ZBED8

Functionⁱ

Miscellaneous

May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

GO - Molecular functionⁱ

DNA binding Source: GO_Central
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein ZBED8 Alternative name(s): Transposon-derived Buster3 transposase-like protein Zinc finger BED domain-containing protein 8
Gene namesⁱ	Name:ZBED8 Synonyms:Buster3, C5orf54
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000221886.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30804 ZBED8
MIMⁱ	615253 gene
neXtProtⁱ	NX_Q8IZ13

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000221886
PharmGKBⁱ	PA164717348

Polymorphism and mutation databases

BioMutaⁱ	ZBED8
DMDMⁱ	74728411

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000348452	1 – 594	Protein ZBED8Add BLAST		594

Proteomic databases

EPDⁱ	Q8IZ13
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZ13
PaxDbⁱ	Q8IZ13
PeptideAtlas More...PeptideAtlasⁱ	Q8IZ13
PRIDEⁱ	Q8IZ13
ProteomicsDBⁱ	71267

PTM databases

iPTMnetⁱ	Q8IZ13
PhosphoSitePlusⁱ	Q8IZ13

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000221886
Genevisibleⁱ	Q8IZ13 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045445 HPA055817

HPAⁱ

HPA045445
HPA055817

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ARP2	P32381	3	EBI-7186123,EBI-2927	From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
METTL21A	Q8WXB1	3	EBI-7186123,EBI-8652459
NAB2	Q15742	5	EBI-7186123,EBI-8641936

Show more details

Protein-protein interaction databases

BioGridⁱ	121989, 14 interactors
IntActⁱ	Q8IZ13, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8IZ13
STRINGⁱ	9606.ENSP00000386184

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IZ13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IHXC Eukaryota ENOG410ZSKF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133692
HOGENOMⁱ	HOG000253000
InParanoidⁱ	Q8IZ13
OMAⁱ	ILMEFET
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	Q8IZ13
TreeFamⁱ	TF328297

Family and domain databases

InterProⁱ	View protein in InterPro IPR012337 RNaseH-like_sf
SUPFAMⁱ	SSF53098 SSF53098, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IZ13-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH 
        60         70         80         90        100
FNRQHGGVAG HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY 
       110        120        130        140        150
LCAKEKNPHT VAEKLVKPCA LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI 
       160        170        180        190        200
DEMSQDILQQ VLEDIKASPL KVGIQLAETT DMDDCSQLMA FVRYIKEREI 
       210        220        230        240        250
VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV CTDGASSMLG 
       260        270        280        290        300
ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF 
       310        320        330        340        350
IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI 
       360        370        380        390        400
NQFLHHKSSN LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS 
       410        420        430        440        450
AREKLSAFVR KFPFWQKRIE KRNFTNFPFL EEIIVSDNEG IFIAAEITLH 
       460        470        480        490        500
LQQLSNFFHG YFSIGDLNEA SKWILDPFLF NIDFVDDSYL MKNDLAELRA 
       510        520        530        540        550
SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT TYLCELGFSS 
       560        570        580        590 
LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL

Length:594

Mass (Da):68,327

Last modified:March 1, 2003 - v1

Checksum:ⁱC786B19C80B75263

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	L → F in AAF18452 (PubMed:10607616).Curated	1
Sequence conflictⁱ	556	T → P in BAB15542 (PubMed:14702039).Curated	1
Sequence conflictⁱ	584	E → D in BAB15542 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046179	523	A → S. Corresponds to variant dbSNP:rs10515808Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF205598 Genomic DNA Translation: AAF18452.1 AK026754 mRNA Translation: BAB15542.1 CH471062 Genomic DNA Translation: EAW61557.1 CH471062 Genomic DNA Translation: EAW61558.1 CH471062 Genomic DNA Translation: EAW61559.1 CH471062 Genomic DNA Translation: EAW61560.1 BC032603 mRNA Translation: AAH32603.1 BC112128 mRNA Translation: AAI12129.1 BC112130 mRNA Translation: AAI12131.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34283.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001290180.1, NM_001303251.1 NP_071373.2, NM_022090.4
UniGeneⁱ	Hs.529464

Genome annotation databases

Ensemblⁱ	ENST00000408953; ENSP00000386184; ENSG00000221886 ENST00000523213; ENSP00000428831; ENSG00000221886
GeneIDⁱ	63920
KEGGⁱ	hsa:63920
UCSC genome browser More...UCSCⁱ	uc003lye.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
Q8IZ13	UPI00042CF732		BUBBU		691
UPI0004BD88E4		EQUPR		613
UPI000643B981		MICMU		606
Transposon-derived Buster3 transposase-like protein		CALJA		594
Chromosome 5 open reading frame 54		PANTR		594
+78

Protein	Similar proteins		Species	Score	Length
Q8IZ13	UPI00042CF732		BUBBU		691
UPI0004BD88E4		EQUPR		613
UPI000643B981		MICMU		606
UPI00019516C5		VICPA		594
Zinc finger BED-type containing 8		FELCA		594
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF205598 Genomic DNA Translation: AAF18452.1 AK026754 mRNA Translation: BAB15542.1 CH471062 Genomic DNA Translation: EAW61557.1 CH471062 Genomic DNA Translation: EAW61558.1 CH471062 Genomic DNA Translation: EAW61559.1 CH471062 Genomic DNA Translation: EAW61560.1 BC032603 mRNA Translation: AAH32603.1 BC112128 mRNA Translation: AAI12129.1 BC112130 mRNA Translation: AAI12131.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34283.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001290180.1, NM_001303251.1 NP_071373.2, NM_022090.4
UniGeneⁱ	Hs.529464

3D structure databases

ProteinModelPortalⁱ	Q8IZ13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121989, 14 interactors
IntActⁱ	Q8IZ13, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q8IZ13
STRINGⁱ	9606.ENSP00000386184

PTM databases

iPTMnetⁱ	Q8IZ13
PhosphoSitePlusⁱ	Q8IZ13

Polymorphism and mutation databases

BioMutaⁱ	ZBED8
DMDMⁱ	74728411

Proteomic databases

EPDⁱ	Q8IZ13
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZ13
PaxDbⁱ	Q8IZ13
PeptideAtlas More...PeptideAtlasⁱ	Q8IZ13
PRIDEⁱ	Q8IZ13
ProteomicsDBⁱ	71267

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000408953; ENSP00000386184; ENSG00000221886 ENST00000523213; ENSP00000428831; ENSG00000221886
GeneIDⁱ	63920
KEGGⁱ	hsa:63920
UCSC genome browser More...UCSCⁱ	uc003lye.2 human

Organism-specific databases

CTDⁱ	63920
EuPathDBⁱ	HostDB:ENSG00000221886.3
GeneCardsⁱ	ZBED8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30804 ZBED8
Human Protein Atlas More...HPAⁱ	HPA045445 HPA055817
MIMⁱ	615253 gene
neXtProtⁱ	NX_Q8IZ13
Open Targets More...OpenTargetsⁱ	ENSG00000221886
PharmGKBⁱ	PA164717348
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHXC Eukaryota ENOG410ZSKF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133692
HOGENOMⁱ	HOG000253000
InParanoidⁱ	Q8IZ13
OMAⁱ	ILMEFET
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	Q8IZ13
TreeFamⁱ	TF328297

Miscellaneous databases

ChiTaRSⁱ	ZBED8 human
GenomeRNAiⁱ	63920
Protein Ontology More...PROⁱ	PR:Q8IZ13
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000221886
Genevisibleⁱ	Q8IZ13 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012337 RNaseH-like_sf
SUPFAMⁱ	SSF53098 SSF53098, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBED8_HUMAN
Accessionⁱ	Q8IZ13Primary (citable) accession number: Q8IZ13 Secondary accession number(s): D3DQJ9, Q9H5S8, Q9UH87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	March 1, 2003
	Last modified:	July 18, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IZ13 (ZBED8_HUMAN)

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Protein ZBED8

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ