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UniProtKB - Q8IYT4 (KATL2_HUMAN)
Protein
Katanin p60 ATPase-containing subunit A-like 2
Gene
KATNAL2
Organism
Homo sapiens (Human)
Status
Functioni
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
UniRule annotationCatalytic activityi
- n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.UniRule annotation EC:5.6.1.1
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 294 – 301 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- isomerase activity Source: UniProtKB-KW
- microtubule binding Source: UniProtKB-UniRule
- microtubule-severing ATPase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Isomerase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IYT4 |
SignaLinki | Q8IYT4 |
SIGNORi | Q8IYT4 |
Names & Taxonomyi
Protein namesi | Recommended name: Katanin p60 ATPase-containing subunit A-like 2UniRule annotation (EC:5.6.1.1UniRule annotation)Short name: Katanin p60 subunit A-like 2UniRule annotation Alternative name(s): p60 katanin-like 2UniRule annotation |
Gene namesi | Name:KATNAL2UniRule annotation |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25387, KATNAL2 |
MIMi | 614697, gene |
neXtProti | NX_Q8IYT4 |
VEuPathDBi | HostDB:ENSG00000167216 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- cytoskeleton UniRule annotation
- spindle 1 Publication
- spindle pole 1 Publication
Note: Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during mitosis.1 Publication
Cytoskeleton
- microtubule Source: UniProtKB
- spindle Source: UniProtKB
- spindle pole Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 83473 |
OpenTargetsi | ENSG00000167216 |
PharmGKBi | PA134921461 |
Miscellaneous databases
Pharosi | Q8IYT4, Tbio |
Genetic variation databases
BioMutai | KATNAL2 |
DMDMi | 189028467 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333792 | 1 – 538 | Katanin p60 ATPase-containing subunit A-like 2Add BLAST | 538 |
Proteomic databases
EPDi | Q8IYT4 |
jPOSTi | Q8IYT4 |
MassIVEi | Q8IYT4 |
MaxQBi | Q8IYT4 |
PaxDbi | Q8IYT4 |
PeptideAtlasi | Q8IYT4 |
PRIDEi | Q8IYT4 |
ProteomicsDBi | 71235 [Q8IYT4-1] 71236 [Q8IYT4-2] |
PTM databases
iPTMneti | Q8IYT4 |
PhosphoSitePlusi | Q8IYT4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167216, Expressed in sural nerve and 143 other tissues |
ExpressionAtlasi | Q8IYT4, baseline and differential |
Genevisiblei | Q8IYT4, HS |
Organism-specific databases
HPAi | ENSG00000167216, Low tissue specificity |
Interactioni
Binary interactionsi
GO - Molecular functioni
- microtubule binding Source: UniProtKB-UniRule
Protein-protein interaction databases
BioGRIDi | 123661, 10 interactors |
IntActi | Q8IYT4, 57 interactors |
STRINGi | 9606.ENSP00000245121 |
Miscellaneous databases
RNActi | Q8IYT4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 57 | LisHUniRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 147 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 112 – 139 | Polar residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
InParanoidi | Q8IYT4 |
OMAi | MKTQGKY |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q8IYT4 |
TreeFami | TF329610 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IYT4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELSYQTLKF THQAREACEM RTEARRKNLL ILISHYLTQE GYIDTANALE
60 70 80 90 100
QETKLGLRRF EVCDNIDLET ILMEYESYYF VKFQKYPKIV KKSSDTAENN
110 120 130 140 150
LPQRSRGKTR RMMNDSCQNL PKINQQRPRS KTTAGKTGDT KSLNKEHPNQ
160 170 180 190 200
EVVDNTRLES ANFGLHISRI RKDSGEENAH PRRGQIIDFQ GLLTDAIKGA
210 220 230 240 250
TSELALNTFD HNPDPSERLL KPLSAFIGMN SEMRELAAVV SRDIYLHNPN
260 270 280 290 300
IKWNDIIGLD AAKQLVKEAV VYPIRYPQLF TGILSPWKGL LLYGPPGTGK
310 320 330 340 350
TLLAKAVATE CKTTFFNISA STIVSKWRGD SEKLVRVLFE LARYHAPSTI
360 370 380 390 400
FLDELESVMS QRGTASGGEH EGSLRMKTEL LVQMDGLARS EDLVFVLAAS
410 420 430 440 450
NLPWELDCAM LRRLEKRILV DLPSREARQA MIYHWLPPVS KSRALELHTE
460 470 480 490 500
LEYSVLSQET EGYSGSDIKL VCREAAMRPV RKIFDALENH QSESSDLPRI
510 520 530
QLDIVTTADF LDVLTHTKPS AKNLAQRYSD WQREFESV
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EIJ8 | K7EIJ8_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 427 | Annotation score: | ||
K7EMW1 | K7EMW1_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 222 | Annotation score: | ||
K7EM02 | K7EM02_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 128 | Annotation score: | ||
K7EPQ6 | K7EPQ6_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 341 | Annotation score: | ||
K7EQ00 | K7EQ00_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 105 | Annotation score: | ||
A0A8I5KR23 | A0A8I5KR23_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 50 | Annotation score: | ||
A0A8I5KR90 | A0A8I5KR90_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 329 | Annotation score: | ||
A0A8I5KRY6 | A0A8I5KRY6_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 111 | Annotation score: | ||
A0A8I5KTG7 | A0A8I5KTG7_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 48 | Annotation score: | ||
A0A8I5KXQ4 | A0A8I5KXQ4_HUMAN | Katanin p60 ATPase-containing subun... | KATNAL2 | 78 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BI560635 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 179 – 180 | AH → GQ in BI560635 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 207 | N → S in BI560635 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043160 | 160 | S → N2 PublicationsCorresponds to variant dbSNP:rs7233515EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033523 | 1 – 72 | Missing in isoform 2. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012254 Genomic DNA No translation available. AC090373 Genomic DNA No translation available. CH471096 Genomic DNA Translation: EAW62904.1 BC034999 mRNA Translation: AAH34999.2 BI560635 mRNA No translation available. DB461284 mRNA No translation available. |
CCDSi | CCDS32828.1 [Q8IYT4-2] |
RefSeqi | NP_112593.2, NM_031303.2 [Q8IYT4-2] XP_006722617.1, XM_006722554.3 [Q8IYT4-1] |
Genome annotation databases
Ensembli | ENST00000245121.10; ENSP00000245121.4; ENSG00000167216.19 [Q8IYT4-2] ENST00000356157.12; ENSP00000348478.6; ENSG00000167216.19 ENST00000683218.1; ENSP00000508137.1; ENSG00000167216.19 |
GeneIDi | 83473 |
KEGGi | hsa:83473 |
MANE-Selecti | ENST00000683218.1; ENSP00000508137.1; NM_001387690.1; NP_001374619.1 |
UCSCi | uc002lco.3, human [Q8IYT4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012254 Genomic DNA No translation available. AC090373 Genomic DNA No translation available. CH471096 Genomic DNA Translation: EAW62904.1 BC034999 mRNA Translation: AAH34999.2 BI560635 mRNA No translation available. DB461284 mRNA No translation available. |
CCDSi | CCDS32828.1 [Q8IYT4-2] |
RefSeqi | NP_112593.2, NM_031303.2 [Q8IYT4-2] XP_006722617.1, XM_006722554.3 [Q8IYT4-1] |
3D structure databases
AlphaFoldDBi | Q8IYT4 |
SMRi | Q8IYT4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123661, 10 interactors |
IntActi | Q8IYT4, 57 interactors |
STRINGi | 9606.ENSP00000245121 |
PTM databases
iPTMneti | Q8IYT4 |
PhosphoSitePlusi | Q8IYT4 |
Genetic variation databases
BioMutai | KATNAL2 |
DMDMi | 189028467 |
Proteomic databases
EPDi | Q8IYT4 |
jPOSTi | Q8IYT4 |
MassIVEi | Q8IYT4 |
MaxQBi | Q8IYT4 |
PaxDbi | Q8IYT4 |
PeptideAtlasi | Q8IYT4 |
PRIDEi | Q8IYT4 |
ProteomicsDBi | 71235 [Q8IYT4-1] 71236 [Q8IYT4-2] |
Protocols and materials databases
Antibodypediai | 22528, 65 antibodies from 15 providers |
DNASUi | 83473 |
Genome annotation databases
Ensembli | ENST00000245121.10; ENSP00000245121.4; ENSG00000167216.19 [Q8IYT4-2] ENST00000356157.12; ENSP00000348478.6; ENSG00000167216.19 ENST00000683218.1; ENSP00000508137.1; ENSG00000167216.19 |
GeneIDi | 83473 |
KEGGi | hsa:83473 |
MANE-Selecti | ENST00000683218.1; ENSP00000508137.1; NM_001387690.1; NP_001374619.1 |
UCSCi | uc002lco.3, human [Q8IYT4-1] |
Organism-specific databases
CTDi | 83473 |
DisGeNETi | 83473 |
GeneCardsi | KATNAL2 |
HGNCi | HGNC:25387, KATNAL2 |
HPAi | ENSG00000167216, Low tissue specificity |
MIMi | 614697, gene |
neXtProti | NX_Q8IYT4 |
OpenTargetsi | ENSG00000167216 |
PharmGKBi | PA134921461 |
VEuPathDBi | HostDB:ENSG00000167216 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0738, Eukaryota |
GeneTreei | ENSGT00940000157302 |
InParanoidi | Q8IYT4 |
OMAi | MKTQGKY |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q8IYT4 |
TreeFami | TF329610 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYT4 |
SignaLinki | Q8IYT4 |
SIGNORi | Q8IYT4 |
Miscellaneous databases
BioGRID-ORCSi | 83473, 11 hits in 1067 CRISPR screens |
ChiTaRSi | KATNAL2, human |
GenomeRNAii | 83473 |
Pharosi | Q8IYT4, Tbio |
PROi | PR:Q8IYT4 |
RNActi | Q8IYT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167216, Expressed in sural nerve and 143 other tissues |
ExpressionAtlasi | Q8IYT4, baseline and differential |
Genevisiblei | Q8IYT4, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_03025, Katanin_p60_AL2, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR027497, Katanin_p60_AL2 IPR006594, LisH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF08513, LisH, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00667, LisH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KATL2_HUMAN | |
Accessioni | Q8IYT4Primary (citable) accession number: Q8IYT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families