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Entry version 170 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Synaptotagmin-like protein 1

Gene

SYTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicle trafficking (By similarity).

Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYJ3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854214, TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-like protein 1
Alternative name(s):
Exophilin-7
Protein JFC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYTL1
Synonyms:SLP1
ORF Names:SB146
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15584, SYTL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608042, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYJ3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000142765

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84958

Open Targets

More...
OpenTargetsi
ENSG00000142765

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134921815

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYJ3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYTL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33301659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902111 – 562Synaptotagmin-like protein 1Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYJ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYJ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYJ3

PeptideAtlas

More...
PeptideAtlasi
Q8IYJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71187 [Q8IYJ3-1]
71188 [Q8IYJ3-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IYJ3-2 [Q8IYJ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142765, Expressed in granulocyte and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYJ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYJ3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142765, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Binds NCF2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124389, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYJ3, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000440704

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYJ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYJ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 87RabBDPROSITE-ProRule annotationAdd BLAST57
Domaini266 – 385C2 1PROSITE-ProRule annotationAdd BLAST120
Domaini398 – 527C2 2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni94 – 255DisorderedSequence analysisAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 154Basic and acidic residuesSequence analysisAdd BLAST61
Compositional biasi204 – 218Polar residuesSequence analysisAdd BLAST15
Compositional biasi233 – 255Polar residuesSequence analysisAdd BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1028, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002711_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYJ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFSEECS

Database of Orthologous Groups

More...
OrthoDBi
916843at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYJ3

TreeFam database of animal gene trees

More...
TreeFami
TF341184

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04020, C2B_SLP_1-2-3-4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010911, Rab_BD
IPR028378, Sytl1
IPR043567, SYTL1-5_C2B

The PANTHER Classification System

More...
PANTHERi
PTHR45716:SF3, PTHR45716:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49562, SSF49562, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQRGHPSQE GLWALPSLPM AHGPKPETEG LLDLSFLTEE EQEAIAGVLQ
60 70 80 90 100
RDARLRQLEE GRVSKLRASV ADPGQLKILT GDWFQEARSQ RHHNAHFGSD
110 120 130 140 150
LVRASMRRKK STRGDQAPGH DREAEAAVKE KEEGPEPRLT IDEAPQERLR
160 170 180 190 200
ETEGPDFPSP SVPLKASDPE EASQAQEDPG QGDQQVCAEE ADPELEPASG
210 220 230 240 250
GEQEPRPQQA QTKAASQILE NGEEAPGPDP SLDRMLSSSS SVSSLNSSTL
260 270 280 290 300
SGSQMSLSGD AEAVQVRGSV HFALHYEPGA AELRVHVIQC QGLAAARRRR
310 320 330 340 350
SDPYVKSYLL PDKQSKRKTA VKKRNLNPVF NETLRYSVPQ AELQGRVLSL
360 370 380 390 400
SVWHRESLGR NIFLGEVEVP LDTWDWGSEP TWLPLQPRVP PSPDDLPSRG
410 420 430 440 450
LLALSLKYVP AGSEGAGLPP SGELHFWVKE ARDLLPLRAG SLDTYVQCFV
460 470 480 490 500
LPDDSQASRQ RTRVVRRSLS PVFNHTMVYD GFGPADLRQA CAELSLWDHG
510 520 530 540 550
ALANRQLGGT RLSLGTGSSY GLQVPWMDST PEEKQLWQAL LEQPCEWVDG
560
LLPLRTNLAP RT
Length:562
Mass (Da):61,857
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i056BE1F16723EE19
GO
Isoform 2 (identifier: Q8IYJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-165: Missing.

Show »
Length:550
Mass (Da):60,635
Checksum:i9FE6477065A8F01A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1N4A0A087X1N4_HUMAN
Synaptotagmin-like protein 1
SYTL1
497Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SSC6Q5SSC6_HUMAN
Synaptotagmin-like protein 1
SYTL1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111S → N in AAK67636 (Ref. 1) Curated1
Sequence conflicti162V → A in AAH15764 (PubMed:15489334).Curated1
Sequence conflicti456Q → R in AAK67636 (Ref. 1) Curated1
Sequence conflicti456Q → R in AAH09224 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007883154 – 165Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY037157 mRNA Translation: AAK67636.1
AK027902 mRNA Translation: BAB55444.1
FO393419 Genomic DNA No translation available.
BC009224 mRNA Translation: AAH09224.2
BC015764 mRNA Translation: AAH15764.1 Different initiation.
BC035725 mRNA Translation: AAH35725.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS298.1 [Q8IYJ3-2]
CCDS53286.1 [Q8IYJ3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001180237.1, NM_001193308.1 [Q8IYJ3-1]
NP_116261.1, NM_032872.2 [Q8IYJ3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318074; ENSP00000316464; ENSG00000142765 [Q8IYJ3-2]
ENST00000543823; ENSP00000440704; ENSG00000142765 [Q8IYJ3-1]
ENST00000616558; ENSP00000481032; ENSG00000142765 [Q8IYJ3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84958

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84958

UCSC genome browser

More...
UCSCi
uc001bnv.3, human [Q8IYJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037157 mRNA Translation: AAK67636.1
AK027902 mRNA Translation: BAB55444.1
FO393419 Genomic DNA No translation available.
BC009224 mRNA Translation: AAH09224.2
BC015764 mRNA Translation: AAH15764.1 Different initiation.
BC035725 mRNA Translation: AAH35725.1
CCDSiCCDS298.1 [Q8IYJ3-2]
CCDS53286.1 [Q8IYJ3-1]
RefSeqiNP_001180237.1, NM_001193308.1 [Q8IYJ3-1]
NP_116261.1, NM_032872.2 [Q8IYJ3-2]

3D structure databases

SMRiQ8IYJ3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124389, 13 interactors
IntActiQ8IYJ3, 14 interactors
STRINGi9606.ENSP00000440704

PTM databases

iPTMnetiQ8IYJ3
PhosphoSitePlusiQ8IYJ3

Genetic variation databases

BioMutaiSYTL1
DMDMi33301659

Proteomic databases

EPDiQ8IYJ3
jPOSTiQ8IYJ3
MassIVEiQ8IYJ3
MaxQBiQ8IYJ3
PaxDbiQ8IYJ3
PeptideAtlasiQ8IYJ3
PRIDEiQ8IYJ3
ProteomicsDBi71187 [Q8IYJ3-1]
71188 [Q8IYJ3-2]
TopDownProteomicsiQ8IYJ3-2 [Q8IYJ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51546, 106 antibodies

The DNASU plasmid repository

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DNASUi
84958

Genome annotation databases

EnsembliENST00000318074; ENSP00000316464; ENSG00000142765 [Q8IYJ3-2]
ENST00000543823; ENSP00000440704; ENSG00000142765 [Q8IYJ3-1]
ENST00000616558; ENSP00000481032; ENSG00000142765 [Q8IYJ3-1]
GeneIDi84958
KEGGihsa:84958
UCSCiuc001bnv.3, human [Q8IYJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84958
DisGeNETi84958

GeneCards: human genes, protein and diseases

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GeneCardsi
SYTL1
HGNCiHGNC:15584, SYTL1
HPAiENSG00000142765, Low tissue specificity
MIMi608042, gene
neXtProtiNX_Q8IYJ3
OpenTargetsiENSG00000142765
PharmGKBiPA134921815
VEuPathDBiHostDB:ENSG00000142765

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000160932
HOGENOMiCLU_002711_4_0_1
InParanoidiQ8IYJ3
OMAiWFSEECS
OrthoDBi916843at2759
PhylomeDBiQ8IYJ3
TreeFamiTF341184

Enzyme and pathway databases

PathwayCommonsiQ8IYJ3
ReactomeiR-HSA-8854214, TBC/RABGAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84958, 21 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYTL1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SYTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84958
PharosiQ8IYJ3, Tbio

Protein Ontology

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PROi
PR:Q8IYJ3
RNActiQ8IYJ3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000142765, Expressed in granulocyte and 158 other tissues
ExpressionAtlasiQ8IYJ3, baseline and differential
GenevisibleiQ8IYJ3, HS

Family and domain databases

CDDicd04020, C2B_SLP_1-2-3-4, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010911, Rab_BD
IPR028378, Sytl1
IPR043567, SYTL1-5_C2B
PANTHERiPTHR45716:SF3, PTHR45716:SF3, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF49562, SSF49562, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50916, RABBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYJ3
Secondary accession number(s): Q5SSC9
, Q96BB6, Q96GU6, Q96S89, Q96SI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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