IZUMO1

Functionⁱ

Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.1 Publication

Miscellaneous

Izumo is the name of a Japanese shrine to marriage.

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 27309808
protein binding involved in heterotypic cell-cell adhesion Source: UniProtKB
protein homodimerization activity Source: UniProtKB
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24739963

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: HGNC
Inferred by curatorⁱ
- 15759005
fusion of sperm to egg plasma membrane involved in single fertilization
Source: HGNC
Inferred from direct assayⁱ
- 15759005
heterotypic cell-cell adhesion Source: UniProtKB
single fertilization Source: UniProtKB
sperm-egg recognition Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Fertilization

Biological process

Fertilization

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1300652 Sperm:Oocyte Membrane Binding

Reactomeⁱ

R-HSA-1300652 Sperm:Oocyte Membrane Binding

Protein family/group databases

TCDBⁱ	8.A.55.1.1 the izumo sperm-egg fusion protein 1 (izumo1) family

TCDBⁱ

8.A.55.1.1 the izumo sperm-egg fusion protein 1 (izumo1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Izumo sperm-egg fusion protein 1 Alternative name(s): Oocyte binding/fusion factor Short name: OBF Sperm-specific protein izumo
Gene namesⁱ	Name:IZUMO1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182264.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28539 IZUMO1
MIMⁱ	609278 gene
neXtProtⁱ	NX_Q8IYV9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 292	ExtracellularSequence analysisAdd BLAST	271
Transmembraneⁱ	293 – 313	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	314 – 350	CytoplasmicSequence analysisAdd BLAST	37

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	71	E → A or K: Mildly decreases interaction with IZUMO1R. 1 Publication	1
Mutagenesisⁱ	148	W → A: Abolishes interaction with IZUMO1R. 1 Publication	1
Mutagenesisⁱ	157	H → A: Nearly abolishes interaction with IZUMO1R. 1 Publication	1
Mutagenesisⁱ	160	R → A or E: Nearly abolishes interaction with IZUMO1R. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284359
Open Targets More...OpenTargetsⁱ	ENSG00000182264
PharmGKBⁱ	PA142671647

Polymorphism and mutation databases

BioMutaⁱ	IZUMO1
DMDMⁱ	296434545

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000045482	22 – 350	Izumo sperm-egg fusion protein 1Add BLAST		329

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	22 ↔ 149	Combined sources2 Publications
Disulfide bondⁱ	25 ↔ 152	Combined sources2 Publications
Disulfide bondⁱ	135 ↔ 159	Combined sources2 Publications
Disulfide bondⁱ	139 ↔ 165	Combined sources2 Publications
Disulfide bondⁱ	182 ↔ 233	PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	325	PhosphoserineBy similarity	1

Post-translational modificationⁱ

N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm.By similarity

Phosphorylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8IYV9
PeptideAtlas More...PeptideAtlasⁱ	Q8IYV9
PRIDEⁱ	Q8IYV9
ProteomicsDBⁱ	71246 71247 [Q8IYV9-2] 71248 [Q8IYV9-3]

PTM databases

iPTMnetⁱ	Q8IYV9
PhosphoSitePlusⁱ	Q8IYV9

Expressionⁱ

Tissue specificityⁱ

Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000182264 Expressed in 83 organ(s), highest expression level in testis
CleanExⁱ	HS_IZUMO1
ExpressionAtlasⁱ	Q8IYV9 baseline and differential
Genevisibleⁱ	Q8IYV9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038104

HPAⁱ

HPA038104

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:27309818, PubMed:27309808). Monomer, homodimer and homooligomer (By similarity). Interacts with IZUMO1R/JUNO. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:27309818, PubMed:27309808).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IZUMO1R	A6ND01-1	13	EBI-16208297,EBI-16208304

With

Entry

#Exp.

IntAct

Notes

IZUMO1R

A6ND01-1

13

EBI-16208297,EBI-16208304

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 27309808
protein binding involved in heterotypic cell-cell adhesion Source: UniProtKB
protein homodimerization activity Source: UniProtKB
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24739963

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	129843, 22 interactors
CORUMⁱ	Q8IYV9
Database of interacting proteins More...DIPⁱ	DIP-62033N
IntActⁱ	Q8IYV9, 1 interactor
STRINGⁱ	9606.ENSP00000327786

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	22 – 25	Combined sources	4
Helixⁱ	27 – 39	Combined sources	13
Helixⁱ	41 – 44	Combined sources	4
Helixⁱ	47 – 49	Combined sources	3
Helixⁱ	50 – 62	Combined sources	13
Helixⁱ	63 – 65	Combined sources	3
Turnⁱ	66 – 69	Combined sources	4
Beta strandⁱ	70 – 72	Combined sources	3
Beta strandⁱ	76 – 78	Combined sources	3
Helixⁱ	80 – 99	Combined sources	20
Helixⁱ	104 – 132	Combined sources	29
Beta strandⁱ	138 – 148	Combined sources	11
Turnⁱ	149 – 151	Combined sources	3
Beta strandⁱ	154 – 160	Combined sources	7
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	168 – 173	Combined sources	6
Beta strandⁱ	178 – 181	Combined sources	4
Helixⁱ	187 – 189	Combined sources	3
Beta strandⁱ	191 – 201	Combined sources	11
Beta strandⁱ	203 – 205	Combined sources	3
Beta strandⁱ	207 – 214	Combined sources	8
Beta strandⁱ	216 – 222	Combined sources	7
Helixⁱ	225 – 227	Combined sources	3
Beta strandⁱ	229 – 241	Combined sources	13
Beta strandⁱ	243 – 253	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IYV9
SMRⁱ	Q8IYV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	167 – 251	Ig-like C2-typePROSITE-ProRule annotationAdd BLAST		85

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	148 – 160	Important for interaction with IZUMO1R1 PublicationAdd BLAST		13

Domainⁱ

The extracellular domain assumes a distinct boomerang shape when not bound to IZUMO1R/JUNO. Interaction with IZUMO1R/JUNO triggers a conformation change, so that the IZUMO1 extracellular domain assumes an upright conformation.1 Publication

Sequence similaritiesⁱ

Belongs to the Izumo family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHEV Eukaryota ENOG410Z8SJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015014
HOGENOMⁱ	HOG000113123
HOVERGENⁱ	HBG081812
InParanoidⁱ	Q8IYV9
OMAⁱ	KEVHACR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AHL
PhylomeDBⁱ	Q8IYV9
TreeFamⁱ	TF338356

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR029389 IZUMO IPR032699 Izumo-Ig IPR032700 IZUMO1
PANTHERⁱ	PTHR35540 PTHR35540, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15005 IZUMO, 1 hit PF16706 Izumo-Ig, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IYV9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH 
        60         70         80         90        100
KAMMERVENA VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS 
       110        120        130        140        150
DVKGDLFVKE LFWMLHLQKE TFATYVARFQ KEAYCPNKCG VMLQTLIWCK 
       160        170        180        190        200
NCKKEVHACR KSYDCGERNV EVPQMEDMIL DCELNWHQAS EGLTDYSFYR 
       210        220        230        240        250
VWGNNTETLV SKGKEATLTK PMVGPEDAGS YRCELGSVNS SPATIINFHV 
       260        270        280        290        300
TVLPKMIKEE KPSPNIVTPG EATTESSISL QPLQPEKMLA SRLLGLLICG 
       310        320        330        340        350
SLALITGLTF AIFRRRKVID FIKSSLFGLG SGAAEQTQVP KEKATDSRQQ

Length:350

Mass (Da):38,930

Last modified:May 18, 2010 - v2

Checksum:ⁱ8741BB3F93ABCFA9

GO

Isoform 2 (identifier: Q8IYV9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
167-194: ERNVEVPQMEDMILDCELNWHQASEGLT → GERTGPSRRNWCRAECGSSSNGRHDPGL
195-350: Missing.

« Hide

        10         20         30         40         50
MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH 
        60         70         80         90        100
KAMMERVENA VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS 
       110        120        130        140        150
DVKGDLFVKE LFWMLHLQKE TFATYVARFQ KEAYCPNKCG VMLQTLIWCK 
       160        170        180        190 
NCKKEVHACR KSYDCGGERT GPSRRNWCRA ECGSSSNGRH DPGL

Note: No experimental confirmation available.

Show »

Length:194

Mass (Da):21,758

Checksum:ⁱ9D56F3FC6B308080

GO

Isoform 3 (identifier: Q8IYV9-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
57-68: VENAVKDFQELS → MRPHCKRGPGVC
69-350: Missing.

« Hide

        10         20         30         40         50
MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH 
        60 
KAMMERMRPH CKRGPGVC

Note: No experimental confirmation available.

Show »

Length:68

Mass (Da):7,339

Checksum:ⁱA637C1EEBC33D4FE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M0R0B8	M0R0B8_HUMAN		Izumo sperm-egg fusion protein 1 Izumo sperm-egg fusion protein 1	IZUMO1	15	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36	L → P in AAS59145 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055399	333	A → V3 PublicationsCorresponds to variant dbSNP:rs2307019Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016960	57 – 68	VENAV…FQELS → MRPHCKRGPGVC in isoform 3. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_016961	69 – 350	Missing in isoform 3. 1 PublicationAdd BLAST	282
Alternative sequenceⁱVSP_016962	167 – 194	ERNVE…SEGLT → GERTGPSRRNWCRAECGSSS NGRHDPGL in isoform 2. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_016963	195 – 350	Missing in isoform 2. 1 PublicationAdd BLAST	156

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB195682 mRNA Translation: BAD91012.1 AY552609 mRNA Translation: AAS59145.1 AY552610 mRNA Translation: AAS59146.1 AC009002 Genomic DNA No translation available. BC034769 mRNA Translation: AAH34769.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12732.1 [Q8IYV9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001308794.1, NM_001321865.1 NP_872381.2, NM_182575.2 [Q8IYV9-1] XP_011525114.1, XM_011526812.2 XP_011525115.1, XM_011526813.2
UniGeneⁱ	Hs.400688

Genome annotation databases

Ensemblⁱ	ENST00000332955; ENSP00000327786; ENSG00000182264 [Q8IYV9-1] ENST00000595517; ENSP00000471815; ENSG00000182264 [Q8IYV9-3] ENST00000595937; ENSP00000470144; ENSG00000182264 [Q8IYV9-2]
GeneIDⁱ	284359
KEGGⁱ	hsa:284359
UCSC genome browser More...UCSCⁱ	uc002pkj.3 human [Q8IYV9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IYV9-2	IZUMO1 isoform 4		PANTR		194	UniRef100_A0A2J8K272
Q8IYV9-3	IZUMO1 isoform 3		PANTR		68	UniRef100_A0A2J8K289

Protein	Similar proteins		Species	Score	Length	Source
Q8IYV9	Izumo sperm-egg fusion 1		CHLSB		352	UniRef90_Q8IYV9
Uncharacterized protein		CERAT		350
Uncharacterized protein		NOMLE		350
Uncharacterized protein		PANPA		350
IZUMO1 isoform 2		PANTR		350
+37
Q8IYV9-2	IZUMO1 isoform 4		PANTR		194	UniRef90_A0A2J8K272
IZUMO1 isoform 4		PONAB		194
Q8IYV9-3	IZUMO1 isoform 3		PANTR		68	UniRef90_A0A2J8K289
IZUMO1 isoform 3		PONAB		68

Protein	Similar proteins		Species	Score	Length	Source
Q8IYV9	Izumo sperm-egg fusion protein 1		RAT		383	UniRef50_Q8IYV9
Izumo sperm-egg fusion 1		CHLSB		352
Uncharacterized protein		PANPA		350
Uncharacterized protein		RHIRO		350
Uncharacterized protein		RHIBE		350
+71
Q8IYV9-2	IZUMO1 isoform 4		PANTR		194	UniRef50_A0A2J8K272
IZUMO1 isoform 4		PONAB		194
Q8IYV9-3	IZUMO1 isoform 3		PANTR		68	UniRef50_A0A2J8K289
IZUMO1 isoform 3		PONAB		68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB195682 mRNA Translation: BAD91012.1 AY552609 mRNA Translation: AAS59145.1 AY552610 mRNA Translation: AAS59146.1 AC009002 Genomic DNA No translation available. BC034769 mRNA Translation: AAH34769.1
CCDSⁱ	CCDS12732.1 [Q8IYV9-1]
RefSeqⁱ	NP_001308794.1, NM_001321865.1 NP_872381.2, NM_182575.2 [Q8IYV9-1] XP_011525114.1, XM_011526812.2 XP_011525115.1, XM_011526813.2
UniGeneⁱ	Hs.400688

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5F4E	X-ray	2.40	A	22-254	[»]
	5F4T	X-ray	3.08	A	22-254	[»]
	5F4V	X-ray	2.90	A	22-268	[»]
	5JK9	X-ray	2.10	A/B/C/D/E/F	22-255	[»]
	5JKC	X-ray	2.90	A	22-255	[»]
	5JKD	X-ray	2.90	A	22-255	[»]
	5JKE	X-ray	2.86	A/C	22-255	[»]
ProteinModelPortalⁱ	Q8IYV9
SMRⁱ	Q8IYV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129843, 22 interactors
CORUMⁱ	Q8IYV9
DIPⁱ	DIP-62033N
IntActⁱ	Q8IYV9, 1 interactor
STRINGⁱ	9606.ENSP00000327786

Protein family/group databases

TCDBⁱ	8.A.55.1.1 the izumo sperm-egg fusion protein 1 (izumo1) family

TCDBⁱ

8.A.55.1.1 the izumo sperm-egg fusion protein 1 (izumo1) family

PTM databases

iPTMnetⁱ	Q8IYV9
PhosphoSitePlusⁱ	Q8IYV9

Polymorphism and mutation databases

BioMutaⁱ	IZUMO1
DMDMⁱ	296434545

Proteomic databases

PaxDbⁱ	Q8IYV9
PeptideAtlasⁱ	Q8IYV9
PRIDEⁱ	Q8IYV9
ProteomicsDBⁱ	71246 71247 [Q8IYV9-2] 71248 [Q8IYV9-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	284359
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000332955; ENSP00000327786; ENSG00000182264 [Q8IYV9-1] ENST00000595517; ENSP00000471815; ENSG00000182264 [Q8IYV9-3] ENST00000595937; ENSP00000470144; ENSG00000182264 [Q8IYV9-2]
GeneIDⁱ	284359
KEGGⁱ	hsa:284359
UCSCⁱ	uc002pkj.3 human [Q8IYV9-1]

Organism-specific databases

CTDⁱ	284359
DisGeNETⁱ	284359
EuPathDBⁱ	HostDB:ENSG00000182264.8
GeneCardsⁱ	IZUMO1
H-InvDBⁱ	HIX0202883
HGNCⁱ	HGNC:28539 IZUMO1
HPAⁱ	HPA038104
MIMⁱ	609278 gene
neXtProtⁱ	NX_Q8IYV9
OpenTargetsⁱ	ENSG00000182264
PharmGKBⁱ	PA142671647
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHEV Eukaryota ENOG410Z8SJ LUCA
GeneTreeⁱ	ENSGT00390000015014
HOGENOMⁱ	HOG000113123
HOVERGENⁱ	HBG081812
InParanoidⁱ	Q8IYV9
OMAⁱ	KEVHACR
OrthoDBⁱ	EOG091G0AHL
PhylomeDBⁱ	Q8IYV9
TreeFamⁱ	TF338356

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1300652 Sperm:Oocyte Membrane Binding

Reactomeⁱ

R-HSA-1300652 Sperm:Oocyte Membrane Binding

Miscellaneous databases

ChiTaRSⁱ	IZUMO1 human
GenomeRNAiⁱ	284359
Protein Ontology More...PROⁱ	PR:Q8IYV9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182264 Expressed in 83 organ(s), highest expression level in testis
CleanExⁱ	HS_IZUMO1
ExpressionAtlasⁱ	Q8IYV9 baseline and differential
Genevisibleⁱ	Q8IYV9 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR029389 IZUMO IPR032699 Izumo-Ig IPR032700 IZUMO1
PANTHERⁱ	PTHR35540 PTHR35540, 1 hit
Pfamⁱ	View protein in Pfam PF15005 IZUMO, 1 hit PF16706 Izumo-Ig, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IZUM1_HUMAN
Accessionⁱ	Q8IYV9Primary (citable) accession number: Q8IYV9 Secondary accession number(s): Q6Q8P6, Q6Q8P7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IYV9 (IZUM1_HUMAN)

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Izumo sperm-egg fusion protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ