UniProtKB - Q8IYX8 (CE57L_HUMAN)
Protein
Centrosomal protein CEP57L1
Gene
CEP57L1
Organism
Homo sapiens (Human)
Status
Functioni
Centrosomal protein which may be required for microtubule attachment to centrosomes.By similarity
GO - Molecular functioni
- gamma-tubulin binding Source: InterPro
- identical protein binding Source: IntAct
- microtubule binding Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8IYX8 |
Names & Taxonomyi
Protein namesi | Recommended name: Centrosomal protein CEP57L1Alternative name(s): Centrosomal protein 57kDa-like protein 1 Centrosomal protein of 57 kDa-related protein Short name: Cep57R Cep57-related protein |
Gene namesi | Name:CEP57L1 Synonyms:C6orf182, CEP57R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183137.14 |
HGNCi | HGNC:21561, CEP57L1 |
neXtProti | NX_Q8IYX8 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Cytoskeleton
- centrosome Source: GO_Central
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 285753 |
OpenTargetsi | ENSG00000183137 |
PharmGKBi | PA134980921 |
Miscellaneous databases
Pharosi | Q8IYX8, Tdark |
Polymorphism and mutation databases
BioMutai | CEP57L1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000189534 | 1 – 460 | Centrosomal protein CEP57L1Add BLAST | 460 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IYX8 |
jPOSTi | Q8IYX8 |
MassIVEi | Q8IYX8 |
MaxQBi | Q8IYX8 |
PaxDbi | Q8IYX8 |
PeptideAtlasi | Q8IYX8 |
PRIDEi | Q8IYX8 |
ProteomicsDBi | 33869 71260 [Q8IYX8-1] |
PTM databases
iPTMneti | Q8IYX8 |
PhosphoSitePlusi | Q8IYX8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183137, Expressed in testis and 141 other tissues |
ExpressionAtlasi | Q8IYX8, baseline and differential |
Genevisiblei | Q8IYX8, HS |
Organism-specific databases
HPAi | ENSG00000183137, Low tissue specificity |
Interactioni
Binary interactionsi
Q8IYX8
CEP57L1 - isoform 2 [Q8IYX8-2]
GO - Molecular functioni
- gamma-tubulin binding Source: InterPro
- identical protein binding Source: IntAct
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 130198, 89 interactors |
IntActi | Q8IYX8, 87 interactors |
MINTi | Q8IYX8 |
STRINGi | 9606.ENSP00000427844 |
Miscellaneous databases
RNActi | Q8IYX8, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 51 – 228 | Sequence analysisAdd BLAST | 178 | |
Coiled coili | 317 – 384 | Sequence analysisAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the translokin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTVF, Eukaryota |
GeneTreei | ENSGT00530000063695 |
InParanoidi | Q8IYX8 |
OrthoDBi | 1255254at2759 |
PhylomeDBi | Q8IYX8 |
TreeFami | TF329178 |
Family and domain databases
InterProi | View protein in InterPro IPR025913, Cep57_CLD IPR024957, Cep57_MT-bd_dom |
Pfami | View protein in Pfam PF14073, Cep57_CLD, 1 hit PF06657, Cep57_MT_bd, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IYX8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSELMHSIV GSYHKPPERV FVPSFTQNEP SQNCHPANLE VTSPKILHSP
60 70 80 90 100
NSQALILALK TLQEKIHRLE LERTQAEDNL NILSREAAQY KKALENETNE
110 120 130 140 150
RNLAHQELIK QKKDISIQLS SAQSRCTLLE KQLEYTKRMV LNVEREKNMI
160 170 180 190 200
LEQQAQLQRE KEQDQMKLYA KLEKLDVLEK ECFRLTTTQK TAEDKIKHLE
210 220 230 240 250
EKLKEEEHQR KLFQDKASEL QTGLEISKII MSSVSNLKHS KEKKKSSKKT
260 270 280 290 300
KCIKRRPPWQ ICSKFGALPF VAEKMRQHRD PHILQKPFNV TETRCLPKPS
310 320 330 340 350
RTTSWCKAIP PDSEKSISIC DNLSELLMAM QDELDQMSME HQELLKQMKE
360 370 380 390 400
TESHSVCDDI ECELECLLKK MEIKGEQISK LKKHQDSVCK LQQKVQNSKM
410 420 430 440 450
SEASGIQQED SYPKGSKNIK NSPRKCLTDT NLFQKNSSFH PIRVHNLQMK
460
LRRDDIMWEQ
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6P2R3 | Q6P2R3_HUMAN | C6orf182 protein | CEP57L1 C6orf182, hCG_34126 | 251 | Annotation score: | ||
G3V140 | G3V140_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 C6orf182, hCG_34126 | 463 | Annotation score: | ||
E5RFY4 | E5RFY4_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 477 | Annotation score: | ||
E5RIV2 | E5RIV2_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 407 | Annotation score: | ||
Q5T6A0 | Q5T6A0_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 360 | Annotation score: | ||
E5RGP2 | E5RGP2_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 166 | Annotation score: | ||
E5RG82 | E5RG82_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 195 | Annotation score: | ||
E5RHF8 | E5RHF8_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 206 | Annotation score: | ||
E5RI49 | E5RI49_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 113 | Annotation score: | ||
E5RJH1 | E5RJH1_HUMAN | Centrosomal protein CEP57L1 | CEP57L1 | 235 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052396 | 194 | D → E. Corresponds to variant dbSNP:rs351733Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055660 | 389 – 391 | CKL → RRL in isoform 2. Curated | 3 | |
Alternative sequenceiVSP_055661 | 392 – 460 | Missing in isoform 2. CuratedAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL355305 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48364.1 BC033448 mRNA Translation: AAH33448.1 |
CCDSi | CCDS5071.1 [Q8IYX8-1] CCDS64491.1 [Q8IYX8-2] |
RefSeqi | NP_001077004.1, NM_001083535.1 [Q8IYX8-1] NP_001258781.1, NM_001271852.1 [Q8IYX8-1] NP_001258782.1, NM_001271853.1 [Q8IYX8-2] NP_776191.1, NM_173830.4 [Q8IYX8-1] XP_016866259.1, XM_017010770.1 |
Genome annotation databases
Ensembli | ENST00000359793; ENSP00000352841; ENSG00000183137 [Q8IYX8-1] ENST00000368968; ENSP00000357964; ENSG00000183137 [Q8IYX8-2] ENST00000517392; ENSP00000427844; ENSG00000183137 [Q8IYX8-1] |
GeneIDi | 285753 |
KEGGi | hsa:285753 |
UCSCi | uc003psx.5, human [Q8IYX8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL355305 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48364.1 BC033448 mRNA Translation: AAH33448.1 |
CCDSi | CCDS5071.1 [Q8IYX8-1] CCDS64491.1 [Q8IYX8-2] |
RefSeqi | NP_001077004.1, NM_001083535.1 [Q8IYX8-1] NP_001258781.1, NM_001271852.1 [Q8IYX8-1] NP_001258782.1, NM_001271853.1 [Q8IYX8-2] NP_776191.1, NM_173830.4 [Q8IYX8-1] XP_016866259.1, XM_017010770.1 |
3D structure databases
SMRi | Q8IYX8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130198, 89 interactors |
IntActi | Q8IYX8, 87 interactors |
MINTi | Q8IYX8 |
STRINGi | 9606.ENSP00000427844 |
PTM databases
iPTMneti | Q8IYX8 |
PhosphoSitePlusi | Q8IYX8 |
Polymorphism and mutation databases
BioMutai | CEP57L1 |
Proteomic databases
EPDi | Q8IYX8 |
jPOSTi | Q8IYX8 |
MassIVEi | Q8IYX8 |
MaxQBi | Q8IYX8 |
PaxDbi | Q8IYX8 |
PeptideAtlasi | Q8IYX8 |
PRIDEi | Q8IYX8 |
ProteomicsDBi | 33869 71260 [Q8IYX8-1] |
Protocols and materials databases
Antibodypediai | 46535, 102 antibodies |
DNASUi | 285753 |
Genome annotation databases
Ensembli | ENST00000359793; ENSP00000352841; ENSG00000183137 [Q8IYX8-1] ENST00000368968; ENSP00000357964; ENSG00000183137 [Q8IYX8-2] ENST00000517392; ENSP00000427844; ENSG00000183137 [Q8IYX8-1] |
GeneIDi | 285753 |
KEGGi | hsa:285753 |
UCSCi | uc003psx.5, human [Q8IYX8-1] |
Organism-specific databases
CTDi | 285753 |
DisGeNETi | 285753 |
EuPathDBi | HostDB:ENSG00000183137.14 |
GeneCardsi | CEP57L1 |
HGNCi | HGNC:21561, CEP57L1 |
HPAi | ENSG00000183137, Low tissue specificity |
neXtProti | NX_Q8IYX8 |
OpenTargetsi | ENSG00000183137 |
PharmGKBi | PA134980921 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTVF, Eukaryota |
GeneTreei | ENSGT00530000063695 |
InParanoidi | Q8IYX8 |
OrthoDBi | 1255254at2759 |
PhylomeDBi | Q8IYX8 |
TreeFami | TF329178 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYX8 |
Miscellaneous databases
BioGRID-ORCSi | 285753, 7 hits in 842 CRISPR screens |
ChiTaRSi | CEP57L1, human |
GenomeRNAii | 285753 |
Pharosi | Q8IYX8, Tdark |
PROi | PR:Q8IYX8 |
RNActi | Q8IYX8, protein |
Gene expression databases
Bgeei | ENSG00000183137, Expressed in testis and 141 other tissues |
ExpressionAtlasi | Q8IYX8, baseline and differential |
Genevisiblei | Q8IYX8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025913, Cep57_CLD IPR024957, Cep57_MT-bd_dom |
Pfami | View protein in Pfam PF14073, Cep57_CLD, 1 hit PF06657, Cep57_MT_bd, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CE57L_HUMAN | |
Accessioni | Q8IYX8Primary (citable) accession number: Q8IYX8 Secondary accession number(s): G5E992 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations