UniProtKB - Q8IYH5 (ZZZ3_HUMAN)
Protein
ZZ-type zinc finger-containing protein 3
Gene
ZZZ3
Organism
Homo sapiens (Human)
Status
Functioni
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 680 – 703 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 817 – 867 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- histone H4 acetylation Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IYH5 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
Protein family/group databases
MEROPSi | A22.007 |
Names & Taxonomyi
Protein namesi | Recommended name: ZZ-type zinc finger-containing protein 3 |
Gene namesi | Name:ZZZ3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24523, ZZZ3 |
neXtProti | NX_Q8IYH5 |
VEuPathDBi | HostDB:ENSG00000036549.12 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- Ada2/Gcn5/Ada3 transcription activator complex Source: GO_Central
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26009 |
OpenTargetsi | ENSG00000036549 |
PharmGKBi | PA134873184 |
Miscellaneous databases
Pharosi | Q8IYH5, Tdark |
Genetic variation databases
BioMutai | ZZZ3 |
DMDMi | 74762495 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287495 | 1 – 903 | ZZ-type zinc finger-containing protein 3Add BLAST | 903 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 130 | PhosphoserineCombined sources | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 135 | PhosphoserineCombined sources | 1 | |
Cross-linki | 276 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 394 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 606 | PhosphoserineCombined sources | 1 | |
Cross-linki | 647 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 701 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 708 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IYH5 |
jPOSTi | Q8IYH5 |
MassIVEi | Q8IYH5 |
MaxQBi | Q8IYH5 |
PaxDbi | Q8IYH5 |
PeptideAtlasi | Q8IYH5 |
PRIDEi | Q8IYH5 |
ProteomicsDBi | 71174 [Q8IYH5-1] 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4] |
PTM databases
iPTMneti | Q8IYH5 |
PhosphoSitePlusi | Q8IYH5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000036549, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q8IYH5, baseline and differential |
Genevisiblei | Q8IYH5, HS |
Organism-specific databases
HPAi | ENSG00000036549, Low tissue specificity |
Interactioni
Subunit structurei
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
2 PublicationsBinary interactionsi
Hide detailsQ8IYH5
Protein-protein interaction databases
BioGRIDi | 117482, 66 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q8IYH5 |
DIPi | DIP-47289N |
IntActi | Q8IYH5, 38 interactors |
MINTi | Q8IYH5 |
STRINGi | 9606.ENSP00000359837 |
Miscellaneous databases
RNActi | Q8IYH5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IYH5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IYH5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 647 – 707 | HTH myb-typePROSITE-ProRule annotationAdd BLAST | 61 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 817 – 867 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QS4F, Eukaryota |
GeneTreei | ENSGT00390000005307 |
HOGENOMi | CLU_319257_0_0_1 |
InParanoidi | Q8IYH5 |
OMAi | TELYEHR |
OrthoDBi | 139813at2759 |
PhylomeDBi | Q8IYH5 |
TreeFami | TF106396 |
Family and domain databases
CDDi | cd02341, ZZ_ZZZ3, 1 hit |
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR037830, ZZZ3 IPR041981, ZZZ3_ZZ |
PANTHERi | PTHR22705, PTHR22705, 2 hits |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF00569, ZZ, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP
60 70 80 90 100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA
110 120 130 140 150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV
160 170 180 190 200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL
210 220 230 240 250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS
260 270 280 290 300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA
310 320 330 340 350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG
360 370 380 390 400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR
410 420 430 440 450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE
460 470 480 490 500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN
510 520 530 540 550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD
560 570 580 590 600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL
610 620 630 640 650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET
660 670 680 690 700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ
710 720 730 740 750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH
760 770 780 790 800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK
810 820 830 840 850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC
860 870 880 890 900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP
ANR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JUA4 | C9JUA4_HUMAN | ZZ-type zinc finger-containing prot... | ZZZ3 | 57 | Annotation score: | ||
C9J283 | C9J283_HUMAN | ZZ-type zinc finger-containing prot... | ZZZ3 | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 596 | D → G in AAH35079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 655 | W → G in CAB45694 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 698 | R → Q in AAH35079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 721 | Y → C in AAH35079 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 807 | Q → R in CAE45800 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 877 | T → A in CAE45870 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035718 | 456 | P → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025509 | 1 – 494 | Missing in isoform 3. 1 PublicationAdd BLAST | 494 | |
Alternative sequenceiVSP_025510 | 495 – 502 | VALKHNKD → MIDLWLYS in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_025511 | 598 | Missing in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_025512 | 661 – 683 | KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_025513 | 684 – 903 | Missing in isoform 4. 1 PublicationAdd BLAST | 220 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1 |
CCDSi | CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3] |
PIRi | T12463 |
RefSeqi | NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 XP_005270783.1, XM_005270726.3 XP_005270784.1, XM_005270727.3 XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1 |
Genome annotation databases
Ensembli | ENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3] ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1] |
GeneIDi | 26009 |
KEGGi | hsa:26009 |
UCSCi | uc001dhq.4, human [Q8IYH5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL080063 mRNA Translation: CAB45694.1 BX641001 mRNA Translation: CAE46004.1 BX640658 mRNA Translation: CAE45800.1 BX640766 mRNA Translation: CAE45870.1 AC093575 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06376.1 BC035397 mRNA Translation: AAH35397.1 BC035079 mRNA Translation: AAH35079.1 BC035818 mRNA Translation: AAH35818.1 AK074119 mRNA Translation: BAB84945.1 |
CCDSi | CCDS677.1 [Q8IYH5-1] CCDS76172.1 [Q8IYH5-3] |
PIRi | T12463 |
RefSeqi | NP_001295166.1, NM_001308237.1 [Q8IYH5-3] NP_056349.1, NM_015534.5 [Q8IYH5-1] XP_005270782.1, XM_005270725.3 XP_005270783.1, XM_005270726.3 XP_005270784.1, XM_005270727.3 XP_005270786.1, XM_005270729.4 [Q8IYH5-3] XP_016856459.1, XM_017000970.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FC7 | NMR | - | A | 807-886 | [»] | |
2YUM | NMR | - | A | 652-713 | [»] | |
6E83 | NMR | - | B | 816-874 | [»] | |
6E86 | NMR | - | B | 816-874 | [»] | |
SMRi | Q8IYH5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117482, 66 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q8IYH5 |
DIPi | DIP-47289N |
IntActi | Q8IYH5, 38 interactors |
MINTi | Q8IYH5 |
STRINGi | 9606.ENSP00000359837 |
Protein family/group databases
MEROPSi | A22.007 |
PTM databases
iPTMneti | Q8IYH5 |
PhosphoSitePlusi | Q8IYH5 |
Genetic variation databases
BioMutai | ZZZ3 |
DMDMi | 74762495 |
Proteomic databases
EPDi | Q8IYH5 |
jPOSTi | Q8IYH5 |
MassIVEi | Q8IYH5 |
MaxQBi | Q8IYH5 |
PaxDbi | Q8IYH5 |
PeptideAtlasi | Q8IYH5 |
PRIDEi | Q8IYH5 |
ProteomicsDBi | 71174 [Q8IYH5-1] 71175 [Q8IYH5-2] 71176 [Q8IYH5-3] 71177 [Q8IYH5-4] |
Protocols and materials databases
Antibodypediai | 33487, 87 antibodies |
DNASUi | 26009 |
Genome annotation databases
Ensembli | ENST00000370798; ENSP00000359834; ENSG00000036549 [Q8IYH5-3] ENST00000370801; ENSP00000359837; ENSG00000036549 [Q8IYH5-1] |
GeneIDi | 26009 |
KEGGi | hsa:26009 |
UCSCi | uc001dhq.4, human [Q8IYH5-1] |
Organism-specific databases
CTDi | 26009 |
DisGeNETi | 26009 |
GeneCardsi | ZZZ3 |
HGNCi | HGNC:24523, ZZZ3 |
HPAi | ENSG00000036549, Low tissue specificity |
neXtProti | NX_Q8IYH5 |
OpenTargetsi | ENSG00000036549 |
PharmGKBi | PA134873184 |
VEuPathDBi | HostDB:ENSG00000036549.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS4F, Eukaryota |
GeneTreei | ENSGT00390000005307 |
HOGENOMi | CLU_319257_0_0_1 |
InParanoidi | Q8IYH5 |
OMAi | TELYEHR |
OrthoDBi | 139813at2759 |
PhylomeDBi | Q8IYH5 |
TreeFami | TF106396 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYH5 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
Miscellaneous databases
BioGRID-ORCSi | 26009, 176 hits in 1025 CRISPR screens |
ChiTaRSi | ZZZ3, human |
EvolutionaryTracei | Q8IYH5 |
GeneWikii | ZZZ3 |
GenomeRNAii | 26009 |
Pharosi | Q8IYH5, Tdark |
PROi | PR:Q8IYH5 |
RNActi | Q8IYH5, protein |
Gene expression databases
Bgeei | ENSG00000036549, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q8IYH5, baseline and differential |
Genevisiblei | Q8IYH5, HS |
Family and domain databases
CDDi | cd02341, ZZ_ZZZ3, 1 hit |
Gene3Di | 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR037830, ZZZ3 IPR041981, ZZZ3_ZZ |
PANTHERi | PTHR22705, PTHR22705, 2 hits |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit PF00569, ZZ, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZZZ3_HUMAN | |
Accessioni | Q8IYH5Primary (citable) accession number: Q8IYH5 Secondary accession number(s): B7WPC6 Q9Y4U0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references