UniProtKB - Q8IZ13 (ZBED8_HUMAN)
Protein
Protein ZBED8
Gene
ZBED8
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.
Enzyme and pathway databases
PathwayCommonsi | Q8IZ13 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein ZBED8Alternative name(s): Transposon-derived Buster3 transposase-like protein Zinc finger BED domain-containing protein 8 |
Gene namesi | Name:ZBED8 Synonyms:Buster3, C5orf54 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30804, ZBED8 |
MIMi | 615253, gene |
neXtProti | NX_Q8IZ13 |
VEuPathDBi | HostDB:ENSG00000221886.3 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 63920 |
OpenTargetsi | ENSG00000221886 |
PharmGKBi | PA164717348 |
Miscellaneous databases
Pharosi | Q8IZ13, Tdark |
Genetic variation databases
BioMutai | ZBED8 |
DMDMi | 74728411 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000348452 | 1 – 594 | Protein ZBED8Add BLAST | 594 |
Proteomic databases
EPDi | Q8IZ13 |
jPOSTi | Q8IZ13 |
MassIVEi | Q8IZ13 |
MaxQBi | Q8IZ13 |
PaxDbi | Q8IZ13 |
PeptideAtlasi | Q8IZ13 |
PRIDEi | Q8IZ13 |
ProteomicsDBi | 71267 |
PTM databases
iPTMneti | Q8IZ13 |
PhosphoSitePlusi | Q8IZ13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000221886, Expressed in heart and 196 other tissues |
Genevisiblei | Q8IZ13, HS |
Organism-specific databases
HPAi | ENSG00000221886, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8IZ13
Protein-protein interaction databases
BioGRIDi | 121989, 17 interactors |
IntActi | Q8IZ13, 15 interactors |
MINTi | Q8IZ13 |
STRINGi | 9606.ENSP00000386184 |
Miscellaneous databases
RNActi | Q8IZ13, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QT83, Eukaryota |
GeneTreei | ENSGT00940000163112 |
HOGENOMi | CLU_021316_5_0_1 |
InParanoidi | Q8IZ13 |
OMAi | EKNPHTI |
OrthoDBi | 875619at2759 |
PhylomeDBi | Q8IZ13 |
TreeFami | TF328297 |
Family and domain databases
InterProi | View protein in InterPro IPR025398, DUF4371 IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF14291, DUF4371, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IZ13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH
60 70 80 90 100
FNRQHGGVAG HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY
110 120 130 140 150
LCAKEKNPHT VAEKLVKPCA LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI
160 170 180 190 200
DEMSQDILQQ VLEDIKASPL KVGIQLAETT DMDDCSQLMA FVRYIKEREI
210 220 230 240 250
VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV CTDGASSMLG
260 270 280 290 300
ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF
310 320 330 340 350
IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI
360 370 380 390 400
NQFLHHKSSN LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS
410 420 430 440 450
AREKLSAFVR KFPFWQKRIE KRNFTNFPFL EEIIVSDNEG IFIAAEITLH
460 470 480 490 500
LQQLSNFFHG YFSIGDLNEA SKWILDPFLF NIDFVDDSYL MKNDLAELRA
510 520 530 540 550
SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT TYLCELGFSS
560 570 580 590
LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 | L → F in AAF18452 (PubMed:10607616).Curated | 1 | |
Sequence conflicti | 556 | T → P in BAB15542 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 584 | E → D in BAB15542 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046179 | 523 | A → S. Corresponds to variant dbSNP:rs10515808Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF205598 Genomic DNA Translation: AAF18452.1 AK026754 mRNA Translation: BAB15542.1 CH471062 Genomic DNA Translation: EAW61557.1 CH471062 Genomic DNA Translation: EAW61558.1 CH471062 Genomic DNA Translation: EAW61559.1 CH471062 Genomic DNA Translation: EAW61560.1 BC032603 mRNA Translation: AAH32603.1 BC112128 mRNA Translation: AAI12129.1 BC112130 mRNA Translation: AAI12131.1 |
CCDSi | CCDS34283.1 |
RefSeqi | NP_001290180.1, NM_001303251.1 NP_071373.2, NM_022090.4 |
Genome annotation databases
Ensembli | ENST00000408953; ENSP00000386184; ENSG00000221886 ENST00000523213; ENSP00000428831; ENSG00000221886 |
GeneIDi | 63920 |
KEGGi | hsa:63920 |
UCSCi | uc003lye.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF205598 Genomic DNA Translation: AAF18452.1 AK026754 mRNA Translation: BAB15542.1 CH471062 Genomic DNA Translation: EAW61557.1 CH471062 Genomic DNA Translation: EAW61558.1 CH471062 Genomic DNA Translation: EAW61559.1 CH471062 Genomic DNA Translation: EAW61560.1 BC032603 mRNA Translation: AAH32603.1 BC112128 mRNA Translation: AAI12129.1 BC112130 mRNA Translation: AAI12131.1 |
CCDSi | CCDS34283.1 |
RefSeqi | NP_001290180.1, NM_001303251.1 NP_071373.2, NM_022090.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121989, 17 interactors |
IntActi | Q8IZ13, 15 interactors |
MINTi | Q8IZ13 |
STRINGi | 9606.ENSP00000386184 |
PTM databases
iPTMneti | Q8IZ13 |
PhosphoSitePlusi | Q8IZ13 |
Genetic variation databases
BioMutai | ZBED8 |
DMDMi | 74728411 |
Proteomic databases
EPDi | Q8IZ13 |
jPOSTi | Q8IZ13 |
MassIVEi | Q8IZ13 |
MaxQBi | Q8IZ13 |
PaxDbi | Q8IZ13 |
PeptideAtlasi | Q8IZ13 |
PRIDEi | Q8IZ13 |
ProteomicsDBi | 71267 |
Protocols and materials databases
Antibodypediai | 45858, 35 antibodies |
Genome annotation databases
Ensembli | ENST00000408953; ENSP00000386184; ENSG00000221886 ENST00000523213; ENSP00000428831; ENSG00000221886 |
GeneIDi | 63920 |
KEGGi | hsa:63920 |
UCSCi | uc003lye.2, human |
Organism-specific databases
CTDi | 63920 |
DisGeNETi | 63920 |
GeneCardsi | ZBED8 |
HGNCi | HGNC:30804, ZBED8 |
HPAi | ENSG00000221886, Low tissue specificity |
MIMi | 615253, gene |
neXtProti | NX_Q8IZ13 |
OpenTargetsi | ENSG00000221886 |
PharmGKBi | PA164717348 |
VEuPathDBi | HostDB:ENSG00000221886.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT83, Eukaryota |
GeneTreei | ENSGT00940000163112 |
HOGENOMi | CLU_021316_5_0_1 |
InParanoidi | Q8IZ13 |
OMAi | EKNPHTI |
OrthoDBi | 875619at2759 |
PhylomeDBi | Q8IZ13 |
TreeFami | TF328297 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZ13 |
Miscellaneous databases
BioGRID-ORCSi | 63920, 5 hits in 872 CRISPR screens |
ChiTaRSi | ZBED8, human |
GenomeRNAii | 63920 |
Pharosi | Q8IZ13, Tdark |
PROi | PR:Q8IZ13 |
RNActi | Q8IZ13, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000221886, Expressed in heart and 196 other tissues |
Genevisiblei | Q8IZ13, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025398, DUF4371 IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF14291, DUF4371, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBED8_HUMAN | |
Accessioni | Q8IZ13Primary (citable) accession number: Q8IZ13 Secondary accession number(s): D3DQJ9, Q9H5S8, Q9UH87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM