UniProtKB - Q8IYM2 (SLN12_HUMAN)

BLAST

>sp|Q8IYM2|SLN12_HUMAN Schlafen family member 12 OS=Homo sapiens OX=9606 GN=SLFN12 PE=2 SV=2
MNISVDLETNYAELVLDVGRVTLGENSRKKMKDCKLRKKQNESVSRAMCALLNSGGGVIK
AEIENEDYSYTKDGIGLDLENSFSNILLFVPEYLDFMQNGNYFLIFVKSWSLNTSGLRIT
TLSSNLYKRDITSAKVMNATAALEFLKDMKKTRGRLYLRPELLAKRPCVDIQEENNMKAL
AGVFFDRTELDRKEKLTFTESTHVEIKNFSTEKLLQRIKEILPQYVSAFANTDGGYLFIG
LNEDKEIIGFKAEMSDLDDLEREIEKSIRKMPVHHFCMEKKKINYSCKFLGVYDKGSLCG
YVCALRVERFCCAVFAKEPDSWHVKDNRVMQLTRKEWIQFMVEAEPKFSSSYEEVISQIN
TSLPAPHSWPLLEWQRQRHHCPGLSGRITYTPENLCRKLFLQHEGLKQLICEEMDSVRKG
SLIFSRSWSVDLGLQENHKVLCDALLISQDSPPVLYTFHMVQDEEFKGYSTQTALTLKQK
LAKIGGYTKKVCVMTKIFYLSPEGMTSCQYDLRSQVIYPESYYFTRRKYLLKALFKALKR
LKSLRDQFSFAENLYQIIGIDCFQKNDKKMFKSCRRLT

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History
Entry version 104 (12 Sep 2018)
Sequence version 2 (03 Apr 2007)
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Protein

Schlafen family member 12

Gene

SLFN12

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Schlafen family member 12
Gene namesⁱ	Name:SLFN12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172123.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25500 SLFN12
MIMⁱ	614955 gene
neXtProtⁱ	NX_Q8IYM2

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55106
Open Targets More...OpenTargetsⁱ	ENSG00000172123
PharmGKBⁱ	PA144596359

Polymorphism and mutation databases

BioMutaⁱ	SLFN12
DMDMⁱ	143585256

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000282984	1 – 578	Schlafen family member 12Add BLAST		578

Proteomic databases

EPDⁱ	Q8IYM2
PaxDbⁱ	Q8IYM2
PeptideAtlas More...PeptideAtlasⁱ	Q8IYM2
PRIDEⁱ	Q8IYM2
ProteomicsDBⁱ	71204

PTM databases

iPTMnetⁱ	Q8IYM2
PhosphoSitePlusⁱ	Q8IYM2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172123 Expressed in 133 organ(s), highest expression level in lung
CleanExⁱ	HS_SLFN12
ExpressionAtlasⁱ	Q8IYM2 baseline and differential
Genevisibleⁱ	Q8IYM2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022523

HPAⁱ

HPA022523

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120416, 3 interactors
IntActⁱ	Q8IYM2, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q8IYM2
STRINGⁱ	9606.ENSP00000302077

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IYM2
SMRⁱ	Q8IYM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Schlafen family. Subgroup II subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410JAUV Eukaryota ENOG4111BZ2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025651
HOGENOMⁱ	HOG000133056
HOVERGENⁱ	HBG057499
InParanoidⁱ	Q8IYM2
OMAⁱ	CRKLFLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0916
PhylomeDBⁱ	Q8IYM2
TreeFamⁱ	TF337168

Family and domain databases

Gene3Dⁱ	3.30.950.30, 1 hit
InterProⁱ	View protein in InterPro IPR029684 Schlafen IPR007421 Schlafen_AAA_dom IPR038461 Schlafen_AAA_dom_sf
PANTHERⁱ	PTHR12155 PTHR12155, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04326 AlbA_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8IYM2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MNISVDLETN YAELVLDVGR VTLGENSRKK MKDCKLRKKQ NESVSRAMCA 
        60         70         80         90        100
LLNSGGGVIK AEIENEDYSY TKDGIGLDLE NSFSNILLFV PEYLDFMQNG 
       110        120        130        140        150
NYFLIFVKSW SLNTSGLRIT TLSSNLYKRD ITSAKVMNAT AALEFLKDMK 
       160        170        180        190        200
KTRGRLYLRP ELLAKRPCVD IQEENNMKAL AGVFFDRTEL DRKEKLTFTE 
       210        220        230        240        250
STHVEIKNFS TEKLLQRIKE ILPQYVSAFA NTDGGYLFIG LNEDKEIIGF 
       260        270        280        290        300
KAEMSDLDDL EREIEKSIRK MPVHHFCMEK KKINYSCKFL GVYDKGSLCG 
       310        320        330        340        350
YVCALRVERF CCAVFAKEPD SWHVKDNRVM QLTRKEWIQF MVEAEPKFSS 
       360        370        380        390        400
SYEEVISQIN TSLPAPHSWP LLEWQRQRHH CPGLSGRITY TPENLCRKLF 
       410        420        430        440        450
LQHEGLKQLI CEEMDSVRKG SLIFSRSWSV DLGLQENHKV LCDALLISQD 
       460        470        480        490        500
SPPVLYTFHM VQDEEFKGYS TQTALTLKQK LAKIGGYTKK VCVMTKIFYL 
       510        520        530        540        550
SPEGMTSCQY DLRSQVIYPE SYYFTRRKYL LKALFKALKR LKSLRDQFSF 
       560        570 
AENLYQIIGI DCFQKNDKKM FKSCRRLT

Length:578

Mass (Da):66,972

Last modified:April 3, 2007 - v2

Checksum:ⁱ858DEC808A50E753

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J4K7	C9J4K7_HUMAN	Schlafen family member 12 Schlafen family member 12	SLFN12	115	Annotation score:
C9JIA1	C9JIA1_HUMAN	Schlafen family member 12 Schlafen family member 12	SLFN12	69	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	361	T → A in BAA91512 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031447	43	S → R1 PublicationCorresponds to variant dbSNP:rs1849733Ensembl.	1
Natural variantⁱVAR_031448	168	C → R1 PublicationCorresponds to variant dbSNP:rs2586514Ensembl.	1
Natural variantⁱVAR_053877	448	S → P. Corresponds to variant dbSNP:rs12946189Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001122 mRNA Translation: BAA91512.1 AK291826 mRNA Translation: BAF84515.1 BC035605 mRNA Translation: AAH35605.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11295.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001275938.1, NM_001289009.1 NP_060512.3, NM_018042.4 XP_005258052.1, XM_005257995.4 XP_011523269.1, XM_011524967.2 XP_016880298.1, XM_017024809.1 XP_016880299.1, XM_017024810.1
UniGeneⁱ	Hs.663548

Genome annotation databases

Ensemblⁱ	ENST00000304905; ENSP00000302077; ENSG00000172123 ENST00000394562; ENSP00000378063; ENSG00000172123 ENST00000452764; ENSP00000394903; ENSG00000172123
GeneIDⁱ	55106
KEGGⁱ	hsa:55106
UCSC genome browser More...UCSCⁱ	uc002hji.6 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8IYM2	Schlafen family member 12 (Fragment)		HUMAN		115	UniRef100_Q8IYM2
Schlafen family member 12 (Fragment)		HUMAN		69

Protein	Similar proteins		Species	Score	Length	Source
Q8IYM2	Schlafen family member 12 (Fragment)		HUMAN		115	UniRef90_Q8IYM2
SLFN12 isoform 1		PANTR		579
Uncharacterized protein		PANPA		579
SLFN12 isoform 1		PONAB		578
Schlafen family member 12		GORGO		578
+5

Protein	Similar proteins		Species	Score	Length	Source
Q8IYM2	Schlafen family member 12 (Fragment)		HUMAN		115	UniRef50_Q8IYM2
SLFN12 isoform 1		PANTR		579
Uncharacterized protein		PANPA		579
SLFN12 isoform 1		PONAB		578
Schlafen family member 12		GORGO		578
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001122 mRNA Translation: BAA91512.1 AK291826 mRNA Translation: BAF84515.1 BC035605 mRNA Translation: AAH35605.1
CCDSⁱ	CCDS11295.1
RefSeqⁱ	NP_001275938.1, NM_001289009.1 NP_060512.3, NM_018042.4 XP_005258052.1, XM_005257995.4 XP_011523269.1, XM_011524967.2 XP_016880298.1, XM_017024809.1 XP_016880299.1, XM_017024810.1
UniGeneⁱ	Hs.663548

3D structure databases

ProteinModelPortalⁱ	Q8IYM2
SMRⁱ	Q8IYM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120416, 3 interactors
IntActⁱ	Q8IYM2, 4 interactors
MINTⁱ	Q8IYM2
STRINGⁱ	9606.ENSP00000302077

PTM databases

iPTMnetⁱ	Q8IYM2
PhosphoSitePlusⁱ	Q8IYM2

Polymorphism and mutation databases

BioMutaⁱ	SLFN12
DMDMⁱ	143585256

Proteomic databases

EPDⁱ	Q8IYM2
PaxDbⁱ	Q8IYM2
PeptideAtlasⁱ	Q8IYM2
PRIDEⁱ	Q8IYM2
ProteomicsDBⁱ	71204

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000304905; ENSP00000302077; ENSG00000172123 ENST00000394562; ENSP00000378063; ENSG00000172123 ENST00000452764; ENSP00000394903; ENSG00000172123
GeneIDⁱ	55106
KEGGⁱ	hsa:55106
UCSCⁱ	uc002hji.6 human

Organism-specific databases

CTDⁱ	55106
DisGeNETⁱ	55106
EuPathDBⁱ	HostDB:ENSG00000172123.12
GeneCardsⁱ	SLFN12
HGNCⁱ	HGNC:25500 SLFN12
HPAⁱ	HPA022523
MIMⁱ	614955 gene
neXtProtⁱ	NX_Q8IYM2
OpenTargetsⁱ	ENSG00000172123
PharmGKBⁱ	PA144596359
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JAUV Eukaryota ENOG4111BZ2 LUCA
GeneTreeⁱ	ENSGT00410000025651
HOGENOMⁱ	HOG000133056
HOVERGENⁱ	HBG057499
InParanoidⁱ	Q8IYM2
OMAⁱ	CRKLFLQ
OrthoDBⁱ	EOG091G0916
PhylomeDBⁱ	Q8IYM2
TreeFamⁱ	TF337168

Miscellaneous databases

GenomeRNAiⁱ	55106
Protein Ontology More...PROⁱ	PR:Q8IYM2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172123 Expressed in 133 organ(s), highest expression level in lung
CleanExⁱ	HS_SLFN12
ExpressionAtlasⁱ	Q8IYM2 baseline and differential
Genevisibleⁱ	Q8IYM2 HS

Family and domain databases

Gene3Dⁱ	3.30.950.30, 1 hit
InterProⁱ	View protein in InterPro IPR029684 Schlafen IPR007421 Schlafen_AAA_dom IPR038461 Schlafen_AAA_dom_sf
PANTHERⁱ	PTHR12155 PTHR12155, 1 hit
Pfamⁱ	View protein in Pfam PF04326 AlbA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SLN12_HUMAN
Accessionⁱ	Q8IYM2Primary (citable) accession number: Q8IYM2 Secondary accession number(s): A8K711, Q9NP47
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
	Last sequence update:	April 3, 2007
	Last modified:	September 12, 2018
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IYM2 (SLN12_HUMAN)

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Schlafen family member 12

SLFN12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ