UniProtKB - Q8IYH5 (ZZZ3_HUMAN)

BLAST

>sp|Q8IYH5|ZZZ3_HUMAN ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1
MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQVRSRSPKKRPEPVPIQ
KGNNNGRTTDLKQQSTRESWVSPRKRGLSSSEKDNIERQAIENCERRQTEPVSPVLKRIK
RCLRSEAPNSSEEDSPIKSDKESVEQRSTVVDNDADFQGTKRACRCLILDDCEKREIKKV
NVSEEGPLNSAVVEEITGYLAVNGVDDSDSAVINCDDCQPDGNTKQNSIGSYVLQEKSVA
ENGDTDTQTSMFLDSRKEDSYIDHKVPCTDSQVQVKLEDHKIVTACLPVEHVNQLTTEPA
TGPFSETQSSLRDSEEEVDVVGDSSASKEQCKENTNNELDTSLESMPASGEPEPSPVLDC
VSAQMMSLSEPQEHRYTLRTSPRRAAPTRGSPTKNSSPYRENGQFEENNLSPNETNATVS
DNVSQSPTNPGEISQNEKGICCDSQNNGSEGVSKPPSEARLNIGHLPSAKESASQHITEE
EDDDPDVYYFESDHVALKHNKDYQRLLQTIAVLEAQRSQAVQDLESLGRHQREALKNPIG
FVEKLQKKADIGLPYPQRVVQLPEIVWDQYTHSLGNFEREFKNRKRHTRRVKLVFDKVGL
PARPKSPLDPKKDGESLSYSMLPLSDGPEGSSSRPQMIRGRLCDDTKPETFNQLWTVEEQ
KKLEQLLIKYPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNL
YIYSKKSSTSRRQHPLNKHLFKPSTFMTSHEPPVYMDEDDDRSCFHSHMNTAVEDASDDE
SIPIMYRNLPEYKELLQFKKLKKQKLQQMQAESGFVQHVGFKCDNCGIEPIQGVRWHCQD
CPPEMSLDFCDSCSDCLHETDIHKEDHQLEPIYRSETFLDRDYCVSQGTSYNYLDPNYFP
ANR

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Format
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History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

ZZ-type zinc finger-containing protein 3

Gene

ZZZ3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	680 – 703	H-T-H motifPROSITE-ProRule annotationAdd BLAST		24
Zinc fingerⁱ	817 – 867	ZZ-typePROSITE-ProRule annotationAdd BLAST		51

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A22.007

MEROPSⁱ

A22.007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ZZ-type zinc finger-containing protein 3
Gene namesⁱ	Name:ZZZ3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000036549.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24523 ZZZ3
neXtProtⁱ	NX_Q8IYH5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26009
Open Targets More...OpenTargetsⁱ	ENSG00000036549
PharmGKBⁱ	PA134873184

Polymorphism and mutation databases

BioMutaⁱ	ZZZ3
DMDMⁱ	74762495

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287495	1 – 903	ZZ-type zinc finger-containing protein 3Add BLAST		903

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	89	PhosphoserineCombined sources	1
Modified residueⁱ	113	PhosphoserineCombined sources	1
Modified residueⁱ	130	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphoserineCombined sources	1
Modified residueⁱ	135	PhosphoserineCombined sources	1
Cross-linkⁱ	276	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	394	N6-acetyllysineBy similarity	1
Modified residueⁱ	606	PhosphoserineCombined sources	1
Cross-linkⁱ	647	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	701	N6-acetyllysineCombined sources	1
Cross-linkⁱ	708	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8IYH5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IYH5
PaxDbⁱ	Q8IYH5
PeptideAtlas More...PeptideAtlasⁱ	Q8IYH5
PRIDEⁱ	Q8IYH5
ProteomicsDBⁱ	71174 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4]

PTM databases

iPTMnetⁱ	Q8IYH5
PhosphoSitePlusⁱ	Q8IYH5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000036549 Expressed in 223 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ZZZ3
ExpressionAtlasⁱ	Q8IYH5 baseline and differential
Genevisibleⁱ	Q8IYH5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053663 HPA054913 HPA066197

HPAⁱ

HPA053663
HPA054913
HPA066197

Interactionⁱ

Subunit structureⁱ

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FAM124A	Q86V42	3	EBI-2795524,EBI-744506
Hoxa1	P09022	3	EBI-2795524,EBI-3957603	From Mus musculus.
KAT2A	Q92830	2	EBI-2795524,EBI-477622

Protein-protein interaction databases

BioGridⁱ	117482, 52 interactors
ComplexPortalⁱ	CPX-1004 PCAF-containing ATAC complex CPX-997 GCN5-containing ATAC complex
CORUMⁱ	Q8IYH5
Database of interacting proteins More...DIPⁱ	DIP-47289N
IntActⁱ	Q8IYH5, 23 interactors
Molecular INTeraction database More...MINTⁱ	Q8IYH5
STRINGⁱ	9606.ENSP00000359837

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	657 – 669	Combined sources	13
Helixⁱ	676 – 687	Combined sources	12
Beta strandⁱ	688 – 690	Combined sources	3
Helixⁱ	692 – 703	Combined sources	12
Helixⁱ	704 – 706	Combined sources	3
Beta strandⁱ	807 – 809	Combined sources	3
Beta strandⁱ	817 – 820	Combined sources	4
Beta strandⁱ	824 – 826	Combined sources	3
Beta strandⁱ	829 – 833	Combined sources	5
Beta strandⁱ	835 – 841	Combined sources	7
Beta strandⁱ	843 – 845	Combined sources	3
Beta strandⁱ	848 – 850	Combined sources	3
Helixⁱ	851 – 853	Combined sources	3
Beta strandⁱ	865 – 867	Combined sources	3
Beta strandⁱ	869 – 872	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IYH5
SMRⁱ	Q8IYH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8IYH5

EvolutionaryTraceⁱ

Q8IYH5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	647 – 707	HTH myb-typePROSITE-ProRule annotationAdd BLAST		61

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	817 – 867	ZZ-typePROSITE-ProRule annotationAdd BLAST		51

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IHEM Eukaryota ENOG410ZINA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005307
HOVERGENⁱ	HBG062668
InParanoidⁱ	Q8IYH5
OMAⁱ	VPCTNSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H07
PhylomeDBⁱ	Q8IYH5
TreeFamⁱ	TF106396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167 SANT, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR000433 Znf_ZZ IPR037830 ZZZ3
PANTHERⁱ	PTHR22705:SF0 PTHR22705:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00249 Myb_DNA-binding, 1 hit PF00569 ZZ, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 1 hit PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL 
       610        620        630        640        650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET 
       660        670        680        690        700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ 
       710        720        730        740        750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH 
       760        770        780        790        800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK 
       810        820        830        840        850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC 
       860        870        880        890        900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP 

ANR

Length:903

Mass (Da):102,023

Last modified:March 1, 2003 - v1

Checksum:ⁱ16ED137C0A8202EA

Isoform 2 (identifier: Q8IYH5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
598-598: Missing.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKGLP 
       610        620        630        640        650
ARPKSPLDPK KDGESLSYSM LPLSDGPEGS SSRPQMIRGR LCDDTKPETF 
       660        670        680        690        700
NQLWTVEEQK KLEQLLIKYP PEEVESRRWQ KIADELGNRT AKQVASRVQK 
       710        720        730        740        750
YFIKLTKAGI PVPGRTPNLY IYSKKSSTSR RQHPLNKHLF KPSTFMTSHE 
       760        770        780        790        800
PPVYMDEDDD RSCFHSHMNT AVEDASDDES IPIMYRNLPE YKELLQFKKL 
       810        820        830        840        850
KKQKLQQMQA ESGFVQHVGF KCDNCGIEPI QGVRWHCQDC PPEMSLDFCD 
       860        870        880        890        900
SCSDCLHETD IHKEDHQLEP IYRSETFLDR DYCVSQGTSY NYLDPNYFPA 

NR

Show »

Length:902

Mass (Da):101,924

Checksum:ⁱB7E306C19A1011D8

Isoform 3 (identifier: Q8IYH5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-494: Missing.
495-502: VALKHNKD → MIDLWLYS

« Hide

        10         20         30         40         50
MIDLWLYSYQ RLLQTIAVLE AQRSQAVQDL ESLGRHQREA LKNPIGFVEK 
        60         70         80         90        100
LQKKADIGLP YPQRVVQLPE IVWDQYTHSL GNFEREFKNR KRHTRRVKLV 
       110        120        130        140        150
FDKVGLPARP KSPLDPKKDG ESLSYSMLPL SDGPEGSSSR PQMIRGRLCD 
       160        170        180        190        200
DTKPETFNQL WTVEEQKKLE QLLIKYPPEE VESRRWQKIA DELGNRTAKQ 
       210        220        230        240        250
VASRVQKYFI KLTKAGIPVP GRTPNLYIYS KKSSTSRRQH PLNKHLFKPS 
       260        270        280        290        300
TFMTSHEPPV YMDEDDDRSC FHSHMNTAVE DASDDESIPI MYRNLPEYKE 
       310        320        330        340        350
LLQFKKLKKQ KLQQMQAESG FVQHVGFKCD NCGIEPIQGV RWHCQDCPPE 
       360        370        380        390        400
MSLDFCDSCS DCLHETDIHK EDHQLEPIYR SETFLDRDYC VSQGTSYNYL 

DPNYFPANR

Note: No experimental confirmation available.

Show »

Length:409

Mass (Da):47,716

Checksum:ⁱE0ADB97A8D186009

Isoform 4 (identifier: Q8IYH5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
661-683: KKLEQLLIKYPPEEVESRRWQKI → VINISKSCRLKKTSKQLTSESVL
684-903: Missing.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL 
       610        620        630        640        650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET 
       660        670        680 
FNQLWTVEEQ VINISKSCRL KKTSKQLTSE SVL

Note: No experimental confirmation available.

Show »

Length:683

Mass (Da):76,126

Checksum:ⁱ50C9B12134DB1D66

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	596	D → G in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	655	W → G in CAB45694 (PubMed:17974005).Curated	1
Sequence conflictⁱ	698	R → Q in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	721	Y → C in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	807	Q → R in CAE45800 (PubMed:17974005).Curated	1
Sequence conflictⁱ	877	T → A in CAE45870 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035718	456	P → S in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_025509	1 – 494	Missing in isoform 3. 1 PublicationAdd BLAST	494
Alternative sequenceⁱVSP_025510	495 – 502	VALKHNKD → MIDLWLYS in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_025511	598	Missing in isoform 2. 2 Publications	1
Alternative sequenceⁱVSP_025512	661 – 683	KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_025513	684 – 903	Missing in isoform 4. 1 PublicationAdd BLAST	220

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3]
PIRⁱ	T12463
NCBI Reference Sequences More...RefSeqⁱ	NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 [Q8IYH5-1] XP_005270783.1, XM_005270726.3 [Q8IYH5-1] XP_005270784.1, XM_005270727.3 [Q8IYH5-2] XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1 [Q8IYH5-2]
UniGeneⁱ	Hs.480506

Genome annotation databases

GeneIDⁱ	26009
KEGGⁱ	hsa:26009
UCSC genome browser More...UCSCⁱ	uc001dhq.4 human [Q8IYH5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IYH5	ZZ-type zinc finger-containing protein 3 (Fragment)		wild yak		916	UniRef90_Q8IYH5
Putative zz-type zinc finger-containing protein 3 (Fragment)		DESRO		915
Uncharacterized protein		OTOGA		910
Zinc finger ZZ-type containing 3		HORSE		910
Uncharacterized protein		AILME		910
+177
Q8IYH5-3	Isoform 3 of ZZ-type zinc finger-containing protein 3		MOUSE		413	UniRef90_Q6KAQ7-3
ZZ-type zinc finger-containing protein 3 isoform X3		DIPOR		410
ZZ-type zinc finger-containing protein 3 isoform X5		Yangtze finless porpoise		409
Uncharacterized protein		MANLE		409
Uncharacterized protein		ICTTR		409
+61
Q8IYH5-4	Uncharacterized protein		CALJA		850	UniRef90_Q8IYH5-4
UPI000809D4D6		Cebus capucinus imitator		850

Protein	Similar proteins		Species	Score	Length	Source
Q8IYH5	ZZ-type zinc finger-containing protein 3		MOUSE		910	UniRef50_Q8IYH5
ZZ-type zinc finger-containing protein 3 (Fragment)		wild yak		916
Putative zz-type zinc finger-containing protein 3 (Fragment)		DESRO		915
Zinc finger ZZ-type containing 3		HORSE		910
Uncharacterized protein		ICTTR		910
+445
Q8IYH5-3	Isoform 3 of ZZ-type zinc finger-containing protein 3		MOUSE		413	UniRef50_Q6KAQ7-3
ZZ-type zinc finger-containing protein 3 isoform X3		DIPOR		410
ZZ-type zinc finger-containing protein 3 isoform X3		Enhydra lutris kenyoni		409
ZZ-type zinc finger-containing protein 3 isoform X3		PHYCD		409
Uncharacterized protein		PAPAN		409
+79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1
CCDSⁱ	CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3]
PIRⁱ	T12463
RefSeqⁱ	NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 [Q8IYH5-1] XP_005270783.1, XM_005270726.3 [Q8IYH5-1] XP_005270784.1, XM_005270727.3 [Q8IYH5-2] XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1 [Q8IYH5-2]
UniGeneⁱ	Hs.480506

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FC7	NMR	-	A	807-886	[»]
	2YUM	NMR	-	A	652-713	[»]
	6E83	NMR	-	B	816-874	[»]
	6E86	NMR	-	B	816-874	[»]
ProteinModelPortalⁱ	Q8IYH5
SMRⁱ	Q8IYH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117482, 52 interactors
ComplexPortalⁱ	CPX-1004 PCAF-containing ATAC complex CPX-997 GCN5-containing ATAC complex
CORUMⁱ	Q8IYH5
DIPⁱ	DIP-47289N
IntActⁱ	Q8IYH5, 23 interactors
MINTⁱ	Q8IYH5
STRINGⁱ	9606.ENSP00000359837

Protein family/group databases

MEROPSⁱ	A22.007

MEROPSⁱ

A22.007

PTM databases

iPTMnetⁱ	Q8IYH5
PhosphoSitePlusⁱ	Q8IYH5

Polymorphism and mutation databases

BioMutaⁱ	ZZZ3
DMDMⁱ	74762495

Proteomic databases

EPDⁱ	Q8IYH5
MaxQBⁱ	Q8IYH5
PaxDbⁱ	Q8IYH5
PeptideAtlasⁱ	Q8IYH5
PRIDEⁱ	Q8IYH5
ProteomicsDBⁱ	71174 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26009
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	26009
KEGGⁱ	hsa:26009
UCSCⁱ	uc001dhq.4 human [Q8IYH5-1]

Organism-specific databases

CTDⁱ	26009
DisGeNETⁱ	26009
EuPathDBⁱ	HostDB:ENSG00000036549.12
GeneCardsⁱ	ZZZ3
HGNCⁱ	HGNC:24523 ZZZ3
HPAⁱ	HPA053663 HPA054913 HPA066197
neXtProtⁱ	NX_Q8IYH5
OpenTargetsⁱ	ENSG00000036549
PharmGKBⁱ	PA134873184
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHEM Eukaryota ENOG410ZINA LUCA
GeneTreeⁱ	ENSGT00390000005307
HOVERGENⁱ	HBG062668
InParanoidⁱ	Q8IYH5
OMAⁱ	VPCTNSE
OrthoDBⁱ	EOG091G0H07
PhylomeDBⁱ	Q8IYH5
TreeFamⁱ	TF106396

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214847 HATs acetylate histones

Reactomeⁱ

R-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSⁱ	ZZZ3 human
EvolutionaryTraceⁱ	Q8IYH5
GeneWikiⁱ	ZZZ3
GenomeRNAiⁱ	26009
Protein Ontology More...PROⁱ	PR:Q8IYH5

Gene expression databases

Bgeeⁱ	ENSG00000036549 Expressed in 223 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ZZZ3
ExpressionAtlasⁱ	Q8IYH5 baseline and differential
Genevisibleⁱ	Q8IYH5 HS

Family and domain databases

CDDⁱ	cd00167 SANT, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR000433 Znf_ZZ IPR037830 ZZZ3
PANTHERⁱ	PTHR22705:SF0 PTHR22705:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF00249 Myb_DNA-binding, 1 hit PF00569 ZZ, 1 hit
SMARTⁱ	View protein in SMART SM00717 SANT, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 1 hit PS01357 ZF_ZZ_1, 1 hit PS50135 ZF_ZZ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZZZ3_HUMAN
Accessionⁱ	Q8IYH5Primary (citable) accession number: Q8IYH5 Secondary accession number(s): B7WPC6 Q9Y4U0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8IYH5 (ZZZ3_HUMAN)

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ZZ-type zinc finger-containing protein 3

ZZZ3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ