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Entry version 125 (07 Oct 2020)
Sequence version 2 (10 Jul 2007)
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Protein

UPF0688 protein C1orf174

Gene

C1orf174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYL3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0688 protein C1orf174
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198912.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27915, C1orf174

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYL3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1orf174

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152013372

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002942441 – 243UPF0688 protein C1orf174Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IYL3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYL3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IYL3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYL3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYL3

PeptideAtlas

More...
PeptideAtlasi
Q8IYL3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYL3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71198

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1886, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IYL3, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198912, Expressed in oocyte and 237 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYL3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198912, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130884, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYL3, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355306

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYL3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IYL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi232 – 240Poly-Asp9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0688 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SBCG, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_096286_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPCENEF

Database of Orthologous Groups

More...
OrthoDBi
1610051at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYL3

TreeFam database of animal gene trees

More...
TreeFami
TF336079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031530, UPF0688

The PANTHER Classification System

More...
PANTHERi
PTHR28491, PTHR28491, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15772, UPF0688, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA
60 70 80 90 100
TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS
110 120 130 140 150
ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA
160 170 180 190 200
EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG
210 220 230 240
NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM
Length:243
Mass (Da):25,977
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80DF42E5FD907454
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35643 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03315253T → R3 PublicationsCorresponds to variant dbSNP:rs4274008Ensembl.1
Natural variantiVAR_033153101A → S. Corresponds to variant dbSNP:rs10909820Ensembl.1
Natural variantiVAR_057829165P → A. Corresponds to variant dbSNP:rs12036962Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289493 mRNA Translation: BAF82182.1
BX005110 Genomic DNA No translation available.
AL691523 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71492.1
BC035643 mRNA Translation: AAH35643.1 Different initiation.
BC067302 mRNA Translation: AAH67302.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53.1

NCBI Reference Sequences

More...
RefSeqi
NP_997239.2, NM_207356.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361605; ENSP00000355306; ENSG00000198912

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
339448

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:339448

UCSC genome browser

More...
UCSCi
uc001alf.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289493 mRNA Translation: BAF82182.1
BX005110 Genomic DNA No translation available.
AL691523 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71492.1
BC035643 mRNA Translation: AAH35643.1 Different initiation.
BC067302 mRNA Translation: AAH67302.1
CCDSiCCDS53.1
RefSeqiNP_997239.2, NM_207356.2

3D structure databases

SMRiQ8IYL3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130884, 24 interactors
IntActiQ8IYL3, 14 interactors
STRINGi9606.ENSP00000355306

PTM databases

GlyConnecti1886, 2 N-Linked glycans (1 site)
GlyGeniQ8IYL3, 1 site
iPTMnetiQ8IYL3
PhosphoSitePlusiQ8IYL3

Polymorphism and mutation databases

BioMutaiC1orf174
DMDMi152013372

Proteomic databases

EPDiQ8IYL3
jPOSTiQ8IYL3
MassIVEiQ8IYL3
MaxQBiQ8IYL3
PaxDbiQ8IYL3
PeptideAtlasiQ8IYL3
PRIDEiQ8IYL3
ProteomicsDBi71198

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2157, 66 antibodies

Genome annotation databases

EnsembliENST00000361605; ENSP00000355306; ENSG00000198912
GeneIDi339448
KEGGihsa:339448
UCSCiuc001alf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
339448
EuPathDBiHostDB:ENSG00000198912.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C1orf174
HGNCiHGNC:27915, C1orf174
HPAiENSG00000198912, Low tissue specificity
neXtProtiNX_Q8IYL3
OpenTargetsiENSG00000198912
PharmGKBiPA143485318

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SBCG, Eukaryota
GeneTreeiENSGT00390000016496
HOGENOMiCLU_096286_0_0_1
InParanoidiQ8IYL3
OMAiTPCENEF
OrthoDBi1610051at2759
PhylomeDBiQ8IYL3
TreeFamiTF336079

Enzyme and pathway databases

PathwayCommonsiQ8IYL3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
339448, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C1orf174, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
339448
PharosiQ8IYL3, Tdark

Protein Ontology

More...
PROi
PR:Q8IYL3
RNActiQ8IYL3, protein

Gene expression databases

BgeeiENSG00000198912, Expressed in oocyte and 237 other tissues
GenevisibleiQ8IYL3, HS

Family and domain databases

InterProiView protein in InterPro
IPR031530, UPF0688
PANTHERiPTHR28491, PTHR28491, 1 hit
PfamiView protein in Pfam
PF15772, UPF0688, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA174_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYL3
Secondary accession number(s): A8K0C8
, A8MUG9, Q5SR20, Q6NX36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 7, 2020
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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