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UniProtKB - Q8IZ08 (GP135_HUMAN)

Entry version 137 (07 Apr 2021)
Sequence version 2 (23 Nov 2004)
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Protein

G-protein coupled receptor 135

Gene

GPR135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZ08

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor 135Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR135
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19991, GPR135

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607970, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZ08

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000181619.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 37CytoplasmicSequence analysis4
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 494CytoplasmicSequence analysisAdd BLAST211

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64582

Open Targets

More...OpenTargetsi		ENSG00000181619

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134863427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZ08, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3309102

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR135

Domain mapping of disease mutations (DMDM)

More...DMDMi		62900365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696121 – 494G-protein coupled receptor 135Add BLAST494

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IZ08

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IZ08

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZ08

PeptideAtlas

More...PeptideAtlasi		Q8IZ08

PRoteomics IDEntifications database

More...PRIDEi		Q8IZ08

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71266

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZ08

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZ08

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000181619, Expressed in testis and 123 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZ08, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000181619, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTNR1B (PubMed:28827538).

Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR135 in the endosomal compartment (PubMed:28827538).

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122207, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZ08, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378548

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8IZ08

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZ08, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182998

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048891_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZ08

Identification of Orthologs from Complete Genome Data

More...OMAi		FYSEMRT

Database of Orthologous Groups

More...OrthoDBi		770796at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZ08

TreeFam database of animal gene trees

More...TreeFami		TF333332

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IZ08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPQPPRPP ASMALLGSQH SGAPSAAGPP GGTSSAATAA VLSFSTVATA 
        60         70         80         90        100
ALGNLSDASG GGTAAAPGGG GLGGSGAARE AGAAVRRPLG PEAAPLLSHG 
       110        120        130        140        150
AAVAAQALVL LLIFLLSSLG NCAVMGVIVK HRQLRTVTNA FILSLSLSDL 
       160        170        180        190        200
LTALLCLPAA FLDLFTPPGG SAPAAAAGPW RGFCAASRFF SSCFGIVSTL 
       210        220        230        240        250
SVALISLDRY CAIVRPPREK IGRRRALQLL AGAWLTALGF SLPWELLGAP 
       260        270        280        290        300
RELAAAQSFH GCLYRTSPDP AQLGAAFSVG LVVACYLLPF LLMCFCHYHI 
       310        320        330        340        350
CKTVRLSDVR VRPVNTYARV LRFFSEVRTA TTVLIMIVFV ICCWGPYCFL 
       360        370        380        390        400
VLLAAARQAQ TMQAPSLLSV VAVWLTWANG AINPVIYAIR NPNISMLLGR 
       410        420        430        440        450
NREEGYRTRN VDAFLPSQGP GLQARSRSRL RNRYANRLGA CNRMSSSNPA 
       460        470        480        490 
SGVAGDVAMW ARKNPVVLFC REGPPEPVTA VTKQPKSEAG DTSL
Length:494
Mass (Da):51,736
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i439A932E2860D4DF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05800 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0242595Q → P. Corresponds to variant dbSNP:rs1752428Ensembl.1
Natural variantiVAR_049402481V → A. Corresponds to variant dbSNP:rs1752427Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY288418 mRNA Translation: AAP72127.1
AB065563 Genomic DNA Translation: BAC05800.1 Sequence problems.
AL159140 Genomic DNA No translation available.
BC032831 mRNA Translation: AAH32831.2
AY255588 mRNA Translation: AAO85100.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9738.1

NCBI Reference Sequences

More...RefSeqi		NP_072093.2, NM_022571.5
XP_016877085.1, XM_017021596.1
XP_016877086.1, XM_017021597.1
XP_016877087.1, XM_017021598.1
XP_016877088.1, XM_017021599.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395116; ENSP00000378548; ENSG00000181619
ENST00000481661; ENSP00000432696; ENSG00000181619

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64582

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64582

UCSC genome browser

More...UCSCi		uc001xed.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288418 mRNA Translation: AAP72127.1
AB065563 Genomic DNA Translation: BAC05800.1 Sequence problems.
AL159140 Genomic DNA No translation available.
BC032831 mRNA Translation: AAH32831.2
AY255588 mRNA Translation: AAO85100.1
CCDSiCCDS9738.1
RefSeqiNP_072093.2, NM_022571.5
XP_016877085.1, XM_017021596.1
XP_016877086.1, XM_017021597.1
XP_016877087.1, XM_017021598.1
XP_016877088.1, XM_017021599.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122207, 6 interactors
IntActiQ8IZ08, 4 interactors
STRINGi9606.ENSP00000378548

Chemistry databases

BindingDBiQ8IZ08
ChEMBLiCHEMBL3309102

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ8IZ08
PhosphoSitePlusiQ8IZ08

Genetic variation databases

BioMutaiGPR135
DMDMi62900365

Proteomic databases

EPDiQ8IZ08
MassIVEiQ8IZ08
PaxDbiQ8IZ08
PeptideAtlasiQ8IZ08
PRIDEiQ8IZ08
ProteomicsDBi71266

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24279, 94 antibodies

The DNASU plasmid repository

More...DNASUi		64582

Genome annotation databases

EnsembliENST00000395116; ENSP00000378548; ENSG00000181619
ENST00000481661; ENSP00000432696; ENSG00000181619
GeneIDi64582
KEGGihsa:64582
UCSCiuc001xed.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64582
DisGeNETi64582

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR135
HGNCiHGNC:19991, GPR135
HPAiENSG00000181619, Tissue enhanced (testis)
MIMi607970, gene
neXtProtiNX_Q8IZ08
OpenTargetsiENSG00000181619
PharmGKBiPA134863427
VEuPathDBiHostDB:ENSG00000181619.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00950000182998
HOGENOMiCLU_048891_0_0_1
InParanoidiQ8IZ08
OMAiFYSEMRT
OrthoDBi770796at2759
PhylomeDBiQ8IZ08
TreeFamiTF333332

Enzyme and pathway databases

PathwayCommonsiQ8IZ08

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64582, 11 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GPR135, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR135

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64582
PharosiQ8IZ08, Tbio

Protein Ontology

More...PROi		PR:Q8IZ08
RNActiQ8IZ08, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000181619, Expressed in testis and 123 other tissues
GenevisibleiQ8IZ08, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP135_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ08
Secondary accession number(s): Q7Z604, Q86SM3, Q8NH39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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