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Protein

Palmitoyltransferase ZDHHC23

Gene

ZDHHC23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: UniProtKB
  • protein palmitoylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC23 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 23
Short name:
DHHC-23
Short name:
zDHHC23
Gene namesi
Name:ZDHHC23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000184307.13
HGNCiHGNC:28654 ZDHHC23
MIMi617334 gene
neXtProtiNX_Q8IYP9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19
Transmembranei110 – 132HelicalSequence analysisAdd BLAST23
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi254887
OpenTargetsiENSG00000184307
PharmGKBiPA134960347

Polymorphism and mutation databases

BioMutaiZDHHC23
DMDMi215274191

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129121 – 409Palmitoyltransferase ZDHHC23Add BLAST409

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiQ8IYP9
MaxQBiQ8IYP9
PaxDbiQ8IYP9
PeptideAtlasiQ8IYP9
PRIDEiQ8IYP9
ProteomicsDBi71212

PTM databases

iPTMnetiQ8IYP9
PhosphoSitePlusiQ8IYP9

Expressioni

Gene expression databases

BgeeiENSG00000184307
CleanExiHS_ZDHHC23
ExpressionAtlasiQ8IYP9 baseline and differential
GenevisibleiQ8IYP9 HS

Organism-specific databases

HPAiHPA016808

Interactioni

Subunit structurei

Interacts with NOS1.By similarity

Protein-protein interaction databases

BioGridi129056, 6 interactors
IntActiQ8IYP9, 1 interactor
STRINGi9606.ENSP00000330485

Structurei

3D structure databases

ProteinModelPortaliQ8IYP9
SMRiQ8IYP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 309DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00880000137864
HOGENOMiHOG000290638
HOVERGENiHBG055654
InParanoidiQ8IYP9
KOiK18932
OrthoDBiEOG091G0BNH
PhylomeDBiQ8IYP9
TreeFamiTF354316

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKGSMKPV KKKKTEEPEL EPLCCCEYID RNGEKNHVAT CLCDCQDLDE
60 70 80 90 100
GCDRWITCKS LQPETCERIM DTISDRLRIP WLRGAKKVNI SIIPPLVLLP
110 120 130 140 150
VFLHVASWHF LLGVVVLTSL PVLALWYYYL THRRKEQTLF FLSLGLFSLG
160 170 180 190 200
YMYYVFLQEV VPKGRVGPVQ LAVLTCGLFL ILLALHRAKK NPGYLSNPAS
210 220 230 240 250
GDRSLSSSQL ECLSRKGQEK TKGFPGADMS GSLNNRTTKD DPKGSSKMPA
260 270 280 290 300
GSPTKAKEDW CAKCQLVRPA RAWHCRICGI CVRRMDHHCV WINSCVGESN
310 320 330 340 350
HQAFILALLI FLLTSVYGIT LTLDTICRDR SVFTALFYCP GVYANYSSAL
360 370 380 390 400
SFTCVWYSVI ITAGMAYIFL IQLINISYNV TEREVQQALR QKTGRRLLCG

LIVDTGLLG
Length:409
Mass (Da):45,983
Last modified:November 25, 2008 - v3
Checksum:i6AD65E37DA8F34AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047389132H → N1 PublicationCorresponds to variant dbSNP:rs17853401Ensembl.1
Natural variantiVAR_047390221T → A1 PublicationCorresponds to variant dbSNP:rs17853402Ensembl.1
Natural variantiVAR_047391247K → R1 PublicationCorresponds to variant dbSNP:rs11921691Ensembl.1
Natural variantiVAR_047392274H → R1 PublicationCorresponds to variant dbSNP:rs17857054Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128687 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79617.1
CH471052 Genomic DNA Translation: EAW79618.1
BC035230 mRNA Translation: AAH35230.2
CCDSiCCDS33827.1
RefSeqiNP_775841.2, NM_173570.4
XP_005247326.1, XM_005247269.1
UniGeneiHs.21902

Genome annotation databases

EnsembliENST00000330212; ENSP00000330485; ENSG00000184307
GeneIDi254887
KEGGihsa:254887
UCSCiuc003eau.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZDH23_HUMAN
AccessioniPrimary (citable) accession number: Q8IYP9
Secondary accession number(s): D3DN76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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