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UniProtKB - Q8IYR0 (CF206_HUMAN)
Protein
Cilia- and flagella-associated protein 206
Gene
CFAP206
Organism
Homo sapiens (Human)
Status
Functioni
Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity).
Required for the establishment of radial spokes in sperm flagella (By similarity).
By similarityGO - Biological processi
- axoneme assembly Source: UniProtKB
- cilium movement Source: UniProtKB
- regulation of cilium beat frequency Source: UniProtKB
- regulation of flagellated sperm motility Source: UniProtKB
- sperm axoneme assembly Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q8IYR0 |
SignaLinki | Q8IYR0 |
Names & Taxonomyi
Protein namesi | Recommended name: Cilia- and flagella-associated protein 206Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21405, CFAP206 |
neXtProti | NX_Q8IYR0 |
VEuPathDBi | HostDB:ENSG00000272514 |
Subcellular locationi
Cytoskeleton
- cilium axoneme By similarity
- cilium basal body By similarity
Cytoskeleton
- axoneme Source: UniProtKB
- ciliary basal body Source: UniProtKB
- radial spoke Source: UniProtKB
Other locations
- motile cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000213204 ENSG00000272514 |
PharmGKBi | PA134983540 |
Miscellaneous databases
Pharosi | Q8IYR0, Tdark |
Genetic variation databases
BioMutai | CFAP206 |
DMDMi | 34395551 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089553 | 1 – 622 | Cilia- and flagella-associated protein 206Add BLAST | 622 |
Proteomic databases
MassIVEi | Q8IYR0 |
PaxDbi | Q8IYR0 |
PeptideAtlasi | Q8IYR0 |
PRIDEi | Q8IYR0 |
ProteomicsDBi | 71214 |
PTM databases
iPTMneti | Q8IYR0 |
PhosphoSitePlusi | Q8IYR0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213204, Expressed in testis and 113 other tissues |
ExpressionAtlasi | Q8IYR0, baseline and differential |
Genevisiblei | Q8IYR0, HS |
Organism-specific databases
HPAi | ENSG00000272514, Group enriched (fallopian tube, testis) |
Interactioni
Binary interactionsi
Q8IYR0
Protein-protein interaction databases
BioGRIDi | 127543, 66 interactors |
IntActi | Q8IYR0, 59 interactors |
MINTi | Q8IYR0 |
STRINGi | 9606.ENSP00000358575 |
Miscellaneous databases
RNActi | Q8IYR0, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8IYR0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 570 – 592 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 570 – 588 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the CFAP206 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QTGJ, Eukaryota |
GeneTreei | ENSGT00390000016036 |
HOGENOMi | CLU_030061_0_0_1 |
InParanoidi | Q8IYR0 |
OMAi | LHDTVRY |
OrthoDBi | 357137at2759 |
PhylomeDBi | Q8IYR0 |
TreeFami | TF323439 |
Family and domain databases
InterProi | View protein in InterPro IPR021897, FAP206 |
PANTHERi | PTHR21442, PTHR21442, 1 hit |
Pfami | View protein in Pfam PF12018, FAP206, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8IYR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM
60 70 80 90 100
DRTLMKSDVQ NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE
110 120 130 140 150
HHRVLESRLG SVTREITDNR ACAKEELESL YRKIISYVLL RSGLGSPTDI
160 170 180 190 200
KTVREVTAAL QSVFPQAELG TFLTLSKKDK ERQLKELTMI VTGIRLFNRD
210 220 230 240 250
CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY TAILEKAAND
260 270 280 290 300
PLMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH
310 320 330 340 350
LEQLKMTIKS KIAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI
360 370 380 390 400
QPFLGAHELY FPERVMQCHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW
410 420 430 440 450
LFPETTANFD KLLIQYRGFC AYTFAATDGL LLPGNPAIGI LKYKEKYYTF
460 470 480 490 500
NSKDAAYSFA ENPEHYIDIV REKAKKNTEL IQLLELHQQF ETFIPYSQMR
510 520 530 540 550
DADKHYIKPI TKCESSTQTN THILPPTIVR SYEWNEWELR RKAIKLANLR
560 570 580 590 600
QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL
610 620
RGGKSEITDE VKVNLTRDVD ET
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBZ4 | D6RBZ4_HUMAN | Cilia- and flagella-associated prot... | CFAP206 | 251 | Annotation score: | ||
D6R9L9 | D6R9L9_HUMAN | Cilia- and flagella-associated prot... | CFAP206 | 95 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 489 | Q → R in BAF85273 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033679 | 154 | R → K. Corresponds to variant dbSNP:rs13219364Ensembl. | 1 | |
Natural variantiVAR_033680 | 170 | G → A. Corresponds to variant dbSNP:rs16879281Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093830 mRNA Translation: BAC04234.1 Sequence problems. AK292584 mRNA Translation: BAF85273.1 AL049697 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48594.1 CH471051 Genomic DNA Translation: EAW48596.1 CH471051 Genomic DNA Translation: EAW48598.1 BC035083 mRNA Translation: AAH35083.2 |
CCDSi | CCDS34498.1 |
RefSeqi | NP_001026913.1, NM_001031743.2 |
Genome annotation databases
Ensembli | ENST00000369562.9; ENSP00000358575.4; ENSG00000272514.6 |
GeneIDi | 154313 |
KEGGi | hsa:154313 |
MANE-Selecti | ENST00000369562.9; ENSP00000358575.4; NM_001031743.3; NP_001026913.1 |
UCSCi | uc003plv.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093830 mRNA Translation: BAC04234.1 Sequence problems. AK292584 mRNA Translation: BAF85273.1 AL049697 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48594.1 CH471051 Genomic DNA Translation: EAW48596.1 CH471051 Genomic DNA Translation: EAW48598.1 BC035083 mRNA Translation: AAH35083.2 |
CCDSi | CCDS34498.1 |
RefSeqi | NP_001026913.1, NM_001031743.2 |
3D structure databases
AlphaFoldDBi | Q8IYR0 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127543, 66 interactors |
IntActi | Q8IYR0, 59 interactors |
MINTi | Q8IYR0 |
STRINGi | 9606.ENSP00000358575 |
PTM databases
iPTMneti | Q8IYR0 |
PhosphoSitePlusi | Q8IYR0 |
Genetic variation databases
BioMutai | CFAP206 |
DMDMi | 34395551 |
Proteomic databases
MassIVEi | Q8IYR0 |
PaxDbi | Q8IYR0 |
PeptideAtlasi | Q8IYR0 |
PRIDEi | Q8IYR0 |
ProteomicsDBi | 71214 |
Protocols and materials databases
Antibodypediai | 73997, 44 antibodies from 9 providers |
DNASUi | 154313 |
Genome annotation databases
Ensembli | ENST00000369562.9; ENSP00000358575.4; ENSG00000272514.6 |
GeneIDi | 154313 |
KEGGi | hsa:154313 |
MANE-Selecti | ENST00000369562.9; ENSP00000358575.4; NM_001031743.3; NP_001026913.1 |
UCSCi | uc003plv.4, human |
Organism-specific databases
CTDi | 154313 |
GeneCardsi | CFAP206 |
HGNCi | HGNC:21405, CFAP206 |
HPAi | ENSG00000272514, Group enriched (fallopian tube, testis) |
neXtProti | NX_Q8IYR0 |
OpenTargetsi | ENSG00000213204 ENSG00000272514 |
PharmGKBi | PA134983540 |
VEuPathDBi | HostDB:ENSG00000272514 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTGJ, Eukaryota |
GeneTreei | ENSGT00390000016036 |
HOGENOMi | CLU_030061_0_0_1 |
InParanoidi | Q8IYR0 |
OMAi | LHDTVRY |
OrthoDBi | 357137at2759 |
PhylomeDBi | Q8IYR0 |
TreeFami | TF323439 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYR0 |
SignaLinki | Q8IYR0 |
Miscellaneous databases
BioGRID-ORCSi | 154313, 8 hits in 1034 CRISPR screens |
ChiTaRSi | CFAP206, human |
GenomeRNAii | 154313 |
Pharosi | Q8IYR0, Tdark |
PROi | PR:Q8IYR0 |
RNActi | Q8IYR0, protein |
Gene expression databases
Bgeei | ENSG00000213204, Expressed in testis and 113 other tissues |
ExpressionAtlasi | Q8IYR0, baseline and differential |
Genevisiblei | Q8IYR0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021897, FAP206 |
PANTHERi | PTHR21442, PTHR21442, 1 hit |
Pfami | View protein in Pfam PF12018, FAP206, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CF206_HUMAN | |
Accessioni | Q8IYR0Primary (citable) accession number: Q8IYR0 Secondary accession number(s): A8K969, E1P507, Q8N9U4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | August 29, 2003 | |
Last modified: | May 25, 2022 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families