSi | RASEF, human |
EvolutionaryTracei | Q8IZ41 |
GenomeRNAii | 158158 |
Pharosi | Q8IZ41, Tbio |
PROi | PR:Q8IZ41 |
RNActi | Q8IZ41, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165105, Expressed in pancreas and 148 other tissues |
Genevisiblei | Q8IZ41, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RASEF_HUMAN | |
Accessioni | Q8IZ41Primary (citable) accession number: Q8IZ41 Secondary accession number(s): A6NC29, Q96N04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations