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Entry version 160 (02 Dec 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Elongin-A2

Gene

ELOA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYF1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955, RNA Polymerase II Transcription Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongin-A2
Short name:
EloA2
Alternative name(s):
RNA polymerase II transcription factor SIII subunit A2
Transcription elongation factor B polypeptide 3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELOA2Imported
Synonyms:TCEB3B, TCEB3L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000206181.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30771, ELOA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609522, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51224

Open Targets

More...
OpenTargetsi
ENSG00000206181

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932220

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYF1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ELOA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559470

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000869631 – 753Elongin-A2Add BLAST753

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYF1

PeptideAtlas

More...
PeptideAtlasi
Q8IYF1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYF1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71165

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYF1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206181, Expressed in sperm and 17 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYF1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYF1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000206181, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119388, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYF1, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331302

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYF1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYF1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 80TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni500 – 659Activation domainBy similarityAdd BLAST160
Regioni528 – 537BC-boxBy similarity10
Regioni528 – 537Interacting with Elongin BC complexBy similarity10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x3-C-x3-[AILV].By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2821, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021679_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYF1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIGVTDH

Database of Orthologous Groups

More...
OrthoDBi
1174517at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYF1

TreeFam database of animal gene trees

More...
TreeFami
TF317259

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010684, RNA_pol_II_trans_fac_SIII_A
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06881, Elongin_A, 1 hit
PF08711, Med26, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00509, TFS2N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47676, SSF47676, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51319, TFIIS_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGSTTLHA VEKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTRPGPQDP EESASRQRFG
110 120 130 140 150
EALQDQEKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSHSRE
160 170 180 190 200
PRAERKCPRI APADSGRYRA SPTRTAPLRM PEGPEPAAPG KQPGRGHTHA
210 220 230 240 250
AQGGPLLCPG CQGQPQGKAV VSHSKGHKSS RQEKRPLCAQ GDWHSPTLIR
260 270 280 290 300
EKSCGACLRE ETPRMPSWAS ARDRQPSDFK TDKEGGQAGS GQRVPALEEA
310 320 330 340 350
PDSHQKRPQH SHSNKKRPSL DGRDPGNGTH GLSPEEKEQL SNDRETQEGK
360 370 380 390 400
PPTAHLDRTS VSSLSEVEEV DMAEEFEQPT LSCEKYLTYD QLRKQKKKTG
410 420 430 440 450
KSATTALGDK QRKANESKGT RESWDSAKKL PPVQESQSER LQAAGADSAG
460 470 480 490 500
PKTVPSHVFS ELWDLSEAWM QANYDPLSDS DSMTSQAKPE ALSSPKFREE
510 520 530 540 550
AAFPGRRVNA KMPVYSGSRP ACQLQVPTLR QQCAQVLRNN PDALSDVGEV
560 570 580 590 600
PYWVLEPVLE GWRPDQLYRR KKDNHALVRE TDELRRNHCF QDFKEEKPQE
610 620 630 640 650
NKTWREQYLR LPDAPEQRLR VMTTNIRSAR GNNPNGREAK MICFKSVAKT
660 670 680 690 700
PYDTSRRQEK SAGDADPENG EIKPASKPAG SSHTPSSQSS SGGGRDSSSS
710 720 730 740 750
ILRWLPEKRA NPCLSSSNEH AAPAAKTRKQ AAKKVAPLMA KAIRDYKRRF

SRR
Length:753
Mass (Da):83,921
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4CFDF5A0D3AD529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55R → L in BAA90665 (PubMed:10692460).Curated1
Sequence conflicti236P → L in BAA90665 (PubMed:10692460).Curated1
Sequence conflicti456S → N in AAH36022 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050965179R → P1 PublicationCorresponds to variant dbSNP:rs2571028Ensembl.1
Natural variantiVAR_050966254C → F1 PublicationCorresponds to variant dbSNP:rs2010834Ensembl.1
Natural variantiVAR_050967403A → S1 PublicationCorresponds to variant dbSNP:rs892586Ensembl.1
Natural variantiVAR_061646446A → T1 PublicationCorresponds to variant dbSNP:rs3744863Ensembl.1
Natural variantiVAR_035914498R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138369139Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB030834 mRNA Translation: BAA90665.1
BC036022 mRNA Translation: AAH36022.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11932.1

NCBI Reference Sequences

More...
RefSeqi
NP_057511.2, NM_016427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332567; ENSP00000331302; ENSG00000206181

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51224

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51224

UCSC genome browser

More...
UCSCi
uc002lcr.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030834 mRNA Translation: BAA90665.1
BC036022 mRNA Translation: AAH36022.1
CCDSiCCDS11932.1
RefSeqiNP_057511.2, NM_016427.2

3D structure databases

SMRiQ8IYF1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119388, 48 interactors
IntActiQ8IYF1, 21 interactors
STRINGi9606.ENSP00000331302

PTM databases

iPTMnetiQ8IYF1
PhosphoSitePlusiQ8IYF1

Polymorphism and mutation databases

BioMutaiELOA2
DMDMi145559470

Proteomic databases

PaxDbiQ8IYF1
PeptideAtlasiQ8IYF1
PRIDEiQ8IYF1
ProteomicsDBi71165

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22536, 69 antibodies

The DNASU plasmid repository

More...
DNASUi
51224

Genome annotation databases

EnsembliENST00000332567; ENSP00000331302; ENSG00000206181
GeneIDi51224
KEGGihsa:51224
UCSCiuc002lcr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51224
DisGeNETi51224
EuPathDBiHostDB:ENSG00000206181.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ELOA2
HGNCiHGNC:30771, ELOA2
HPAiENSG00000206181, Tissue enriched (testis)
MIMi609522, gene
neXtProtiNX_Q8IYF1
OpenTargetsiENSG00000206181
PharmGKBiPA134932220

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2821, Eukaryota
GeneTreeiENSGT00390000002428
HOGENOMiCLU_021679_1_0_1
InParanoidiQ8IYF1
OMAiYIGVTDH
OrthoDBi1174517at2759
PhylomeDBiQ8IYF1
TreeFamiTF317259

Enzyme and pathway databases

PathwayCommonsiQ8IYF1
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955, RNA Polymerase II Transcription Elongation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51224, 5 hits in 839 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51224
PharosiQ8IYF1, Tdark

Protein Ontology

More...
PROi
PR:Q8IYF1
RNActiQ8IYF1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000206181, Expressed in sperm and 17 other tissues
ExpressionAtlasiQ8IYF1, baseline and differential
GenevisibleiQ8IYF1, HS

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR010684, RNA_pol_II_trans_fac_SIII_A
IPR003617, TFIIS/CRSP70_N_sub
IPR035441, TFIIS/LEDGF_dom_sf
IPR017923, TFIIS_N
PfamiView protein in Pfam
PF06881, Elongin_A, 1 hit
PF08711, Med26, 1 hit
SMARTiView protein in SMART
SM00509, TFS2N, 1 hit
SUPFAMiSSF47676, SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS51319, TFIIS_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELOA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYF1
Secondary accession number(s): Q9P2V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 17, 2007
Last modified: December 2, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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