UniProtKB - Q8IYL3 (CA174_HUMAN)
Protein
UPF0688 protein C1orf174
Gene
C1orf174
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: UPF0688 protein C1orf174 |
Gene namesi | Name:C1orf174 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27915, C1orf174 |
neXtProti | NX_Q8IYL3 |
VEuPathDBi | HostDB:ENSG00000198912.10 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198912 |
PharmGKBi | PA143485318 |
Miscellaneous databases
Pharosi | Q8IYL3, Tdark |
Genetic variation databases
BioMutai | C1orf174 |
DMDMi | 152013372 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294244 | 1 – 243 | UPF0688 protein C1orf174Add BLAST | 243 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 189 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IYL3 |
jPOSTi | Q8IYL3 |
MassIVEi | Q8IYL3 |
MaxQBi | Q8IYL3 |
PaxDbi | Q8IYL3 |
PeptideAtlasi | Q8IYL3 |
PRIDEi | Q8IYL3 |
ProteomicsDBi | 71198 |
PTM databases
GlyConnecti | 1886, 2 N-Linked glycans (1 site) |
GlyGeni | Q8IYL3, 1 site |
iPTMneti | Q8IYL3 |
PhosphoSitePlusi | Q8IYL3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198912, Expressed in oocyte and 237 other tissues |
Genevisiblei | Q8IYL3, HS |
Organism-specific databases
HPAi | ENSG00000198912, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8IYL3
Protein-protein interaction databases
BioGRIDi | 130884, 25 interactors |
IntActi | Q8IYL3, 14 interactors |
STRINGi | 9606.ENSP00000355306 |
Miscellaneous databases
RNActi | Q8IYL3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 232 – 240 | Poly-Asp | 9 |
Sequence similaritiesi
Belongs to the UPF0688 family.Curated
Phylogenomic databases
eggNOGi | ENOG502SBCG, Eukaryota |
GeneTreei | ENSGT00390000016496 |
HOGENOMi | CLU_096286_0_0_1 |
InParanoidi | Q8IYL3 |
OMAi | TPCENEF |
OrthoDBi | 1610051at2759 |
PhylomeDBi | Q8IYL3 |
TreeFami | TF336079 |
Family and domain databases
InterProi | View protein in InterPro IPR031530, UPF0688 |
PANTHERi | PTHR28491, PTHR28491, 1 hit |
Pfami | View protein in Pfam PF15772, UPF0688, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IYL3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA
60 70 80 90 100
TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS
110 120 130 140 150
ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA
160 170 180 190 200
EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG
210 220 230 240
NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM
Sequence cautioni
The sequence AAH35643 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033152 | 53 | T → R3 PublicationsCorresponds to variant dbSNP:rs4274008Ensembl. | 1 | |
Natural variantiVAR_033153 | 101 | A → S. Corresponds to variant dbSNP:rs10909820Ensembl. | 1 | |
Natural variantiVAR_057829 | 165 | P → A. Corresponds to variant dbSNP:rs12036962Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289493 mRNA Translation: BAF82182.1 BX005110 Genomic DNA No translation available. AL691523 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71492.1 BC035643 mRNA Translation: AAH35643.1 Different initiation. BC067302 mRNA Translation: AAH67302.1 |
CCDSi | CCDS53.1 |
RefSeqi | NP_997239.2, NM_207356.2 |
Genome annotation databases
Ensembli | ENST00000361605; ENSP00000355306; ENSG00000198912 |
GeneIDi | 339448 |
KEGGi | hsa:339448 |
UCSCi | uc001alf.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289493 mRNA Translation: BAF82182.1 BX005110 Genomic DNA No translation available. AL691523 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71492.1 BC035643 mRNA Translation: AAH35643.1 Different initiation. BC067302 mRNA Translation: AAH67302.1 |
CCDSi | CCDS53.1 |
RefSeqi | NP_997239.2, NM_207356.2 |
3D structure databases
SMRi | Q8IYL3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130884, 25 interactors |
IntActi | Q8IYL3, 14 interactors |
STRINGi | 9606.ENSP00000355306 |
PTM databases
GlyConnecti | 1886, 2 N-Linked glycans (1 site) |
GlyGeni | Q8IYL3, 1 site |
iPTMneti | Q8IYL3 |
PhosphoSitePlusi | Q8IYL3 |
Genetic variation databases
BioMutai | C1orf174 |
DMDMi | 152013372 |
Proteomic databases
EPDi | Q8IYL3 |
jPOSTi | Q8IYL3 |
MassIVEi | Q8IYL3 |
MaxQBi | Q8IYL3 |
PaxDbi | Q8IYL3 |
PeptideAtlasi | Q8IYL3 |
PRIDEi | Q8IYL3 |
ProteomicsDBi | 71198 |
Protocols and materials databases
Antibodypediai | 2157, 66 antibodies |
Genome annotation databases
Ensembli | ENST00000361605; ENSP00000355306; ENSG00000198912 |
GeneIDi | 339448 |
KEGGi | hsa:339448 |
UCSCi | uc001alf.4, human |
Organism-specific databases
CTDi | 339448 |
GeneCardsi | C1orf174 |
HGNCi | HGNC:27915, C1orf174 |
HPAi | ENSG00000198912, Low tissue specificity |
neXtProti | NX_Q8IYL3 |
OpenTargetsi | ENSG00000198912 |
PharmGKBi | PA143485318 |
VEuPathDBi | HostDB:ENSG00000198912.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SBCG, Eukaryota |
GeneTreei | ENSGT00390000016496 |
HOGENOMi | CLU_096286_0_0_1 |
InParanoidi | Q8IYL3 |
OMAi | TPCENEF |
OrthoDBi | 1610051at2759 |
PhylomeDBi | Q8IYL3 |
TreeFami | TF336079 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYL3 |
Miscellaneous databases
BioGRID-ORCSi | 339448, 3 hits in 875 CRISPR screens |
ChiTaRSi | C1orf174, human |
GenomeRNAii | 339448 |
Pharosi | Q8IYL3, Tdark |
PROi | PR:Q8IYL3 |
RNActi | Q8IYL3, protein |
Gene expression databases
Bgeei | ENSG00000198912, Expressed in oocyte and 237 other tissues |
Genevisiblei | Q8IYL3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031530, UPF0688 |
PANTHERi | PTHR28491, PTHR28491, 1 hit |
Pfami | View protein in Pfam PF15772, UPF0688, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CA174_HUMAN | |
Accessioni | Q8IYL3Primary (citable) accession number: Q8IYL3 Secondary accession number(s): A8K0C8 Q6NX36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 10, 2007 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries