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Entry version 98 (26 Feb 2020)
Sequence version 3 (18 May 2010)
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Protein

Uncharacterized protein C16orf71

Gene

C16orf71

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C16orf71
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25081 C16orf71

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYS4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000166246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149565

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYS4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C16orf71

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002943451 – 520Uncharacterized protein C16orf71Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYS4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYS4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYS4

PeptideAtlas

More...
PeptideAtlasi
Q8IYS4

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYS4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71223

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166246 Expressed in right testis and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYS4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYS4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126999, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYS4, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299320

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYS4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYMM Eukaryota
ENOG4111414 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015381

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037635_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYS4

Database of Orthologous Groups

More...
OrthoDBi
1111863at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYS4

TreeFam database of animal gene trees

More...
TreeFami
TF336688

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031531 DUF4701

The PANTHER Classification System

More...
PANTHERi
PTHR35977 PTHR35977, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15773 DUF4701, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8IYS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNDKGMAP SLGSPWASQM GPWDAILKAV KDQLPSLDSD SPLSDYGEEE
60 70 80 90 100
LFIFQRNQTS LIPDLSEELA EDPADGDKSR AWVAAAEESL PEPVLVPAEL
110 120 130 140 150
ATEPGCRQNT RTKDASSQEG RDPGRPFESS GEVSALLGMA EEPPRWLEGD
160 170 180 190 200
LGSLSFNTKG SQGPPWDPQA EATLSCHEGD PKAEPLSTAS QESVNRRALR
210 220 230 240 250
QERRKMIETD ILQKVTRDAC GPTSSDKGGV KEAPCHAAES APRSKMPLVE
260 270 280 290 300
PPEGPPVLSL QQLEAWDLDD ILQSLAGQED NQGNRAPGTV WWAADHRQVQ
310 320 330 340 350
DRMVPSAHNR LMEQLALLCT TQSKASACAR KVPADTPQDT KEADSGSRCA
360 370 380 390 400
SRKQGSQAGP GPQLAQGMRL NAESPTIFID LRQMELPDHL SPESSSHSSS
410 420 430 440 450
DSEEEEEEEM AALGDAEGAS PSSLGLRTCT GKSQLLQQLR AFQKGTAQPE
460 470 480 490 500
LPASKGPAGG RAQAPEDTAG SRTGRKQHMK LCAKGQSAQA RLPRGRPRAL
510 520
GDVPEPGAAR EALMPPLEQL
Length:520
Mass (Da):55,682
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E160E14948B36E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPW6K7EPW6_HUMAN
Uncharacterized protein C16orf71
C16orf71
537Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENX3K7ENX3_HUMAN
Uncharacterized protein C16orf71
C16orf71
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT50A0A087WT50_HUMAN
Uncharacterized protein C16orf71
C16orf71
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19Q → R in AAH35024 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03315788E → D. Corresponds to variant dbSNP:rs17137215Ensembl.1
Natural variantiVAR_033158143P → S. Corresponds to variant dbSNP:rs17137230Ensembl.1
Natural variantiVAR_033159190S → L. Corresponds to variant dbSNP:rs35599524Ensembl.1
Natural variantiVAR_033160232E → K. Corresponds to variant dbSNP:rs35002791Ensembl.1
Natural variantiVAR_033161241A → V. Corresponds to variant dbSNP:rs7202010Ensembl.1
Natural variantiVAR_033162302R → C2 PublicationsCorresponds to variant dbSNP:rs2075469Ensembl.1
Natural variantiVAR_033163354Q → R2 PublicationsCorresponds to variant dbSNP:rs737700Ensembl.1
Natural variantiVAR_061618465P → L1 PublicationCorresponds to variant dbSNP:rs17853375Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF447587 mRNA Translation: AAM22870.1
AC020663 Genomic DNA No translation available.
BC035024 mRNA Translation: AAH35024.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10521.1

NCBI Reference Sequences

More...
RefSeqi
NP_631909.2, NM_139170.2
XP_016878465.1, XM_017022976.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299320; ENSP00000299320; ENSG00000166246

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
146562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146562

UCSC genome browser

More...
UCSCi
uc002cxn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447587 mRNA Translation: AAM22870.1
AC020663 Genomic DNA No translation available.
BC035024 mRNA Translation: AAH35024.1
CCDSiCCDS10521.1
RefSeqiNP_631909.2, NM_139170.2
XP_016878465.1, XM_017022976.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126999, 29 interactors
IntActiQ8IYS4, 25 interactors
STRINGi9606.ENSP00000299320

PTM databases

iPTMnetiQ8IYS4
PhosphoSitePlusiQ8IYS4

Polymorphism and mutation databases

BioMutaiC16orf71
DMDMi296439389

Proteomic databases

jPOSTiQ8IYS4
MassIVEiQ8IYS4
PaxDbiQ8IYS4
PeptideAtlasiQ8IYS4
PRIDEiQ8IYS4
ProteomicsDBi71223

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
146562

Genome annotation databases

EnsembliENST00000299320; ENSP00000299320; ENSG00000166246
GeneIDi146562
KEGGihsa:146562
UCSCiuc002cxn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146562

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C16orf71
HGNCiHGNC:25081 C16orf71
HPAiHPA049468
neXtProtiNX_Q8IYS4
OpenTargetsiENSG00000166246
PharmGKBiPA145149565

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYMM Eukaryota
ENOG4111414 LUCA
GeneTreeiENSGT00390000015381
HOGENOMiCLU_037635_0_0_1
InParanoidiQ8IYS4
OrthoDBi1111863at2759
PhylomeDBiQ8IYS4
TreeFamiTF336688

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
146562
PharosiQ8IYS4 Tdark

Protein Ontology

More...
PROi
PR:Q8IYS4
RNActiQ8IYS4 protein

Gene expression databases

BgeeiENSG00000166246 Expressed in right testis and 95 other tissues
ExpressionAtlasiQ8IYS4 baseline and differential
GenevisibleiQ8IYS4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031531 DUF4701
PANTHERiPTHR35977 PTHR35977, 1 hit
PfamiView protein in Pfam
PF15773 DUF4701, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP071_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYS4
Secondary accession number(s): Q8NCV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 98 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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