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Entry version 118 (13 Nov 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Coiled-coil domain-containing protein 146

Gene

CCDC146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

A report observed N-glycosylation at Asn-815 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidence is required to confirm this result.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 146
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC146
Synonyms:KIAA1505
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29296 CCDC146

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYE0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000135205

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381475

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYE0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC146

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167006541

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172521 – 955Coiled-coil domain-containing protein 146Add BLAST955

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYE0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYE0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYE0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYE0

PeptideAtlas

More...
PeptideAtlasi
Q8IYE0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYE0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71162 [Q8IYE0-1]
71163 [Q8IYE0-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8IYE0

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYE0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135205 Expressed in 178 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYE0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYE0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020082
HPA020105

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121678, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYE0, 75 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYE0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili114 – 141Sequence analysisAdd BLAST28
Coiled coili169 – 321Sequence analysisAdd BLAST153
Coiled coili400 – 461Sequence analysisAdd BLAST62
Coiled coili534 – 640Sequence analysisAdd BLAST107
Coiled coili667 – 832Sequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 15Poly-Glu7
Compositional biasi98 – 103Poly-Gln6
Compositional biasi501 – 504Poly-Lys4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF2S Eukaryota
ENOG410XSB7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYE0

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYHNQYR

Database of Orthologous Groups

More...
OrthoDBi
135458at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYE0

TreeFam database of animal gene trees

More...
TreeFami
TF328680

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDSSTDTEK EEEEEKDEKD QEPIYAIVPT INIQDERFVD LSETPAFIFL
60 70 80 90 100
HELHAMGKLP GTRMAALKAK YTLLHDAVMS TQESEVQLLQ NAKRFTEQIQ
110 120 130 140 150
QQQFHLQQAD NFPEAFSTEV SKMREQLLKY QNEYNAVKER EFHNQYRLNS
160 170 180 190 200
LKEEKIIIVK EFEKITKPGE MEKKMKILRE STEELRKEIM QKKLEIKNLR
210 220 230 240 250
EDLASKQKQL LKEQKELEEL LGHQVVLKDE VAHHQTIPVQ IGKEIEKITR
260 270 280 290 300
KKVEMEKKKI VLEQEVKTLN DSLKKVENKV SAIVDEKENV IKEVEGKRAL
310 320 330 340 350
LEIKEREHNQ LVKLLELARE NEATSLTERG ILDLNLRNSL IDKQNYHDEL
360 370 380 390 400
SRKQREKERD FRNLRKMELL LKVSWDALRQ TQALHQRLLL EMEAIPKDDS
410 420 430 440 450
TLSERRRELH KEVEVAKRNL AQQKIISEME SKLVEQQLAE ENKLLKEQEN
460 470 480 490 500
MKELVVNLLR MTQIKIDEKE QKSKDFLKAQ QKYTNIVKEM KAKDLEIRIH
510 520 530 540 550
KKKKCEIYRR LREFAKLYDT IRNERNKFVN LLHKAHQKVN EIKERHKMSL
560 570 580 590 600
NELEILRNSA VSQERKLQNS MLKHANNVTI RESMQNDVRK IVSKLQEMKE
610 620 630 640 650
KKEAQLNNID RLANTITMIE EEMVQLRKRY EKAVQHRNES GVQLIEREEE
660 670 680 690 700
ICIFYEKINI QEKMKLNGEI EIHLLEEKIQ FLKMKIAEKQ RQICVTQKLL
710 720 730 740 750
PAKRSLDADL AVLQIQFSQC TDRIKDLEKQ FVKPDGENRA RFLPGKDLTE
760 770 780 790 800
KEMIQKLDKL ELQLAKKEEK LLEKDFIYEQ VSRLTDRLCS KTQGCKQDTL
810 820 830 840 850
LLAKKMNGYQ RRIKNATEKM MALVAELSMK QALTIELQKE VREKEDFIFT
860 870 880 890 900
CNSRIEKGLP LNKEIEKEWL KVLRDEEMHA LAIAEKSQEF LEADNRQLPN
910 920 930 940 950
GVYTTAEQRP NAYIPEADAT LPLPKPYGAL APFKPSEPGA NMRHIRKPVI

KPVEI
Length:955
Mass (Da):112,806
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB434DD95EF1019FF
GO
Isoform 2 (identifier: Q8IYE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     392-423: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):79,031
Checksum:iC242C0AD54AB19E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRR4C9JRR4_HUMAN
Coiled-coil domain-containing prote...
CCDC146
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96029 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti655Y → H in BAF85180 (PubMed:14702039).Curated1
Sequence conflicti829M → I in BAF85180 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061583263E → Q1 PublicationCorresponds to variant dbSNP:rs17853516Ensembl.1
Natural variantiVAR_050742345N → S1 PublicationCorresponds to variant dbSNP:rs1109968Ensembl.1
Natural variantiVAR_061584466I → T. Corresponds to variant dbSNP:rs58545343Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309261 – 254Missing in isoform 2. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_030927392 – 423Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB040938 mRNA Translation: BAA96029.1 Different initiation.
AK292491 mRNA Translation: BAF85180.1
BC036053 mRNA Translation: AAH36053.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34671.1 [Q8IYE0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_065930.2, NM_020879.2 [Q8IYE0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285871; ENSP00000285871; ENSG00000135205 [Q8IYE0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57639

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57639

UCSC genome browser

More...
UCSCi
uc003uga.3 human [Q8IYE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040938 mRNA Translation: BAA96029.1 Different initiation.
AK292491 mRNA Translation: BAF85180.1
BC036053 mRNA Translation: AAH36053.1
CCDSiCCDS34671.1 [Q8IYE0-1]
RefSeqiNP_065930.2, NM_020879.2 [Q8IYE0-1]

3D structure databases

SMRiQ8IYE0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121678, 37 interactors
IntActiQ8IYE0, 75 interactors
STRINGi9606.ENSP00000285871

PTM databases

CarbonylDBiQ8IYE0
iPTMnetiQ8IYE0
PhosphoSitePlusiQ8IYE0

Polymorphism and mutation databases

BioMutaiCCDC146
DMDMi167006541

Proteomic databases

EPDiQ8IYE0
jPOSTiQ8IYE0
MassIVEiQ8IYE0
PaxDbiQ8IYE0
PeptideAtlasiQ8IYE0
PRIDEiQ8IYE0
ProteomicsDBi71162 [Q8IYE0-1]
71163 [Q8IYE0-2]

Genome annotation databases

EnsembliENST00000285871; ENSP00000285871; ENSG00000135205 [Q8IYE0-1]
GeneIDi57639
KEGGihsa:57639
UCSCiuc003uga.3 human [Q8IYE0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57639

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC146
HGNCiHGNC:29296 CCDC146
HPAiHPA020082
HPA020105
neXtProtiNX_Q8IYE0
OpenTargetsiENSG00000135205
PharmGKBiPA162381475

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF2S Eukaryota
ENOG410XSB7 LUCA
GeneTreeiENSGT00530000063534
HOGENOMiHOG000006542
InParanoidiQ8IYE0
OMAiEYHNQYR
OrthoDBi135458at2759
PhylomeDBiQ8IYE0
TreeFamiTF328680

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC146 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57639
PharosiQ8IYE0

Protein Ontology

More...
PROi
PR:Q8IYE0

Gene expression databases

BgeeiENSG00000135205 Expressed in 178 organ(s), highest expression level in caput epididymis
ExpressionAtlasiQ8IYE0 baseline and differential
GenevisibleiQ8IYE0 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC146_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYE0
Secondary accession number(s): A8K8X6, Q9P223
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 13, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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