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Entry version 121 (12 Aug 2020)
Sequence version 2 (24 Nov 2009)
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Protein

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Gene

CMTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m7GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N7 methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1171 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei148S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei167S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Active sitei2351 Publication1
Binding sitei235S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei275Proton acceptorPROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processmRNA capping, mRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.296, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYT2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC:2.1.1.2961 Publication)
Alternative name(s):
Cap methyltransferase 2
Cap2 2'O-ribose methyltransferase 2
Short name:
HMTr2
Short name:
MTr2
FtsJ methyltransferase domain-containing protein 1
Protein adrift homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CMTR2
Synonyms:AFT, FTSJD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180917.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25635, CMTR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616190, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi74K → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi77L → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi78S → A: Only mildly affects mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi85W → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi86H → A: Only mildly affects mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi89T → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi113Q → A: Only mildly affects mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi117K → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi142H → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi145E → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1
Mutagenesisi235D → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi275K → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi307K → A: Strongly reduces mRNA cap binding and catalytic activity of the enzyme. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55783

Open Targets

More...
OpenTargetsi
ENSG00000180917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389041

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYT2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CMTR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261801 – 770Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2Add BLAST770

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYT2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYT2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IYT2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYT2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYT2

PeptideAtlas

More...
PeptideAtlasi
Q8IYT2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYT2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71233

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180917, Expressed in epithelial cell of pancreas and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYT2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYT2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000180917, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120897, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYT2, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337512

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYT2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYT2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 322Adrift-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST214

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3674, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161773

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019427_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYT2

KEGG Orthology (KO)

More...
KOi
K14590

Identification of Orthologs from Complete Genome Data

More...
OMAi
MIMDDRL

Database of Orthologous Groups

More...
OrthoDBi
1327262at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYT2

TreeFam database of animal gene trees

More...
TreeFami
TF314897

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025807, Adrift-typ_MeTrfase
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01728, FtsJ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51614, SAM_MT_ADRIFT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8IYT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKCRKTPVQ QLASPASFSP DILADIFELF AKNFSYGKPL NNEWQLPDPS
60 70 80 90 100
EIFTCDHTEL NAFLDLKNSL NEVKNLLSDK KLDEWHEHTA FTNKAGKIIS
110 120 130 140 150
HVRKSVNAEL CTQAWCKFHE ILCSFPLIPQ EAFQNGKLNS LHLCEAPGAF
160 170 180 190 200
IASLNHYLKS HRFPCHWSWV ANTLNPYHEA NDDLMMIMDD RLIANTLHWW
210 220 230 240 250
YFGPDNTGDI MTLKFLTGLQ NFISSMATVH LVTADGSFDC QGNPGEQEAL
260 270 280 290 300
VSSLHYCEVV TALTTLGNGG SFVLKMFTMF EHCSINLMYL LNCCFDQVHV
310 320 330 340 350
FKPATSKAGN SEVYVVCLHY KGREAIHPLL SKMTLNFGTE MKRKALFPHH
360 370 380 390 400
VIPDSFLKRH EECCVFFHKY QLETISENIR LFECMGKAEQ EKLNNLRDCA
410 420 430 440 450
IQYFMQKFQL KHLSRNNWLV KKSSIGCSTN TKWFGQRNKY FKTYNERKML
460 470 480 490 500
EALSWKDKVA KGYFNSWAEE HGVYHPGQSS ILEGTASNLE CHLWHILEGK
510 520 530 540 550
KLPKVKCSPF CNGEILKTLN EAIEKSLGGA FNLDSKFRPK QQYSCSCHVF
560 570 580 590 600
SEELIFSELC SLTECLQDEQ VVVPSNQIKC LLVGFSTLRN IKMHIPLEVR
610 620 630 640 650
LLESAELTTF SCSLLHDGDP TYQRLFLDCL LHSLRELHTG DVMILPVLSC
660 670 680 690 700
FTRFMAGLIF VLHSCFRFIT FVCPTSSDPL RTCAVLLCVG YQDLPNPVFR
710 720 730 740 750
YLQSVNELLS TLLNSDSPQQ VLQFVPMEVL LKGALLDFLW DLNAAIAKRH
760 770
LHFIIQRERE EIINSLQLQN
Length:770
Mass (Da):88,120
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5BE4A2B31AE3580
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR19H3BR19_HUMAN
Cap-specific mRNA (nucleoside-2'-O-...
CMTR2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTZ7H3BTZ7_HUMAN
Cap-specific mRNA (nucleoside-2'-O-...
CMTR2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNZ8H3BNZ8_HUMAN
Cap-specific mRNA (nucleoside-2'-O-...
CMTR2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS00H3BS00_HUMAN
Cap-specific mRNA (nucleoside-2'-O-...
CMTR2
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUK2H3BUK2_HUMAN
Cap-specific mRNA (nucleoside-2'-O-...
CMTR2
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM49718 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91058 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14452 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27F → L in AAM49718 (Ref. 5) Curated1
Sequence conflicti53F → Y in AAM49718 (Ref. 5) Curated1
Sequence conflicti56D → E in AAM49718 (Ref. 5) Curated1
Sequence conflicti75N → K in AAM49718 (Ref. 5) Curated1
Sequence conflicti85 – 86WH → LD in AAM49718 (Ref. 5) Curated2
Sequence conflicti201 – 202YF → HL in AAM49718 (Ref. 5) Curated2
Sequence conflicti222F → I in AAM49718 (Ref. 5) Curated1
Sequence conflicti317C → S in AAM49718 (Ref. 5) Curated1
Sequence conflicti683C → S in BAA92047 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03999860L → F2 PublicationsCorresponds to variant dbSNP:rs3096380Ensembl.1
Natural variantiVAR_039999163F → Y1 PublicationCorresponds to variant dbSNP:rs17853360Ensembl.1
Natural variantiVAR_040000416N → S1 PublicationCorresponds to variant dbSNP:rs3803704Ensembl.1
Natural variantiVAR_040001608T → K. Corresponds to variant dbSNP:rs3096381Ensembl.1
Natural variantiVAR_040002753F → L. Corresponds to variant dbSNP:rs16970857Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000289 mRNA Translation: BAA91058.1 Frameshift.
AK002033 mRNA Translation: BAA92047.1
AK023183 mRNA Translation: BAB14452.1 Different initiation.
AK315056 mRNA Translation: BAG37532.1
AC106736 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59246.1
CH471166 Genomic DNA Translation: EAW59247.1
BC034468 mRNA Translation: AAH34468.1
BC035005 mRNA Translation: AAH35005.1
AF458590 mRNA Translation: AAM49718.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10898.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093112.1, NM_001099642.1
NP_001311303.1, NM_001324374.1
NP_001311306.1, NM_001324377.1
NP_001311307.1, NM_001324378.1
NP_001311308.1, NM_001324379.1
NP_060818.4, NM_018348.5
XP_011521530.1, XM_011523228.1
XP_011521531.1, XM_011523229.1
XP_016878933.1, XM_017023444.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338099; ENSP00000337512; ENSG00000180917
ENST00000434935; ENSP00000411148; ENSG00000180917

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55783

UCSC genome browser

More...
UCSCi
uc002ezy.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000289 mRNA Translation: BAA91058.1 Frameshift.
AK002033 mRNA Translation: BAA92047.1
AK023183 mRNA Translation: BAB14452.1 Different initiation.
AK315056 mRNA Translation: BAG37532.1
AC106736 Genomic DNA No translation available.
CH471166 Genomic DNA Translation: EAW59246.1
CH471166 Genomic DNA Translation: EAW59247.1
BC034468 mRNA Translation: AAH34468.1
BC035005 mRNA Translation: AAH35005.1
AF458590 mRNA Translation: AAM49718.1 Frameshift.
CCDSiCCDS10898.1
RefSeqiNP_001093112.1, NM_001099642.1
NP_001311303.1, NM_001324374.1
NP_001311306.1, NM_001324377.1
NP_001311307.1, NM_001324378.1
NP_001311308.1, NM_001324379.1
NP_060818.4, NM_018348.5
XP_011521530.1, XM_011523228.1
XP_011521531.1, XM_011523229.1
XP_016878933.1, XM_017023444.1

3D structure databases

SMRiQ8IYT2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120897, 10 interactors
IntActiQ8IYT2, 6 interactors
STRINGi9606.ENSP00000337512

PTM databases

iPTMnetiQ8IYT2
PhosphoSitePlusiQ8IYT2

Polymorphism and mutation databases

BioMutaiCMTR2
DMDMi269849596

Proteomic databases

EPDiQ8IYT2
jPOSTiQ8IYT2
MassIVEiQ8IYT2
MaxQBiQ8IYT2
PaxDbiQ8IYT2
PeptideAtlasiQ8IYT2
PRIDEiQ8IYT2
ProteomicsDBi71233

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
44554, 77 antibodies

The DNASU plasmid repository

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DNASUi
55783

Genome annotation databases

EnsembliENST00000338099; ENSP00000337512; ENSG00000180917
ENST00000434935; ENSP00000411148; ENSG00000180917
GeneIDi55783
KEGGihsa:55783
UCSCiuc002ezy.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55783
DisGeNETi55783
EuPathDBiHostDB:ENSG00000180917.16

GeneCards: human genes, protein and diseases

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GeneCardsi
CMTR2
HGNCiHGNC:25635, CMTR2
HPAiENSG00000180917, Low tissue specificity
MIMi616190, gene
neXtProtiNX_Q8IYT2
OpenTargetsiENSG00000180917
PharmGKBiPA162389041

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3674, Eukaryota
GeneTreeiENSGT00940000161773
HOGENOMiCLU_019427_0_0_1
InParanoidiQ8IYT2
KOiK14590
OMAiMIMDDRL
OrthoDBi1327262at2759
PhylomeDBiQ8IYT2
TreeFamiTF314897

Enzyme and pathway databases

BRENDAi2.1.1.296, 2681
PathwayCommonsiQ8IYT2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55783, 56 hits in 860 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CMTR2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55783
PharosiQ8IYT2, Tbio

Protein Ontology

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PROi
PR:Q8IYT2
RNActiQ8IYT2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000180917, Expressed in epithelial cell of pancreas and 218 other tissues
ExpressionAtlasiQ8IYT2, baseline and differential
GenevisibleiQ8IYT2, HS

Family and domain databases

InterProiView protein in InterPro
IPR025807, Adrift-typ_MeTrfase
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01728, FtsJ, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51614, SAM_MT_ADRIFT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYT2
Secondary accession number(s): B2RCD5
, D3DWS1, Q8NE77, Q8NFR5, Q9H8Z4, Q9NUS3, Q9NXF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 24, 2009
Last modified: August 12, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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