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Protein

REST corepressor 2

Gene

RCOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Gene namesi
Name:RCOR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167771.5
HGNCiHGNC:27455 RCOR2
neXtProtiNX_Q8IZ40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167771
PharmGKBiPA134876257

Polymorphism and mutation databases

BioMutaiRCOR2
DMDMi147744586

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267761 – 523REST corepressor 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphoserineBy similarity1
Modified residuei479Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IZ40
MaxQBiQ8IZ40
PaxDbiQ8IZ40
PeptideAtlasiQ8IZ40
PRIDEiQ8IZ40
ProteomicsDBi71276

PTM databases

iPTMnetiQ8IZ40
PhosphoSitePlusiQ8IZ40

Miscellaneous databases

PMAP-CutDBiQ8IZ40

Expressioni

Gene expression databases

BgeeiENSG00000167771 Expressed in 162 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_RCOR2
GenevisibleiQ8IZ40 HS

Organism-specific databases

HPAiHPA021638

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603413EBI-723853,EBI-710124

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129510, 12 interactors
IntActiQ8IZ40, 7 interactors
STRINGi9606.ENSP00000301459

Structurei

3D structure databases

ProteinModelPortaliQ8IZ40
SMRiQ8IZ40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129ELM2PROSITE-ProRule annotationAdd BLAST86
Domaini130 – 181SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini327 – 378SANT 2PROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 314Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi430 – 521Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the CoREST family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00840000129748
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ8IZ40
OMAiAHDSMIR
OrthoDBiEOG091G096Y
PhylomeDBiQ8IZ40
TreeFamiTF106450

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits

Sequencei

Sequence statusi: Complete.

Q8IZ40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTVPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG GVSEGEPDPA DPKREPLPSR PLNARPGPGK KEVQVSQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPGAPVPM
410 420 430 440 450
EEARRGAPLP APALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAAPRHS
510 520
ARPGPQPPPT LIGTPLEPPA PSL
Length:523
Mass (Da):58,012
Last modified:May 15, 2007 - v2
Checksum:iEA9E53BC578B5A2E
GO

Sequence cautioni

The sequence AAH10608 differs from that shown. Chimera.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422I → T in AAH23587 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025516514T → A1 PublicationCorresponds to variant dbSNP:rs320108Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003780 Genomic DNA No translation available.
BC010608 mRNA Translation: AAH10608.1 Sequence problems.
BC023587 mRNA Translation: AAH23587.1
CCDSiCCDS8052.1
RefSeqiNP_775858.2, NM_173587.3
UniGeneiHs.98788

Genome annotation databases

EnsembliENST00000301459; ENSP00000301459; ENSG00000167771
GeneIDi283248
KEGGihsa:283248
UCSCiuc001nyc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003780 Genomic DNA No translation available.
BC010608 mRNA Translation: AAH10608.1 Sequence problems.
BC023587 mRNA Translation: AAH23587.1
CCDSiCCDS8052.1
RefSeqiNP_775858.2, NM_173587.3
UniGeneiHs.98788

3D structure databases

ProteinModelPortaliQ8IZ40
SMRiQ8IZ40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129510, 12 interactors
IntActiQ8IZ40, 7 interactors
STRINGi9606.ENSP00000301459

PTM databases

iPTMnetiQ8IZ40
PhosphoSitePlusiQ8IZ40

Polymorphism and mutation databases

BioMutaiRCOR2
DMDMi147744586

Proteomic databases

EPDiQ8IZ40
MaxQBiQ8IZ40
PaxDbiQ8IZ40
PeptideAtlasiQ8IZ40
PRIDEiQ8IZ40
ProteomicsDBi71276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301459; ENSP00000301459; ENSG00000167771
GeneIDi283248
KEGGihsa:283248
UCSCiuc001nyc.3 human

Organism-specific databases

CTDi283248
EuPathDBiHostDB:ENSG00000167771.5
GeneCardsiRCOR2
HGNCiHGNC:27455 RCOR2
HPAiHPA021638
neXtProtiNX_Q8IZ40
OpenTargetsiENSG00000167771
PharmGKBiPA134876257
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00840000129748
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ8IZ40
OMAiAHDSMIR
OrthoDBiEOG091G096Y
PhylomeDBiQ8IZ40
TreeFamiTF106450

Miscellaneous databases

ChiTaRSiRCOR2 human
GenomeRNAii283248
PMAP-CutDBiQ8IZ40
PROiPR:Q8IZ40

Gene expression databases

BgeeiENSG00000167771 Expressed in 162 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_RCOR2
GenevisibleiQ8IZ40 HS

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRCOR2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ40
Secondary accession number(s): Q96FP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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