UniProtKB - Q8IYM2 (SLN12_HUMAN)
Protein
Schlafen family member 12
Gene
SLFN12
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Schlafen family member 12 |
Gene namesi | Name:SLFN12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25500, SLFN12 |
MIMi | 614955, gene |
neXtProti | NX_Q8IYM2 |
VEuPathDBi | HostDB:ENSG00000172123.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55106 |
OpenTargetsi | ENSG00000172123 |
PharmGKBi | PA144596359 |
Miscellaneous databases
Pharosi | Q8IYM2, Tbio |
Genetic variation databases
BioMutai | SLFN12 |
DMDMi | 143585256 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000282984 | 1 – 578 | Schlafen family member 12Add BLAST | 578 |
Proteomic databases
EPDi | Q8IYM2 |
jPOSTi | Q8IYM2 |
MassIVEi | Q8IYM2 |
PaxDbi | Q8IYM2 |
PeptideAtlasi | Q8IYM2 |
PRIDEi | Q8IYM2 |
ProteomicsDBi | 71204 |
PTM databases
iPTMneti | Q8IYM2 |
PhosphoSitePlusi | Q8IYM2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172123, Expressed in monocyte and 151 other tissues |
ExpressionAtlasi | Q8IYM2, baseline and differential |
Genevisiblei | Q8IYM2, HS |
Organism-specific databases
HPAi | ENSG00000172123, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8IYM2
Protein-protein interaction databases
BioGRIDi | 120416, 4 interactors |
IntActi | Q8IYM2, 21 interactors |
MINTi | Q8IYM2 |
STRINGi | 9606.ENSP00000378063 |
Miscellaneous databases
RNActi | Q8IYM2, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502RU3F, Eukaryota |
GeneTreei | ENSGT00410000025651 |
HOGENOMi | CLU_034558_0_0_1 |
InParanoidi | Q8IYM2 |
OMAi | CMEKKNI |
OrthoDBi | 211385at2759 |
PhylomeDBi | Q8IYM2 |
TreeFami | TF337168 |
Family and domain databases
Gene3Di | 3.30.950.30, 1 hit |
InterProi | View protein in InterPro IPR029684, Schlafen IPR007421, Schlafen_AlbA_2_dom IPR038461, Schlafen_AlbA_2_dom_sf |
PANTHERi | PTHR12155, PTHR12155, 1 hit |
Pfami | View protein in Pfam PF04326, AlbA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8IYM2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNISVDLETN YAELVLDVGR VTLGENSRKK MKDCKLRKKQ NESVSRAMCA
60 70 80 90 100
LLNSGGGVIK AEIENEDYSY TKDGIGLDLE NSFSNILLFV PEYLDFMQNG
110 120 130 140 150
NYFLIFVKSW SLNTSGLRIT TLSSNLYKRD ITSAKVMNAT AALEFLKDMK
160 170 180 190 200
KTRGRLYLRP ELLAKRPCVD IQEENNMKAL AGVFFDRTEL DRKEKLTFTE
210 220 230 240 250
STHVEIKNFS TEKLLQRIKE ILPQYVSAFA NTDGGYLFIG LNEDKEIIGF
260 270 280 290 300
KAEMSDLDDL EREIEKSIRK MPVHHFCMEK KKINYSCKFL GVYDKGSLCG
310 320 330 340 350
YVCALRVERF CCAVFAKEPD SWHVKDNRVM QLTRKEWIQF MVEAEPKFSS
360 370 380 390 400
SYEEVISQIN TSLPAPHSWP LLEWQRQRHH CPGLSGRITY TPENLCRKLF
410 420 430 440 450
LQHEGLKQLI CEEMDSVRKG SLIFSRSWSV DLGLQENHKV LCDALLISQD
460 470 480 490 500
SPPVLYTFHM VQDEEFKGYS TQTALTLKQK LAKIGGYTKK VCVMTKIFYL
510 520 530 540 550
SPEGMTSCQY DLRSQVIYPE SYYFTRRKYL LKALFKALKR LKSLRDQFSF
560 570
AENLYQIIGI DCFQKNDKKM FKSCRRLT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J4K7 | C9J4K7_HUMAN | Schlafen family member 12 | SLFN12 | 115 | Annotation score: | ||
C9JIA1 | C9JIA1_HUMAN | Schlafen family member 12 | SLFN12 | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 361 | T → A in BAA91512 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031447 | 43 | S → R1 PublicationCorresponds to variant dbSNP:rs1849733Ensembl. | 1 | |
Natural variantiVAR_031448 | 168 | C → R1 PublicationCorresponds to variant dbSNP:rs2586514Ensembl. | 1 | |
Natural variantiVAR_053877 | 448 | S → P. Corresponds to variant dbSNP:rs12946189Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001122 mRNA Translation: BAA91512.1 AK291826 mRNA Translation: BAF84515.1 BC035605 mRNA Translation: AAH35605.1 |
CCDSi | CCDS11295.1 |
RefSeqi | NP_001275938.1, NM_001289009.1 NP_060512.3, NM_018042.4 XP_005258052.1, XM_005257995.4 XP_011523269.1, XM_011524967.2 XP_016880298.1, XM_017024809.1 XP_016880299.1, XM_017024810.1 |
Genome annotation databases
Ensembli | ENST00000304905; ENSP00000302077; ENSG00000172123 ENST00000394562; ENSP00000378063; ENSG00000172123 ENST00000452764; ENSP00000394903; ENSG00000172123 |
GeneIDi | 55106 |
KEGGi | hsa:55106 |
UCSCi | uc002hji.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001122 mRNA Translation: BAA91512.1 AK291826 mRNA Translation: BAF84515.1 BC035605 mRNA Translation: AAH35605.1 |
CCDSi | CCDS11295.1 |
RefSeqi | NP_001275938.1, NM_001289009.1 NP_060512.3, NM_018042.4 XP_005258052.1, XM_005257995.4 XP_011523269.1, XM_011524967.2 XP_016880298.1, XM_017024809.1 XP_016880299.1, XM_017024810.1 |
3D structure databases
SMRi | Q8IYM2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120416, 4 interactors |
IntActi | Q8IYM2, 21 interactors |
MINTi | Q8IYM2 |
STRINGi | 9606.ENSP00000378063 |
PTM databases
iPTMneti | Q8IYM2 |
PhosphoSitePlusi | Q8IYM2 |
Genetic variation databases
BioMutai | SLFN12 |
DMDMi | 143585256 |
Proteomic databases
EPDi | Q8IYM2 |
jPOSTi | Q8IYM2 |
MassIVEi | Q8IYM2 |
PaxDbi | Q8IYM2 |
PeptideAtlasi | Q8IYM2 |
PRIDEi | Q8IYM2 |
ProteomicsDBi | 71204 |
Protocols and materials databases
Antibodypediai | 43970, 118 antibodies |
Genome annotation databases
Ensembli | ENST00000304905; ENSP00000302077; ENSG00000172123 ENST00000394562; ENSP00000378063; ENSG00000172123 ENST00000452764; ENSP00000394903; ENSG00000172123 |
GeneIDi | 55106 |
KEGGi | hsa:55106 |
UCSCi | uc002hji.6, human |
Organism-specific databases
CTDi | 55106 |
DisGeNETi | 55106 |
GeneCardsi | SLFN12 |
HGNCi | HGNC:25500, SLFN12 |
HPAi | ENSG00000172123, Low tissue specificity |
MIMi | 614955, gene |
neXtProti | NX_Q8IYM2 |
OpenTargetsi | ENSG00000172123 |
PharmGKBi | PA144596359 |
VEuPathDBi | HostDB:ENSG00000172123.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU3F, Eukaryota |
GeneTreei | ENSGT00410000025651 |
HOGENOMi | CLU_034558_0_0_1 |
InParanoidi | Q8IYM2 |
OMAi | CMEKKNI |
OrthoDBi | 211385at2759 |
PhylomeDBi | Q8IYM2 |
TreeFami | TF337168 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYM2 |
Miscellaneous databases
BioGRID-ORCSi | 55106, 5 hits in 869 CRISPR screens |
ChiTaRSi | SLFN12, human |
GenomeRNAii | 55106 |
Pharosi | Q8IYM2, Tbio |
PROi | PR:Q8IYM2 |
RNActi | Q8IYM2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172123, Expressed in monocyte and 151 other tissues |
ExpressionAtlasi | Q8IYM2, baseline and differential |
Genevisiblei | Q8IYM2, HS |
Family and domain databases
Gene3Di | 3.30.950.30, 1 hit |
InterProi | View protein in InterPro IPR029684, Schlafen IPR007421, Schlafen_AlbA_2_dom IPR038461, Schlafen_AlbA_2_dom_sf |
PANTHERi | PTHR12155, PTHR12155, 1 hit |
Pfami | View protein in Pfam PF04326, AlbA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SLN12_HUMAN | |
Accessioni | Q8IYM2Primary (citable) accession number: Q8IYM2 Secondary accession number(s): A8K711, Q9NP47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families