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Protein

Threonine synthase-like 1

Gene

THNSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Keywordsi

LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase-like 1
Short name:
TSH1
Gene namesi
Name:THNSL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000185875.12
HGNCiHGNC:26160 THNSL1
MIMi611260 gene
neXtProtiNX_Q8IYQ7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185875
PharmGKBiPA134906927

Chemistry databases

DrugBankiDB00156 L-Threonine
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaiTHNSL1
DMDMi62511212

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856461 – 743Threonine synthase-like 1Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281N6-acetyllysineCombined sources1
Modified residuei351N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8IYQ7
MaxQBiQ8IYQ7
PaxDbiQ8IYQ7
PeptideAtlasiQ8IYQ7
PRIDEiQ8IYQ7
ProteomicsDBi71213

PTM databases

iPTMnetiQ8IYQ7
PhosphoSitePlusiQ8IYQ7

Expressioni

Gene expression databases

BgeeiENSG00000185875 Expressed in 168 organ(s), highest expression level in secondary oocyte
CleanExiHS_THNSL1
GenevisibleiQ8IYQ7 HS

Organism-specific databases

HPAiHPA037585

Interactioni

Protein-protein interaction databases

BioGridi122980, 30 interactors
IntActiQ8IYQ7, 6 interactors
STRINGi9606.ENSP00000365534

Structurei

3D structure databases

ProteinModelPortaliQ8IYQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiKOG2616 Eukaryota
COG0498 LUCA
COG0703 LUCA
GeneTreeiENSGT00530000063879
HOGENOMiHOG000065776
HOVERGENiHBG055015
InParanoidiQ8IYQ7
OMAiPVDVCIP
OrthoDBiEOG091G08UM
PhylomeDBiQ8IYQ7
TreeFamiTF329641

Family and domain databases

CDDicd00464 SK, 1 hit
Gene3Di3.90.1380.10, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF01202 SKI, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHFNRCHHL KKITQKCFSS IHVKTDKHAQ RFLSRTFALA ELRKSWYSTH
60 70 80 90 100
SLVGDKNIIL MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS
110 120 130 140 150
EKLQDVGNEQ FLEEEGKAVL NFSASGSVIS LTGSNPMHDA SMWHLKKNGI
160 170 180 190 200
IVYLDVPLLD LICRLKLMKT DRIVGQNSGT SMKDLLKFRR QYYKKWYDAR
210 220 230 240 250
VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPE DCEQKVSAKF
260 270 280 290 300
FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYVE RAQILLERCI
310 320 330 340 350
HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF
360 370 380 390 400
KDLSLQLMPH IFAHCIPPSC NYMILVATSG DTGSAVLNGF SRLNKNDKQR
410 420 430 440 450
IAVVAFFPEN GVSDFQKAQI IGSQRENGWA VGVESDFDFC QTAIKRIFND
460 470 480 490 500
SDFTGFLTVE YGTILSSANS INWGRLLPQV VYHASAYLDL VSQGFISFGS
510 520 530 540 550
PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNHVL TDFIKTGHYD
560 570 580 590 600
LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNRLESQHHF
610 620 630 640 650
QIEKALVEKL QQDFVADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA
660 670 680 690 700
DRVQDKTCPV IISSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA
710 720 730 740
LPPLHEALLE RTKQQEKMEY QVCAADMNVL KSHVEQLVQN QFI
Length:743
Mass (Da):83,070
Last modified:April 12, 2005 - v2
Checksum:i0C166A57EF34A682
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94T → N in AAH35132 (PubMed:15489334).Curated1
Sequence conflicti705H → R in AAH35132 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052545154L → P. Corresponds to variant dbSNP:rs35827877Ensembl.1
Natural variantiVAR_061893239P → R. Corresponds to variant dbSNP:rs41279890Ensembl.1
Natural variantiVAR_052546248A → E. Corresponds to variant dbSNP:rs34929144Ensembl.1
Natural variantiVAR_058869399Q → R. Corresponds to variant dbSNP:rs41279894Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125249 mRNA Translation: BAG54173.1
AL512598 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86113.1
CH471072 Genomic DNA Translation: EAW86114.1
BC035132 mRNA Translation: AAH35132.1
CCDSiCCDS7147.1
RefSeqiNP_079114.3, NM_024838.4
XP_005252654.1, XM_005252597.2
XP_016872154.1, XM_017016665.1
UniGeneiHs.645274

Genome annotation databases

EnsembliENST00000376356; ENSP00000365534; ENSG00000185875
ENST00000524413; ENSP00000434887; ENSG00000185875
GeneIDi79896
KEGGihsa:79896
UCSCiuc001isi.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125249 mRNA Translation: BAG54173.1
AL512598 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86113.1
CH471072 Genomic DNA Translation: EAW86114.1
BC035132 mRNA Translation: AAH35132.1
CCDSiCCDS7147.1
RefSeqiNP_079114.3, NM_024838.4
XP_005252654.1, XM_005252597.2
XP_016872154.1, XM_017016665.1
UniGeneiHs.645274

3D structure databases

ProteinModelPortaliQ8IYQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122980, 30 interactors
IntActiQ8IYQ7, 6 interactors
STRINGi9606.ENSP00000365534

Chemistry databases

DrugBankiDB00156 L-Threonine
DB00114 Pyridoxal Phosphate

PTM databases

iPTMnetiQ8IYQ7
PhosphoSitePlusiQ8IYQ7

Polymorphism and mutation databases

BioMutaiTHNSL1
DMDMi62511212

Proteomic databases

EPDiQ8IYQ7
MaxQBiQ8IYQ7
PaxDbiQ8IYQ7
PeptideAtlasiQ8IYQ7
PRIDEiQ8IYQ7
ProteomicsDBi71213

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376356; ENSP00000365534; ENSG00000185875
ENST00000524413; ENSP00000434887; ENSG00000185875
GeneIDi79896
KEGGihsa:79896
UCSCiuc001isi.6 human

Organism-specific databases

CTDi79896
EuPathDBiHostDB:ENSG00000185875.12
GeneCardsiTHNSL1
HGNCiHGNC:26160 THNSL1
HPAiHPA037585
MIMi611260 gene
neXtProtiNX_Q8IYQ7
OpenTargetsiENSG00000185875
PharmGKBiPA134906927
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2616 Eukaryota
COG0498 LUCA
COG0703 LUCA
GeneTreeiENSGT00530000063879
HOGENOMiHOG000065776
HOVERGENiHBG055015
InParanoidiQ8IYQ7
OMAiPVDVCIP
OrthoDBiEOG091G08UM
PhylomeDBiQ8IYQ7
TreeFamiTF329641

Miscellaneous databases

GenomeRNAii79896
PROiPR:Q8IYQ7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185875 Expressed in 168 organ(s), highest expression level in secondary oocyte
CleanExiHS_THNSL1
GenevisibleiQ8IYQ7 HS

Family and domain databases

CDDicd00464 SK, 1 hit
Gene3Di3.90.1380.10, 1 hit
HAMAPiMF_00109 Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR031322 Shikimate/glucono_kinase
IPR000623 Shikimate_kinase/TSH1
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF01202 SKI, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHNS1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYQ7
Secondary accession number(s): B3KWL1, D3DRV3, Q5VV21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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