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Entry version 133 (13 Feb 2019)
Sequence version 2 (30 Aug 2005)
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Protein

Peptidase M20 domain-containing protein 2

Gene

PM20D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dipeptidase activity Source: MGI

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidase M20 domain-containing protein 2
Alternative name(s):
Aminoacylase-1-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PM20D2
Synonyms:ACY1L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146281.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21408 PM20D2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615913 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000146281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399803

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PM20D2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121944459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002863401 – 436Peptidase M20 domain-containing protein 2Add BLAST436

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYS1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYS1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYS1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYS1

PeptideAtlas

More...
PeptideAtlasi
Q8IYS1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYS1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71220

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYS1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYS1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146281 Expressed in 205 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYS1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030325
HPA030326
HPA030327

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TDO2P487754EBI-11339910,EBI-743494

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126427, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYS1, 25 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IYS1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYS1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFYV Eukaryota
COG1473 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251261

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095598

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYS1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYAITDT

Database of Orthologous Groups

More...
OrthoDBi
455218at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYS1

TreeFam database of animal gene trees

More...
TreeFami
TF332656

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05672 M20_ACY1L2_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036264 Bact_exopeptidase_dim_dom
IPR017144 Pept_M20A_amidohydro_pred
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037226 Amidohydrolase_ACY1L2_prd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55031 SSF55031, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGGERPVE GGACNGRSEL ELLKLRSAEC IDEAAERLGA LSRAIWSQPE
60 70 80 90 100
LAYEEHHAHR VLTHFFEREP PAASWAVQPH YQLPTAFRAE WEPPEARAPS
110 120 130 140 150
ATPRPLHLGF LCEYDALPGI GHACGHNLIA EVGAAAALGV RGALEGLPRP
160 170 180 190 200
PPPVKVVVLG TPAEEDGGGK IDLIEAGAFT NLDVVFMAHP SQENAAYLPD
210 220 230 240 250
MAEHDVTVKY YGKASHSASY PWEGLNALDA AVLAYNNLSV FRQQMKPTWR
260 270 280 290 300
VHGIIKNGGV KPNIIPSYSE LIYYFRAPSM KELQVLTKKA EDCFRAAALA
310 320 330 340 350
SGCTVEIKGG AHDYYNVLPN KSLWKAYMEN GRKLGIEFIS EDTMLNGPSG
360 370 380 390 400
STDFGNVSFV VPGIHPYFHI GSNALNHTEQ YTEAAGSQEA QFYTLRTAKA
410 420 430
LAMTALDVIF KPELLEGIRE DFKLKLQEEQ FVNAVE
Length:436
Mass (Da):47,776
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC387E3CD2B29A94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171I → V in AAH45583 (PubMed:15489334).Curated1
Sequence conflicti189H → N in AAH45583 (PubMed:15489334).Curated1
Sequence conflicti434A → V in AAH45583 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032081333K → E. Corresponds to variant dbSNP:rs10944433Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK302464 mRNA Translation: BAG63754.1
AL353135 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48559.1
BC035036 mRNA Translation: AAH35036.2
BC045583 mRNA Translation: AAH45583.1
BX640865 mRNA Translation: CAE45925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34499.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010853.1, NM_001010853.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.356247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275072; ENSP00000275072; ENSG00000146281

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
135293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:135293

UCSC genome browser

More...
UCSCi
uc003pmz.6 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302464 mRNA Translation: BAG63754.1
AL353135 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48559.1
BC035036 mRNA Translation: AAH35036.2
BC045583 mRNA Translation: AAH45583.1
BX640865 mRNA Translation: CAE45925.1
CCDSiCCDS34499.1
RefSeqiNP_001010853.1, NM_001010853.2
UniGeneiHs.356247

3D structure databases

ProteinModelPortaliQ8IYS1
SMRiQ8IYS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126427, 24 interactors
IntActiQ8IYS1, 25 interactors

PTM databases

iPTMnetiQ8IYS1
PhosphoSitePlusiQ8IYS1

Polymorphism and mutation databases

BioMutaiPM20D2
DMDMi121944459

Proteomic databases

EPDiQ8IYS1
jPOSTiQ8IYS1
MaxQBiQ8IYS1
PaxDbiQ8IYS1
PeptideAtlasiQ8IYS1
PRIDEiQ8IYS1
ProteomicsDBi71220

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275072; ENSP00000275072; ENSG00000146281
GeneIDi135293
KEGGihsa:135293
UCSCiuc003pmz.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135293
EuPathDBiHostDB:ENSG00000146281.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PM20D2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006063
HGNCiHGNC:21408 PM20D2
HPAiHPA030325
HPA030326
HPA030327
MIMi615913 gene
neXtProtiNX_Q8IYS1
OpenTargetsiENSG00000146281
PharmGKBiPA162399803

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFYV Eukaryota
COG1473 LUCA
GeneTreeiENSGT00390000003365
HOGENOMiHOG000251261
HOVERGENiHBG095598
InParanoidiQ8IYS1
OMAiHYAITDT
OrthoDBi455218at2759
PhylomeDBiQ8IYS1
TreeFamiTF332656

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
135293

Protein Ontology

More...
PROi
PR:Q8IYS1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146281 Expressed in 205 organ(s), highest expression level in quadriceps femoris
GenevisibleiQ8IYS1 HS

Family and domain databases

CDDicd05672 M20_ACY1L2_like, 1 hit
InterProiView protein in InterPro
IPR036264 Bact_exopeptidase_dim_dom
IPR017144 Pept_M20A_amidohydro_pred
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
PIRSFiPIRSF037226 Amidohydrolase_ACY1L2_prd, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP20D2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYS1
Secondary accession number(s): B4DYJ2
, Q5T7J9, Q6MZV2, Q86XD9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 30, 2005
Last modified: February 13, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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