UniProtKB - Q8IZ08 (GP135_HUMAN)
Protein
G-protein coupled receptor 135
Gene
GPR135
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).1 Publication
GO - Molecular functioni
- arrestin family protein binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8IZ08 |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 135Curated |
Gene namesi | Name:GPR135 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19991, GPR135 |
MIMi | 607970, gene |
neXtProti | NX_Q8IZ08 |
VEuPathDBi | HostDB:ENSG00000181619.11 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Colocalizes with ARRB2/beta-arrestin-2 in the endosome.1 Publication
Endosome
- endosome Source: UniProtKB
- endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 13 – 33 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 34 – 37 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 38 – 58 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 81 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 82 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 125 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 126 – 146 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 147 – 164 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 185 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 226 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 227 – 247 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 262 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 263 – 283 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 494 | CytoplasmicSequence analysisAdd BLAST | 211 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 64582 |
OpenTargetsi | ENSG00000181619 |
PharmGKBi | PA134863427 |
Miscellaneous databases
Pharosi | Q8IZ08, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3309102 |
Genetic variation databases
BioMutai | GPR135 |
DMDMi | 62900365 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069612 | 1 – 494 | G-protein coupled receptor 135Add BLAST | 494 |
Proteomic databases
EPDi | Q8IZ08 |
MassIVEi | Q8IZ08 |
PaxDbi | Q8IZ08 |
PeptideAtlasi | Q8IZ08 |
PRIDEi | Q8IZ08 |
ProteomicsDBi | 71266 |
PTM databases
iPTMneti | Q8IZ08 |
PhosphoSitePlusi | Q8IZ08 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181619, Expressed in testis and 123 other tissues |
Genevisiblei | Q8IZ08, HS |
Organism-specific databases
HPAi | ENSG00000181619, Tissue enhanced (testis) |
Interactioni
Subunit structurei
GO - Molecular functioni
- arrestin family protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 122207, 6 interactors |
IntActi | Q8IZ08, 4 interactors |
STRINGi | 9606.ENSP00000378548 |
Chemistry databases
BindingDBi | Q8IZ08 |
Miscellaneous databases
RNActi | Q8IZ08, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_048891_0_0_1 |
InParanoidi | Q8IZ08 |
OMAi | FYSEMRT |
OrthoDBi | 770796at2759 |
PhylomeDBi | Q8IZ08 |
TreeFami | TF333332 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IZ08-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA
60 70 80 90 100
ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG
110 120 130 140 150
AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL
160 170 180 190 200
LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL
210 220 230 240 250
SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP
260 270 280 290 300
RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI
310 320 330 340 350
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL
360 370 380 390 400
VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR
410 420 430 440 450
NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA
460 470 480 490
SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL
Sequence cautioni
The sequence BAC05800 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024259 | 5 | Q → P. Corresponds to variant dbSNP:rs1752428Ensembl. | 1 | |
Natural variantiVAR_049402 | 481 | V → A. Corresponds to variant dbSNP:rs1752427Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288418 mRNA Translation: AAP72127.1 AB065563 Genomic DNA Translation: BAC05800.1 Sequence problems. AL159140 Genomic DNA No translation available. BC032831 mRNA Translation: AAH32831.2 AY255588 mRNA Translation: AAO85100.1 |
CCDSi | CCDS9738.1 |
RefSeqi | NP_072093.2, NM_022571.5 XP_016877085.1, XM_017021596.1 XP_016877086.1, XM_017021597.1 XP_016877087.1, XM_017021598.1 XP_016877088.1, XM_017021599.1 |
Genome annotation databases
Ensembli | ENST00000395116; ENSP00000378548; ENSG00000181619 ENST00000481661; ENSP00000432696; ENSG00000181619 |
GeneIDi | 64582 |
KEGGi | hsa:64582 |
UCSCi | uc001xed.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288418 mRNA Translation: AAP72127.1 AB065563 Genomic DNA Translation: BAC05800.1 Sequence problems. AL159140 Genomic DNA No translation available. BC032831 mRNA Translation: AAH32831.2 AY255588 mRNA Translation: AAO85100.1 |
CCDSi | CCDS9738.1 |
RefSeqi | NP_072093.2, NM_022571.5 XP_016877085.1, XM_017021596.1 XP_016877086.1, XM_017021597.1 XP_016877087.1, XM_017021598.1 XP_016877088.1, XM_017021599.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122207, 6 interactors |
IntActi | Q8IZ08, 4 interactors |
STRINGi | 9606.ENSP00000378548 |
Chemistry databases
BindingDBi | Q8IZ08 |
ChEMBLi | CHEMBL3309102 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q8IZ08 |
PhosphoSitePlusi | Q8IZ08 |
Genetic variation databases
BioMutai | GPR135 |
DMDMi | 62900365 |
Proteomic databases
EPDi | Q8IZ08 |
MassIVEi | Q8IZ08 |
PaxDbi | Q8IZ08 |
PeptideAtlasi | Q8IZ08 |
PRIDEi | Q8IZ08 |
ProteomicsDBi | 71266 |
Protocols and materials databases
Antibodypediai | 24279, 91 antibodies |
DNASUi | 64582 |
Genome annotation databases
Ensembli | ENST00000395116; ENSP00000378548; ENSG00000181619 ENST00000481661; ENSP00000432696; ENSG00000181619 |
GeneIDi | 64582 |
KEGGi | hsa:64582 |
UCSCi | uc001xed.3, human |
Organism-specific databases
CTDi | 64582 |
DisGeNETi | 64582 |
GeneCardsi | GPR135 |
HGNCi | HGNC:19991, GPR135 |
HPAi | ENSG00000181619, Tissue enhanced (testis) |
MIMi | 607970, gene |
neXtProti | NX_Q8IZ08 |
OpenTargetsi | ENSG00000181619 |
PharmGKBi | PA134863427 |
VEuPathDBi | HostDB:ENSG00000181619.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00950000182998 |
HOGENOMi | CLU_048891_0_0_1 |
InParanoidi | Q8IZ08 |
OMAi | FYSEMRT |
OrthoDBi | 770796at2759 |
PhylomeDBi | Q8IZ08 |
TreeFami | TF333332 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZ08 |
Miscellaneous databases
BioGRID-ORCSi | 64582, 9 hits in 876 CRISPR screens |
ChiTaRSi | GPR135, human |
GeneWikii | GPR135 |
GenomeRNAii | 64582 |
Pharosi | Q8IZ08, Tbio |
PROi | PR:Q8IZ08 |
RNActi | Q8IZ08, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181619, Expressed in testis and 123 other tissues |
Genevisiblei | Q8IZ08, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP135_HUMAN | |
Accessioni | Q8IZ08Primary (citable) accession number: Q8IZ08 Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants