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Entry version 110 (16 Oct 2019)
Sequence version 3 (18 Jul 2018)
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Protein

Coiled-coil domain-containing protein 116

Gene

CCDC116

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 116
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC116
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26688 CCDC116

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYX3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
164592

Open Targets

More...
OpenTargetsi
ENSG00000161180

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149301

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYX3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC116

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117949387

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002540521 – 613Coiled-coil domain-containing protein 116Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei386PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYX3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYX3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYX3

PeptideAtlas

More...
PeptideAtlasi
Q8IYX3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYX3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71256 [Q8IYX3-1]
71257 [Q8IYX3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYX3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYX3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161180 Expressed in 79 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYX3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYX3 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127896, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYX3, 32 interactors

Molecular INTeraction database

More...
MINTi
Q8IYX3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292779

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili79 – 104Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 158Poly-Ser7

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVER Eukaryota
ENOG41116BA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYX3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGRFTKK

Database of Orthologous Groups

More...
OrthoDBi
694022at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYX3

TreeFam database of animal gene trees

More...
TreeFami
TF337163

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031532 DUF4702

The PANTHER Classification System

More...
PANTHERi
PTHR36861 PTHR36861, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15774 DUF4702, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q8IYX3-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARCRHHSGY LADDEASHSM CSARVQLPKK PLVPEMRPAC KPGRVPHPPS
60 70 80 90 100
TCGSSALQGQ RRNKRHPQPF GHFLDFLTES QVLDSLETVV EKATERMAAM
110 120 130 140 150
KTEAGVPLVE VQDPVEVPSG GRRAHARPSL STVHRHRVRP TLCTGHPNNY
160 170 180 190 200
PSSSSSMSNC HSSLMAGCLG SHSRDSDLGA QGSLPPVRDK LLLEKNLKRL
210 220 230 240 250
LQLEREGKGL SQSCSQRDSL LWDSLGSQTS FQWTQEQPLS WFSGLLGSSS
260 270 280 290 300
GVPEASEPRP GEQEPIFRKR EFNKEIKSLL SQLESLDLPG YCPLREPHRT
310 320 330 340 350
LNFLADHRLF PALQSVVSQA VDKLRGAHCR DGRPLFPTSL EPTSDLPPLG
360 370 380 390 400
SEPAKPTNGG QPYASPRPTV SSPKMLQRKR KDRGGSPSMS SAQVATRFKL
410 420 430 440 450
KSPCSSSRFT KKKPLPSISS KSSMSHFSNR LYEELADFLT QQAASLVIRK
460 470 480 490 500
YEFEKDLSKQ LGFFSFPITH VLRDLSLGLK KVKGSRIHLS SETHRSCLLR
510 520 530 540 550
KLEESKRARQ ASRLSTSHCS TETPSVQQEP ATHTAQDQAT EPCRSLYTNL
560 570 580 590 600
PASRQLSPLE PKLYMSACTG MGSSPPKSKD MDNEGRDKAE IEDEDEDEFK
610
DEDQDEDKDE DGV
Length:613
Mass (Da):67,946
Last modified:July 18, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB4396CBD001BA19
GO
Isoform 1 (identifier: Q8IYX3-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-613: RQASRLSTSH...QDEDKDEDGV → AAVSLEA

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):56,940
Checksum:i2FC1C03E0579374C
GO
Isoform 3 (identifier: Q8IYX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-613: SPCSSSRFTK...QDEDKDEDGV → VTPTEKPNVP...QEKGSLTHHS

Show »
Length:526
Mass (Da):57,184
Checksum:iB61DF39AB6E77B01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW89C9JW89_HUMAN
Coiled-coil domain-containing prote...
CCDC116
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02880396R → C. Corresponds to variant dbSNP:rs861854Ensembl.1
Natural variantiVAR_028804121G → R. Corresponds to variant dbSNP:rs371513Ensembl.1
Natural variantiVAR_028805122R → W. Corresponds to variant dbSNP:rs861853Ensembl.1
Natural variantiVAR_028806199R → W. Corresponds to variant dbSNP:rs12170285Ensembl.1
Natural variantiVAR_061578293P → L. Corresponds to variant dbSNP:rs41279987Ensembl.1
Natural variantiVAR_028807436A → T. Corresponds to variant dbSNP:rs11705259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059645402 – 613SPCSS…DEDGV → VTPTEKPNVPSPSLHSREEA PDSDPKLQNPPVSLSSSQRA QPWQGLHLTLPTPGIVVEVA CSQGHLRGPVTPPLSSPYPR SSCYLLPELSPVASSSPASL CPEVTSSKVGPGMSLQEKGS LTHHS in isoform 3. Add BLAST212
Alternative sequenceiVSP_059646509 – 613RQASR…DEDGV → AAVSLEA in isoform 1. Add BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093365 mRNA Translation: BAC04145.1
AK302030 mRNA Translation: BAH13611.1
AP000553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59466.1
BC033499 mRNA Translation: AAH33499.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13791.1 [Q8IYX3-2]
CCDS87008.1 [Q8IYX3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001317995.1, NM_001331066.1 [Q8IYX3-3]
NP_689825.2, NM_152612.2 [Q8IYX3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292779; ENSP00000292779; ENSG00000161180 [Q8IYX3-2]
ENST00000607942; ENSP00000476296; ENSG00000161180 [Q8IYX3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
164592

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:164592

UCSC genome browser

More...
UCSCi
uc002zve.4 human [Q8IYX3-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093365 mRNA Translation: BAC04145.1
AK302030 mRNA Translation: BAH13611.1
AP000553 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59466.1
BC033499 mRNA Translation: AAH33499.1
CCDSiCCDS13791.1 [Q8IYX3-2]
CCDS87008.1 [Q8IYX3-3]
RefSeqiNP_001317995.1, NM_001331066.1 [Q8IYX3-3]
NP_689825.2, NM_152612.2 [Q8IYX3-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127896, 12 interactors
IntActiQ8IYX3, 32 interactors
MINTiQ8IYX3
STRINGi9606.ENSP00000292779

PTM databases

iPTMnetiQ8IYX3
PhosphoSitePlusiQ8IYX3

Polymorphism and mutation databases

BioMutaiCCDC116
DMDMi117949387

Proteomic databases

jPOSTiQ8IYX3
MassIVEiQ8IYX3
PaxDbiQ8IYX3
PeptideAtlasiQ8IYX3
PRIDEiQ8IYX3
ProteomicsDBi71256 [Q8IYX3-1]
71257 [Q8IYX3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
164592

Genome annotation databases

EnsembliENST00000292779; ENSP00000292779; ENSG00000161180 [Q8IYX3-2]
ENST00000607942; ENSP00000476296; ENSG00000161180 [Q8IYX3-3]
GeneIDi164592
KEGGihsa:164592
UCSCiuc002zve.4 human [Q8IYX3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164592
DisGeNETi164592

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC116
HGNCiHGNC:26688 CCDC116
neXtProtiNX_Q8IYX3
OpenTargetsiENSG00000161180
PharmGKBiPA145149301

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVER Eukaryota
ENOG41116BA LUCA
GeneTreeiENSGT00390000002259
HOGENOMiHOG000170864
InParanoidiQ8IYX3
OMAiSGRFTKK
OrthoDBi694022at2759
PhylomeDBiQ8IYX3
TreeFamiTF337163

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
164592
PharosiQ8IYX3

Protein Ontology

More...
PROi
PR:Q8IYX3

Gene expression databases

BgeeiENSG00000161180 Expressed in 79 organ(s), highest expression level in right testis
ExpressionAtlasiQ8IYX3 baseline and differential
GenevisibleiQ8IYX3 HS

Family and domain databases

InterProiView protein in InterPro
IPR031532 DUF4702
PANTHERiPTHR36861 PTHR36861, 1 hit
PfamiView protein in Pfam
PF15774 DUF4702, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC116_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYX3
Secondary accession number(s): B7Z7H5, Q8N9Y9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 18, 2018
Last modified: October 16, 2019
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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