UniProtKB - Q8IYH5 (ZZZ3_HUMAN)

>sp|Q8IYH5|ZZZ3_HUMAN ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1
MAASRSTRVTRSTVGLNGLDESFCGRTLRNRSIAHPEEISSNSQVRSRSPKKRPEPVPIQ
KGNNNGRTTDLKQQSTRESWVSPRKRGLSSSEKDNIERQAIENCERRQTEPVSPVLKRIK
RCLRSEAPNSSEEDSPIKSDKESVEQRSTVVDNDADFQGTKRACRCLILDDCEKREIKKV
NVSEEGPLNSAVVEEITGYLAVNGVDDSDSAVINCDDCQPDGNTKQNSIGSYVLQEKSVA
ENGDTDTQTSMFLDSRKEDSYIDHKVPCTDSQVQVKLEDHKIVTACLPVEHVNQLTTEPA
TGPFSETQSSLRDSEEEVDVVGDSSASKEQCKENTNNELDTSLESMPASGEPEPSPVLDC
VSAQMMSLSEPQEHRYTLRTSPRRAAPTRGSPTKNSSPYRENGQFEENNLSPNETNATVS
DNVSQSPTNPGEISQNEKGICCDSQNNGSEGVSKPPSEARLNIGHLPSAKESASQHITEE
EDDDPDVYYFESDHVALKHNKDYQRLLQTIAVLEAQRSQAVQDLESLGRHQREALKNPIG
FVEKLQKKADIGLPYPQRVVQLPEIVWDQYTHSLGNFEREFKNRKRHTRRVKLVFDKVGL
PARPKSPLDPKKDGESLSYSMLPLSDGPEGSSSRPQMIRGRLCDDTKPETFNQLWTVEEQ
KKLEQLLIKYPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNL
YIYSKKSSTSRRQHPLNKHLFKPSTFMTSHEPPVYMDEDDDRSCFHSHMNTAVEDASDDE
SIPIMYRNLPEYKELLQFKKLKKQKLQQMQAESGFVQHVGFKCDNCGIEPIQGVRWHCQD
CPPEMSLDFCDSCSDCLHETDIHKEDHQLEPIYRSETFLDRDYCVSQGTSYNYLDPNYFP
ANR

Entry version 175 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
Previous versions | rss

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Protein

ZZ-type zinc finger-containing protein 3

Gene

ZZZ3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	680 – 703	H-T-H motifPROSITE-ProRule annotationAdd BLAST		24
Zinc fingerⁱ	817 – 867	ZZ-typePROSITE-ProRule annotationAdd BLAST		51

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H4 acetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q8IYH5
Reactomeⁱ	R-HSA-3214847, HATs acetylate histones

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	A22.007

MEROPSⁱ

A22.007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ZZ-type zinc finger-containing protein 3
Gene namesⁱ	Name:ZZZ3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24523, ZZZ3
neXtProtⁱ	NX_Q8IYH5
VEuPathDBⁱ	HostDB:ENSG00000036549.12

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26009
Open Targets More...OpenTargetsⁱ	ENSG00000036549
PharmGKBⁱ	PA134873184

Miscellaneous databases

Pharosⁱ	Q8IYH5, Tdark

Pharosⁱ

Q8IYH5, Tdark

Genetic variation databases

BioMutaⁱ	ZZZ3
DMDMⁱ	74762495

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287495	1 – 903	ZZ-type zinc finger-containing protein 3Add BLAST		903

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	89	PhosphoserineCombined sources	1
Modified residueⁱ	113	PhosphoserineCombined sources	1
Modified residueⁱ	130	PhosphoserineCombined sources	1
Modified residueⁱ	131	PhosphoserineCombined sources	1
Modified residueⁱ	135	PhosphoserineCombined sources	1
Cross-linkⁱ	276	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	394	N6-acetyllysineBy similarity	1
Modified residueⁱ	606	PhosphoserineCombined sources	1
Cross-linkⁱ	647	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	701	N6-acetyllysineCombined sources	1
Cross-linkⁱ	708	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8IYH5
jPOSTⁱ	Q8IYH5
MassIVEⁱ	Q8IYH5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IYH5
PaxDbⁱ	Q8IYH5
PeptideAtlas More...PeptideAtlasⁱ	Q8IYH5
PRIDEⁱ	Q8IYH5
ProteomicsDBⁱ	71174 [Q8IYH5-1] 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4]

PTM databases

iPTMnetⁱ	Q8IYH5
PhosphoSitePlusⁱ	Q8IYH5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000036549, Expressed in corpus callosum and 238 other tissues
ExpressionAtlasⁱ	Q8IYH5, baseline and differential
Genevisibleⁱ	Q8IYH5, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000036549, Low tissue specificity

HPAⁱ

ENSG00000036549, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

2 Publications

Binary interactionsⁱ

Hide details

Q8IYH5

With	#Exp.	IntAct
CARD9 - isoform 2 [Q9H257-2]	3	EBI-2795524,EBI-11530605
EFHC2 [Q5JST6]	3	EBI-2795524,EBI-2349927
FAM124A [Q86V42]	3	EBI-2795524,EBI-744506
GOLGA2 [Q08379]	3	EBI-2795524,EBI-618309
KAT2A [Q92830]	2	EBI-2795524,EBI-477622
PICK1 [Q9NRD5]	3	EBI-2795524,EBI-79165
PPP1R13B [Q96KQ4]	3	EBI-2795524,EBI-1105153
TRAF2 [Q12933]	3	EBI-2795524,EBI-355744
WDR5 [P61964]	3	EBI-2795524,EBI-540834
Hoxa1 [P09022] from Mus musculus.	3	EBI-2795524,EBI-3957603

Protein-protein interaction databases

BioGRIDⁱ	117482, 66 interactors
ComplexPortalⁱ	CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex
CORUMⁱ	Q8IYH5
Database of interacting proteins More...DIPⁱ	DIP-47289N
IntActⁱ	Q8IYH5, 50 interactors
Molecular INTeraction database More...MINTⁱ	Q8IYH5
STRINGⁱ	9606.ENSP00000359837

Miscellaneous databases

RNActⁱ	Q8IYH5, protein

RNActⁱ

Q8IYH5, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	657 – 669	Combined sources	13
Helixⁱ	676 – 687	Combined sources	12
Beta strandⁱ	688 – 690	Combined sources	3
Helixⁱ	692 – 703	Combined sources	12
Helixⁱ	704 – 706	Combined sources	3
Beta strandⁱ	807 – 809	Combined sources	3
Beta strandⁱ	817 – 820	Combined sources	4
Beta strandⁱ	824 – 826	Combined sources	3
Beta strandⁱ	829 – 833	Combined sources	5
Beta strandⁱ	835 – 841	Combined sources	7
Beta strandⁱ	843 – 845	Combined sources	3
Beta strandⁱ	848 – 850	Combined sources	3
Helixⁱ	851 – 853	Combined sources	3
Beta strandⁱ	865 – 867	Combined sources	3
Beta strandⁱ	869 – 872	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q8IYH5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8IYH5

EvolutionaryTraceⁱ

Q8IYH5

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	647 – 707	HTH myb-typePROSITE-ProRule annotationAdd BLAST		61

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 149	DisorderedSequence analysisAdd BLAST	149
Regionⁱ	297 – 358	DisorderedSequence analysisAdd BLAST	62
Regionⁱ	373 – 481	DisorderedSequence analysisAdd BLAST	109
Regionⁱ	602 – 636	DisorderedSequence analysisAdd BLAST	35

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	1 – 17	Polar residuesSequence analysisAdd BLAST	17
Compositional biasⁱ	61 – 86	Polar residuesSequence analysisAdd BLAST	26
Compositional biasⁱ	87 – 149	Basic and acidic residuesSequence analysisAdd BLAST	63
Compositional biasⁱ	327 – 344	Polar residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	384 – 453	Polar residuesSequence analysisAdd BLAST	70

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	817 – 867	ZZ-typePROSITE-ProRule annotationAdd BLAST		51

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG502QS4F, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005307
HOGENOMⁱ	CLU_319257_0_0_1
InParanoidⁱ	Q8IYH5
OMAⁱ	TELYEHR
Database of Orthologous Groups More...OrthoDBⁱ	139813at2759
PhylomeDBⁱ	Q8IYH5
TreeFamⁱ	TF106396

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167, SANT, 1 hit cd02341, ZZ_ZZZ3, 1 hit
Gene3Dⁱ	3.30.60.90, 1 hit
InterProⁱ	View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR037830, ZZZ3 IPR041981, ZZZ3_ZZ
PANTHERⁱ	PTHR22705, PTHR22705, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF00569, ZZ, 1 hit
SMARTⁱ	View protein in SMART SM00717, SANT, 1 hit
SUPFAMⁱ	SSF46689, SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294, HTH_MYB, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL 
       610        620        630        640        650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET 
       660        670        680        690        700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ 
       710        720        730        740        750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH 
       760        770        780        790        800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK 
       810        820        830        840        850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC 
       860        870        880        890        900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP 

ANR

Length:903

Mass (Da):102,023

Last modified:March 1, 2003 - v1

Checksum:ⁱ16ED137C0A8202EA

Isoform 2 (identifier: Q8IYH5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
598-598: Missing.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKGLP 
       610        620        630        640        650
ARPKSPLDPK KDGESLSYSM LPLSDGPEGS SSRPQMIRGR LCDDTKPETF 
       660        670        680        690        700
NQLWTVEEQK KLEQLLIKYP PEEVESRRWQ KIADELGNRT AKQVASRVQK 
       710        720        730        740        750
YFIKLTKAGI PVPGRTPNLY IYSKKSSTSR RQHPLNKHLF KPSTFMTSHE 
       760        770        780        790        800
PPVYMDEDDD RSCFHSHMNT AVEDASDDES IPIMYRNLPE YKELLQFKKL 
       810        820        830        840        850
KKQKLQQMQA ESGFVQHVGF KCDNCGIEPI QGVRWHCQDC PPEMSLDFCD 
       860        870        880        890        900
SCSDCLHETD IHKEDHQLEP IYRSETFLDR DYCVSQGTSY NYLDPNYFPA 

NR

Show »

Length:902

Mass (Da):101,924

Checksum:ⁱB7E306C19A1011D8

Isoform 3 (identifier: Q8IYH5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-494: Missing.
495-502: VALKHNKD → MIDLWLYS

« Hide

        10         20         30         40         50
MIDLWLYSYQ RLLQTIAVLE AQRSQAVQDL ESLGRHQREA LKNPIGFVEK 
        60         70         80         90        100
LQKKADIGLP YPQRVVQLPE IVWDQYTHSL GNFEREFKNR KRHTRRVKLV 
       110        120        130        140        150
FDKVGLPARP KSPLDPKKDG ESLSYSMLPL SDGPEGSSSR PQMIRGRLCD 
       160        170        180        190        200
DTKPETFNQL WTVEEQKKLE QLLIKYPPEE VESRRWQKIA DELGNRTAKQ 
       210        220        230        240        250
VASRVQKYFI KLTKAGIPVP GRTPNLYIYS KKSSTSRRQH PLNKHLFKPS 
       260        270        280        290        300
TFMTSHEPPV YMDEDDDRSC FHSHMNTAVE DASDDESIPI MYRNLPEYKE 
       310        320        330        340        350
LLQFKKLKKQ KLQQMQAESG FVQHVGFKCD NCGIEPIQGV RWHCQDCPPE 
       360        370        380        390        400
MSLDFCDSCS DCLHETDIHK EDHQLEPIYR SETFLDRDYC VSQGTSYNYL 

DPNYFPANR

Show »

Length:409

Mass (Da):47,716

Checksum:ⁱE0ADB97A8D186009

Isoform 4 (identifier: Q8IYH5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
661-683: KKLEQLLIKYPPEEVESRRWQKI → VINISKSCRLKKTSKQLTSESVL
684-903: Missing.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP 
        60         70         80         90        100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA 
       110        120        130        140        150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV 
       160        170        180        190        200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL 
       210        220        230        240        250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS 
       260        270        280        290        300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA 
       310        320        330        340        350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG 
       360        370        380        390        400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR 
       410        420        430        440        450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE 
       460        470        480        490        500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN 
       510        520        530        540        550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD 
       560        570        580        590        600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL 
       610        620        630        640        650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET 
       660        670        680 
FNQLWTVEEQ VINISKSCRL KKTSKQLTSE SVL

Show »

Length:683

Mass (Da):76,126

Checksum:ⁱ50C9B12134DB1D66

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JUA4	C9JUA4_HUMAN	ZZ-type zinc finger-containing prot... ZZ-type zinc finger-containing protein 3	ZZZ3	57	Annotation score:
C9J283	C9J283_HUMAN	ZZ-type zinc finger-containing prot... ZZ-type zinc finger-containing protein 3	ZZZ3	36	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	596	D → G in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	655	W → G in CAB45694 (PubMed:17974005).Curated	1
Sequence conflictⁱ	698	R → Q in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	721	Y → C in AAH35079 (PubMed:15489334).Curated	1
Sequence conflictⁱ	807	Q → R in CAE45800 (PubMed:17974005).Curated	1
Sequence conflictⁱ	877	T → A in CAE45870 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035718	456	P → S in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_025509	1 – 494	Missing in isoform 3. 1 PublicationAdd BLAST	494
Alternative sequenceⁱVSP_025510	495 – 502	VALKHNKD → MIDLWLYS in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_025511	598	Missing in isoform 2. 2 Publications	1
Alternative sequenceⁱVSP_025512	661 – 683	KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_025513	684 – 903	Missing in isoform 4. 1 PublicationAdd BLAST	220

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3]
PIRⁱ	T12463
NCBI Reference Sequences More...RefSeqⁱ	NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 XP_005270783.1, XM_005270726.3 XP_005270784.1, XM_005270727.3 XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1

Genome annotation databases

Ensemblⁱ	ENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3] ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1]
GeneIDⁱ	26009
KEGGⁱ	hsa:26009
UCSC genome browser More...UCSCⁱ	uc001dhq.4, human [Q8IYH5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IYH5-3	Zinc finger ZZ-type containing 3		PANTR		409	UniRef100_A0A2I3RAV1
Uncharacterized protein		RHIRO		409
Zinc finger ZZ-type containing 3		PANPA		409
Zinc finger ZZ-type containing 3		GORGO		409
ZZZ3 isoform 1		PANTR		409

Protein	Similar proteins		Species	Score	Length	Source
Q8IYH5	Zinc finger ZZ-type containing 3		FELCA		988	UniRef90_Q8IYH5
ZZ-type zinc finger-containing protein 3 (Fragment)		HUMAN		36
ZZZ3 isoform 10 (Fragment)		PONAB		36
ZZZ3 isoform 3 (Fragment)		PANTR		36
Zinc finger ZZ-type containing 3		LYNCA		931
+192
Q8IYH5-3	Isoform 2 of ZZ-type zinc finger-containing protein 3		MOUSE		409	UniRef90_Q6KAQ7-2
ZZ-type zinc finger-containing protein 3 isoform X6		LEPWE		423
ZZ-type zinc finger-containing protein 3 isoform X3		pale spear-nosed bat		417
ZZ-type zinc finger-containing protein 3 isoform X3		VICPA		415
ZZ-type zinc finger-containing protein 3 isoform X3		DIPOR		410
+55
Q8IYH5-4	ZZ-type zinc finger-containing protein 3 isoform X1		PIG		679	UniRef90_Q8IYH5-4

Protein	Similar proteins		Species	Score	Length	Source
Q8IYH5	ZZ-type zinc finger-containing protein 3		MOUSE		910	UniRef50_Q8IYH5
Zinc finger ZZ-type containing 3		FELCA		988
ZZ-type zinc finger-containing protein 3 (Fragment)		HUMAN		36
ZZZ3 isoform 10 (Fragment)		PONAB		36
ZZZ3 isoform 3 (Fragment)		PANTR		36
+909
Q8IYH5-3	Isoform 3 of ZZ-type zinc finger-containing protein 3		MOUSE		413	UniRef50_Q6KAQ7-3
Zinc finger ZZ-type containing 3		CAVPO		409
ZZ-type zinc finger-containing protein 3 isoform X3		MESAU		409
ZZ-type zinc finger-containing protein 3 isoform X3		PERMB		409
ZZ-type zinc finger-containing protein 3-like isoform X2		CARAU		413
+100
Q8IYH5-4	ZZ-type zinc finger-containing protein 3 isoform X1		PIG		679	UniRef50_Q8IYH5-4
ZZ-type zinc finger-containing protein 3 (Fragment)		PELCR		714
ZZZ3 protein (Fragment)		Nyctiprogne leucopyga		714
ZZZ3 protein (Fragment)		CINMU		715
Uncharacterized protein (Fragment)		MUNRE		616
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1
CCDSⁱ	CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3]
PIRⁱ	T12463
RefSeqⁱ	NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 XP_005270783.1, XM_005270726.3 XP_005270784.1, XM_005270727.3 XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FC7	NMR	-	A	807-886	[»]
	2YUM	NMR	-	A	652-713	[»]
	6E83	NMR	-	B	816-874	[»]
	6E86	NMR	-	B	816-874	[»]
SMRⁱ	Q8IYH5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	117482, 66 interactors
ComplexPortalⁱ	CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex
CORUMⁱ	Q8IYH5
DIPⁱ	DIP-47289N
IntActⁱ	Q8IYH5, 50 interactors
MINTⁱ	Q8IYH5
STRINGⁱ	9606.ENSP00000359837

Protein family/group databases

MEROPSⁱ	A22.007

MEROPSⁱ

A22.007

PTM databases

iPTMnetⁱ	Q8IYH5
PhosphoSitePlusⁱ	Q8IYH5

Genetic variation databases

BioMutaⁱ	ZZZ3
DMDMⁱ	74762495

Proteomic databases

EPDⁱ	Q8IYH5
jPOSTⁱ	Q8IYH5
MassIVEⁱ	Q8IYH5
MaxQBⁱ	Q8IYH5
PaxDbⁱ	Q8IYH5
PeptideAtlasⁱ	Q8IYH5
PRIDEⁱ	Q8IYH5
ProteomicsDBⁱ	71174 [Q8IYH5-1] 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4]

Protocols and materials databases

Antibodypediaⁱ	33487, 86 antibodies
The DNASU plasmid repository More...DNASUⁱ	26009

Genome annotation databases

Ensemblⁱ	ENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3] ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1]
GeneIDⁱ	26009
KEGGⁱ	hsa:26009
UCSCⁱ	uc001dhq.4, human [Q8IYH5-1]

Organism-specific databases

CTDⁱ	26009
DisGeNETⁱ	26009
GeneCardsⁱ	ZZZ3
HGNCⁱ	HGNC:24523, ZZZ3
HPAⁱ	ENSG00000036549, Low tissue specificity
neXtProtⁱ	NX_Q8IYH5
OpenTargetsⁱ	ENSG00000036549
PharmGKBⁱ	PA134873184
VEuPathDBⁱ	HostDB:ENSG00000036549.12
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QS4F, Eukaryota
GeneTreeⁱ	ENSGT00390000005307
HOGENOMⁱ	CLU_319257_0_0_1
InParanoidⁱ	Q8IYH5
OMAⁱ	TELYEHR
OrthoDBⁱ	139813at2759
PhylomeDBⁱ	Q8IYH5
TreeFamⁱ	TF106396

Enzyme and pathway databases

PathwayCommonsⁱ	Q8IYH5
Reactomeⁱ	R-HSA-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID-ORCSⁱ	26009, 176 hits in 1025 CRISPR screens
ChiTaRSⁱ	ZZZ3, human
EvolutionaryTraceⁱ	Q8IYH5
GeneWikiⁱ	ZZZ3
GenomeRNAiⁱ	26009
Pharosⁱ	Q8IYH5, Tdark
Protein Ontology More...PROⁱ	PR:Q8IYH5
RNActⁱ	Q8IYH5, protein

Gene expression databases

Bgeeⁱ	ENSG00000036549, Expressed in corpus callosum and 238 other tissues
ExpressionAtlasⁱ	Q8IYH5, baseline and differential
Genevisibleⁱ	Q8IYH5, HS

Family and domain databases

CDDⁱ	cd00167, SANT, 1 hit cd02341, ZZ_ZZZ3, 1 hit
Gene3Dⁱ	3.30.60.90, 1 hit
InterProⁱ	View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR037830, ZZZ3 IPR041981, ZZZ3_ZZ
PANTHERⁱ	PTHR22705, PTHR22705, 2 hits
Pfamⁱ	View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF00569, ZZ, 1 hit
SMARTⁱ	View protein in SMART SM00717, SANT, 1 hit
SUPFAMⁱ	SSF46689, SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51294, HTH_MYB, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZZZ3_HUMAN
Accessionⁱ	Q8IYH5Primary (citable) accession number: Q8IYH5 Secondary accession number(s): B7WPC6 Q9Y4U0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	March 1, 2003
	Last modified:	June 2, 2021
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8IYH5 (ZZZ3_HUMAN)

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ZZ-type zinc finger-containing protein 3

ZZZ3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q8IYH5

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Zinc finger

Keywords - Domaini

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Experimental Info

Natural variant

Alternative sequence

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Keywords - Coding sequence diversityi

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Sequence databases

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Protocols and materials databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ