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Entry version 142 (07 Oct 2020)
Sequence version 3 (02 Nov 2010)
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Protein

Osteoclast-associated immunoglobulin-like receptor

Gene

OSCAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYS5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Osteoclast-associated immunoglobulin-like receptor
Short name:
Osteoclast-associated receptor
Short name:
hOSCAR
Alternative name(s):
Polymeric immunoglobulin receptor 3
Short name:
PIgR-3
Short name:
PIgR3
Short name:
Poly-Ig receptor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSCAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170909.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29960, OSCAR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606862, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYS5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
126014

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398474

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYS5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSCAR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031095119 – 282Osteoclast-associated immunoglobulin-like receptorAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 100By similarity
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYS5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYS5

PeptideAtlas

More...
PeptideAtlasi
Q8IYS5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYS5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71224 [Q8IYS5-1]
71225 [Q8IYS5-2]
71226 [Q8IYS5-3]
71227 [Q8IYS5-4]
71228 [Q8IYS5-5]
71229 [Q8IYS5-6]
71230 [Q8IYS5-7]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IYS5, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170909, Expressed in blood and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYS5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYS5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170909, Group enriched (blood, bone marrow, lung, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8IYS5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479089

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYS5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYS5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 116Ig-like 1Add BLAST95
Domaini126 – 219Ig-like 2Add BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502T2B6, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYS5

KEGG Orthology (KO)

More...
KOi
K14377

Database of Orthologous Groups

More...
OrthoDBi
1327293at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYS5

TreeFam database of animal gene trees

More...
TreeFami
TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895, Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYS5-1) [UniParc]FASTAAdd to basket
Also known as: OSCAR-S1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVLILQLL TLWPLCHTDI TPSVPPASYH PKPWLGAQPA TVVTPGVNVT
60 70 80 90 100
LRCRAPQPAW RFGLFKPGEI APLLFRDVSS ELAEFFLEEV TPAQGGIYRC
110 120 130 140 150
CYRRPDWGPG VWSQPSDVLE LLVTEELPRP SLVALPGPVV GPGANVSLRC
160 170 180 190 200
AGRLRNMSFV LYREGVAAPL QYRHSAQPWA DFTLLGARAP GTYSCYYHTP
210 220 230 240 250
SAPYVLSQRS EVLVISWEGE GPEARPASSA PGMQAPGPPP SDPGAQAPSL
260 270 280
SSFRPRGLVL QPLLPQTQDS WDPAPPPSDP GV
Length:282
Mass (Da):30,481
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C0A86B90DA6F5CD
GO
Isoform 2 (identifier: Q8IYS5-2) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M1

The sequence of this isoform differs from the canonical sequence as follows:
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:263
Mass (Da):28,832
Checksum:iA8657336B9DD1237
GO
Isoform 3 (identifier: Q8IYS5-3) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M2

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:267
Mass (Da):29,229
Checksum:iAA9C139695285E4A
GO
Isoform 4 (identifier: Q8IYS5-4) [UniParc]FASTAAdd to basket
Also known as: OSCAR-S2

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP

Show »
Length:271
Mass (Da):29,278
Checksum:i45660528C75F9A8A
GO
Isoform 5 (identifier: Q8IYS5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-134: Missing.

Show »
Length:276
Mass (Da):29,857
Checksum:i74AF3F9451D97806
GO
Isoform 7 (identifier: Q8IYS5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → VAIIV

Show »
Length:286
Mass (Da):30,877
Checksum:i6F3E049373829FCA
GO
Isoform 6 (identifier: Q8IYS5-6) [UniParc]FASTAAdd to basket
Also known as: OSCAR-M3

The sequence of this isoform differs from the canonical sequence as follows:
     13-25: WPLCHTDITPSVP → FP
     219-282: GEGPEARPAS...PAPPPSDPGV → DSGSSDYTRG...QNRAPAGIRP

Show »
Length:252
Mass (Da):27,629
Checksum:iCE0BFD7C3FB9DF53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV17A0A087WV17_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR14A0A0A0MR14_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRF2A0A0A0MRF2_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1R2A0A087X1R2_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0P3A0A087X0P3_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MWV3A8MWV3_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMM7A0A0G2JMM7_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNK2A0A0G2JNK2_HUMAN
Osteoclast-associated immunoglobuli...
OSCAR
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158S → N in AAM19095 (Ref. 1) Curated1
Sequence conflicti194S → G in BAC03586 (PubMed:14702039).Curated1
Sequence conflicti194S → G in AX746784 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03710897I → S4 PublicationsCorresponds to variant dbSNP:rs1657535Ensembl.1
Natural variantiVAR_047393229S → Y. Corresponds to variant dbSNP:rs8106130Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02935213 – 25WPLCH…TPSVP → FP in isoform 4 and isoform 6. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_02935324V → VAIIV in isoform 3 and isoform 7. 2 Publications1
Alternative sequenceiVSP_029354129 – 134Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_029355219 – 282GEGPE…SDPGV → DSGSSDYTRGNLVRLGLAGL VLISLGALVTFDWRSQNRAP AGIRP in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF251702 mRNA Translation: AAM19095.1
AF391162 mRNA Translation: AAL68495.1
AF391163 mRNA Translation: AAL68496.1
AF391164 mRNA Translation: AAL68497.1
AF474152 mRNA Translation: AAQ05766.1
AF474153 mRNA Translation: AAQ05767.1
AX746784 mRNA No translation available.
AK091111 mRNA Translation: BAC03586.1
AK130199 mRNA No translation available.
AC012314 Genomic DNA No translation available.
BC035023 mRNA Translation: AAH35023.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12873.1 [Q8IYS5-3]
CCDS12874.1 [Q8IYS5-6]
CCDS12875.1 [Q8IYS5-2]
CCDS12876.1 [Q8IYS5-7]
CCDS62789.1 [Q8IYS5-4]
CCDS74444.1 [Q8IYS5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269278.1, NM_001282349.1
NP_001269279.1, NM_001282350.1
NP_570127.3, NM_130771.4
NP_573398.2, NM_133168.4
NP_573399.2, NM_133169.4
NP_996554.2, NM_206818.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284648; ENSP00000365808; ENSG00000170909
ENST00000391761; ENSP00000375641; ENSG00000170909
ENST00000610577; ENSP00000478594; ENSG00000276982 [Q8IYS5-7]
ENST00000610915; ENSP00000479317; ENSG00000277088 [Q8IYS5-4]
ENST00000610985; ENSP00000484755; ENSG00000274703 [Q8IYS5-7]
ENST00000611143; ENSP00000477994; ENSG00000278533 [Q8IYS5-3]
ENST00000611480; ENSP00000480193; ENSG00000275551 [Q8IYS5-1]
ENST00000611535; ENSP00000483744; ENSG00000275736 [Q8IYS5-2]
ENST00000611715; ENSP00000478382; ENSG00000278533 [Q8IYS5-4]
ENST00000611719; ENSP00000478099; ENSG00000275644 [Q8IYS5-4]
ENST00000611918; ENSP00000482460; ENSG00000276982 [Q8IYS5-4]
ENST00000611987; ENSP00000478027; ENSG00000276982 [Q8IYS5-3]
ENST00000612289; ENSP00000482414; ENSG00000277088 [Q8IYS5-1]
ENST00000612406; ENSP00000478224; ENSG00000273511 [Q8IYS5-7]
ENST00000612953; ENSP00000479954; ENSG00000275644 [Q8IYS5-7]
ENST00000613426; ENSP00000480900; ENSG00000275736 [Q8IYS5-1]
ENST00000613814; ENSP00000484125; ENSG00000275736 [Q8IYS5-4]
ENST00000614003; ENSP00000481647; ENSG00000274703 [Q8IYS5-1]
ENST00000614380; ENSP00000482734; ENSG00000277088 [Q8IYS5-7]
ENST00000615074; ENSP00000477845; ENSG00000275736 [Q8IYS5-7]
ENST00000615546; ENSP00000482402; ENSG00000275551 [Q8IYS5-4]
ENST00000616215; ENSP00000479628; ENSG00000170909
ENST00000616227; ENSP00000479849; ENSG00000275736 [Q8IYS5-7]
ENST00000616232; ENSP00000484567; ENSG00000274703 [Q8IYS5-4]
ENST00000616461; ENSP00000482610; ENSG00000278533 [Q8IYS5-7]
ENST00000616758; ENSP00000481785; ENSG00000278533 [Q8IYS5-1]
ENST00000617187; ENSP00000481805; ENSG00000275551 [Q8IYS5-7]
ENST00000617210; ENSP00000482359; ENSG00000278378 [Q8IYS5-3]
ENST00000617622; ENSP00000480863; ENSG00000273511 [Q8IYS5-1]
ENST00000617834; ENSP00000481147; ENSG00000275551 [Q8IYS5-3]
ENST00000617993; ENSP00000481261; ENSG00000278378 [Q8IYS5-7]
ENST00000618710; ENSP00000484323; ENSG00000278378 [Q8IYS5-1]
ENST00000619170; ENSP00000482545; ENSG00000273511 [Q8IYS5-3]
ENST00000619287; ENSP00000484977; ENSG00000275736 [Q8IYS5-6]
ENST00000619631; ENSP00000484878; ENSG00000273511 [Q8IYS5-4]
ENST00000620283; ENSP00000483090; ENSG00000274703 [Q8IYS5-3]
ENST00000620647; ENSP00000478216; ENSG00000275644 [Q8IYS5-1]
ENST00000621284; ENSP00000477825; ENSG00000275736 [Q8IYS5-4]
ENST00000621290; ENSP00000482791; ENSG00000275736 [Q8IYS5-3]
ENST00000621328; ENSP00000482997; ENSG00000275644 [Q8IYS5-3]
ENST00000621506; ENSP00000480424; ENSG00000278378 [Q8IYS5-4]
ENST00000621788; ENSP00000481926; ENSG00000275736 [Q8IYS5-3]
ENST00000622288; ENSP00000484602; ENSG00000277088 [Q8IYS5-3]
ENST00000622326; ENSP00000481257; ENSG00000276982 [Q8IYS5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
126014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126014

UCSC genome browser

More...
UCSCi
uc002qdc.5, human [Q8IYS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251702 mRNA Translation: AAM19095.1
AF391162 mRNA Translation: AAL68495.1
AF391163 mRNA Translation: AAL68496.1
AF391164 mRNA Translation: AAL68497.1
AF474152 mRNA Translation: AAQ05766.1
AF474153 mRNA Translation: AAQ05767.1
AX746784 mRNA No translation available.
AK091111 mRNA Translation: BAC03586.1
AK130199 mRNA No translation available.
AC012314 Genomic DNA No translation available.
BC035023 mRNA Translation: AAH35023.1
CCDSiCCDS12873.1 [Q8IYS5-3]
CCDS12874.1 [Q8IYS5-6]
CCDS12875.1 [Q8IYS5-2]
CCDS12876.1 [Q8IYS5-7]
CCDS62789.1 [Q8IYS5-4]
CCDS74444.1 [Q8IYS5-1]
RefSeqiNP_001269278.1, NM_001282349.1
NP_001269279.1, NM_001282350.1
NP_570127.3, NM_130771.4
NP_573398.2, NM_133168.4
NP_573399.2, NM_133169.4
NP_996554.2, NM_206818.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CJ8X-ray2.02A31-215[»]
5CJBX-ray2.40A31-215[»]
5EIQX-ray2.01A28-215[»]
5EIVX-ray2.41A/B26-215[»]
SMRiQ8IYS5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ8IYS5, 2 interactors
STRINGi9606.ENSP00000479089

PTM databases

GlyGeniQ8IYS5, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ8IYS5

Polymorphism and mutation databases

BioMutaiOSCAR
DMDMi311033418

Proteomic databases

jPOSTiQ8IYS5
MassIVEiQ8IYS5
PaxDbiQ8IYS5
PeptideAtlasiQ8IYS5
PRIDEiQ8IYS5
ProteomicsDBi71224 [Q8IYS5-1]
71225 [Q8IYS5-2]
71226 [Q8IYS5-3]
71227 [Q8IYS5-4]
71228 [Q8IYS5-5]
71229 [Q8IYS5-6]
71230 [Q8IYS5-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32787, 239 antibodies

The DNASU plasmid repository

More...
DNASUi
126014

Genome annotation databases

EnsembliENST00000284648; ENSP00000365808; ENSG00000170909
ENST00000391761; ENSP00000375641; ENSG00000170909
ENST00000610577; ENSP00000478594; ENSG00000276982 [Q8IYS5-7]
ENST00000610915; ENSP00000479317; ENSG00000277088 [Q8IYS5-4]
ENST00000610985; ENSP00000484755; ENSG00000274703 [Q8IYS5-7]
ENST00000611143; ENSP00000477994; ENSG00000278533 [Q8IYS5-3]
ENST00000611480; ENSP00000480193; ENSG00000275551 [Q8IYS5-1]
ENST00000611535; ENSP00000483744; ENSG00000275736 [Q8IYS5-2]
ENST00000611715; ENSP00000478382; ENSG00000278533 [Q8IYS5-4]
ENST00000611719; ENSP00000478099; ENSG00000275644 [Q8IYS5-4]
ENST00000611918; ENSP00000482460; ENSG00000276982 [Q8IYS5-4]
ENST00000611987; ENSP00000478027; ENSG00000276982 [Q8IYS5-3]
ENST00000612289; ENSP00000482414; ENSG00000277088 [Q8IYS5-1]
ENST00000612406; ENSP00000478224; ENSG00000273511 [Q8IYS5-7]
ENST00000612953; ENSP00000479954; ENSG00000275644 [Q8IYS5-7]
ENST00000613426; ENSP00000480900; ENSG00000275736 [Q8IYS5-1]
ENST00000613814; ENSP00000484125; ENSG00000275736 [Q8IYS5-4]
ENST00000614003; ENSP00000481647; ENSG00000274703 [Q8IYS5-1]
ENST00000614380; ENSP00000482734; ENSG00000277088 [Q8IYS5-7]
ENST00000615074; ENSP00000477845; ENSG00000275736 [Q8IYS5-7]
ENST00000615546; ENSP00000482402; ENSG00000275551 [Q8IYS5-4]
ENST00000616215; ENSP00000479628; ENSG00000170909
ENST00000616227; ENSP00000479849; ENSG00000275736 [Q8IYS5-7]
ENST00000616232; ENSP00000484567; ENSG00000274703 [Q8IYS5-4]
ENST00000616461; ENSP00000482610; ENSG00000278533 [Q8IYS5-7]
ENST00000616758; ENSP00000481785; ENSG00000278533 [Q8IYS5-1]
ENST00000617187; ENSP00000481805; ENSG00000275551 [Q8IYS5-7]
ENST00000617210; ENSP00000482359; ENSG00000278378 [Q8IYS5-3]
ENST00000617622; ENSP00000480863; ENSG00000273511 [Q8IYS5-1]
ENST00000617834; ENSP00000481147; ENSG00000275551 [Q8IYS5-3]
ENST00000617993; ENSP00000481261; ENSG00000278378 [Q8IYS5-7]
ENST00000618710; ENSP00000484323; ENSG00000278378 [Q8IYS5-1]
ENST00000619170; ENSP00000482545; ENSG00000273511 [Q8IYS5-3]
ENST00000619287; ENSP00000484977; ENSG00000275736 [Q8IYS5-6]
ENST00000619631; ENSP00000484878; ENSG00000273511 [Q8IYS5-4]
ENST00000620283; ENSP00000483090; ENSG00000274703 [Q8IYS5-3]
ENST00000620647; ENSP00000478216; ENSG00000275644 [Q8IYS5-1]
ENST00000621284; ENSP00000477825; ENSG00000275736 [Q8IYS5-4]
ENST00000621290; ENSP00000482791; ENSG00000275736 [Q8IYS5-3]
ENST00000621328; ENSP00000482997; ENSG00000275644 [Q8IYS5-3]
ENST00000621506; ENSP00000480424; ENSG00000278378 [Q8IYS5-4]
ENST00000621788; ENSP00000481926; ENSG00000275736 [Q8IYS5-3]
ENST00000622288; ENSP00000484602; ENSG00000277088 [Q8IYS5-3]
ENST00000622326; ENSP00000481257; ENSG00000276982 [Q8IYS5-1]
GeneIDi126014
KEGGihsa:126014
UCSCiuc002qdc.5, human [Q8IYS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126014
DisGeNETi126014
EuPathDBiHostDB:ENSG00000170909.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OSCAR
HGNCiHGNC:29960, OSCAR
HPAiENSG00000170909, Group enriched (blood, bone marrow, lung, lymphoid tissue)
MIMi606862, gene
neXtProtiNX_Q8IYS5
PharmGKBiPA162398474

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502T2B6, Eukaryota
InParanoidiQ8IYS5
KOiK14377
OrthoDBi1327293at2759
PhylomeDBiQ8IYS5
TreeFamiTF336644

Enzyme and pathway databases

PathwayCommonsiQ8IYS5
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
126014, 3 hits in 868 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
OSCAR_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126014
PharosiQ8IYS5, Tbio

Protein Ontology

More...
PROi
PR:Q8IYS5
RNActiQ8IYS5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170909, Expressed in blood and 113 other tissues
ExpressionAtlasiQ8IYS5, baseline and differential
GenevisibleiQ8IYS5, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
PfamiView protein in Pfam
PF13895, Ig_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSCAR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYS5
Secondary accession number(s): B7WNS2
, Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 2, 2010
Last modified: October 7, 2020
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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