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UniProtKB - Q8IZ13 (ZBED8_HUMAN)

Entry version 125 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Protein ZBED8

Gene

ZBED8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZ13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ZBED8
Alternative name(s):
Transposon-derived Buster3 transposase-like protein
Zinc finger BED domain-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBED8
Synonyms:Buster3, C5orf54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30804, ZBED8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615253, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZ13

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000221886.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		63920

Open Targets

More...OpenTargetsi		ENSG00000221886

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164717348

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZ13, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZBED8

Domain mapping of disease mutations (DMDM)

More...DMDMi		74728411

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003484521 – 594Protein ZBED8Add BLAST594

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IZ13

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IZ13

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IZ13

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IZ13

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZ13

PeptideAtlas

More...PeptideAtlasi		Q8IZ13

PRoteomics IDEntifications database

More...PRIDEi		Q8IZ13

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71267

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZ13

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZ13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000221886, Expressed in heart and 196 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZ13, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000221886, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121989, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZ13, 15 interactors

Molecular INTeraction database

More...MINTi		Q8IZ13

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386184

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZ13, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT83, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021316_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZ13

Identification of Orthologs from Complete Genome Data

More...OMAi		EKNPHTI

Database of Orthologous Groups

More...OrthoDBi		875619at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZ13

TreeFam database of animal gene trees

More...TreeFami		TF328297

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025398, DUF4371
IPR012337, RNaseH-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14291, DUF4371, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53098, SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IZ13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH 
        60         70         80         90        100
FNRQHGGVAG HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY 
       110        120        130        140        150
LCAKEKNPHT VAEKLVKPCA LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI 
       160        170        180        190        200
DEMSQDILQQ VLEDIKASPL KVGIQLAETT DMDDCSQLMA FVRYIKEREI 
       210        220        230        240        250
VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV CTDGASSMLG 
       260        270        280        290        300
ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF 
       310        320        330        340        350
IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI 
       360        370        380        390        400
NQFLHHKSSN LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS 
       410        420        430        440        450
AREKLSAFVR KFPFWQKRIE KRNFTNFPFL EEIIVSDNEG IFIAAEITLH 
       460        470        480        490        500
LQQLSNFFHG YFSIGDLNEA SKWILDPFLF NIDFVDDSYL MKNDLAELRA 
       510        520        530        540        550
SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT TYLCELGFSS 
       560        570        580        590 
LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL
Length:594
Mass (Da):68,327
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC786B19C80B75263
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63L → F in AAF18452 (PubMed:10607616).Curated1
Sequence conflicti556T → P in BAB15542 (PubMed:14702039).Curated1
Sequence conflicti584E → D in BAB15542 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046179523A → S. Corresponds to variant dbSNP:rs10515808Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF205598 Genomic DNA Translation: AAF18452.1
AK026754 mRNA Translation: BAB15542.1
CH471062 Genomic DNA Translation: EAW61557.1
CH471062 Genomic DNA Translation: EAW61558.1
CH471062 Genomic DNA Translation: EAW61559.1
CH471062 Genomic DNA Translation: EAW61560.1
BC032603 mRNA Translation: AAH32603.1
BC112128 mRNA Translation: AAI12129.1
BC112130 mRNA Translation: AAI12131.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34283.1

NCBI Reference Sequences

More...RefSeqi		NP_001290180.1, NM_001303251.1
NP_071373.2, NM_022090.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000408953; ENSP00000386184; ENSG00000221886
ENST00000523213; ENSP00000428831; ENSG00000221886

Database of genes from NCBI RefSeq genomes

More...GeneIDi		63920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:63920

UCSC genome browser

More...UCSCi		uc003lye.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205598 Genomic DNA Translation: AAF18452.1
AK026754 mRNA Translation: BAB15542.1
CH471062 Genomic DNA Translation: EAW61557.1
CH471062 Genomic DNA Translation: EAW61558.1
CH471062 Genomic DNA Translation: EAW61559.1
CH471062 Genomic DNA Translation: EAW61560.1
BC032603 mRNA Translation: AAH32603.1
BC112128 mRNA Translation: AAI12129.1
BC112130 mRNA Translation: AAI12131.1
CCDSiCCDS34283.1
RefSeqiNP_001290180.1, NM_001303251.1
NP_071373.2, NM_022090.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121989, 17 interactors
IntActiQ8IZ13, 15 interactors
MINTiQ8IZ13
STRINGi9606.ENSP00000386184

PTM databases

iPTMnetiQ8IZ13
PhosphoSitePlusiQ8IZ13

Genetic variation databases

BioMutaiZBED8
DMDMi74728411

Proteomic databases

EPDiQ8IZ13
jPOSTiQ8IZ13
MassIVEiQ8IZ13
MaxQBiQ8IZ13
PaxDbiQ8IZ13
PeptideAtlasiQ8IZ13
PRIDEiQ8IZ13
ProteomicsDBi71267

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45858, 35 antibodies

Genome annotation databases

EnsembliENST00000408953; ENSP00000386184; ENSG00000221886
ENST00000523213; ENSP00000428831; ENSG00000221886
GeneIDi63920
KEGGihsa:63920
UCSCiuc003lye.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		63920
DisGeNETi63920

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZBED8
HGNCiHGNC:30804, ZBED8
HPAiENSG00000221886, Low tissue specificity
MIMi615253, gene
neXtProtiNX_Q8IZ13
OpenTargetsiENSG00000221886
PharmGKBiPA164717348
VEuPathDBiHostDB:ENSG00000221886.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QT83, Eukaryota
GeneTreeiENSGT00940000163112
HOGENOMiCLU_021316_5_0_1
InParanoidiQ8IZ13
OMAiEKNPHTI
OrthoDBi875619at2759
PhylomeDBiQ8IZ13
TreeFamiTF328297

Enzyme and pathway databases

PathwayCommonsiQ8IZ13

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		63920, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZBED8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		63920
PharosiQ8IZ13, Tdark

Protein Ontology

More...PROi		PR:Q8IZ13
RNActiQ8IZ13, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000221886, Expressed in heart and 196 other tissues
GenevisibleiQ8IZ13, HS

Family and domain databases

InterProiView protein in InterPro
IPR025398, DUF4371
IPR012337, RNaseH-like_sf
PfamiView protein in Pfam
PF14291, DUF4371, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBED8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ13
Secondary accession number(s): D3DQJ9, Q9H5S8, Q9UH87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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