UniProtKB - Q8IYL2 (TRM44_HUMAN)
Protein
Probable tRNA (uracil-O(2)-)-methyltransferase
Gene
TRMT44
Organism
Homo sapiens (Human)
Status
Functioni
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O2-)-methyltransferase.By similarity
Catalytic activityi
- S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteineEC:2.1.1.211
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 713 – 743 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- tRNA (uracil) methyltransferase activity Source: GO_Central
GO - Biological processi
- tRNA methylation Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IYL2 |
Reactomei | R-HSA-6782315, tRNA modification in the nucleus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Probable tRNA (uracil-O(2)-)-methyltransferase (EC:2.1.1.211)Alternative name(s): Methyltransferase-like protein 19 |
Gene namesi | Name:TRMT44 Synonyms:C4orf23, METTL19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155275.18 |
HGNCi | HGNC:26653, TRMT44 |
MIMi | 614309, gene |
neXtProti | NX_Q8IYL2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 152992 |
PharmGKBi | PA145008869 |
Miscellaneous databases
Pharosi | Q8IYL2, Tdark |
Polymorphism and mutation databases
BioMutai | TRMT44 |
DMDMi | 115311883 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249894 | 1 – 757 | Probable tRNA (uracil-O(2)-)-methyltransferaseAdd BLAST | 757 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 533 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IYL2 |
jPOSTi | Q8IYL2 |
MassIVEi | Q8IYL2 |
MaxQBi | Q8IYL2 |
PaxDbi | Q8IYL2 |
PeptideAtlasi | Q8IYL2 |
PRIDEi | Q8IYL2 |
ProteomicsDBi | 71195 [Q8IYL2-1] 71196 [Q8IYL2-2] 71197 [Q8IYL2-3] |
PTM databases
iPTMneti | Q8IYL2 |
PhosphoSitePlusi | Q8IYL2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155275, Expressed in right ovary and 117 other tissues |
ExpressionAtlasi | Q8IYL2, baseline and differential |
Genevisiblei | Q8IYL2, HS |
Organism-specific databases
HPAi | ENSG00000155275, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127475, 31 interactors |
IntActi | Q8IYL2, 9 interactors |
STRINGi | 9606.ENSP00000374387 |
Miscellaneous databases
RNActi | Q8IYL2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TRM44 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 713 – 743 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3790, Eukaryota |
GeneTreei | ENSGT00390000000645 |
HOGENOMi | CLU_021025_0_0_1 |
InParanoidi | Q8IYL2 |
OMAi | FIYEDLA |
OrthoDBi | 1146281at2759 |
PhylomeDBi | Q8IYL2 |
TreeFami | TF106127 |
Family and domain databases
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR011671, tRNA_uracil_MeTrfase IPR000571, Znf_CCCH |
PANTHERi | PTHR21210, PTHR21210, 1 hit |
Pfami | View protein in Pfam PF07757, AdoMet_MTase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IYL2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEVGRTGIS YPGALLPQGF WAAVEVWLER PQVANKRLCG ARLEARWSAA
60 70 80 90 100
LPCAEARGPG TSAGSEQKER GPGPGQGSPG GGPGPRSLSG PEQGTACCEL
110 120 130 140 150
EEAQGQCQQE EAQREAASVP LRDSGHPGHA EGREGDFPAA DLDSLWEDFS
160 170 180 190 200
QSLARGNSEL LAFLTSSGAG SQPEAQRELD VVLRTVIPKT SPHCPLTTPR
210 220 230 240 250
REIVVQDVLN GTITFLPLEE DDEGNLKVKM SNVYQIQLSH SKEEWFISVL
260 270 280 290 300
IFCPERWHSD GIVYPKPTWL GEELLAKLAK WSVENKKSDF KSTLSLISIM
310 320 330 340 350
KYSKAYQELK EKYKEMVKVW PEVTDPEKFV YEDVAIAAYL LILWEEERAE
360 370 380 390 400
RRLTARQSFV DLGCGNGLLV HILSSEGHPG RGIDVRRRKI WDMYGPQTQL
410 420 430 440 450
EEDAITPNDK TLFPDVDWLI GNHSDELTPW IPVIAARSSY NCRFFVLPCC
460 470 480 490 500
FFDFIGRYSR RQSKKTQYRE YLDFIKEVGF TCGFHVDEDC LRIPSTKRVC
510 520 530 540 550
LVGKSRTYPS SREASVDEKR TQYIKSRRGC PVSPPGWELS PSPRWVAAGS
560 570 580 590 600
AGHCDGQQAL DARVGCVTRA WAAEHGAGPQ AEGPWLPGFH PREKAERVRN
610 620 630 640 650
CAALPRDFID QVVLQVANLL LGGKQLNTRS SRNGSLKTWN GGESLSLAEV
660 670 680 690 700
ANELDTETLR RLKRECGGLQ TLLRNSHQVF QVVNGRVHIR DWREETLWKT
710 720 730 740 750
KQPEAKQRLL SEACKTRLCW FFMHHPDGCA LSTDCCPFAH GPAELRPPRT
TPRKKIS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YDS2 | H0YDS2_HUMAN | Probable tRNA (uracil-O(2)-)-methyl... | TRMT44 | 220 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066601 | 300 | M → L1 PublicationCorresponds to variant dbSNP:rs73211375Ensembl. | 1 | |
Natural variantiVAR_027515 | 352 | R → G. Corresponds to variant dbSNP:rs1880024Ensembl. | 1 | |
Natural variantiVAR_066602 | 455 | I → V1 PublicationCorresponds to variant dbSNP:rs34873641Ensembl. | 1 | |
Natural variantiVAR_066603 | 641 | G → A1 PublicationCorresponds to variant dbSNP:rs150441746Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039538 | 1 – 392 | Missing in isoform 3. 1 PublicationAdd BLAST | 392 | |
Alternative sequenceiVSP_020589 | 1 – 241 | Missing in isoform 2. 1 PublicationAdd BLAST | 241 | |
Alternative sequenceiVSP_020590 | 242 – 254 | KEEWF…LIFCP → MCIKFSSVIAKKN in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_020591 | 643 – 652 | ESLSLAEVAN → GKLSTILGRG in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_020592 | 653 – 757 | Missing in isoform 2. 1 PublicationAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093044 mRNA Translation: BAC04031.1 AC104825 Genomic DNA No translation available. AC105345 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82337.1 BC035655 mRNA Translation: AAH35655.1 |
CCDSi | CCDS3402.2 [Q8IYL2-1] |
RefSeqi | NP_689757.2, NM_152544.2 [Q8IYL2-1] |
Genome annotation databases
Ensembli | ENST00000389737; ENSP00000374387; ENSG00000155275 [Q8IYL2-1] ENST00000513449; ENSP00000424643; ENSG00000155275 [Q8IYL2-2] |
GeneIDi | 152992 |
KEGGi | hsa:152992 |
UCSCi | uc003glf.2, human [Q8IYL2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093044 mRNA Translation: BAC04031.1 AC104825 Genomic DNA No translation available. AC105345 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82337.1 BC035655 mRNA Translation: AAH35655.1 |
CCDSi | CCDS3402.2 [Q8IYL2-1] |
RefSeqi | NP_689757.2, NM_152544.2 [Q8IYL2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127475, 31 interactors |
IntActi | Q8IYL2, 9 interactors |
STRINGi | 9606.ENSP00000374387 |
PTM databases
iPTMneti | Q8IYL2 |
PhosphoSitePlusi | Q8IYL2 |
Polymorphism and mutation databases
BioMutai | TRMT44 |
DMDMi | 115311883 |
Proteomic databases
EPDi | Q8IYL2 |
jPOSTi | Q8IYL2 |
MassIVEi | Q8IYL2 |
MaxQBi | Q8IYL2 |
PaxDbi | Q8IYL2 |
PeptideAtlasi | Q8IYL2 |
PRIDEi | Q8IYL2 |
ProteomicsDBi | 71195 [Q8IYL2-1] 71196 [Q8IYL2-2] 71197 [Q8IYL2-3] |
Protocols and materials databases
Antibodypediai | 43421, 31 antibodies |
DNASUi | 152992 |
Genome annotation databases
Ensembli | ENST00000389737; ENSP00000374387; ENSG00000155275 [Q8IYL2-1] ENST00000513449; ENSP00000424643; ENSG00000155275 [Q8IYL2-2] |
GeneIDi | 152992 |
KEGGi | hsa:152992 |
UCSCi | uc003glf.2, human [Q8IYL2-1] |
Organism-specific databases
CTDi | 152992 |
DisGeNETi | 152992 |
EuPathDBi | HostDB:ENSG00000155275.18 |
GeneCardsi | TRMT44 |
HGNCi | HGNC:26653, TRMT44 |
HPAi | ENSG00000155275, Low tissue specificity |
MIMi | 614309, gene |
neXtProti | NX_Q8IYL2 |
PharmGKBi | PA145008869 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3790, Eukaryota |
GeneTreei | ENSGT00390000000645 |
HOGENOMi | CLU_021025_0_0_1 |
InParanoidi | Q8IYL2 |
OMAi | FIYEDLA |
OrthoDBi | 1146281at2759 |
PhylomeDBi | Q8IYL2 |
TreeFami | TF106127 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYL2 |
Reactomei | R-HSA-6782315, tRNA modification in the nucleus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 152992, 3 hits in 842 CRISPR screens |
ChiTaRSi | TRMT44, human |
GenomeRNAii | 152992 |
Pharosi | Q8IYL2, Tdark |
PROi | PR:Q8IYL2 |
RNActi | Q8IYL2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155275, Expressed in right ovary and 117 other tissues |
ExpressionAtlasi | Q8IYL2, baseline and differential |
Genevisiblei | Q8IYL2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR011671, tRNA_uracil_MeTrfase IPR000571, Znf_CCCH |
PANTHERi | PTHR21210, PTHR21210, 1 hit |
Pfami | View protein in Pfam PF07757, AdoMet_MTase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRM44_HUMAN | |
Accessioni | Q8IYL2Primary (citable) accession number: Q8IYL2 Secondary accession number(s): Q8NA95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | September 19, 2006 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations