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Protein
Submitted name:

GA binding protein transcription factor, alpha subunit 60kDa

Gene

GABPA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
GA binding protein transcription factor, alpha subunit 60kDaImported
Gene namesi
Name:GABPAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28485

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8IYS3
PRIDEiQ8IYS3

Expressioni

Gene expression databases

GenevisibleiQ8IYS3 HS

Structurei

3D structure databases

ProteinModelPortaliQ8IYS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 251PNTInterPro annotationAdd BLAST84
Domaini320 – 400ETSInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ETS family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOVERGENiHBG051687

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR024668 GABP_asu_N
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016312 TF_GA-bd_asu
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF11620 GABP-alpha, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001703 GABP_alpha, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYAPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPERS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGIEPKLNI LEIVKPADTV EVVIDPDAHH AESEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIQWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVQSAT PTTIKVINSS AKAAKVQRAP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVTE CEQKKLAKMQ LHGIAQPVTA VALSTASLQT

EKDN
Length:454
Mass (Da):51,311
Last modified:March 1, 2003 - v1
Checksum:i1AF2BD61C79191DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035031 mRNA Translation: AAH35031.1
RefSeqiNP_002031.2, NM_002040.3
UniGeneiHs.473470

Genome annotation databases

GeneIDi2551

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035031 mRNA Translation: AAH35031.1
RefSeqiNP_002031.2, NM_002040.3
UniGeneiHs.473470

3D structure databases

ProteinModelPortaliQ8IYS3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ8IYS3
PRIDEiQ8IYS3

Protocols and materials databases

DNASUi2551
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2551

Organism-specific databases

CTDi2551
PharmGKBiPA28485

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOVERGENiHBG051687

Miscellaneous databases

ChiTaRSiGABPA human
GenomeRNAii2551

Gene expression databases

GenevisibleiQ8IYS3 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR024668 GABP_asu_N
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016312 TF_GA-bd_asu
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF11620 GABP-alpha, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001703 GABP_alpha, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IYS3_HUMAN
AccessioniPrimary (citable) accession number: Q8IYS3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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