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Entry version 143 (26 Feb 2020)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger protein DZIP1L

Gene

DZIP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in primary cilium formation (PubMed:19852954, PubMed:28530676). Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (PubMed:28530676).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri166 – 189C2H2-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein DZIP1LCurated
Alternative name(s):
DAZ-interacting protein 1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DZIP1LImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26551 DZIP1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617570 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Polycystic kidney disease 5 (PKD5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of polycystic kidney disease, a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts may also occur in other organs, particularly the liver. PKD5 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07896290A → V in PKD5. 1 PublicationCorresponds to variant dbSNP:rs555349004EnsemblClinVar.1
Natural variantiVAR_07896391Q → H in PKD5. 1 PublicationCorresponds to variant dbSNP:rs1135402754EnsemblClinVar.1
Natural variantiVAR_078964155 – 767Missing in PKD5. 1 PublicationAdd BLAST613

Keywords - Diseasei

Ciliopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
199221

MalaCards human disease database

More...
MalaCardsi
DZIP1L
MIMi617610 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000158163

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
731 Autosomal recessive polycystic kidney disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951988

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYY4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DZIP1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313061 – 767Zinc finger protein DZIP1LAdd BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei426PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IYY4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYY4

PeptideAtlas

More...
PeptideAtlasi
Q8IYY4

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYY4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71261 [Q8IYY4-1]
71262 [Q8IYY4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158163 Expressed in right uterine tube and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYY4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYY4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEPTIN2 (PubMed:28530676).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128259, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYY4, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332148

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYY4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYY4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili205 – 406Sequence analysisAdd BLAST202

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri166 – 189C2H2-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJJY Eukaryota
ENOG4111HTD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018051_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYY4

KEGG Orthology (KO)

More...
KOi
K16470

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIGRKHR

Database of Orthologous Groups

More...
OrthoDBi
1162102at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYY4

TreeFam database of animal gene trees

More...
TreeFami
TF330044

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032714 DZIP1_N
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13815 Dzip-like_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSPAATAEG LSGPLFGAYT FPTFKFQPRH DSMDWRRIST LDVDRVAREL
60 70 80 90 100
DVATLQENIA GITFCNLDRE VCSRCGQPVD PALLKVLRLA QLIIEYLLHC
110 120 130 140 150
QDCLSASVAQ LEARLQTSLG QQQRGQQELG RQADELKGVR EESRRRRKMI
160 170 180 190 200
STLQQLLMQT GTHSYHTCHL CDKTFMNATF LRGHIQRRHA GVAEGGKQKK
210 220 230 240 250
QEQPVEEVLE ELRAKLKWTQ GELEAQREAE RQRQLQEAEL IHQREIEAKK
260 270 280 290 300
EFDKWKEQEW TKLYGEIDKL KKLFWDEFKN VAKQNSTLEE KLRALQSHSV
310 320 330 340 350
MESKLGSLRD EESEEWLRQA RELQALREKT EIQKTEWKRK VKELHEEHMA
360 370 380 390 400
EKKELQEENQ RLQASLSQDQ KKAAAQSQCQ ISTLRAQLQE QARIIASQEE
410 420 430 440 450
MIQSLSLRKV EGIHKVPKAV DTEEDSPEEE MEDSQDEQHK VLAALRRNPT
460 470 480 490 500
LLKHFRPILE DTLEEKLESM GIRKDAKGIS IQTLRHLESL LRVQREQKAR
510 520 530 540 550
KFSEFLSLRG KLVKEVTSRA KERQENGAVV SQPDGQPSVK SQQSTLVTRE
560 570 580 590 600
AQPKTRTLQV ALPSTPAEPP PPTRQSHGSH GSSLTQVSAP APRPGLHGPS
610 620 630 640 650
STPPSSGPGM STPPFSSEED SEGDRVQRVS LQPPKVPSRM VPRPKDDWDW
660 670 680 690 700
SDTETSEENA QPPGQGSGTL VQSMVKNLEK QLEAPAKKPA GGVSLFFMPN
710 720 730 740 750
AGPQRAATPG RKPQLSEDES DLEISSLEDL PLDLDQREKP KPLSRSKLPE
760
KFGTGPQSSG QPRVPAW
Length:767
Mass (Da):86,848
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB491D287A667CCB9
GO
Isoform 2 (identifier: Q8IYY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-539: V → G
     540-767: Missing.

Show »
Length:539
Mass (Da):62,428
Checksum:i4C0C364A36703840
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4G2H7C4G2_HUMAN
Zinc finger protein DZIP1L
DZIP1L
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD19C9JD19_HUMAN
Zinc finger protein DZIP1L
DZIP1L
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRW2C9JRW2_HUMAN
Zinc finger protein DZIP1L
DZIP1L
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158M → T in BAB71474 (PubMed:14702039).Curated1
Sequence conflicti382S → N in BAB71474 (PubMed:14702039).Curated1
Sequence conflicti529V → A in AAH33308 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07896290A → V in PKD5. 1 PublicationCorresponds to variant dbSNP:rs555349004EnsemblClinVar.1
Natural variantiVAR_07896391Q → H in PKD5. 1 PublicationCorresponds to variant dbSNP:rs1135402754EnsemblClinVar.1
Natural variantiVAR_078964155 – 767Missing in PKD5. 1 PublicationAdd BLAST613
Natural variantiVAR_042756321R → W1 PublicationCorresponds to variant dbSNP:rs2724693Ensembl.1
Natural variantiVAR_042757545T → A1 PublicationCorresponds to variant dbSNP:rs446644Ensembl.1
Natural variantiVAR_042758551A → V. Corresponds to variant dbSNP:rs11917468Ensembl.1
Natural variantiVAR_042759593R → H1 PublicationCorresponds to variant dbSNP:rs374045Ensembl.1
Natural variantiVAR_042760645K → E. Corresponds to variant dbSNP:rs442800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033158539V → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_033159540 – 767Missing in isoform 2. 1 PublicationAdd BLAST228

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057406 mRNA Translation: BAB71474.1
AC023049 Genomic DNA No translation available.
BC033308 mRNA Translation: AAH33308.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3096.1 [Q8IYY4-1]
CCDS54645.1 [Q8IYY4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001164009.1, NM_001170538.1 [Q8IYY4-2]
NP_775814.2, NM_173543.2 [Q8IYY4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327532; ENSP00000332148; ENSG00000158163 [Q8IYY4-1]
ENST00000469243; ENSP00000419486; ENSG00000158163 [Q8IYY4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
199221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:199221

UCSC genome browser

More...
UCSCi
uc003erq.4 human [Q8IYY4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057406 mRNA Translation: BAB71474.1
AC023049 Genomic DNA No translation available.
BC033308 mRNA Translation: AAH33308.1
CCDSiCCDS3096.1 [Q8IYY4-1]
CCDS54645.1 [Q8IYY4-2]
RefSeqiNP_001164009.1, NM_001170538.1 [Q8IYY4-2]
NP_775814.2, NM_173543.2 [Q8IYY4-1]

3D structure databases

SMRiQ8IYY4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128259, 6 interactors
IntActiQ8IYY4, 10 interactors
STRINGi9606.ENSP00000332148

PTM databases

iPTMnetiQ8IYY4
PhosphoSitePlusiQ8IYY4

Polymorphism and mutation databases

BioMutaiDZIP1L
DMDMi296434487

Proteomic databases

jPOSTiQ8IYY4
MassIVEiQ8IYY4
PaxDbiQ8IYY4
PeptideAtlasiQ8IYY4
PRIDEiQ8IYY4
ProteomicsDBi71261 [Q8IYY4-1]
71262 [Q8IYY4-2]

Genome annotation databases

EnsembliENST00000327532; ENSP00000332148; ENSG00000158163 [Q8IYY4-1]
ENST00000469243; ENSP00000419486; ENSG00000158163 [Q8IYY4-2]
GeneIDi199221
KEGGihsa:199221
UCSCiuc003erq.4 human [Q8IYY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
199221
DisGeNETi199221

GeneCards: human genes, protein and diseases

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GeneCardsi
DZIP1L
HGNCiHGNC:26551 DZIP1L
HPAiHPA030404
MalaCardsiDZIP1L
MIMi617570 gene
617610 phenotype
neXtProtiNX_Q8IYY4
OpenTargetsiENSG00000158163
Orphaneti731 Autosomal recessive polycystic kidney disease
PharmGKBiPA134951988

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IJJY Eukaryota
ENOG4111HTD LUCA
GeneTreeiENSGT00940000160898
HOGENOMiCLU_018051_0_1_1
InParanoidiQ8IYY4
KOiK16470
OMAiHIGRKHR
OrthoDBi1162102at2759
PhylomeDBiQ8IYY4
TreeFamiTF330044

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DZIP1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
199221
PharosiQ8IYY4 Tbio

Protein Ontology

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PROi
PR:Q8IYY4
RNActiQ8IYY4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000158163 Expressed in right uterine tube and 180 other tissues
ExpressionAtlasiQ8IYY4 baseline and differential
GenevisibleiQ8IYY4 HS

Family and domain databases

InterProiView protein in InterPro
IPR032714 DZIP1_N
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13815 Dzip-like_N, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDZI1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYY4
Secondary accession number(s): C9JUG5, Q96M38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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