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Protein

Exocyst complex component 8

Gene

EXOC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

  • endosome organization Source: UniProtKB
  • exocyst assembly Source: GO_Central
  • exocyst localization Source: GO_Central
  • extracellular matrix disassembly Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of macroautophagy Source: ParkinsonsUK-UCL

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 8
Alternative name(s):
Exocyst complex 84 kDa subunit
Gene namesi
Name:EXOC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116903.7
HGNCiHGNC:24659 EXOC8
MIMi615283 gene
neXtProtiNX_Q8IYI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi149371
OpenTargetsiENSG00000116903
PharmGKBiPA134991382

Polymorphism and mutation databases

BioMutaiEXOC8
DMDMi74750763

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275501 – 725Exocyst complex component 8Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei142PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYI6
MaxQBiQ8IYI6
PaxDbiQ8IYI6
PeptideAtlasiQ8IYI6
PRIDEiQ8IYI6
ProteomicsDBi71180

PTM databases

iPTMnetiQ8IYI6
PhosphoSitePlusiQ8IYI6

Expressioni

Gene expression databases

BgeeiENSG00000116903 Expressed in 203 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_EXOC8
GenevisibleiQ8IYI6 HS

Organism-specific databases

HPAiHPA027438

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH domain) with GTP-bound RALA and RALB (PubMed:14525976, PubMed:18756269). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127206, 58 interactors
CORUMiQ8IYI6
IntActiQ8IYI6, 89 interactors
MINTiQ8IYI6
STRINGi9606.ENSP00000353564

Structurei

3D structure databases

ProteinModelPortaliQ8IYI6
SMRiQ8IYI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 282PHPROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 117Poly-Ala10
Compositional biasi316 – 319Poly-Glu4

Sequence similaritiesi

Belongs to the EXO84 family.Curated

Phylogenomic databases

eggNOGiKOG2215 Eukaryota
ENOG410XT7U LUCA
GeneTreeiENSGT00390000015936
HOGENOMiHOG000006737
HOVERGENiHBG081489
InParanoidiQ8IYI6
KOiK19986
OMAiHAFLMND
OrthoDBiEOG091G0349
PhylomeDBiQ8IYI6
TreeFamiTF105819

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR033961 Exo84
IPR032403 Exo84_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21426 PTHR21426, 1 hit
PfamiView protein in Pfam
PF16528 Exo84_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IYI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMAMSDSGA SRLRRQLESG GFEARLYVKQ LSQQSDGDRD LQEHRQRIQA
60 70 80 90 100
LAEETAQNLK RNVYQNYRQF IETAREISYL ESEMYQLSHL LTEQKSSLES
110 120 130 140 150
IPLTLLPAAA AAGAAAASGG EEGVGGAGGR DHLRGQAGFF STPGGASRDG
160 170 180 190 200
SGPGEEGKQR TLTTLLEKVE GCRHLLETPG QYLVYNGDLV EYDADHMAQL
210 220 230 240 250
QRVHGFLMND CLLVATWLPQ RRGMYRYNAL YSLDGLAVVN VKDNPPMKDM
260 270 280 290 300
FKLLMFPESR IFQAENAKIK REWLEVLEDT KRALSEKRRR EQEEAAAPRG
310 320 330 340 350
PPQVTSKATN PFEDDEEEEP AVPEVEEEKV DLSMEWIQEL PEDLDVCIAQ
360 370 380 390 400
RDFEGAVDLL DKLNHYLEDK PSPPPVKELR AKVEERVRQL TEVLVFELSP
410 420 430 440 450
DRSLRGGPKA TRRAVSQLIR LGQCTKACEL FLRNRAAAVH TAIRQLRIEG
460 470 480 490 500
ATLLYIHKLC HVFFTSLLET AREFEIDFAG TDSGCYSAFV VWARSAMGMF
510 520 530 540 550
VDAFSKQVFD SKESLSTAAE CVKVAKEHCQ QLGDIGLDLT FIIHALLVKD
560 570 580 590 600
IQGALHSYKE IIIEATKHRN SEEMWRRMNL MTPEALGKLK EEMKSCGVSN
610 620 630 640 650
FEQYTGDDCW VNLSYTVVAF TKQTMGFLEE ALKLYFPELH MVLLESLVEI
660 670 680 690 700
ILVAVQHVDY SLRCEQDPEK KAFIRQNASF LYETVLPVVE KRFEEGVGKP
710 720
AKQLQDLRNA SRLIRVNPES TTSVV
Length:725
Mass (Da):81,799
Last modified:July 5, 2004 - v2
Checksum:iF4E5E344EF24FDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096460 mRNA Translation: BAG53295.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69955.1
BC035763 mRNA Translation: AAH35763.2
CCDSiCCDS1593.1
RefSeqiNP_787072.2, NM_175876.4
UniGeneiHs.356198
Hs.554892

Genome annotation databases

EnsembliENST00000366645; ENSP00000355605; ENSG00000116903
GeneIDi149371
KEGGihsa:149371
UCSCiuc001huq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096460 mRNA Translation: BAG53295.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69955.1
BC035763 mRNA Translation: AAH35763.2
CCDSiCCDS1593.1
RefSeqiNP_787072.2, NM_175876.4
UniGeneiHs.356198
Hs.554892

3D structure databases

ProteinModelPortaliQ8IYI6
SMRiQ8IYI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127206, 58 interactors
CORUMiQ8IYI6
IntActiQ8IYI6, 89 interactors
MINTiQ8IYI6
STRINGi9606.ENSP00000353564

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ8IYI6
PhosphoSitePlusiQ8IYI6

Polymorphism and mutation databases

BioMutaiEXOC8
DMDMi74750763

Proteomic databases

EPDiQ8IYI6
MaxQBiQ8IYI6
PaxDbiQ8IYI6
PeptideAtlasiQ8IYI6
PRIDEiQ8IYI6
ProteomicsDBi71180

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366645; ENSP00000355605; ENSG00000116903
GeneIDi149371
KEGGihsa:149371
UCSCiuc001huq.4 human

Organism-specific databases

CTDi149371
DisGeNETi149371
EuPathDBiHostDB:ENSG00000116903.7
GeneCardsiEXOC8
HGNCiHGNC:24659 EXOC8
HPAiHPA027438
MIMi615283 gene
neXtProtiNX_Q8IYI6
OpenTargetsiENSG00000116903
PharmGKBiPA134991382
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2215 Eukaryota
ENOG410XT7U LUCA
GeneTreeiENSGT00390000015936
HOGENOMiHOG000006737
HOVERGENiHBG081489
InParanoidiQ8IYI6
KOiK19986
OMAiHAFLMND
OrthoDBiEOG091G0349
PhylomeDBiQ8IYI6
TreeFamiTF105819

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

GeneWikiiEXOC8
GenomeRNAii149371
PROiPR:Q8IYI6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116903 Expressed in 203 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_EXOC8
GenevisibleiQ8IYI6 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR033961 Exo84
IPR032403 Exo84_C
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21426 PTHR21426, 1 hit
PfamiView protein in Pfam
PF16528 Exo84_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC8_HUMAN
AccessioniPrimary (citable) accession number: Q8IYI6
Secondary accession number(s): B3KU33, Q5TE82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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