DND1

Functionⁱ

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

AU-rich element binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18155131

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

germ cell development Source: Ensembl
multicellular organism development Source: UniProtKB-KW
negative regulation of gene silencing by miRNA
Source: UniProtKB
Inferred from direct assayⁱ
- 18155131

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, RNA-binding

Molecular function

Developmental protein, RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dead end protein homolog 1 Alternative name(s): RNA-binding motif, single-stranded-interacting protein 4
Gene namesⁱ	Name:DND1 Synonyms:RBMS4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000256453.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23799 DND1
MIMⁱ	609385 gene
neXtProtⁱ	NX_Q8IYX4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	373863
Open Targets More...OpenTargetsⁱ	ENSG00000256453
PharmGKBⁱ	PA134931157

Polymorphism and mutation databases

BioMutaⁱ	DND1
DMDMⁱ	60389799

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081568	1 – 353	Dead end protein homolog 1Add BLAST		353

Proteomic databases

EPDⁱ	Q8IYX4
PaxDbⁱ	Q8IYX4
PeptideAtlas More...PeptideAtlasⁱ	Q8IYX4
PRIDEⁱ	Q8IYX4
ProteomicsDBⁱ	71258

PTM databases

iPTMnetⁱ	Q8IYX4
PhosphoSitePlusⁱ	Q8IYX4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000256453 Expressed in 69 organ(s), highest expression level in testis
CleanExⁱ	HS_DND1
Genevisibleⁱ	Q8IYX4 HS

Interactionⁱ

Subunit structureⁱ

Interacts with APOBEC3.By similarity

Protein-protein interaction databases

BioGridⁱ	131887, 10 interactors
IntActⁱ	Q8IYX4, 1 interactor
STRINGⁱ	9606.ENSP00000445366

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IYX4
SMRⁱ	Q8IYX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	58 – 136	RRM 1PROSITE-ProRule annotationAdd BLAST		79
Domainⁱ	140 – 213	RRM 2PROSITE-ProRule annotationAdd BLAST		74

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IUE0 Eukaryota ENOG410YAVC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074366
HOGENOMⁱ	HOG000112240
HOVERGENⁱ	HBG051370
InParanoidⁱ	Q8IYX4
OMAⁱ	MQSKREC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EUB
PhylomeDBⁱ	Q8IYX4
TreeFamⁱ	TF314932

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12487 RRM1_DND1, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR034414 DND1_RRM1 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IYX4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV 
        60         70         80         90        100
GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF 
       110        120        130        140        150
AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT 
       160        170        180        190        200
RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV 
       210        220        230        240        250
EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL 
       260        270        280        290        300
GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP 
       310        320        330        340        350
FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM 

VKQ

Length:353

Mass (Da):38,687

Last modified:March 1, 2003 - v1

Checksum:ⁱ15014AA66BFD4F0F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY321065 mRNA Translation: AAQ63635.1 BC033496 mRNA Translation: AAH33496.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4236.1
NCBI Reference Sequences More...RefSeqⁱ	NP_919225.1, NM_194249.2
UniGeneⁱ	Hs.591262

Genome annotation databases

Ensemblⁱ	ENST00000542735; ENSP00000445366; ENSG00000256453
GeneIDⁱ	373863
KEGGⁱ	hsa:373863
UCSC genome browser More...UCSCⁱ	uc003lgt.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IYX4	dead end protein homolog 1		TARSY		356	UniRef90_Q8IYX4
DND microRNA-mediated repression inhibitor 1		MYOLU		354
DND microRNA-mediated repression inhibitor 1		MACMU		353
DND microRNA-mediated repression inhibitor 1		MACFA		353
DND microRNA-mediated repression inhibitor 1		CERAT		353
+35

Protein	Similar proteins		Species	Score	Length	Source
Q8IYX4	Dead end protein homolog 1		MOUSE		352	UniRef50_Q6VY05
dead end protein homolog 1 isoform X1		MESAU		354
Dead end protein-like 1		CRIGR		352
DND microRNA-mediated repression inhibitor 1		RAT		352
Uncharacterized protein (Fragment)		AILME		344
+73

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY321065 mRNA Translation: AAQ63635.1 BC033496 mRNA Translation: AAH33496.1
CCDSⁱ	CCDS4236.1
RefSeqⁱ	NP_919225.1, NM_194249.2
UniGeneⁱ	Hs.591262

3D structure databases

ProteinModelPortalⁱ	Q8IYX4
SMRⁱ	Q8IYX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131887, 10 interactors
IntActⁱ	Q8IYX4, 1 interactor
STRINGⁱ	9606.ENSP00000445366

PTM databases

iPTMnetⁱ	Q8IYX4
PhosphoSitePlusⁱ	Q8IYX4

Polymorphism and mutation databases

BioMutaⁱ	DND1
DMDMⁱ	60389799

Proteomic databases

EPDⁱ	Q8IYX4
PaxDbⁱ	Q8IYX4
PeptideAtlasⁱ	Q8IYX4
PRIDEⁱ	Q8IYX4
ProteomicsDBⁱ	71258

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	373863
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000542735; ENSP00000445366; ENSG00000256453
GeneIDⁱ	373863
KEGGⁱ	hsa:373863
UCSCⁱ	uc003lgt.4 human

Organism-specific databases

CTDⁱ	373863
DisGeNETⁱ	373863
EuPathDBⁱ	HostDB:ENSG00000256453.1
GeneCardsⁱ	DND1
HGNCⁱ	HGNC:23799 DND1
MIMⁱ	609385 gene
neXtProtⁱ	NX_Q8IYX4
OpenTargetsⁱ	ENSG00000256453
PharmGKBⁱ	PA134931157
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IUE0 Eukaryota ENOG410YAVC LUCA
GeneTreeⁱ	ENSGT00550000074366
HOGENOMⁱ	HOG000112240
HOVERGENⁱ	HBG051370
InParanoidⁱ	Q8IYX4
OMAⁱ	MQSKREC
OrthoDBⁱ	EOG091G0EUB
PhylomeDBⁱ	Q8IYX4
TreeFamⁱ	TF314932

Miscellaneous databases

GenomeRNAiⁱ	373863
Protein Ontology More...PROⁱ	PR:Q8IYX4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000256453 Expressed in 69 organ(s), highest expression level in testis
CleanExⁱ	HS_DND1
Genevisibleⁱ	Q8IYX4 HS

Family and domain databases

CDDⁱ	cd12487 RRM1_DND1, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR034414 DND1_RRM1 IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DND1_HUMAN
Accessionⁱ	Q8IYX4Primary (citable) accession number: Q8IYX4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q8IYX4 (DND1_HUMAN)

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Dead end protein homolog 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ