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UniProtKB - Q8IYX8 (CE57L_HUMAN)

Entry version 140 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Centrosomal protein CEP57L1

Gene

CEP57L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IYX8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein CEP57L1
Alternative name(s):
Centrosomal protein 57kDa-like protein 1
Centrosomal protein of 57 kDa-related protein
Short name:
Cep57R
Cep57-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP57L1
Synonyms:C6orf182, CEP57R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000183137.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:21561, CEP57L1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IYX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		285753

Open Targets

More...OpenTargetsi		ENSG00000183137

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134980921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IYX8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEP57L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001895341 – 460Centrosomal protein CEP57L1Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IYX8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IYX8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IYX8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IYX8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IYX8

PeptideAtlas

More...PeptideAtlasi		Q8IYX8

PRoteomics IDEntifications database

More...PRIDEi		Q8IYX8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33869
71260 [Q8IYX8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IYX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IYX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183137, Expressed in testis and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IYX8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IYX8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183137, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IYX8
With#Exp.IntAct
CALCOCO2 [Q13137]3EBI-1104570,EBI-739580
CCDC136 - isoform 2 [Q96JN2-2]3EBI-1104570,EBI-10171416
CEP55 [Q53EZ4]4EBI-1104570,EBI-747776
itself4EBI-1104570,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-1104570,EBI-10181988
CEP63 [Q96MT8]3EBI-1104570,EBI-741977
CEP70 [Q8NHQ1]3EBI-1104570,EBI-739624
DVL3 [Q92997]3EBI-1104570,EBI-739789
GOLGA2 [Q08379]6EBI-1104570,EBI-618309
GRIPAP1 [Q4V328]6EBI-1104570,EBI-717919
INADL [A5PKX9]3EBI-1104570,EBI-12035052
KATNAL1 [Q9BW62]9EBI-1104570,EBI-743591
KRT31 [Q15323]3EBI-1104570,EBI-948001
KRT40 [Q6A162]3EBI-1104570,EBI-10171697
LMO1 [P25800]3EBI-1104570,EBI-8639312
LZTS2 [Q9BRK4]3EBI-1104570,EBI-741037
MCC [P23508]3EBI-1104570,EBI-307531
MDFI [Q99750]6EBI-1104570,EBI-724076
MFAP1 [P55081]3EBI-1104570,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-1104570,EBI-10172526
MTUS2 [Q5JR59]3EBI-1104570,EBI-742948
PICK1 [Q9NRD5]3EBI-1104570,EBI-79165
PNMA5 [Q96PV4]3EBI-1104570,EBI-10171633
PRDM6 [Q9NQX0]3EBI-1104570,EBI-11320284
SNAPC3 [Q92966]3EBI-1104570,EBI-1760638
TFIP11 [Q9UBB9]3EBI-1104570,EBI-1105213
TXLNA [P40222]3EBI-1104570,EBI-359793
TXLNB [Q8N3L3]3EBI-1104570,EBI-6116822
YES1 [P07947]3EBI-1104570,EBI-515331
ZNF572 [Q7Z3I7]4EBI-1104570,EBI-10172590
ZNF655 [Q8N720]3EBI-1104570,EBI-625509
CEP57L1 - isoform 2 [Q8IYX8-2]
With#Exp.IntAct
ALOX5 [P09917]3EBI-10181988,EBI-79934
AP1M1 [Q9BXS5]3EBI-10181988,EBI-541426
BYSL [Q13895]5EBI-10181988,EBI-358049
CARD9 [Q9H257]3EBI-10181988,EBI-751319
CBY2 [Q8NA61]3EBI-10181988,EBI-741724
CCDC102B [Q68D86]3EBI-10181988,EBI-10171570
CCDC136 - isoform 2 [Q96JN2-2]3EBI-10181988,EBI-10171416
CCDC57 [Q2TAC2]3EBI-10181988,EBI-2808286
CDR2 [Q01850]3EBI-10181988,EBI-1181367
CEP44 [Q9C0F1]3EBI-10181988,EBI-744115
CEP55 [Q53EZ4]3EBI-10181988,EBI-747776
CEP63 [Q96MT8]3EBI-10181988,EBI-741977
CEP70 [Q8NHQ1]3EBI-10181988,EBI-739624
CFAP206 [Q8IYR0]3EBI-10181988,EBI-749051
DYDC1 [Q8WWB3]3EBI-10181988,EBI-740680
ELOA [Q14241]3EBI-10181988,EBI-742350
EXOC8 [Q8IYI6]3EBI-10181988,EBI-742102
FAM161A [Q3B820]3EBI-10181988,EBI-719941
FAM9B [Q8IZU0]3EBI-10181988,EBI-10175124
GADD45G [O95257]3EBI-10181988,EBI-448202
GOLGA1 [Q92805]3EBI-10181988,EBI-6164177
GOLGA2 [Q08379]3EBI-10181988,EBI-618309
HAUS1 [Q96CS2]3EBI-10181988,EBI-2514791
HDDC3 [Q8N4P3]3EBI-10181988,EBI-750003
HGS [O14964]3EBI-10181988,EBI-740220
IKZF1 [Q13422]3EBI-10181988,EBI-745305
KATNAL1 [Q9BW62]3EBI-10181988,EBI-743591
KIFC3 [Q9BVG8]3EBI-10181988,EBI-2125614
KLC3 [Q6P597]3EBI-10181988,EBI-1643885
KLC4 [Q9NSK0]3EBI-10181988,EBI-949319
KRT13 [A1A4E9]3EBI-10181988,EBI-10171552
KRT19 [P08727]3EBI-10181988,EBI-742756
KRT31 [Q15323]3EBI-10181988,EBI-948001
KRT38 [O76015]3EBI-10181988,EBI-1047263
KRT40 [Q6A162]3EBI-10181988,EBI-10171697
LENG1 [Q96BZ8]3EBI-10181988,EBI-726510
LMO3 [Q8TAP4]3EBI-10181988,EBI-742259
LZTS2 [Q9BRK4]3EBI-10181988,EBI-741037
MAGEA1 [P43355]3EBI-10181988,EBI-740978
MAGEA2B [Q96E03]3EBI-10181988,EBI-10239285
MEOX2 [P50222]3EBI-10181988,EBI-748397
MFAP1 [P55081]3EBI-10181988,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-10181988,EBI-10172526
MORF4L1 [Q9UBU8]3EBI-10181988,EBI-399246
MTUS2 [Q5JR59]3EBI-10181988,EBI-742948
NUP62 [P37198]3EBI-10181988,EBI-347978
PKN1 [Q16512]3EBI-10181988,EBI-602382
PNMA5 [Q96PV4]5EBI-10181988,EBI-10171633
PPL [O60437]3EBI-10181988,EBI-368321
RAD51D [O75771]3EBI-10181988,EBI-1055693
RINT1 [Q6NUQ1]3EBI-10181988,EBI-726876
ROPN1 [Q9HAT0]3EBI-10181988,EBI-1378139
SNAP47 [Q5SQN1]3EBI-10181988,EBI-10244848
SNAPC3 [Q92966]3EBI-10181988,EBI-1760638
TAB3 [Q8N5C8]3EBI-10181988,EBI-359964
TRAF2 [Q12933]3EBI-10181988,EBI-355744
TRAPPC2L [Q9UL33]3EBI-10181988,EBI-747601
TRIM54 [Q9BYV2]3EBI-10181988,EBI-2130429
TRIP6 [Q15654]3EBI-10181988,EBI-742327
TSGA10 [Q9BZW7]3EBI-10181988,EBI-744794
TXLNA [P40222]3EBI-10181988,EBI-359793
TXLNB [Q8N3L3]3EBI-10181988,EBI-6116822
Q9H6143EBI-10181988,EBI-10249899

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		130198, 79 interactors

Protein interaction database and analysis system

More...IntActi		Q8IYX8, 87 interactors

Molecular INTeraction database

More...MINTi		Q8IYX8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000427844

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IYX8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IYX8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili51 – 228Sequence analysisAdd BLAST178
Coiled coili317 – 384Sequence analysisAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the translokin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTVF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063695

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IYX8

KEGG Orthology (KO)

More...KOi		K16762

Database of Orthologous Groups

More...OrthoDBi		1255254at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IYX8

TreeFam database of animal gene trees

More...TreeFami		TF329178

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025913, Cep57_CLD
IPR024957, Cep57_MT-bd_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14073, Cep57_CLD, 1 hit
PF06657, Cep57_MT_bd, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSELMHSIV GSYHKPPERV FVPSFTQNEP SQNCHPANLE VTSPKILHSP 
        60         70         80         90        100
NSQALILALK TLQEKIHRLE LERTQAEDNL NILSREAAQY KKALENETNE 
       110        120        130        140        150
RNLAHQELIK QKKDISIQLS SAQSRCTLLE KQLEYTKRMV LNVEREKNMI 
       160        170        180        190        200
LEQQAQLQRE KEQDQMKLYA KLEKLDVLEK ECFRLTTTQK TAEDKIKHLE 
       210        220        230        240        250
EKLKEEEHQR KLFQDKASEL QTGLEISKII MSSVSNLKHS KEKKKSSKKT 
       260        270        280        290        300
KCIKRRPPWQ ICSKFGALPF VAEKMRQHRD PHILQKPFNV TETRCLPKPS 
       310        320        330        340        350
RTTSWCKAIP PDSEKSISIC DNLSELLMAM QDELDQMSME HQELLKQMKE 
       360        370        380        390        400
TESHSVCDDI ECELECLLKK MEIKGEQISK LKKHQDSVCK LQQKVQNSKM 
       410        420        430        440        450
SEASGIQQED SYPKGSKNIK NSPRKCLTDT NLFQKNSSFH PIRVHNLQMK 
       460
LRRDDIMWEQ
Length:460
Mass (Da):53,649
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60BFD7F54078A9F5
GO
Isoform 2 (identifier: Q8IYX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-391: CKL → RRL
     392-460: Missing.

Show »
Length:391
Mass (Da):45,629
Checksum:iA3E0FB5D1E92F5FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P2R3Q6P2R3_HUMAN
C6orf182 protein
CEP57L1 C6orf182, hCG_34126
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V140G3V140_HUMAN
Centrosomal protein CEP57L1
CEP57L1 C6orf182, hCG_34126
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFY4E5RFY4_HUMAN
Centrosomal protein CEP57L1
CEP57L1
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIV2E5RIV2_HUMAN
Centrosomal protein CEP57L1
CEP57L1
407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6A0Q5T6A0_HUMAN
Centrosomal protein CEP57L1
CEP57L1
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGP2E5RGP2_HUMAN
Centrosomal protein CEP57L1
CEP57L1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHF8E5RHF8_HUMAN
Centrosomal protein CEP57L1
CEP57L1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG21E5RG21_HUMAN
Centrosomal protein CEP57L1
CEP57L1
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG82E5RG82_HUMAN
Centrosomal protein CEP57L1
CEP57L1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI49E5RI49_HUMAN
Centrosomal protein CEP57L1
CEP57L1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052396194D → E. Corresponds to variant dbSNP:rs351733Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055660389 – 391CKL → RRL in isoform 2. Curated3
Alternative sequenceiVSP_055661392 – 460Missing in isoform 2. CuratedAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL355305 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48364.1
BC033448 mRNA Translation: AAH33448.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5071.1 [Q8IYX8-1]
CCDS64491.1 [Q8IYX8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001077004.1, NM_001083535.1 [Q8IYX8-1]
NP_001258781.1, NM_001271852.1 [Q8IYX8-1]
NP_001258782.1, NM_001271853.1 [Q8IYX8-2]
NP_776191.1, NM_173830.4 [Q8IYX8-1]
XP_016866259.1, XM_017010770.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359793; ENSP00000352841; ENSG00000183137 [Q8IYX8-1]
ENST00000368968; ENSP00000357964; ENSG00000183137 [Q8IYX8-2]
ENST00000517392; ENSP00000427844; ENSG00000183137 [Q8IYX8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285753

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285753

UCSC genome browser

More...UCSCi		uc003psx.5, human [Q8IYX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355305 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48364.1
BC033448 mRNA Translation: AAH33448.1
CCDSiCCDS5071.1 [Q8IYX8-1]
CCDS64491.1 [Q8IYX8-2]
RefSeqiNP_001077004.1, NM_001083535.1 [Q8IYX8-1]
NP_001258781.1, NM_001271852.1 [Q8IYX8-1]
NP_001258782.1, NM_001271853.1 [Q8IYX8-2]
NP_776191.1, NM_173830.4 [Q8IYX8-1]
XP_016866259.1, XM_017010770.1

3D structure databases

SMRiQ8IYX8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130198, 79 interactors
IntActiQ8IYX8, 87 interactors
MINTiQ8IYX8
STRINGi9606.ENSP00000427844

PTM databases

iPTMnetiQ8IYX8
PhosphoSitePlusiQ8IYX8

Polymorphism and mutation databases

BioMutaiCEP57L1

Proteomic databases

EPDiQ8IYX8
jPOSTiQ8IYX8
MassIVEiQ8IYX8
MaxQBiQ8IYX8
PaxDbiQ8IYX8
PeptideAtlasiQ8IYX8
PRIDEiQ8IYX8
ProteomicsDBi33869
71260 [Q8IYX8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46535, 102 antibodies

The DNASU plasmid repository

More...DNASUi		285753

Genome annotation databases

EnsembliENST00000359793; ENSP00000352841; ENSG00000183137 [Q8IYX8-1]
ENST00000368968; ENSP00000357964; ENSG00000183137 [Q8IYX8-2]
ENST00000517392; ENSP00000427844; ENSG00000183137 [Q8IYX8-1]
GeneIDi285753
KEGGihsa:285753
UCSCiuc003psx.5, human [Q8IYX8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285753
DisGeNETi285753
EuPathDBiHostDB:ENSG00000183137.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEP57L1
HGNCiHGNC:21561, CEP57L1
HPAiENSG00000183137, Low tissue specificity
neXtProtiNX_Q8IYX8
OpenTargetsiENSG00000183137
PharmGKBiPA134980921

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTVF, Eukaryota
GeneTreeiENSGT00530000063695
InParanoidiQ8IYX8
KOiK16762
OrthoDBi1255254at2759
PhylomeDBiQ8IYX8
TreeFamiTF329178

Enzyme and pathway databases

PathwayCommonsiQ8IYX8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		285753, 7 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEP57L1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285753
PharosiQ8IYX8, Tdark

Protein Ontology

More...PROi		PR:Q8IYX8
RNActiQ8IYX8, protein

Gene expression databases

BgeeiENSG00000183137, Expressed in testis and 141 other tissues
ExpressionAtlasiQ8IYX8, baseline and differential
GenevisibleiQ8IYX8, HS

Family and domain databases

InterProiView protein in InterPro
IPR025913, Cep57_CLD
IPR024957, Cep57_MT-bd_dom
PfamiView protein in Pfam
PF14073, Cep57_CLD, 1 hit
PF06657, Cep57_MT_bd, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE57L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYX8
Secondary accession number(s): G5E992
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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