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UniProtKB - Q8IYH5 (ZZZ3_HUMAN)

Entry version 174 (07 Apr 2021)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

ZZ-type zinc finger-containing protein 3

Gene

ZZZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi680 – 703H-T-H motifPROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • histone H4 acetylation Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IYH5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones

Protein family/group databases

MEROPS protease database

More...MEROPSi		A22.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ZZ-type zinc finger-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZZZ3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24523, ZZZ3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IYH5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000036549.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26009

Open Targets

More...OpenTargetsi		ENSG00000036549

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134873184

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IYH5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZZZ3

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874951 – 903ZZ-type zinc finger-containing protein 3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei394N6-acetyllysineBy similarity1
Modified residuei606PhosphoserineCombined sources1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei701N6-acetyllysineCombined sources1
Cross-linki708Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IYH5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IYH5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IYH5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IYH5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IYH5

PeptideAtlas

More...PeptideAtlasi		Q8IYH5

PRoteomics IDEntifications database

More...PRIDEi		Q8IYH5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71174 [Q8IYH5-1]
71175 [Q8IYH5-2]
71176 [Q8IYH5-3]
71177 [Q8IYH5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IYH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IYH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000036549, Expressed in corpus callosum and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IYH5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IYH5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000036549, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117482, 66 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IYH5

Database of interacting proteins

More...DIPi		DIP-47289N

Protein interaction database and analysis system

More...IntActi		Q8IYH5, 38 interactors

Molecular INTeraction database

More...MINTi		Q8IYH5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359837

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IYH5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IYH5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IYH5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini647 – 707HTH myb-typePROSITE-ProRule annotationAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS4F, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_319257_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IYH5

Identification of Orthologs from Complete Genome Data

More...OMAi		TELYEHR

Database of Orthologous Groups

More...OrthoDBi		139813at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IYH5

TreeFam database of animal gene trees

More...TreeFami		TF106396

Family and domain databases

Conserved Domains Database

More...CDDi		cd02341, ZZ_ZZZ3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR037830, ZZZ3
IPR041981, ZZZ3_ZZ

The PANTHER Classification System

More...PANTHERi		PTHR22705, PTHR22705, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF00569, ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00717, SANT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51294, HTH_MYB, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL 
       610        620        630        640        650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET 
       660        670        680        690        700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ 
       710        720        730        740        750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH 
       760        770        780        790        800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK 
       810        820        830        840        850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC 
       860        870        880        890        900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP 

ANR
Length:903
Mass (Da):102,023
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16ED137C0A8202EA
GO
Isoform 2 (identifier: Q8IYH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-598: Missing.

Show »
Length:902
Mass (Da):101,924
Checksum:iB7E306C19A1011D8
GO
Isoform 3 (identifier: Q8IYH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-494: Missing.
     495-502: VALKHNKD → MIDLWLYS

Show »
Length:409
Mass (Da):47,716
Checksum:iE0ADB97A8D186009
GO
Isoform 4 (identifier: Q8IYH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-683: KKLEQLLIKYPPEEVESRRWQKI → VINISKSCRLKKTSKQLTSESVL
     684-903: Missing.

Show »
Length:683
Mass (Da):76,126
Checksum:i50C9B12134DB1D66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUA4C9JUA4_HUMAN
ZZ-type zinc finger-containing prot...
ZZZ3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J283C9J283_HUMAN
ZZ-type zinc finger-containing prot...
ZZZ3
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti596D → G in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti655W → G in CAB45694 (PubMed:17974005).Curated1
Sequence conflicti698R → Q in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti721Y → C in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti807Q → R in CAE45800 (PubMed:17974005).Curated1
Sequence conflicti877T → A in CAE45870 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035718456P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255091 – 494Missing in isoform 3. 1 PublicationAdd BLAST494
Alternative sequenceiVSP_025510495 – 502VALKHNKD → MIDLWLYS in isoform 3. 1 Publication8
Alternative sequenceiVSP_025511598Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_025512661 – 683KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025513684 – 903Missing in isoform 4. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL080063 mRNA Translation: CAB45694.1
BX641001 mRNA Translation: CAE46004.1
BX640658 mRNA Translation: CAE45800.1
BX640766 mRNA Translation: CAE45870.1
AC093575 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06376.1
BC035397 mRNA Translation: AAH35397.1
BC035079 mRNA Translation: AAH35079.1
BC035818 mRNA Translation: AAH35818.1
AK074119 mRNA Translation: BAB84945.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS677.1 [Q8IYH5-1]
CCDS76172.1 [Q8IYH5-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T12463

NCBI Reference Sequences

More...RefSeqi		NP_001295166.1, NM_001308237.1 [Q8IYH5-3]
NP_056349.1, NM_015534.5 [Q8IYH5-1]
XP_005270782.1, XM_005270725.3
XP_005270783.1, XM_005270726.3
XP_005270784.1, XM_005270727.3
XP_005270786.1, XM_005270729.4 [Q8IYH5-3]
XP_016856459.1, XM_017000970.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3]
ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26009

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26009

UCSC genome browser

More...UCSCi		uc001dhq.4, human [Q8IYH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080063 mRNA Translation: CAB45694.1
BX641001 mRNA Translation: CAE46004.1
BX640658 mRNA Translation: CAE45800.1
BX640766 mRNA Translation: CAE45870.1
AC093575 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06376.1
BC035397 mRNA Translation: AAH35397.1
BC035079 mRNA Translation: AAH35079.1
BC035818 mRNA Translation: AAH35818.1
AK074119 mRNA Translation: BAB84945.1
CCDSiCCDS677.1 [Q8IYH5-1]
CCDS76172.1 [Q8IYH5-3]
PIRiT12463
RefSeqiNP_001295166.1, NM_001308237.1 [Q8IYH5-3]
NP_056349.1, NM_015534.5 [Q8IYH5-1]
XP_005270782.1, XM_005270725.3
XP_005270783.1, XM_005270726.3
XP_005270784.1, XM_005270727.3
XP_005270786.1, XM_005270729.4 [Q8IYH5-3]
XP_016856459.1, XM_017000970.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FC7NMR-A807-886[»]
2YUMNMR-A652-713[»]
6E83NMR-B816-874[»]
6E86NMR-B816-874[»]
SMRiQ8IYH5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117482, 66 interactors
ComplexPortaliCPX-1004, PCAF-containing ATAC complex
CPX-997, GCN5-containing ATAC complex
CORUMiQ8IYH5
DIPiDIP-47289N
IntActiQ8IYH5, 38 interactors
MINTiQ8IYH5
STRINGi9606.ENSP00000359837

Protein family/group databases

MEROPSiA22.007

PTM databases

iPTMnetiQ8IYH5
PhosphoSitePlusiQ8IYH5

Genetic variation databases

BioMutaiZZZ3
DMDMi74762495

Proteomic databases

EPDiQ8IYH5
jPOSTiQ8IYH5
MassIVEiQ8IYH5
MaxQBiQ8IYH5
PaxDbiQ8IYH5
PeptideAtlasiQ8IYH5
PRIDEiQ8IYH5
ProteomicsDBi71174 [Q8IYH5-1]
71175 [Q8IYH5-2]
71176 [Q8IYH5-3]
71177 [Q8IYH5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33487, 87 antibodies

The DNASU plasmid repository

More...DNASUi		26009

Genome annotation databases

EnsembliENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3]
ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1]
GeneIDi26009
KEGGihsa:26009
UCSCiuc001dhq.4, human [Q8IYH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26009
DisGeNETi26009

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZZZ3
HGNCiHGNC:24523, ZZZ3
HPAiENSG00000036549, Low tissue specificity
neXtProtiNX_Q8IYH5
OpenTargetsiENSG00000036549
PharmGKBiPA134873184
VEuPathDBiHostDB:ENSG00000036549.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QS4F, Eukaryota
GeneTreeiENSGT00390000005307
HOGENOMiCLU_319257_0_0_1
InParanoidiQ8IYH5
OMAiTELYEHR
OrthoDBi139813at2759
PhylomeDBiQ8IYH5
TreeFamiTF106396

Enzyme and pathway databases

PathwayCommonsiQ8IYH5
ReactomeiR-HSA-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26009, 176 hits in 1025 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZZZ3, human
EvolutionaryTraceiQ8IYH5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZZZ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26009
PharosiQ8IYH5, Tdark

Protein Ontology

More...PROi		PR:Q8IYH5
RNActiQ8IYH5, protein

Gene expression databases

BgeeiENSG00000036549, Expressed in corpus callosum and 237 other tissues
ExpressionAtlasiQ8IYH5, baseline and differential
GenevisibleiQ8IYH5, HS

Family and domain databases

CDDicd02341, ZZ_ZZZ3, 1 hit
Gene3Di3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017930, Myb_dom
IPR001005, SANT/Myb
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR037830, ZZZ3
IPR041981, ZZZ3_ZZ
PANTHERiPTHR22705, PTHR22705, 2 hits
PfamiView protein in Pfam
PF00249, Myb_DNA-binding, 1 hit
PF00569, ZZ, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51294, HTH_MYB, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZZZ3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYH5
Secondary accession number(s): B7WPC6
, Q6N004, Q6N070, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: April 7, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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