UniProtKB - Q8IYF3 (TEX11_HUMAN)
Protein
Testis-expressed protein 11
Gene
TEX11
Organism
Homo sapiens (Human)
Status
Functioni
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.By similarity
GO - Biological processi
- chiasma assembly Source: Ensembl
- fertilization Source: Ensembl
- male gonad development Source: Ensembl
- male meiosis chromosome segregation Source: GO_Central
- meiotic gene conversion Source: UniProtKB
- negative regulation of apoptotic process Source: Ensembl
- reciprocal meiotic recombination Source: UniProtKB
- resolution of meiotic recombination intermediates Source: Ensembl
- synaptonemal complex assembly Source: GO_Central
Keywordsi
Biological process | Meiosis |
Enzyme and pathway databases
PathwayCommonsi | Q8IYF3 |
Names & Taxonomyi
Protein namesi | Recommended name: Testis-expressed protein 11 |
Gene namesi | Name:TEX11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000120498.13 |
HGNCi | HGNC:11733, TEX11 |
MIMi | 300311, gene |
neXtProti | NX_Q8IYF3 |
Subcellular locationi
Other locations
- Chromosome By similarity
Note: Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes.By similarity
Nucleus
- central element Source: GO_Central
Keywords - Cellular componenti
ChromosomePathology & Biotechi
Involvement in diseasei
Spermatogenic failure, X-linked, 2 (SPGFX2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073889 | 171 | M → V in SPGFX2. 2 PublicationsCorresponds to variant dbSNP:rs143246552EnsemblClinVar. | 1 | |
Natural variantiVAR_073890 | 698 | A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 56159 |
MalaCardsi | TEX11 |
MIMi | 309120, phenotype |
OpenTargetsi | ENSG00000120498 |
Orphaneti | 399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation |
PharmGKBi | PA36450 |
Miscellaneous databases
Pharosi | Q8IYF3, Tbio |
Polymorphism and mutation databases
BioMutai | TEX11 |
DMDMi | 156637425 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296955 | 1 – 940 | Testis-expressed protein 11Add BLAST | 940 |
Proteomic databases
MassIVEi | Q8IYF3 |
PaxDbi | Q8IYF3 |
PeptideAtlasi | Q8IYF3 |
PRIDEi | Q8IYF3 |
ProteomicsDBi | 71166 [Q8IYF3-1] 71167 [Q8IYF3-2] 71168 [Q8IYF3-3] |
PTM databases
iPTMneti | Q8IYF3 |
PhosphoSitePlusi | Q8IYF3 |
Expressioni
Tissue specificityi
Testis-specific. Not expressed in adult ovaries.1 Publication
Gene expression databases
Bgeei | ENSG00000120498, Expressed in pancreas and 82 other tissues |
Genevisiblei | Q8IYF3, HS |
Organism-specific databases
HPAi | ENSG00000120498, Group enriched (pancreas, testis) |
Interactioni
Subunit structurei
Interacts with SYCP2.
Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
Interacts with SHOC1 (PubMed:29742103).
By similarity1 PublicationBinary interactionsi
Q8IYF3
Isoform 3 [Q8IYF3-3]
Protein-protein interaction databases
BioGRIDi | 121093, 100 interactors |
IntActi | Q8IYF3, 74 interactors |
MINTi | Q8IYF3 |
STRINGi | 9606.ENSP00000379226 |
Miscellaneous databases
RNActi | Q8IYF3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SPO22 family.Curated
Phylogenomic databases
eggNOGi | KOG4814, Eukaryota |
GeneTreei | ENSGT00390000006492 |
HOGENOMi | CLU_018086_0_0_1 |
InParanoidi | Q8IYF3 |
OMAi | CAIQLWN |
OrthoDBi | 681770at2759 |
PhylomeDBi | Q8IYF3 |
TreeFami | TF333356 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR013940, Spo22/ZIP4/TEX11 IPR042861, TEX11 IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR47083, PTHR47083, 1 hit |
Pfami | View protein in Pfam PF08631, SPO22, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IYF3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF
60 70 80 90 100
SDIANINRES MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV
110 120 130 140 150
ACKLLSMCEA SFASEQSIQR LIMMNMRIGK EWLDAGNFLI ADECFQAAVA
160 170 180 190 200
SLEQLYVKLI QRSSPEADLT MEKITVESDH FRVLSYQAES AVAQGDFQRA
210 220 230 240 250
SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE SSFWLSQSYD
260 270 280 290 300
IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS
310 320 330 340 350
SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER
360 370 380 390 400
ESVGFHFLTI IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL
410 420 430 440 450
AHQTGRQLTA ESMNWLHNIL WRQAASSFEV QNYTDALQWY YYSLRFYSTD
460 470 480 490 500
EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV AEAERHDPRN VFTQFYIFKI
510 520 530 540 550
AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM LLSLAAQFAL
560 570 580 590 600
ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK
610 620 630 640 650
KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD
660 670 680 690 700
KDPVMMREFF ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST
710 720 730 740 750
AFEQTMFLSR ALEEIQTCND IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK
760 770 780 790 800
LNDPLLESFL ESVWELPHLE TKTFETIAII AMEKPAHYPL IALKALKKAL
810 820 830 840 850
LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE VWGYFEDALS
860 870 880 890 900
HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL
910 920 930 940
TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD
Sequence cautioni
The sequence AAK31973 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | T → A in BAB71520 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 600 | K → E in BAB71465 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034635 | 130 | K → R. Corresponds to variant dbSNP:rs6525433Ensembl. | 1 | |
Natural variantiVAR_073889 | 171 | M → V in SPGFX2. 2 PublicationsCorresponds to variant dbSNP:rs143246552EnsemblClinVar. | 1 | |
Natural variantiVAR_034636 | 451 | E → K1 PublicationCorresponds to variant dbSNP:rs4844247Ensembl. | 1 | |
Natural variantiVAR_073890 | 698 | A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027260 | 1 – 325 | Missing in isoform 2. 1 PublicationAdd BLAST | 325 | |
Alternative sequenceiVSP_027261 | 1 – 27 | MISAH…VAGTT → MDNDDFFSMDFK in isoform 3. 3 PublicationsAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057391 mRNA Translation: BAB71465.1 AK057523 mRNA Translation: BAB71520.1 AK292471 mRNA Translation: BAF85160.1 AL139109 Genomic DNA No translation available. AL627071 Genomic DNA No translation available. AL627390 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05331.1 BC036016 mRNA Translation: AAH36016.2 AF285594 mRNA Translation: AAK31973.1 Different initiation. |
CCDSi | CCDS35323.1 [Q8IYF3-1] CCDS43968.1 [Q8IYF3-3] |
RefSeqi | NP_001003811.1, NM_001003811.1 [Q8IYF3-1] NP_112566.2, NM_031276.2 [Q8IYF3-3] XP_011529298.1, XM_011530996.1 [Q8IYF3-2] |
Genome annotation databases
Ensembli | ENST00000344304; ENSP00000340995; ENSG00000120498 [Q8IYF3-1] ENST00000374320; ENSP00000363440; ENSG00000120498 [Q8IYF3-2] ENST00000374333; ENSP00000363453; ENSG00000120498 [Q8IYF3-3] ENST00000395889; ENSP00000379226; ENSG00000120498 [Q8IYF3-1] |
GeneIDi | 56159 |
KEGGi | hsa:56159 |
UCSCi | uc004dyk.4, human [Q8IYF3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057391 mRNA Translation: BAB71465.1 AK057523 mRNA Translation: BAB71520.1 AK292471 mRNA Translation: BAF85160.1 AL139109 Genomic DNA No translation available. AL627071 Genomic DNA No translation available. AL627390 Genomic DNA No translation available. CH471132 Genomic DNA Translation: EAX05331.1 BC036016 mRNA Translation: AAH36016.2 AF285594 mRNA Translation: AAK31973.1 Different initiation. |
CCDSi | CCDS35323.1 [Q8IYF3-1] CCDS43968.1 [Q8IYF3-3] |
RefSeqi | NP_001003811.1, NM_001003811.1 [Q8IYF3-1] NP_112566.2, NM_031276.2 [Q8IYF3-3] XP_011529298.1, XM_011530996.1 [Q8IYF3-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121093, 100 interactors |
IntActi | Q8IYF3, 74 interactors |
MINTi | Q8IYF3 |
STRINGi | 9606.ENSP00000379226 |
PTM databases
iPTMneti | Q8IYF3 |
PhosphoSitePlusi | Q8IYF3 |
Polymorphism and mutation databases
BioMutai | TEX11 |
DMDMi | 156637425 |
Proteomic databases
MassIVEi | Q8IYF3 |
PaxDbi | Q8IYF3 |
PeptideAtlasi | Q8IYF3 |
PRIDEi | Q8IYF3 |
ProteomicsDBi | 71166 [Q8IYF3-1] 71167 [Q8IYF3-2] 71168 [Q8IYF3-3] |
Protocols and materials databases
Antibodypediai | 508, 74 antibodies |
DNASUi | 56159 |
Genome annotation databases
Ensembli | ENST00000344304; ENSP00000340995; ENSG00000120498 [Q8IYF3-1] ENST00000374320; ENSP00000363440; ENSG00000120498 [Q8IYF3-2] ENST00000374333; ENSP00000363453; ENSG00000120498 [Q8IYF3-3] ENST00000395889; ENSP00000379226; ENSG00000120498 [Q8IYF3-1] |
GeneIDi | 56159 |
KEGGi | hsa:56159 |
UCSCi | uc004dyk.4, human [Q8IYF3-1] |
Organism-specific databases
CTDi | 56159 |
DisGeNETi | 56159 |
EuPathDBi | HostDB:ENSG00000120498.13 |
GeneCardsi | TEX11 |
HGNCi | HGNC:11733, TEX11 |
HPAi | ENSG00000120498, Group enriched (pancreas, testis) |
MalaCardsi | TEX11 |
MIMi | 300311, gene 309120, phenotype |
neXtProti | NX_Q8IYF3 |
OpenTargetsi | ENSG00000120498 |
Orphaneti | 399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation |
PharmGKBi | PA36450 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4814, Eukaryota |
GeneTreei | ENSGT00390000006492 |
HOGENOMi | CLU_018086_0_0_1 |
InParanoidi | Q8IYF3 |
OMAi | CAIQLWN |
OrthoDBi | 681770at2759 |
PhylomeDBi | Q8IYF3 |
TreeFami | TF333356 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYF3 |
Miscellaneous databases
BioGRID-ORCSi | 56159, 2 hits in 474 CRISPR screens |
ChiTaRSi | TEX11, human |
GenomeRNAii | 56159 |
Pharosi | Q8IYF3, Tbio |
PROi | PR:Q8IYF3 |
RNActi | Q8IYF3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120498, Expressed in pancreas and 82 other tissues |
Genevisiblei | Q8IYF3, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR013940, Spo22/ZIP4/TEX11 IPR042861, TEX11 IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR47083, PTHR47083, 1 hit |
Pfami | View protein in Pfam PF08631, SPO22, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 2 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEX11_HUMAN | |
Accessioni | Q8IYF3Primary (citable) accession number: Q8IYF3 Secondary accession number(s): A8K8V6 Q9BXU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations