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UniProtKB - Q8IYL2 (TRM44_HUMAN)

Entry version 129 (02 Dec 2020)
Sequence version 2 (19 Sep 2006)
Previous versions | rss
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Protein

Probable tRNA (uracil-O(2)-)-methyltransferase

Gene

TRMT44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O2-)-methyltransferase.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri713 – 743C3H1-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IYL2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable tRNA (uracil-O(2)-)-methyltransferase (EC:2.1.1.211)
Alternative name(s):
Methyltransferase-like protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT44
Synonyms:C4orf23, METTL19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000155275.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:26653, TRMT44

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614309, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IYL2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		152992

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145008869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IYL2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRMT44

Domain mapping of disease mutations (DMDM)

More...DMDMi		115311883

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002498941 – 757Probable tRNA (uracil-O(2)-)-methyltransferaseAdd BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IYL2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IYL2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IYL2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IYL2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IYL2

PeptideAtlas

More...PeptideAtlasi		Q8IYL2

PRoteomics IDEntifications database

More...PRIDEi		Q8IYL2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71195 [Q8IYL2-1]
71196 [Q8IYL2-2]
71197 [Q8IYL2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IYL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IYL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155275, Expressed in right ovary and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IYL2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IYL2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155275, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127475, 31 interactors

Protein interaction database and analysis system

More...IntActi		Q8IYL2, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000374387

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IYL2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRM44 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri713 – 743C3H1-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3790, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000645

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021025_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IYL2

Identification of Orthologs from Complete Genome Data

More...OMAi		FIYEDLA

Database of Orthologous Groups

More...OrthoDBi		1146281at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IYL2

TreeFam database of animal gene trees

More...TreeFami		TF106127

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029063, SAM-dependent_MTases
IPR011671, tRNA_uracil_MeTrfase
IPR000571, Znf_CCCH

The PANTHER Classification System

More...PANTHERi		PTHR21210, PTHR21210, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07757, AdoMet_MTase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103, ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEVGRTGIS YPGALLPQGF WAAVEVWLER PQVANKRLCG ARLEARWSAA 
        60         70         80         90        100
LPCAEARGPG TSAGSEQKER GPGPGQGSPG GGPGPRSLSG PEQGTACCEL 
       110        120        130        140        150
EEAQGQCQQE EAQREAASVP LRDSGHPGHA EGREGDFPAA DLDSLWEDFS 
       160        170        180        190        200
QSLARGNSEL LAFLTSSGAG SQPEAQRELD VVLRTVIPKT SPHCPLTTPR 
       210        220        230        240        250
REIVVQDVLN GTITFLPLEE DDEGNLKVKM SNVYQIQLSH SKEEWFISVL 
       260        270        280        290        300
IFCPERWHSD GIVYPKPTWL GEELLAKLAK WSVENKKSDF KSTLSLISIM 
       310        320        330        340        350
KYSKAYQELK EKYKEMVKVW PEVTDPEKFV YEDVAIAAYL LILWEEERAE 
       360        370        380        390        400
RRLTARQSFV DLGCGNGLLV HILSSEGHPG RGIDVRRRKI WDMYGPQTQL 
       410        420        430        440        450
EEDAITPNDK TLFPDVDWLI GNHSDELTPW IPVIAARSSY NCRFFVLPCC 
       460        470        480        490        500
FFDFIGRYSR RQSKKTQYRE YLDFIKEVGF TCGFHVDEDC LRIPSTKRVC 
       510        520        530        540        550
LVGKSRTYPS SREASVDEKR TQYIKSRRGC PVSPPGWELS PSPRWVAAGS 
       560        570        580        590        600
AGHCDGQQAL DARVGCVTRA WAAEHGAGPQ AEGPWLPGFH PREKAERVRN 
       610        620        630        640        650
CAALPRDFID QVVLQVANLL LGGKQLNTRS SRNGSLKTWN GGESLSLAEV 
       660        670        680        690        700
ANELDTETLR RLKRECGGLQ TLLRNSHQVF QVVNGRVHIR DWREETLWKT 
       710        720        730        740        750
KQPEAKQRLL SEACKTRLCW FFMHHPDGCA LSTDCCPFAH GPAELRPPRT 

TPRKKIS
Length:757
Mass (Da):84,629
Last modified:September 19, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71E5E4614D6718DC
GO
Isoform 2 (identifier: Q8IYL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.
     242-254: KEEWFISVLIFCP → MCIKFSSVIAKKN
     643-652: ESLSLAEVAN → GKLSTILGRG
     653-757: Missing.

Show »
Length:411
Mass (Da):46,592
Checksum:i85DA290CC8BBC78D
GO
Isoform 3 (identifier: Q8IYL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:365
Mass (Da):41,327
Checksum:iFD7F525D425F08EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDS2H0YDS2_HUMAN
Probable tRNA (uracil-O(2)-)-methyl...
TRMT44
220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066601300M → L1 PublicationCorresponds to variant dbSNP:rs73211375Ensembl.1
Natural variantiVAR_027515352R → G. Corresponds to variant dbSNP:rs1880024Ensembl.1
Natural variantiVAR_066602455I → V1 PublicationCorresponds to variant dbSNP:rs34873641Ensembl.1
Natural variantiVAR_066603641G → A1 PublicationCorresponds to variant dbSNP:rs150441746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0395381 – 392Missing in isoform 3. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_0205891 – 241Missing in isoform 2. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_020590242 – 254KEEWF…LIFCP → MCIKFSSVIAKKN in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_020591643 – 652ESLSLAEVAN → GKLSTILGRG in isoform 2. 1 Publication10
Alternative sequenceiVSP_020592653 – 757Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093044 mRNA Translation: BAC04031.1
AC104825 Genomic DNA No translation available.
AC105345 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82337.1
BC035655 mRNA Translation: AAH35655.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3402.2 [Q8IYL2-1]

NCBI Reference Sequences

More...RefSeqi		NP_689757.2, NM_152544.2 [Q8IYL2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389737; ENSP00000374387; ENSG00000155275 [Q8IYL2-1]
ENST00000513449; ENSP00000424643; ENSG00000155275 [Q8IYL2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		152992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:152992

UCSC genome browser

More...UCSCi		uc003glf.2, human [Q8IYL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093044 mRNA Translation: BAC04031.1
AC104825 Genomic DNA No translation available.
AC105345 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82337.1
BC035655 mRNA Translation: AAH35655.1
CCDSiCCDS3402.2 [Q8IYL2-1]
RefSeqiNP_689757.2, NM_152544.2 [Q8IYL2-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127475, 31 interactors
IntActiQ8IYL2, 9 interactors
STRINGi9606.ENSP00000374387

PTM databases

iPTMnetiQ8IYL2
PhosphoSitePlusiQ8IYL2

Polymorphism and mutation databases

BioMutaiTRMT44
DMDMi115311883

Proteomic databases

EPDiQ8IYL2
jPOSTiQ8IYL2
MassIVEiQ8IYL2
MaxQBiQ8IYL2
PaxDbiQ8IYL2
PeptideAtlasiQ8IYL2
PRIDEiQ8IYL2
ProteomicsDBi71195 [Q8IYL2-1]
71196 [Q8IYL2-2]
71197 [Q8IYL2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43421, 31 antibodies

The DNASU plasmid repository

More...DNASUi		152992

Genome annotation databases

EnsembliENST00000389737; ENSP00000374387; ENSG00000155275 [Q8IYL2-1]
ENST00000513449; ENSP00000424643; ENSG00000155275 [Q8IYL2-2]
GeneIDi152992
KEGGihsa:152992
UCSCiuc003glf.2, human [Q8IYL2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		152992
DisGeNETi152992
EuPathDBiHostDB:ENSG00000155275.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRMT44
HGNCiHGNC:26653, TRMT44
HPAiENSG00000155275, Low tissue specificity
MIMi614309, gene
neXtProtiNX_Q8IYL2
PharmGKBiPA145008869

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3790, Eukaryota
GeneTreeiENSGT00390000000645
HOGENOMiCLU_021025_0_0_1
InParanoidiQ8IYL2
OMAiFIYEDLA
OrthoDBi1146281at2759
PhylomeDBiQ8IYL2
TreeFamiTF106127

Enzyme and pathway databases

PathwayCommonsiQ8IYL2
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		152992, 3 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRMT44, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		152992
PharosiQ8IYL2, Tdark

Protein Ontology

More...PROi		PR:Q8IYL2
RNActiQ8IYL2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155275, Expressed in right ovary and 117 other tissues
ExpressionAtlasiQ8IYL2, baseline and differential
GenevisibleiQ8IYL2, HS

Family and domain databases

InterProiView protein in InterPro
IPR029063, SAM-dependent_MTases
IPR011671, tRNA_uracil_MeTrfase
IPR000571, Znf_CCCH
PANTHERiPTHR21210, PTHR21210, 1 hit
PfamiView protein in Pfam
PF07757, AdoMet_MTase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRM44_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYL2
Secondary accession number(s): Q8NA95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: December 2, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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