UniProtKB - Q8IYX4 (DND1_HUMAN)
Protein
Dead end protein homolog 1
Gene
DND1
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).By similarity1 Publication
GO - Molecular functioni
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA binding Source: GO_Central
- RNA binding Source: GO_Central
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: CACAO
- germ cell development Source: Ensembl
- mRNA stabilization Source: GO_Central
- multicellular organism development Source: UniProtKB-KW
- negative regulation of gene silencing by miRNA Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IYX4 |
Names & Taxonomyi
Protein namesi | Recommended name: Dead end protein homolog 1Alternative name(s): RNA-binding motif, single-stranded-interacting protein 4 |
Gene namesi | Name:DND1 Synonyms:RBMS4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23799, DND1 |
MIMi | 609385, gene |
neXtProti | NX_Q8IYX4 |
VEuPathDBi | HostDB:ENSG00000256453.1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 373863 |
OpenTargetsi | ENSG00000256453 |
PharmGKBi | PA134931157 |
Miscellaneous databases
Pharosi | Q8IYX4, Tbio |
Genetic variation databases
BioMutai | DND1 |
DMDMi | 60389799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081568 | 1 – 353 | Dead end protein homolog 1Add BLAST | 353 |
Proteomic databases
EPDi | Q8IYX4 |
MassIVEi | Q8IYX4 |
PaxDbi | Q8IYX4 |
PeptideAtlasi | Q8IYX4 |
PRIDEi | Q8IYX4 |
ProteomicsDBi | 71258 |
PTM databases
iPTMneti | Q8IYX4 |
PhosphoSitePlusi | Q8IYX4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000256453, Expressed in testis and 85 other tissues |
Genevisiblei | Q8IYX4, HS |
Organism-specific databases
HPAi | ENSG00000256453, Group enriched (brain, testis) |
Interactioni
Subunit structurei
Interacts with APOBEC3.
By similarityBinary interactionsi
Q8IYX4
With | #Exp. | IntAct |
---|---|---|
RBPMS2 [Q6ZRY4] | 3 | EBI-12071340,EBI-11987469 |
Protein-protein interaction databases
BioGRIDi | 131887, 13 interactors |
IntActi | Q8IYX4, 8 interactors |
STRINGi | 9606.ENSP00000445366 |
Miscellaneous databases
RNActi | Q8IYX4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 136 | RRM 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 140 – 213 | RRM 2PROSITE-ProRule annotationAdd BLAST | 74 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0117, Eukaryota |
GeneTreei | ENSGT00940000159225 |
HOGENOMi | CLU_022960_0_0_1 |
InParanoidi | Q8IYX4 |
OMAi | KCELCVD |
OrthoDBi | 1384330at2759 |
PhylomeDBi | Q8IYX4 |
TreeFami | TF314932 |
Family and domain databases
CDDi | cd12487, RRM1_DND1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034414, DND1_RRM1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IYX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV
60 70 80 90 100
GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF
110 120 130 140 150
AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT
160 170 180 190 200
RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV
210 220 230 240 250
EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL
260 270 280 290 300
GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
310 320 330 340 350
FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM
VKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY321065 mRNA Translation: AAQ63635.1 BC033496 mRNA Translation: AAH33496.1 |
CCDSi | CCDS4236.1 |
RefSeqi | NP_919225.1, NM_194249.2 |
Genome annotation databases
Ensembli | ENST00000542735; ENSP00000445366; ENSG00000256453 |
GeneIDi | 373863 |
KEGGi | hsa:373863 |
UCSCi | uc003lgt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY321065 mRNA Translation: AAQ63635.1 BC033496 mRNA Translation: AAH33496.1 |
CCDSi | CCDS4236.1 |
RefSeqi | NP_919225.1, NM_194249.2 |
3D structure databases
SMRi | Q8IYX4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131887, 13 interactors |
IntActi | Q8IYX4, 8 interactors |
STRINGi | 9606.ENSP00000445366 |
PTM databases
iPTMneti | Q8IYX4 |
PhosphoSitePlusi | Q8IYX4 |
Genetic variation databases
BioMutai | DND1 |
DMDMi | 60389799 |
Proteomic databases
EPDi | Q8IYX4 |
MassIVEi | Q8IYX4 |
PaxDbi | Q8IYX4 |
PeptideAtlasi | Q8IYX4 |
PRIDEi | Q8IYX4 |
ProteomicsDBi | 71258 |
Protocols and materials databases
Antibodypediai | 49888, 222 antibodies |
DNASUi | 373863 |
Genome annotation databases
Ensembli | ENST00000542735; ENSP00000445366; ENSG00000256453 |
GeneIDi | 373863 |
KEGGi | hsa:373863 |
UCSCi | uc003lgt.4, human |
Organism-specific databases
CTDi | 373863 |
DisGeNETi | 373863 |
GeneCardsi | DND1 |
HGNCi | HGNC:23799, DND1 |
HPAi | ENSG00000256453, Group enriched (brain, testis) |
MIMi | 609385, gene |
neXtProti | NX_Q8IYX4 |
OpenTargetsi | ENSG00000256453 |
PharmGKBi | PA134931157 |
VEuPathDBi | HostDB:ENSG00000256453.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0117, Eukaryota |
GeneTreei | ENSGT00940000159225 |
HOGENOMi | CLU_022960_0_0_1 |
InParanoidi | Q8IYX4 |
OMAi | KCELCVD |
OrthoDBi | 1384330at2759 |
PhylomeDBi | Q8IYX4 |
TreeFami | TF314932 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYX4 |
Miscellaneous databases
BioGRID-ORCSi | 373863, 19 hits in 868 CRISPR screens |
GenomeRNAii | 373863 |
Pharosi | Q8IYX4, Tbio |
PROi | PR:Q8IYX4 |
RNActi | Q8IYX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000256453, Expressed in testis and 85 other tissues |
Genevisiblei | Q8IYX4, HS |
Family and domain databases
CDDi | cd12487, RRM1_DND1, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034414, DND1_RRM1 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DND1_HUMAN | |
Accessioni | Q8IYX4Primary (citable) accession number: Q8IYX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM