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Entry version 162 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein

ZZ-type zinc finger-containing protein 3

Gene

ZZZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi680 – 703H-T-H motifPROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214847 HATs acetylate histones

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A22.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ZZ-type zinc finger-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZZZ3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24523 ZZZ3

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8IYH5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26009

Open Targets

More...
OpenTargetsi
ENSG00000036549

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134873184

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZZZ3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762495

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874951 – 903ZZ-type zinc finger-containing protein 3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei394N6-acetyllysineBy similarity1
Modified residuei606PhosphoserineCombined sources1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei701N6-acetyllysineCombined sources1
Cross-linki708Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IYH5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYH5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IYH5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IYH5

PeptideAtlas

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PeptideAtlasi
Q8IYH5

PRoteomics IDEntifications database

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PRIDEi
Q8IYH5

ProteomicsDB human proteome resource

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ProteomicsDBi
71174 [Q8IYH5-1]
71175 [Q8IYH5-2]
71176 [Q8IYH5-3]
71177 [Q8IYH5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IYH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IYH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000036549 Expressed in 223 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IYH5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IYH5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053663
HPA054913
HPA066197

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117482, 53 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8IYH5

Database of interacting proteins

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DIPi
DIP-47289N

Protein interaction database and analysis system

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IntActi
Q8IYH5, 23 interactors

Molecular INTeraction database

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MINTi
Q8IYH5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000359837

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IYH5

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q8IYH5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini647 – 707HTH myb-typePROSITE-ProRule annotationAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHEM Eukaryota
ENOG410ZINA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005307

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IYH5

Identification of Orthologs from Complete Genome Data

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OMAi
QNSTGSY

Database of Orthologous Groups

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OrthoDBi
139813at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IYH5

TreeFam database of animal gene trees

More...
TreeFami
TF106396

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 1 hit
cd02341 ZZ_ZZZ3, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR000433 Znf_ZZ
IPR037830 ZZZ3
IPR041981 ZZZ3_ZZ

The PANTHER Classification System

More...
PANTHERi
PTHR22705 PTHR22705, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF00569 ZZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00717 SANT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294 HTH_MYB, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP
60 70 80 90 100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA
110 120 130 140 150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV
160 170 180 190 200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL
210 220 230 240 250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS
260 270 280 290 300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA
310 320 330 340 350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG
360 370 380 390 400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR
410 420 430 440 450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE
460 470 480 490 500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN
510 520 530 540 550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD
560 570 580 590 600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL
610 620 630 640 650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET
660 670 680 690 700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ
710 720 730 740 750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH
760 770 780 790 800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK
810 820 830 840 850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC
860 870 880 890 900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP

ANR
Length:903
Mass (Da):102,023
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16ED137C0A8202EA
GO
Isoform 2 (identifier: Q8IYH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-598: Missing.

Show »
Length:902
Mass (Da):101,924
Checksum:iB7E306C19A1011D8
GO
Isoform 3 (identifier: Q8IYH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-494: Missing.
     495-502: VALKHNKD → MIDLWLYS

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):47,716
Checksum:iE0ADB97A8D186009
GO
Isoform 4 (identifier: Q8IYH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-683: KKLEQLLIKYPPEEVESRRWQKI → VINISKSCRLKKTSKQLTSESVL
     684-903: Missing.

Note: No experimental confirmation available.
Show »
Length:683
Mass (Da):76,126
Checksum:i50C9B12134DB1D66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti596D → G in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti655W → G in CAB45694 (PubMed:17974005).Curated1
Sequence conflicti698R → Q in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti721Y → C in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti807Q → R in CAE45800 (PubMed:17974005).Curated1
Sequence conflicti877T → A in CAE45870 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035718456P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255091 – 494Missing in isoform 3. 1 PublicationAdd BLAST494
Alternative sequenceiVSP_025510495 – 502VALKHNKD → MIDLWLYS in isoform 3. 1 Publication8
Alternative sequenceiVSP_025511598Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_025512661 – 683KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025513684 – 903Missing in isoform 4. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL080063 mRNA Translation: CAB45694.1
BX641001 mRNA Translation: CAE46004.1
BX640658 mRNA Translation: CAE45800.1
BX640766 mRNA Translation: CAE45870.1
AC093575 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06376.1
BC035397 mRNA Translation: AAH35397.1
BC035079 mRNA Translation: AAH35079.1
BC035818 mRNA Translation: AAH35818.1
AK074119 mRNA Translation: BAB84945.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS677.1 [Q8IYH5-1]
CCDS76172.1 [Q8IYH5-3]

Protein sequence database of the Protein Information Resource

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PIRi
T12463

NCBI Reference Sequences

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RefSeqi
NP_001295166.1, NM_001308237.1 [Q8IYH5-3]
NP_056349.1, NM_015534.5 [Q8IYH5-1]
XP_005270782.1, XM_005270725.3 [Q8IYH5-1]
XP_005270783.1, XM_005270726.3 [Q8IYH5-1]
XP_005270784.1, XM_005270727.3 [Q8IYH5-2]
XP_005270786.1, XM_005270729.4 [Q8IYH5-3]
XP_016856459.1, XM_017000970.1 [Q8IYH5-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
26009

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26009

UCSC genome browser

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UCSCi
uc001dhq.4 human [Q8IYH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080063 mRNA Translation: CAB45694.1
BX641001 mRNA Translation: CAE46004.1
BX640658 mRNA Translation: CAE45800.1
BX640766 mRNA Translation: CAE45870.1
AC093575 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06376.1
BC035397 mRNA Translation: AAH35397.1
BC035079 mRNA Translation: AAH35079.1
BC035818 mRNA Translation: AAH35818.1
AK074119 mRNA Translation: BAB84945.1
CCDSiCCDS677.1 [Q8IYH5-1]
CCDS76172.1 [Q8IYH5-3]
PIRiT12463
RefSeqiNP_001295166.1, NM_001308237.1 [Q8IYH5-3]
NP_056349.1, NM_015534.5 [Q8IYH5-1]
XP_005270782.1, XM_005270725.3 [Q8IYH5-1]
XP_005270783.1, XM_005270726.3 [Q8IYH5-1]
XP_005270784.1, XM_005270727.3 [Q8IYH5-2]
XP_005270786.1, XM_005270729.4 [Q8IYH5-3]
XP_016856459.1, XM_017000970.1 [Q8IYH5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FC7NMR-A807-886[»]
2YUMNMR-A652-713[»]
6E83NMR-B816-874[»]
6E86NMR-B816-874[»]
SMRiQ8IYH5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117482, 53 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ8IYH5
DIPiDIP-47289N
IntActiQ8IYH5, 23 interactors
MINTiQ8IYH5
STRINGi9606.ENSP00000359837

Protein family/group databases

MEROPSiA22.007

PTM databases

iPTMnetiQ8IYH5
PhosphoSitePlusiQ8IYH5

Polymorphism and mutation databases

BioMutaiZZZ3
DMDMi74762495

Proteomic databases

EPDiQ8IYH5
jPOSTiQ8IYH5
MaxQBiQ8IYH5
PaxDbiQ8IYH5
PeptideAtlasiQ8IYH5
PRIDEiQ8IYH5
ProteomicsDBi71174 [Q8IYH5-1]
71175 [Q8IYH5-2]
71176 [Q8IYH5-3]
71177 [Q8IYH5-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
26009
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26009
KEGGihsa:26009
UCSCiuc001dhq.4 human [Q8IYH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26009
DisGeNETi26009

GeneCards: human genes, protein and diseases

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GeneCardsi
ZZZ3
HGNCiHGNC:24523 ZZZ3
HPAiHPA053663
HPA054913
HPA066197
neXtProtiNX_Q8IYH5
OpenTargetsiENSG00000036549
PharmGKBiPA134873184

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHEM Eukaryota
ENOG410ZINA LUCA
GeneTreeiENSGT00390000005307
InParanoidiQ8IYH5
OMAiQNSTGSY
OrthoDBi139813at2759
PhylomeDBiQ8IYH5
TreeFamiTF106396

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZZZ3 human
EvolutionaryTraceiQ8IYH5

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZZZ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26009

Protein Ontology

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PROi
PR:Q8IYH5

Gene expression databases

BgeeiENSG00000036549 Expressed in 223 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8IYH5 baseline and differential
GenevisibleiQ8IYH5 HS

Family and domain databases

CDDicd00167 SANT, 1 hit
cd02341 ZZ_ZZZ3, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
IPR000433 Znf_ZZ
IPR037830 ZZZ3
IPR041981 ZZZ3_ZZ
PANTHERiPTHR22705 PTHR22705, 1 hit
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZZZ3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYH5
Secondary accession number(s): B7WPC6
, Q6N004, Q6N070, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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