C1orf174

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UPF0688 protein C1orf174
Gene namesⁱ	Name:C1orf174
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198912.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27915 C1orf174
neXtProtⁱ	NX_Q8IYL3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198912
PharmGKBⁱ	PA143485318

Polymorphism and mutation databases

BioMutaⁱ	C1orf174
DMDMⁱ	152013372

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000294244	1 – 243	UPF0688 protein C1orf174Add BLAST		243

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	148	PhosphoserineCombined sources		1
Modified residueⁱ	189	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IYL3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IYL3
PaxDbⁱ	Q8IYL3
PeptideAtlas More...PeptideAtlasⁱ	Q8IYL3
PRIDEⁱ	Q8IYL3
ProteomicsDBⁱ	71198

PTM databases

GlyConnectⁱ	1886
iPTMnetⁱ	Q8IYL3
PhosphoSitePlusⁱ	Q8IYL3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198912 Expressed in 223 organ(s), highest expression level in oocyte
CleanExⁱ	HS_C1orf174
Genevisibleⁱ	Q8IYL3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008270 HPA065778

HPAⁱ

HPA008270
HPA065778

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
IKZF1	Q13422	3	EBI-715898,EBI-745305
PDIK1L	Q8N165	9	EBI-715898,EBI-6423298
TERF2IP	Q9NYB0	2	EBI-715898,EBI-750109

Protein-protein interaction databases

BioGridⁱ	130884, 19 interactors
IntActⁱ	Q8IYL3, 12 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IYL3
SMRⁱ	Q8IYL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	232 – 240	Poly-Asp		9

Sequence similaritiesⁱ

Belongs to the UPF0688 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IXWN Eukaryota ENOG410XZ19 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016496
HOGENOMⁱ	HOG000111263
HOVERGENⁱ	HBG097321
InParanoidⁱ	Q8IYL3
OMAⁱ	SAKTACL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N6K
PhylomeDBⁱ	Q8IYL3
TreeFamⁱ	TF336079

Family and domain databases

InterProⁱ	View protein in InterPro IPR031530 UPF0688
PANTHERⁱ	PTHR28491 PTHR28491, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15772 UPF0688, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IYL3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA 
        60         70         80         90        100
TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS 
       110        120        130        140        150
ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA 
       160        170        180        190        200
EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG 
       210        220        230        240 
NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM

Length:243

Mass (Da):25,977

Last modified:July 10, 2007 - v2

Checksum:ⁱ80DF42E5FD907454

GO

Sequence cautionⁱ

The sequence AAH35643 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033152	53	T → R3 PublicationsCorresponds to variant dbSNP:rs4274008Ensembl.	1
Natural variantⁱVAR_033153	101	A → S. Corresponds to variant dbSNP:rs10909820Ensembl.	1
Natural variantⁱVAR_057829	165	P → A. Corresponds to variant dbSNP:rs12036962Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289493 mRNA Translation: BAF82182.1 BX005110 Genomic DNA No translation available. AL691523 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71492.1 BC035643 mRNA Translation: AAH35643.1 Different initiation. BC067302 mRNA Translation: AAH67302.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53.1
NCBI Reference Sequences More...RefSeqⁱ	NP_997239.2, NM_207356.2
UniGeneⁱ	Hs.103939

Genome annotation databases

Ensemblⁱ	ENST00000361605; ENSP00000355306; ENSG00000198912
GeneIDⁱ	339448
KEGGⁱ	hsa:339448
UCSC genome browser More...UCSCⁱ	uc001alf.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IYL3	Uncharacterized protein		MANLE		247	UniRef90_Q8IYL3
Uncharacterized protein		MACMU		245
Uncharacterized protein		COLAP		245
Uncharacterized protein		MACFA		244
C1orf174 isoform 1		PONAB		244
+29

Protein	Similar proteins		Species	Score	Length	Source
Q8IYL3	UPF0688 protein C1orf174 homolog		MOUSE		230	UniRef50_Q8IYL3
Uncharacterized protein		MANLE		247
Uncharacterized protein		MACMU		245
Uncharacterized protein		COLAP		245
Uncharacterized protein		MACFA		244
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289493 mRNA Translation: BAF82182.1 BX005110 Genomic DNA No translation available. AL691523 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71492.1 BC035643 mRNA Translation: AAH35643.1 Different initiation. BC067302 mRNA Translation: AAH67302.1
CCDSⁱ	CCDS53.1
RefSeqⁱ	NP_997239.2, NM_207356.2
UniGeneⁱ	Hs.103939

3D structure databases

ProteinModelPortalⁱ	Q8IYL3
SMRⁱ	Q8IYL3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130884, 19 interactors
IntActⁱ	Q8IYL3, 12 interactors

PTM databases

GlyConnectⁱ	1886
iPTMnetⁱ	Q8IYL3
PhosphoSitePlusⁱ	Q8IYL3

Polymorphism and mutation databases

BioMutaⁱ	C1orf174
DMDMⁱ	152013372

Proteomic databases

EPDⁱ	Q8IYL3
MaxQBⁱ	Q8IYL3
PaxDbⁱ	Q8IYL3
PeptideAtlasⁱ	Q8IYL3
PRIDEⁱ	Q8IYL3
ProteomicsDBⁱ	71198

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361605; ENSP00000355306; ENSG00000198912
GeneIDⁱ	339448
KEGGⁱ	hsa:339448
UCSCⁱ	uc001alf.4 human

Organism-specific databases

CTDⁱ	339448
EuPathDBⁱ	HostDB:ENSG00000198912.10
GeneCardsⁱ	C1orf174
H-InvDBⁱ	HIX0023581
HGNCⁱ	HGNC:27915 C1orf174
HPAⁱ	HPA008270 HPA065778
neXtProtⁱ	NX_Q8IYL3
OpenTargetsⁱ	ENSG00000198912
PharmGKBⁱ	PA143485318
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXWN Eukaryota ENOG410XZ19 LUCA
GeneTreeⁱ	ENSGT00390000016496
HOGENOMⁱ	HOG000111263
HOVERGENⁱ	HBG097321
InParanoidⁱ	Q8IYL3
OMAⁱ	SAKTACL
OrthoDBⁱ	EOG091G0N6K
PhylomeDBⁱ	Q8IYL3
TreeFamⁱ	TF336079

Miscellaneous databases

ChiTaRSⁱ	C1orf174 human
GenomeRNAiⁱ	339448
Protein Ontology More...PROⁱ	PR:Q8IYL3

Gene expression databases

Bgeeⁱ	ENSG00000198912 Expressed in 223 organ(s), highest expression level in oocyte
CleanExⁱ	HS_C1orf174
Genevisibleⁱ	Q8IYL3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031530 UPF0688
PANTHERⁱ	PTHR28491 PTHR28491, 1 hit
Pfamⁱ	View protein in Pfam PF15772 UPF0688, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CA174_HUMAN
Accessionⁱ	Q8IYL3Primary (citable) accession number: Q8IYL3 Secondary accession number(s): A8K0C8 , A8MUG9, Q5SR20, Q6NX36
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
	Last sequence update:	July 10, 2007
	Last modified:	November 7, 2018
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IYL3 (CA174_HUMAN)

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UPF0688 protein C1orf174

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ