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Protein

Schlafen family member 12

Gene

SLFN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 12
Gene namesi
Name:SLFN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172123.12
HGNCiHGNC:25500 SLFN12
MIMi614955 gene
neXtProtiNX_Q8IYM2

Pathology & Biotechi

Organism-specific databases

DisGeNETi55106
OpenTargetsiENSG00000172123
PharmGKBiPA144596359

Polymorphism and mutation databases

BioMutaiSLFN12
DMDMi143585256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829841 – 578Schlafen family member 12Add BLAST578

Proteomic databases

EPDiQ8IYM2
PaxDbiQ8IYM2
PeptideAtlasiQ8IYM2
PRIDEiQ8IYM2
ProteomicsDBi71204

PTM databases

iPTMnetiQ8IYM2
PhosphoSitePlusiQ8IYM2

Expressioni

Gene expression databases

BgeeiENSG00000172123 Expressed in 133 organ(s), highest expression level in lung
CleanExiHS_SLFN12
ExpressionAtlasiQ8IYM2 baseline and differential
GenevisibleiQ8IYM2 HS

Organism-specific databases

HPAiHPA022523

Interactioni

Protein-protein interaction databases

BioGridi120416, 3 interactors
IntActiQ8IYM2, 4 interactors
MINTiQ8IYM2
STRINGi9606.ENSP00000302077

Structurei

3D structure databases

ProteinModelPortaliQ8IYM2
SMRiQ8IYM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family. Subgroup II subfamily.Curated

Phylogenomic databases

eggNOGiENOG410JAUV Eukaryota
ENOG4111BZ2 LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000133056
HOVERGENiHBG057499
InParanoidiQ8IYM2
OMAiCRKLFLQ
OrthoDBiEOG091G0916
PhylomeDBiQ8IYM2
TreeFamiTF337168

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
PANTHERiPTHR12155 PTHR12155, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IYM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNISVDLETN YAELVLDVGR VTLGENSRKK MKDCKLRKKQ NESVSRAMCA
60 70 80 90 100
LLNSGGGVIK AEIENEDYSY TKDGIGLDLE NSFSNILLFV PEYLDFMQNG
110 120 130 140 150
NYFLIFVKSW SLNTSGLRIT TLSSNLYKRD ITSAKVMNAT AALEFLKDMK
160 170 180 190 200
KTRGRLYLRP ELLAKRPCVD IQEENNMKAL AGVFFDRTEL DRKEKLTFTE
210 220 230 240 250
STHVEIKNFS TEKLLQRIKE ILPQYVSAFA NTDGGYLFIG LNEDKEIIGF
260 270 280 290 300
KAEMSDLDDL EREIEKSIRK MPVHHFCMEK KKINYSCKFL GVYDKGSLCG
310 320 330 340 350
YVCALRVERF CCAVFAKEPD SWHVKDNRVM QLTRKEWIQF MVEAEPKFSS
360 370 380 390 400
SYEEVISQIN TSLPAPHSWP LLEWQRQRHH CPGLSGRITY TPENLCRKLF
410 420 430 440 450
LQHEGLKQLI CEEMDSVRKG SLIFSRSWSV DLGLQENHKV LCDALLISQD
460 470 480 490 500
SPPVLYTFHM VQDEEFKGYS TQTALTLKQK LAKIGGYTKK VCVMTKIFYL
510 520 530 540 550
SPEGMTSCQY DLRSQVIYPE SYYFTRRKYL LKALFKALKR LKSLRDQFSF
560 570
AENLYQIIGI DCFQKNDKKM FKSCRRLT
Length:578
Mass (Da):66,972
Last modified:April 3, 2007 - v2
Checksum:i858DEC808A50E753
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4K7C9J4K7_HUMAN
Schlafen family member 12
SLFN12
115Annotation score:
C9JIA1C9JIA1_HUMAN
Schlafen family member 12
SLFN12
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361T → A in BAA91512 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03144743S → R1 PublicationCorresponds to variant dbSNP:rs1849733Ensembl.1
Natural variantiVAR_031448168C → R1 PublicationCorresponds to variant dbSNP:rs2586514Ensembl.1
Natural variantiVAR_053877448S → P. Corresponds to variant dbSNP:rs12946189Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001122 mRNA Translation: BAA91512.1
AK291826 mRNA Translation: BAF84515.1
BC035605 mRNA Translation: AAH35605.1
CCDSiCCDS11295.1
RefSeqiNP_001275938.1, NM_001289009.1
NP_060512.3, NM_018042.4
XP_005258052.1, XM_005257995.4
XP_011523269.1, XM_011524967.2
XP_016880298.1, XM_017024809.1
XP_016880299.1, XM_017024810.1
UniGeneiHs.663548

Genome annotation databases

EnsembliENST00000304905; ENSP00000302077; ENSG00000172123
ENST00000394562; ENSP00000378063; ENSG00000172123
ENST00000452764; ENSP00000394903; ENSG00000172123
GeneIDi55106
KEGGihsa:55106
UCSCiuc002hji.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001122 mRNA Translation: BAA91512.1
AK291826 mRNA Translation: BAF84515.1
BC035605 mRNA Translation: AAH35605.1
CCDSiCCDS11295.1
RefSeqiNP_001275938.1, NM_001289009.1
NP_060512.3, NM_018042.4
XP_005258052.1, XM_005257995.4
XP_011523269.1, XM_011524967.2
XP_016880298.1, XM_017024809.1
XP_016880299.1, XM_017024810.1
UniGeneiHs.663548

3D structure databases

ProteinModelPortaliQ8IYM2
SMRiQ8IYM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120416, 3 interactors
IntActiQ8IYM2, 4 interactors
MINTiQ8IYM2
STRINGi9606.ENSP00000302077

PTM databases

iPTMnetiQ8IYM2
PhosphoSitePlusiQ8IYM2

Polymorphism and mutation databases

BioMutaiSLFN12
DMDMi143585256

Proteomic databases

EPDiQ8IYM2
PaxDbiQ8IYM2
PeptideAtlasiQ8IYM2
PRIDEiQ8IYM2
ProteomicsDBi71204

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304905; ENSP00000302077; ENSG00000172123
ENST00000394562; ENSP00000378063; ENSG00000172123
ENST00000452764; ENSP00000394903; ENSG00000172123
GeneIDi55106
KEGGihsa:55106
UCSCiuc002hji.6 human

Organism-specific databases

CTDi55106
DisGeNETi55106
EuPathDBiHostDB:ENSG00000172123.12
GeneCardsiSLFN12
HGNCiHGNC:25500 SLFN12
HPAiHPA022523
MIMi614955 gene
neXtProtiNX_Q8IYM2
OpenTargetsiENSG00000172123
PharmGKBiPA144596359
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAUV Eukaryota
ENOG4111BZ2 LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000133056
HOVERGENiHBG057499
InParanoidiQ8IYM2
OMAiCRKLFLQ
OrthoDBiEOG091G0916
PhylomeDBiQ8IYM2
TreeFamiTF337168

Miscellaneous databases

GenomeRNAii55106
PROiPR:Q8IYM2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172123 Expressed in 133 organ(s), highest expression level in lung
CleanExiHS_SLFN12
ExpressionAtlasiQ8IYM2 baseline and differential
GenevisibleiQ8IYM2 HS

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
PANTHERiPTHR12155 PTHR12155, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLN12_HUMAN
AccessioniPrimary (citable) accession number: Q8IYM2
Secondary accession number(s): A8K711, Q9NP47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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