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Protein

Protein ZBED8

Gene

ZBED8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZBED8
Alternative name(s):
Transposon-derived Buster3 transposase-like protein
Zinc finger BED domain-containing protein 8
Gene namesi
Name:ZBED8
Synonyms:Buster3, C5orf54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000221886.3
HGNCiHGNC:30804 ZBED8
MIMi615253 gene
neXtProtiNX_Q8IZ13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221886
PharmGKBiPA164717348

Polymorphism and mutation databases

BioMutaiZBED8
DMDMi74728411

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484521 – 594Protein ZBED8Add BLAST594

Proteomic databases

EPDiQ8IZ13
MaxQBiQ8IZ13
PaxDbiQ8IZ13
PeptideAtlasiQ8IZ13
PRIDEiQ8IZ13
ProteomicsDBi71267

PTM databases

iPTMnetiQ8IZ13
PhosphoSitePlusiQ8IZ13

Expressioni

Gene expression databases

BgeeiENSG00000221886
GenevisibleiQ8IZ13 HS

Organism-specific databases

HPAiHPA045445
HPA055817

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121989, 14 interactors
IntActiQ8IZ13, 12 interactors
MINTiQ8IZ13
STRINGi9606.ENSP00000386184

Structurei

3D structure databases

ProteinModelPortaliQ8IZ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHXC Eukaryota
ENOG410ZSKF LUCA
GeneTreeiENSGT00860000133692
HOGENOMiHOG000253000
InParanoidiQ8IZ13
OMAiILMEFET
OrthoDBiEOG091G09O3
PhylomeDBiQ8IZ13
TreeFamiTF328297

Family and domain databases

InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH
60 70 80 90 100
FNRQHGGVAG HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY
110 120 130 140 150
LCAKEKNPHT VAEKLVKPCA LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI
160 170 180 190 200
DEMSQDILQQ VLEDIKASPL KVGIQLAETT DMDDCSQLMA FVRYIKEREI
210 220 230 240 250
VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV CTDGASSMLG
260 270 280 290 300
ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF
310 320 330 340 350
IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI
360 370 380 390 400
NQFLHHKSSN LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS
410 420 430 440 450
AREKLSAFVR KFPFWQKRIE KRNFTNFPFL EEIIVSDNEG IFIAAEITLH
460 470 480 490 500
LQQLSNFFHG YFSIGDLNEA SKWILDPFLF NIDFVDDSYL MKNDLAELRA
510 520 530 540 550
SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT TYLCELGFSS
560 570 580 590
LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL
Length:594
Mass (Da):68,327
Last modified:March 1, 2003 - v1
Checksum:iC786B19C80B75263
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63L → F in AAF18452 (PubMed:10607616).Curated1
Sequence conflicti556T → P in BAB15542 (PubMed:14702039).Curated1
Sequence conflicti584E → D in BAB15542 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046179523A → S. Corresponds to variant dbSNP:rs10515808Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205598 Genomic DNA Translation: AAF18452.1
AK026754 mRNA Translation: BAB15542.1
CH471062 Genomic DNA Translation: EAW61557.1
CH471062 Genomic DNA Translation: EAW61558.1
CH471062 Genomic DNA Translation: EAW61559.1
CH471062 Genomic DNA Translation: EAW61560.1
BC032603 mRNA Translation: AAH32603.1
BC112128 mRNA Translation: AAI12129.1
BC112130 mRNA Translation: AAI12131.1
CCDSiCCDS34283.1
RefSeqiNP_001290180.1, NM_001303251.1
NP_071373.2, NM_022090.4
UniGeneiHs.529464

Genome annotation databases

EnsembliENST00000408953; ENSP00000386184; ENSG00000221886
ENST00000523213; ENSP00000428831; ENSG00000221886
GeneIDi63920
KEGGihsa:63920
UCSCiuc003lye.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBED8_HUMAN
AccessioniPrimary (citable) accession number: Q8IZ13
Secondary accession number(s): D3DQJ9, Q9H5S8, Q9UH87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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