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Entry version 155 (12 Aug 2020)
Sequence version 3 (17 Apr 2007)
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Protein

Ankyrin repeat domain-containing protein 13A

Gene

ANKRD13A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin-dependent protein binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZ07

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13A
Alternative name(s):
Protein KE03
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD13A
Synonyms:ANKRD13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000076513.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21268, ANKRD13A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615123, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZ07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi491 – 495AIQQS → GIQQA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 527-G--A-531 and 557-G--A-561. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531, 557-G--A-561 and 582-G--A-586. 1 Publication5
Mutagenesisi527 – 531AIQES → GIQEA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 557-G--A-561. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 491-G--A-495 and 557-G--A-561. Strongly inhibits 'Lys-63'-linked ubiquitin binding; when associated with 557-G--A-561 and 582-G--A-586. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 557-G--A-561 and 582-G--A-586. 1 Publication5
Mutagenesisi557 – 561AMELS → GMELA: Slightly inhibits 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531. Inhibits 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495 and 527-G--A-531. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 582-V--S-586. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 527-G--A-531 and 582-G--A-586. 1 Publication5
Mutagenesisi582 – 586VLQLS → GLQLA: Abolishes 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 557-G--A-561. Strongly inhibits 'Lys-63'-linked ubiquitin binding; when associated with 527-G--A-531 and 557-G--A-561. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 527-G--A-531 and 557-G--A-561. 1 Publication5

Organism-specific databases

DisGeNET

More...
DisGeNETi
88455

Open Targets

More...
OpenTargetsi
ENSG00000076513

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZ07, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD13A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669091 – 590Ankyrin repeat domain-containing protein 13AAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei205PhosphoserineBy similarity1
Modified residuei586PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZ07

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZ07

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZ07

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZ07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZ07

PeptideAtlas

More...
PeptideAtlasi
Q8IZ07

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZ07

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71265

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZ07

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8IZ07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZ07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000076513, Expressed in placenta and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZ07, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZ07, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000076513, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the UIM 3 and 4 repeats) with EGFR (ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124582, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZ07, 31 interactors

Molecular INTeraction database

More...
MINTi
Q8IZ07

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261739

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZ07, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZ07

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 69ANK 1Add BLAST30
Repeati73 – 102ANK 2Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini483 – 502UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini519 – 538UIM 2PROSITE-ProRule annotationAdd BLAST20
Domaini549 – 568UIM 3PROSITE-ProRule annotationAdd BLAST20
Domaini574 – 590UIM 4PROSITE-ProRule annotationAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UIM repeats 3 and 4 are required for binding to ubiquitinated EGFR and 'Lys-63'-linked ubiquitin.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0522, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182928

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026137_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZ07

KEGG Orthology (KO)

More...
KOi
K21437

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSYEAQY

Database of Orthologous Groups

More...
OrthoDBi
425969at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZ07

TreeFam database of animal gene trees

More...
TreeFami
TF314176

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021832, ANKRD13
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003903, UIM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12447, PTHR12447, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11904, GPCR_chapero_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00726, UIM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50330, UIM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IZ07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSACDAGDH YPLHLLVWKN DYRQLEKELQ GQNVEAVDPR GRTLLHLAVS
60 70 80 90 100
LGHLESARVL LRHKADVTKE NRQGWTVLHE AVSTGDPEMV YTVLQHRDYH
110 120 130 140 150
NTSMALEGVP ELLQKILEAP DFYVQMKWEF TSWVPLVSRI CPNDVCRIWK
160 170 180 190 200
SGAKLRVDIT LLGFENMSWI RGRRSFIFKG EDNWAELMEV NHDDKVVTTE
210 220 230 240 250
RFDLSQEMER LTLDLMKPKS REVERRLTSP VINTSLDTKN IAFERTKSGF
260 270 280 290 300
WGWRTDKAEV VNGYEAKVYT VNNVNVITKI RTEHLTEEEK KRYKADRNPL
310 320 330 340 350
ESLLGTVEHQ FGAQGDLTTE CATANNPTAI TPDEYFNEEF DLKDRDIGRP
360 370 380 390 400
KELTIRTQKF KAMLWMCEEF PLSLVEQVIP IIDLMARTSA HFARLRDFIK
410 420 430 440 450
LEFPPGFPVK IEIPLFHVLN ARITFGNVNG CSTAEESVSQ NVEGTQADSA
460 470 480 490 500
SHITNFEVDQ SVFEIPESYY VQDNGRNVHL QDEDYEIMQF AIQQSLLESS
510 520 530 540 550
RSQELSGPAS NGGISQTNTY DAQYERAIQE SLLTSTEGLC PSALSETSRF
560 570 580 590
DNDLQLAMEL SAKELEEWEL RLQEEEAELQ QVLQLSLTDK
Length:590
Mass (Da):67,619
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25D0B712D1A1B0B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R3U2S4R3U2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD13A
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIN8H0YIN8_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD13A
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W150F8W150_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD13A
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3D2S4R3D2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD13A
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC17109 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti193D → G in AAC17109 (Ref. 2) Curated1
Sequence conflicti296D → G in AAH32833 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048276505L → P. Corresponds to variant dbSNP:rs2287174Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC032833 mRNA Translation: AAH32833.2
AF064604 mRNA Translation: AAC17109.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9140.1

NCBI Reference Sequences

More...
RefSeqi
NP_149112.1, NM_033121.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261739; ENSP00000261739; ENSG00000076513

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
88455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:88455

UCSC genome browser

More...
UCSCi
uc001tpx.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032833 mRNA Translation: AAH32833.2
AF064604 mRNA Translation: AAC17109.1 Frameshift.
CCDSiCCDS9140.1
RefSeqiNP_149112.1, NM_033121.1

3D structure databases

SMRiQ8IZ07
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124582, 52 interactors
IntActiQ8IZ07, 31 interactors
MINTiQ8IZ07
STRINGi9606.ENSP00000261739

PTM databases

iPTMnetiQ8IZ07
MetOSiteiQ8IZ07
PhosphoSitePlusiQ8IZ07

Polymorphism and mutation databases

BioMutaiANKRD13A
DMDMi145559439

Proteomic databases

EPDiQ8IZ07
jPOSTiQ8IZ07
MassIVEiQ8IZ07
MaxQBiQ8IZ07
PaxDbiQ8IZ07
PeptideAtlasiQ8IZ07
PRIDEiQ8IZ07
ProteomicsDBi71265

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49620, 71 antibodies

The DNASU plasmid repository

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DNASUi
88455

Genome annotation databases

EnsembliENST00000261739; ENSP00000261739; ENSG00000076513
GeneIDi88455
KEGGihsa:88455
UCSCiuc001tpx.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
88455
DisGeNETi88455
EuPathDBiHostDB:ENSG00000076513.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD13A
HGNCiHGNC:21268, ANKRD13A
HPAiENSG00000076513, Low tissue specificity
MIMi615123, gene
neXtProtiNX_Q8IZ07
OpenTargetsiENSG00000076513
PharmGKBiPA134884324

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0522, Eukaryota
GeneTreeiENSGT00950000182928
HOGENOMiCLU_026137_2_0_1
InParanoidiQ8IZ07
KOiK21437
OMAiHSYEAQY
OrthoDBi425969at2759
PhylomeDBiQ8IZ07
TreeFamiTF314176

Enzyme and pathway databases

PathwayCommonsiQ8IZ07

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
88455, 1 hit in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD13A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
88455
PharosiQ8IZ07, Tdark

Protein Ontology

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PROi
PR:Q8IZ07
RNActiQ8IZ07, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000076513, Expressed in placenta and 221 other tissues
ExpressionAtlasiQ8IZ07, baseline and differential
GenevisibleiQ8IZ07, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR021832, ANKRD13
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR003903, UIM_dom
PANTHERiPTHR12447, PTHR12447, 1 hit
PfamiView protein in Pfam
PF11904, GPCR_chapero_1, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00726, UIM, 3 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50330, UIM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAN13A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZ07
Secondary accession number(s): O60736
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: April 17, 2007
Last modified: August 12, 2020
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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