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Entry version 97 (13 Feb 2019)
Sequence version 2 (06 Feb 2007)
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Protein

Biorientation of chromosomes in cell division protein 1-like 2

Gene

BOD1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1-like 2Curated
Alternative name(s):
Biorientation of chromosomes in cell division protein 1 pseudogeneCurated
Protein FAM44CCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BOD1L2Imported
Synonyms:BOD1PImported, FAM44CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000228075.4

Human Gene Nomenclature Database

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HGNCi
HGNC:28505 BOD1L2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000228075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA166048984

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BOD1L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125987827

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870331 – 172Biorientation of chromosomes in cell division protein 1-like 2Add BLAST172

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYS8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYS8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYS8

PeptideAtlas

More...
PeptideAtlasi
Q8IYS8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYS8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71231

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000228075 Expressed in 49 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYS8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036293

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129806, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYS8, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000467843

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IYS8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 13Poly-Gly10
Compositional biasi21 – 24Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BOD1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCC4 Eukaryota
ENOG4110P49 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154979

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYS8

Identification of Orthologs from Complete Genome Data

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OMAi
NHIFRPH

Database of Orthologous Groups

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OrthoDBi
1333373at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYS8

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026955 Bod1-like

The PANTHER Classification System

More...
PANTHERi
PTHR31532 PTHR31532, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGGGGGSG GAGPASTRAS GGGGPINPAS LPPGDPQLIA IIVGQLKSRG
60 70 80 90 100
LFDSFRRDCK ADVDTKPAYQ NLSQKADNFV STHLDKQEWN PPANDNQLHD
110 120 130 140 150
GLRQSVVQSG RSEAGVDRIS SQVVDPKLNH IFRPQIEQII HEFLVAQKEA
160 170
AVPALPPEPE GQDPPAPSQD TS
Length:172
Mass (Da):18,075
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6590AAD1F999A6E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46L → P in BAG54606 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK127964 mRNA Translation: BAG54606.1
AC100775 mRNA No translation available.
BC021740 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS59322.1

NCBI Reference Sequences

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RefSeqi
NP_001244893.1, NM_001257964.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.127882

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000585477; ENSP00000467843; ENSG00000228075

Database of genes from NCBI RefSeq genomes

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GeneIDi
284257

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284257

UCSC genome browser

More...
UCSCi
uc002lgm.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127964 mRNA Translation: BAG54606.1
AC100775 mRNA No translation available.
BC021740 mRNA No translation available.
CCDSiCCDS59322.1
RefSeqiNP_001244893.1, NM_001257964.1
UniGeneiHs.127882

3D structure databases

ProteinModelPortaliQ8IYS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129806, 2 interactors
IntActiQ8IYS8, 5 interactors
STRINGi9606.ENSP00000467843

PTM databases

iPTMnetiQ8IYS8
PhosphoSitePlusiQ8IYS8

Polymorphism and mutation databases

BioMutaiBOD1L2
DMDMi125987827

Proteomic databases

EPDiQ8IYS8
jPOSTiQ8IYS8
MaxQBiQ8IYS8
PaxDbiQ8IYS8
PeptideAtlasiQ8IYS8
PRIDEiQ8IYS8
ProteomicsDBi71231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585477; ENSP00000467843; ENSG00000228075
GeneIDi284257
KEGGihsa:284257
UCSCiuc002lgm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284257
EuPathDBiHostDB:ENSG00000228075.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BOD1L2
HGNCiHGNC:28505 BOD1L2
HPAiHPA036293
neXtProtiNX_Q8IYS8
OpenTargetsiENSG00000228075
PharmGKBiPA166048984

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KCC4 Eukaryota
ENOG4110P49 LUCA
GeneTreeiENSGT00940000154979
InParanoidiQ8IYS8
OMAiNHIFRPH
OrthoDBi1333373at2759
PhylomeDBiQ8IYS8

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284257

Protein Ontology

More...
PROi
PR:Q8IYS8

Gene expression databases

BgeeiENSG00000228075 Expressed in 49 organ(s), highest expression level in testis
GenevisibleiQ8IYS8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026955 Bod1-like
PANTHERiPTHR31532 PTHR31532, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBD1L2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYS8
Secondary accession number(s): B3KXU4, Q8WW13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 6, 2007
Last modified: February 13, 2019
This is version 97 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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