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UniProtKB - Q8IYF3 (TEX11_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 3 (24 Jul 2007)
Previous versions | rss
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Protein

Testis-expressed protein 11

Gene

TEX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IYF3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IYF3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-expressed protein 11
Alternative name(s):
Protein ZIP4 homologBy similarity
Short name:
ZIP4H
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEX11
Synonyms:ZIP4By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11733, TEX11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300311, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IYF3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120498

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure, X-linked, 2 (SPGFX2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073889171M → V in SPGFX2. 2 PublicationsCorresponds to variant dbSNP:rs143246552Ensembl.1
Natural variantiVAR_073890698A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555Ensembl.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		56159

MalaCards human disease database

More...MalaCardsi		TEX11
MIMi309120, phenotype

Open Targets

More...OpenTargetsi		ENSG00000120498

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IYF3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TEX11

Domain mapping of disease mutations (DMDM)

More...DMDMi		156637425

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002969551 – 940Testis-expressed protein 11Add BLAST940

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IYF3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IYF3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IYF3

PeptideAtlas

More...PeptideAtlasi		Q8IYF3

PRoteomics IDEntifications database

More...PRIDEi		Q8IYF3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71166 [Q8IYF3-1]
71167 [Q8IYF3-2]
71168 [Q8IYF3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IYF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IYF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific. Not expressed in adult ovaries.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120498, Expressed in pancreas and 82 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IYF3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120498, Tissue enriched (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYCP2.

Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).

Interacts with SHOC1 (PubMed:29742103).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IYF3
With#Exp.IntAct
BEX1 [Q9HBH7]3EBI-742397,EBI-7162175
BORCS8 [Q96FH0]5EBI-742397,EBI-744076
C6orf226 [Q5I0X4]3EBI-742397,EBI-10244057
CBY2 [Q8NA61]3EBI-742397,EBI-741724
CCDC198 [Q9NVL8]3EBI-742397,EBI-10238351
CDKN1A [P38936]4EBI-742397,EBI-375077
CENPP [Q6IPU0]3EBI-742397,EBI-10250303
COL20A1 - isoform 2 [Q9P218-2]3EBI-742397,EBI-10318410
CXCL14 [O95715]3EBI-742397,EBI-2798068
DUSP21 [Q9H596]3EBI-742397,EBI-7357329
FAM156A [Q8NDB6]3EBI-742397,EBI-749727
FBF1 - isoform 6 [Q8TES7-6]3EBI-742397,EBI-10244131
GATAD2B [Q8WXI9]3EBI-742397,EBI-923440
HYI [Q5T013]4EBI-742397,EBI-749235
ING3 [A0A0C4DG38]3EBI-742397,EBI-10263367
LIN37 [Q96GY3]2EBI-742397,EBI-748884
MAPK9 [P45984]3EBI-742397,EBI-713568
MAPKBP1 [O60336]3EBI-742397,EBI-947402
MYEF2 - isoform 2 [Q9P2K5-2]3EBI-742397,EBI-10318831
NEFL [I6L9F6]4EBI-742397,EBI-10178578
POM121 [Q96HA1]4EBI-742397,EBI-739990
PPP1R18 [Q6NYC8]3EBI-742397,EBI-2557469
REXO1L1P [Q8IX06]3EBI-742397,EBI-10262361
RIBC1 [Q8N443]3EBI-742397,EBI-10265323
SEPTIN1 [Q8WYJ6]3EBI-742397,EBI-693002
SNW1 [Q13573]3EBI-742397,EBI-632715
SNX7 [Q9UNH6]4EBI-742397,EBI-751422
STMN2 [Q93045]5EBI-742397,EBI-714194
TBC1D22B [Q9NU19]3EBI-742397,EBI-8787464
TIPIN [Q9BVW5]3EBI-742397,EBI-2515360
TSC22D4 [Q8IV54]3EBI-742397,EBI-10261521
UTP14C [Q08E77]3EBI-742397,EBI-10225961
Isoform 3 [Q8IYF3-3]
With#Exp.IntAct
ATXN3 [P54252]6EBI-11523345,EBI-946046
BCL2L2 [Q92843]3EBI-11523345,EBI-707714
BORCS8 [Q96FH0]5EBI-11523345,EBI-744076
BRMS1L [Q5PSV4]3EBI-11523345,EBI-5666615
CBY2 - isoform 2 [Q8NA61-2]3EBI-11523345,EBI-11524851
CCDC198 [E9PSE9]4EBI-11523345,EBI-11748295
CD74 - isoform p35 [P04233-2]3EBI-11523345,EBI-12222807
CEP85L - isoform 5 [Q5SZL2-5]3EBI-11523345,EBI-12344751
DMTN [Q08495]3EBI-11523345,EBI-715275
DUSP21 [Q9H596]3EBI-11523345,EBI-7357329
EFHC1 [Q5JVL4]6EBI-11523345,EBI-743105
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-11523345,EBI-12013806
FAM161B [Q96MY7]3EBI-11523345,EBI-7225287
FAM217A [Q8IXS0]3EBI-11523345,EBI-10694567
GPSM3 [Q9Y4H4]3EBI-11523345,EBI-347538
GRXCR1 [A8MXD5]3EBI-11523345,EBI-5235612
HOXB5 [P09067]3EBI-11523345,EBI-3893317
ING3 [A0A0C4DG38]3EBI-11523345,EBI-10263367
KANK2 [Q63ZY3]3EBI-11523345,EBI-2556193
KCTD10 [Q9H3F6]3EBI-11523345,EBI-2505886
KRT6B [P04259]3EBI-11523345,EBI-740907
LRCH2 - isoform 2 [Q5VUJ6-2]3EBI-11523345,EBI-12287681
LRRC36 [Q1X8D7]3EBI-11523345,EBI-12218159
MAPK9 [P45984]3EBI-11523345,EBI-713568
MAPKBP1 [O60336]3EBI-11523345,EBI-947402
MRFAP1 [Q9Y605]3EBI-11523345,EBI-995714
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-11523345,EBI-10172876
NEFL [I6L9F6]3EBI-11523345,EBI-10178578
PPP1R18 [Q6NYC8]3EBI-11523345,EBI-2557469
PRPSAP2 [O60256]3EBI-11523345,EBI-724960
PTPDC1 [A2A3K4]3EBI-11523345,EBI-11603375
SCAF8 [Q9UPN6]3EBI-11523345,EBI-7954236
SNX6 [Q9UNH7]3EBI-11523345,EBI-949294
SOX5 - isoform 4 [P35711-4]3EBI-11523345,EBI-11954419
STMN2 [Q93045]3EBI-11523345,EBI-714194
USP15 - isoform 2 [Q9Y4E8-2]3EBI-11523345,EBI-12041225
UTP14C [Q5TAP6]3EBI-11523345,EBI-11737646
ZNF414 [Q96IQ9]3EBI-11523345,EBI-744257

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121093, 100 interactors

Protein interaction database and analysis system

More...IntActi		Q8IYF3, 75 interactors

Molecular INTeraction database

More...MINTi		Q8IYF3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IYF3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IYF3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IYF3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPO22 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4814, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018086_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IYF3

Identification of Orthologs from Complete Genome Data

More...OMAi		SMDFKEV

Database of Orthologous Groups

More...OrthoDBi		681770at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IYF3

TreeFam database of animal gene trees

More...TreeFami		TF333356

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013940, Spo22/ZIP4/TEX11
IPR042861, TEX11
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...PANTHERi		PTHR47083, PTHR47083, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08631, SPO22, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IYF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF 
        60         70         80         90        100
SDIANINRES MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV 
       110        120        130        140        150
ACKLLSMCEA SFASEQSIQR LIMMNMRIGK EWLDAGNFLI ADECFQAAVA 
       160        170        180        190        200
SLEQLYVKLI QRSSPEADLT MEKITVESDH FRVLSYQAES AVAQGDFQRA 
       210        220        230        240        250
SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE SSFWLSQSYD 
       260        270        280        290        300
IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS 
       310        320        330        340        350
SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER 
       360        370        380        390        400
ESVGFHFLTI IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL 
       410        420        430        440        450
AHQTGRQLTA ESMNWLHNIL WRQAASSFEV QNYTDALQWY YYSLRFYSTD 
       460        470        480        490        500
EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV AEAERHDPRN VFTQFYIFKI 
       510        520        530        540        550
AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM LLSLAAQFAL 
       560        570        580        590        600
ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK 
       610        620        630        640        650
KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD 
       660        670        680        690        700
KDPVMMREFF ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST 
       710        720        730        740        750
AFEQTMFLSR ALEEIQTCND IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK 
       760        770        780        790        800
LNDPLLESFL ESVWELPHLE TKTFETIAII AMEKPAHYPL IALKALKKAL 
       810        820        830        840        850
LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE VWGYFEDALS 
       860        870        880        890        900
HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL 
       910        920        930        940
TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD
Length:940
Mass (Da):107,889
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20A3B0BF58B82EF9
GO
Isoform 2 (identifier: Q8IYF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Show »
Length:615
Mass (Da):71,284
Checksum:i004C5FCD1B5BA3C4
GO
Isoform 3 (identifier: Q8IYF3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MISAHCNLRLLCSSDSSASASQVAGTT → MDNDDFFSMDFK

Show »
Length:925
Mass (Da):106,689
Checksum:i94CD50F30C857FD1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK31973 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65T → A in BAB71520 (PubMed:14702039).Curated1
Sequence conflicti600K → E in BAB71465 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034635130K → R. Corresponds to variant dbSNP:rs6525433Ensembl.1
Natural variantiVAR_073889171M → V in SPGFX2. 2 PublicationsCorresponds to variant dbSNP:rs143246552Ensembl.1
Natural variantiVAR_034636451E → K1 PublicationCorresponds to variant dbSNP:rs4844247Ensembl.1
Natural variantiVAR_073890698A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272601 – 325Missing in isoform 2. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_0272611 – 27MISAH…VAGTT → MDNDDFFSMDFK in isoform 3. 3 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057391 mRNA Translation: BAB71465.1
AK057523 mRNA Translation: BAB71520.1
AK292471 mRNA Translation: BAF85160.1
AL139109 Genomic DNA No translation available.
AL627071 Genomic DNA No translation available.
AL627390 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05331.1
BC036016 mRNA Translation: AAH36016.2
AF285594 mRNA Translation: AAK31973.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35323.1 [Q8IYF3-1]
CCDS43968.1 [Q8IYF3-3]

NCBI Reference Sequences

More...RefSeqi		NP_001003811.1, NM_001003811.1 [Q8IYF3-1]
NP_112566.2, NM_031276.2 [Q8IYF3-3]
XP_011529298.1, XM_011530996.1 [Q8IYF3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344304.3; ENSP00000340995.3; ENSG00000120498.14
ENST00000374320.6; ENSP00000363440.2; ENSG00000120498.14 [Q8IYF3-2]
ENST00000374333.7; ENSP00000363453.2; ENSG00000120498.14 [Q8IYF3-3]
ENST00000395889.6; ENSP00000379226.2; ENSG00000120498.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56159

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000374333.7; ENSP00000363453.2; NM_031276.3; NP_112566.2 [Q8IYF3-3]

UCSC genome browser

More...UCSCi		uc004dyk.4, human [Q8IYF3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057391 mRNA Translation: BAB71465.1
AK057523 mRNA Translation: BAB71520.1
AK292471 mRNA Translation: BAF85160.1
AL139109 Genomic DNA No translation available.
AL627071 Genomic DNA No translation available.
AL627390 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05331.1
BC036016 mRNA Translation: AAH36016.2
AF285594 mRNA Translation: AAK31973.1 Different initiation.
CCDSiCCDS35323.1 [Q8IYF3-1]
CCDS43968.1 [Q8IYF3-3]
RefSeqiNP_001003811.1, NM_001003811.1 [Q8IYF3-1]
NP_112566.2, NM_031276.2 [Q8IYF3-3]
XP_011529298.1, XM_011530996.1 [Q8IYF3-2]

3D structure databases

AlphaFoldDBiQ8IYF3
SMRiQ8IYF3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121093, 100 interactors
IntActiQ8IYF3, 75 interactors
MINTiQ8IYF3
STRINGi9606.ENSP00000379226

PTM databases

iPTMnetiQ8IYF3
PhosphoSitePlusiQ8IYF3

Genetic variation databases

BioMutaiTEX11
DMDMi156637425

Proteomic databases

EPDiQ8IYF3
MassIVEiQ8IYF3
PaxDbiQ8IYF3
PeptideAtlasiQ8IYF3
PRIDEiQ8IYF3
ProteomicsDBi71166 [Q8IYF3-1]
71167 [Q8IYF3-2]
71168 [Q8IYF3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		508, 81 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		56159

Genome annotation databases

EnsembliENST00000344304.3; ENSP00000340995.3; ENSG00000120498.14
ENST00000374320.6; ENSP00000363440.2; ENSG00000120498.14 [Q8IYF3-2]
ENST00000374333.7; ENSP00000363453.2; ENSG00000120498.14 [Q8IYF3-3]
ENST00000395889.6; ENSP00000379226.2; ENSG00000120498.14
GeneIDi56159
KEGGihsa:56159
MANE-SelectiENST00000374333.7; ENSP00000363453.2; NM_031276.3; NP_112566.2 [Q8IYF3-3]
UCSCiuc004dyk.4, human [Q8IYF3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56159
DisGeNETi56159

GeneCards: human genes, protein and diseases

More...GeneCardsi		TEX11
HGNCiHGNC:11733, TEX11
HPAiENSG00000120498, Tissue enriched (pancreas)
MalaCardsiTEX11
MIMi300311, gene
309120, phenotype
neXtProtiNX_Q8IYF3
OpenTargetsiENSG00000120498
Orphaneti399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation
PharmGKBiPA36450
VEuPathDBiHostDB:ENSG00000120498

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4814, Eukaryota
GeneTreeiENSGT00390000006492
HOGENOMiCLU_018086_0_0_1
InParanoidiQ8IYF3
OMAiSMDFKEV
OrthoDBi681770at2759
PhylomeDBiQ8IYF3
TreeFamiTF333356

Enzyme and pathway databases

PathwayCommonsiQ8IYF3
SignaLinkiQ8IYF3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56159, 10 hits in 701 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TEX11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56159
PharosiQ8IYF3, Tbio

Protein Ontology

More...PROi		PR:Q8IYF3
RNActiQ8IYF3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120498, Expressed in pancreas and 82 other tissues
GenevisibleiQ8IYF3, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013940, Spo22/ZIP4/TEX11
IPR042861, TEX11
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR47083, PTHR47083, 1 hit
PfamiView protein in Pfam
PF08631, SPO22, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 2 hits
SUPFAMiSSF48452, SSF48452, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYF3
Secondary accession number(s): A8K8V6
, Q5JQQ8, Q96LZ4, Q96M47, Q9BXU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 25, 2022
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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