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Entry version 132 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

SET and MYND domain-containing protein 4

Gene

SMYD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei427S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei573S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei595S-adenosyl-L-methioninePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SET and MYND domain-containing protein 4 (EC:2.1.1.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMYD4
Synonyms:KIAA1936
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21067 SMYD4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYR2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114826

Open Targets

More...
OpenTargetsi
ENSG00000186532

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925431

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYR2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMYD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452956

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002277841 – 804SET and MYND domain-containing protein 4Add BLAST804

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYR2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYR2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYR2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYR2

PeptideAtlas

More...
PeptideAtlasi
Q8IYR2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYR2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71215

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186532 Expressed in 149 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYR2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYR2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030059

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125376, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYR2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304360

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYR2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini233 – 574SETPROSITE-ProRule annotationAdd BLAST342

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni112 – 114S-adenosyl-L-methionine bindingBy similarity3
Regioni539 – 540S-adenosyl-L-methionine bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 335MYND-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2084 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111079

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000118355

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYR2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPIPGCD

Database of Orthologous Groups

More...
OrthoDBi
1278034at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYR2

TreeFam database of animal gene trees

More...
TreeFami
TF106441

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR011990 TPR-like_helical_dom_sf
IPR002893 Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00856 SET, 1 hit
PF01753 zf-MYND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IYR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLPVDEWKS YLLQKWASLP TSVQVTISTA ETLRDIFLHS SSLLQPEDEL
60 70 80 90 100
FLKRLSKGYL VGKDSDAPLF YREEGNKKFQ EKDYTGAAVL YSKGVSHSRP
110 120 130 140 150
NTEDMSLCHA NRSAALFHLG QYETCLKDIN RAQTHGYPER LQPKIMLRKA
160 170 180 190 200
ECLVALGRLQ EASQTISDLE RNFTATPALA DVLPQTLQRN LHRLKMKMQE
210 220 230 240 250
KDSLTESFPA ALAKTLEDAA LREENEQLSN ASSSIGLCVD PLKGRCLVAT
260 270 280 290 300
KDILPGELLV QEDAFVSVLN PGELPPPHHG LDSKWDTRVT NGDLYCHRCL
310 320 330 340 350
KHTLATVPCD GCSYAKYCSQ ECLQQAWELY HRTECPLGGL LLTLGVFCHI
360 370 380 390 400
ALRLTLLVGF EDVRKIITKL CDKISNKDIC LPESNNQVKT LNYGLGESEK
410 420 430 440 450
NGNIVETPIP GCDINGKYEN NYNAVFNLLP HTENHSPEHK FLCALCVSAL
460 470 480 490 500
CRQLEAASLQ AIPTERIVNS SQLKAAVTPE LCPDVTIWGV AMLRHMLQLQ
510 520 530 540 550
CNAQAMTTIQ HTGPKGSIVT DSRQVRLATG IFPVISLLNH SCSPNTSVSF
560 570 580 590 600
ISTVATIRAS QRIRKGQEIL HCYGPHKSRM GVAERQQKLR SQYFFDCACP
610 620 630 640 650
ACQTEAHRMA AGPRWEAFCC NSCGAPMQGD DVLRCGSRSC AESAVSRDHL
660 670 680 690 700
VSRLQDLQQQ VRVAQKLLRD GELERAVQRL SGCQRDAESF LWAEHAVVGE
710 720 730 740 750
IADGLARACA ALGDWQKSAT HLQRSLYVVE VRHGPSSVEM GHELFKLAQI
760 770 780 790 800
FFNGFAVPEA LSTIQKAEEV LSLHCGPWDD EIQELQKMKS CLLDLPPTPV

GPAL
Length:804
Mass (Da):89,225
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i982F8BFEF40A49A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L428I3L428_HUMAN
SET and MYND domain-containing prot...
SMYD4
558Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2P4I3L2P4_HUMAN
SET and MYND domain-containing prot...
SMYD4
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L496I3L496_HUMAN
SET and MYND domain-containing prot...
SMYD4
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1V4I3L1V4_HUMAN
SET and MYND domain-containing prot...
SMYD4
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326A → V in AAH35077 (PubMed:15489334).Curated1
Sequence conflicti511H → R in BAC04538 (PubMed:14702039).Curated1
Sequence conflicti514P → S in BAC04538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057495101N → D. Corresponds to variant dbSNP:rs9907701Ensembl.1
Natural variantiVAR_025626131R → I2 PublicationsCorresponds to variant dbSNP:rs7224496Ensembl.1
Natural variantiVAR_057496236G → S. Corresponds to variant dbSNP:rs9913923Ensembl.1
Natural variantiVAR_057497374I → M. Corresponds to variant dbSNP:rs9890631Ensembl.1
Natural variantiVAR_057498382P → R. Corresponds to variant dbSNP:rs3809875Ensembl.1
Natural variantiVAR_025628562R → W1 PublicationCorresponds to variant dbSNP:rs11549830Ensembl.1
Natural variantiVAR_064755601A → P Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_025627727Y → C3 PublicationsCorresponds to variant dbSNP:rs9902398Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057769 mRNA Translation: BAB71564.1
AK095369 mRNA Translation: BAC04538.1
BC035077 mRNA Translation: AAH35077.1
AB067523 mRNA Translation: BAB67829.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11013.1

NCBI Reference Sequences

More...
RefSeqi
NP_443160.2, NM_052928.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305513; ENSP00000304360; ENSG00000186532

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114826

UCSC genome browser

More...
UCSCi
uc002ftm.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057769 mRNA Translation: BAB71564.1
AK095369 mRNA Translation: BAC04538.1
BC035077 mRNA Translation: AAH35077.1
AB067523 mRNA Translation: BAB67829.1
CCDSiCCDS11013.1
RefSeqiNP_443160.2, NM_052928.2

3D structure databases

SMRiQ8IYR2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125376, 4 interactors
IntActiQ8IYR2, 4 interactors
STRINGi9606.ENSP00000304360

PTM databases

iPTMnetiQ8IYR2
PhosphoSitePlusiQ8IYR2

Polymorphism and mutation databases

BioMutaiSMYD4
DMDMi296452956

Proteomic databases

EPDiQ8IYR2
jPOSTiQ8IYR2
MassIVEiQ8IYR2
MaxQBiQ8IYR2
PaxDbiQ8IYR2
PeptideAtlasiQ8IYR2
PRIDEiQ8IYR2
ProteomicsDBi71215

Genome annotation databases

EnsembliENST00000305513; ENSP00000304360; ENSG00000186532
GeneIDi114826
KEGGihsa:114826
UCSCiuc002ftm.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114826
DisGeNETi114826

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMYD4
HGNCiHGNC:21067 SMYD4
HPAiHPA030059
neXtProtiNX_Q8IYR2
OpenTargetsiENSG00000186532
PharmGKBiPA134925431

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00730000111079
HOGENOMiHOG000118355
InParanoidiQ8IYR2
OMAiTPIPGCD
OrthoDBi1278034at2759
PhylomeDBiQ8IYR2
TreeFamiTF106441

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMYD4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SMYD4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114826
PharosiQ8IYR2

Protein Ontology

More...
PROi
PR:Q8IYR2

Gene expression databases

BgeeiENSG00000186532 Expressed in 149 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ8IYR2 baseline and differential
GenevisibleiQ8IYR2 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR001214 SET_dom
IPR011990 TPR-like_helical_dom_sf
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMYD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYR2
Secondary accession number(s): Q8N1P2
, Q8NAT0, Q96LV4, Q96PV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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