Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 103 (22 Apr 2020)
Sequence version 2 (05 May 2009)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Coiled-coil domain-containing protein 13

Gene

CCDC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 13Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26358 CCDC13

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000244607

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974073

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYE1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894091 – 715Coiled-coil domain-containing protein 13Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineBy similarity1
Modified residuei469PhosphoserineBy similarity1
Modified residuei536PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYE1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYE1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYE1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYE1

PeptideAtlas

More...
PeptideAtlasi
Q8IYE1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYE1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71164

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYE1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000244607 Expressed in right uterine tube and 154 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYE1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000244607 Tissue enhanced (brain, fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCM1, CEP290 and PCNT.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8IYE1, 62 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYE1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYE1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 105Sequence analysisAdd BLAST90
Coiled coili134 – 458Sequence analysisAdd BLAST325
Coiled coili554 – 608Sequence analysisAdd BLAST55
Coiled coili653 – 683Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGKT Eukaryota
ENOG410YWT6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026686_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYE1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NINTMND

Database of Orthologous Groups

More...
OrthoDBi
1533296at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYE1

TreeFam database of animal gene trees

More...
TreeFami
TF328506

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038929 CCDC13

The PANTHER Classification System

More...
PANTHERi
PTHR31935 PTHR31935, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADESSQNT LRLQFKAMQE MQHKRLQKQM EKKREKELSL KSRADDQEEP
60 70 80 90 100
LEVSDGLSLL HAGEPNSKNS FEKRVLEDEI EHLRNELRET VDENGRLYKL
110 120 130 140 150
LKERDFEIKH LKKKIEEDRF AFTGTAGVAG DVVATKIVEL SKKNRLLMAE
160 170 180 190 200
SEGAKTRVKQ LTNRIQELER ELQTALTRLS AKGATDAGAK PPRAQMGDRA
210 220 230 240 250
LLETPEVKAL QDRLVATNLK MSDLRNQIQS VKQELRMAQK VLAREVGEDI
260 270 280 290 300
NVQQLLSSPG TWRGRAQQIL VLQSKVQELE KQLGQARSQS AGTASDELSV
310 320 330 340 350
YPDPRKLSAQ EKNLLRIRSL EREKQEGLEK LASERDVLQR ELEELKKKFE
360 370 380 390 400
GMRSRNKLLS SEMKTLKSQM GTLVEKGRHD DELIDALMDQ LKQLQEILGS
410 420 430 440 450
LSLQEEKTRV SQHHLDQQLN SEAQRSNSLV AQLQAMVAER EAKVRQLEME
460 470 480 490 500
IGQLNVHYLR NKGVGEGSSG REVSPAYTQF LEDPGLTKSP ASAGDHVGRL
510 520 530 540 550
GSSRSVTSLG HTLVESALTR PSLPSPHRTS PRFSDSPEQK GWQAQVSEIK
560 570 580 590 600
ALWQAAEVER DRLTEFVTVL QKRVEESNSK LLESERKLQE ERHRTVVLEQ
610 620 630 640 650
HLEKIRLEPG KASASQRAAP RTKTGLPTSN NRHNPTGSEK KDPSFAQLSD
660 670 680 690 700
VPVESQMEEL TTRLAIQVEE NEMLKAALGS ALRGKEEDFR MYHEILGQVK
710
SVFLQALRQQ KTGKQ
Length:715
Mass (Da):80,884
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i066B05A9D5EDECF3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05509325R → W. Corresponds to variant dbSNP:rs17238798Ensembl.1
Natural variantiVAR_055094375E → V1 PublicationCorresponds to variant dbSNP:rs17853515Ensembl.1
Natural variantiVAR_033664547S → T. Corresponds to variant dbSNP:rs12495805Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006059 Genomic DNA No translation available.
BC036050 mRNA Translation: AAH36050.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2705.1

NCBI Reference Sequences

More...
RefSeqi
NP_653320.3, NM_144719.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310232; ENSP00000309836; ENSG00000244607

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
152206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:152206

UCSC genome browser

More...
UCSCi
uc003cly.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006059 Genomic DNA No translation available.
BC036050 mRNA Translation: AAH36050.1
CCDSiCCDS2705.1
RefSeqiNP_653320.3, NM_144719.3

3D structure databases

SMRiQ8IYE1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8IYE1, 62 interactors
STRINGi9606.ENSP00000309836

PTM databases

iPTMnetiQ8IYE1
PhosphoSitePlusiQ8IYE1

Polymorphism and mutation databases

BioMutaiCCDC13
DMDMi229462823

Proteomic databases

EPDiQ8IYE1
jPOSTiQ8IYE1
MassIVEiQ8IYE1
PaxDbiQ8IYE1
PeptideAtlasiQ8IYE1
PRIDEiQ8IYE1
ProteomicsDBi71164

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48468 71 antibodies

Genome annotation databases

EnsembliENST00000310232; ENSP00000309836; ENSG00000244607
GeneIDi152206
KEGGihsa:152206
UCSCiuc003cly.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152206

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC13
HGNCiHGNC:26358 CCDC13
HPAiENSG00000244607 Tissue enhanced (brain, fallopian tube, testis)
neXtProtiNX_Q8IYE1
OpenTargetsiENSG00000244607
PharmGKBiPA134974073

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGKT Eukaryota
ENOG410YWT6 LUCA
GeneTreeiENSGT00390000000596
HOGENOMiCLU_026686_0_0_1
InParanoidiQ8IYE1
OMAiNINTMND
OrthoDBi1533296at2759
PhylomeDBiQ8IYE1
TreeFamiTF328506

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC13 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
152206
PharosiQ8IYE1 Tbio

Protein Ontology

More...
PROi
PR:Q8IYE1
RNActiQ8IYE1 protein

Gene expression databases

BgeeiENSG00000244607 Expressed in right uterine tube and 154 other tissues
GenevisibleiQ8IYE1 HS

Family and domain databases

InterProiView protein in InterPro
IPR038929 CCDC13
PANTHERiPTHR31935 PTHR31935, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 5, 2009
Last modified: April 22, 2020
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again