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Protein

Dead end protein homolog 1

Gene

DND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).By similarity1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dead end protein homolog 1
Alternative name(s):
RNA-binding motif, single-stranded-interacting protein 4
Gene namesi
Name:DND1
Synonyms:RBMS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000256453.1
HGNCiHGNC:23799 DND1
MIMi609385 gene
neXtProtiNX_Q8IYX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi373863
OpenTargetsiENSG00000256453
PharmGKBiPA134931157

Polymorphism and mutation databases

BioMutaiDND1
DMDMi60389799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815681 – 353Dead end protein homolog 1Add BLAST353

Proteomic databases

EPDiQ8IYX4
PaxDbiQ8IYX4
PeptideAtlasiQ8IYX4
PRIDEiQ8IYX4
ProteomicsDBi71258

PTM databases

iPTMnetiQ8IYX4
PhosphoSitePlusiQ8IYX4

Expressioni

Gene expression databases

BgeeiENSG00000256453 Expressed in 69 organ(s), highest expression level in testis
CleanExiHS_DND1
GenevisibleiQ8IYX4 HS

Interactioni

Subunit structurei

Interacts with APOBEC3.By similarity

Protein-protein interaction databases

BioGridi131887, 10 interactors
IntActiQ8IYX4, 1 interactor
STRINGi9606.ENSP00000445366

Structurei

3D structure databases

ProteinModelPortaliQ8IYX4
SMRiQ8IYX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 136RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini140 – 213RRM 2PROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IUE0 Eukaryota
ENOG410YAVC LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000112240
HOVERGENiHBG051370
InParanoidiQ8IYX4
OMAiMQSKREC
OrthoDBiEOG091G0EUB
PhylomeDBiQ8IYX4
TreeFamiTF314932

Family and domain databases

CDDicd12487 RRM1_DND1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034414 DND1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV
60 70 80 90 100
GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF
110 120 130 140 150
AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT
160 170 180 190 200
RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV
210 220 230 240 250
EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL
260 270 280 290 300
GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
310 320 330 340 350
FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM

VKQ
Length:353
Mass (Da):38,687
Last modified:March 1, 2003 - v1
Checksum:i15014AA66BFD4F0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321065 mRNA Translation: AAQ63635.1
BC033496 mRNA Translation: AAH33496.1
CCDSiCCDS4236.1
RefSeqiNP_919225.1, NM_194249.2
UniGeneiHs.591262

Genome annotation databases

EnsembliENST00000542735; ENSP00000445366; ENSG00000256453
GeneIDi373863
KEGGihsa:373863
UCSCiuc003lgt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY321065 mRNA Translation: AAQ63635.1
BC033496 mRNA Translation: AAH33496.1
CCDSiCCDS4236.1
RefSeqiNP_919225.1, NM_194249.2
UniGeneiHs.591262

3D structure databases

ProteinModelPortaliQ8IYX4
SMRiQ8IYX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131887, 10 interactors
IntActiQ8IYX4, 1 interactor
STRINGi9606.ENSP00000445366

PTM databases

iPTMnetiQ8IYX4
PhosphoSitePlusiQ8IYX4

Polymorphism and mutation databases

BioMutaiDND1
DMDMi60389799

Proteomic databases

EPDiQ8IYX4
PaxDbiQ8IYX4
PeptideAtlasiQ8IYX4
PRIDEiQ8IYX4
ProteomicsDBi71258

Protocols and materials databases

DNASUi373863
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542735; ENSP00000445366; ENSG00000256453
GeneIDi373863
KEGGihsa:373863
UCSCiuc003lgt.4 human

Organism-specific databases

CTDi373863
DisGeNETi373863
EuPathDBiHostDB:ENSG00000256453.1
GeneCardsiDND1
HGNCiHGNC:23799 DND1
MIMi609385 gene
neXtProtiNX_Q8IYX4
OpenTargetsiENSG00000256453
PharmGKBiPA134931157
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUE0 Eukaryota
ENOG410YAVC LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000112240
HOVERGENiHBG051370
InParanoidiQ8IYX4
OMAiMQSKREC
OrthoDBiEOG091G0EUB
PhylomeDBiQ8IYX4
TreeFamiTF314932

Miscellaneous databases

GenomeRNAii373863
PROiPR:Q8IYX4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256453 Expressed in 69 organ(s), highest expression level in testis
CleanExiHS_DND1
GenevisibleiQ8IYX4 HS

Family and domain databases

CDDicd12487 RRM1_DND1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034414 DND1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDND1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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