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Entry version 154 (18 Sep 2019)
Sequence version 1 (01 Mar 2003)
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Protein

ATP-dependent RNA helicase SUPV3L1, mitochondrial

Gene

SUPV3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Helicase activity toward DNA substrate is inhibited by micromolar concentrations of 5,6-dichloro-1-(beta-D-ribofuranosyl)benzotriazole (DRBT) and 4,5,6,7-tetrabromobenzotriazole (TBBT). Helicase activity toward RNA substrate is inhibited by elevated concentrations of TBBT. Inhibited by some ring-expanded nucleoside analogs.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=41.9 µM for ATP2 Publications

    pH dependencei

    Optimum pH is 5.0.2 Publications

    Temperature dependencei

    Optimum temperature is 30 degrees Celsius.2 Publications

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi207 – 214ATPPROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHelicase, Hydrolase
    LigandATP-binding, Nucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC:3.6.4.131 Publication)
    Alternative name(s):
    Suppressor of var1 3-like protein 1
    Short name:
    SUV3-like protein 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SUPV3L1
    Synonyms:SUV3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11471 SUPV3L1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605122 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8IYB8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion, Mitochondrion nucleoid, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi207G → V: Abolishes ATPase and dsDNA and dsRNA helicase activities. 1 Publication1
    Mutagenesisi213K → A or R: Abolishes ATPase activity. Abolishes helicase activity and reduces double-stranded RNA degradation. Does not abolish formation of the mitochondrial RNA-degrading complex. 2 Publications1
    Mutagenesisi576 – 581Missing : Does not abolish ATPase activity. Shows a loss of double-stranded RNA-binding, helicase and degrading activities. 1 Publication6

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6832

    Open Targets

    More...
    OpenTargetsi
    ENSG00000156502

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA36257

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3642

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SUPV3L1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74759699

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 22MitochondrionSequence analysisAdd BLAST22
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031054523 – 786ATP-dependent RNA helicase SUPV3L1, mitochondrialAdd BLAST764

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99N6-acetyllysineCombined sources1
    Modified residuei220N6-acetyllysineCombined sources1
    Modified residuei725PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8IYB8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8IYB8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8IYB8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8IYB8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8IYB8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8IYB8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8IYB8

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    71153

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8IYB8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8IYB8

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q8IYB8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Broadly expressed.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000156502 Expressed in 223 organ(s), highest expression level in lower esophagus muscularis layer

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8IYB8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8IYB8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA038380
    HPA038405

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer; in free form.

    Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1.

    Interacts with LAMTOR5/HBXIP, WRN and BLM.

    3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    LZTS2Q9BRK43EBI-2876787,EBI-741037

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    112699, 32 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8IYB8, 24 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q8IYB8

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000352678

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1786
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8IYB8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini194 – 334Helicase ATP-bindingAdd BLAST141
    Domaini353 – 518Helicase C-terminalPROSITE-ProRule annotationAdd BLAST166

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni650 – 786Interaction with LAMTOR5, important for protein stability1 PublicationAdd BLAST137

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the helicase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0953 Eukaryota
    ENOG410XSEY LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000003100

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000175283

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8IYB8

    KEGG Orthology (KO)

    More...
    KOi
    K17675

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ADMIQHI

    Database of Orthologous Groups

    More...
    OrthoDBi
    1106167at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8IYB8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106432

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001650 Helicase_C
    IPR027417 P-loop_NTPase
    IPR022192 SUV3_C
    IPR041082 Suv3_C_1
    IPR041453 Suv3_N

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF12513 SUV3_C, 1 hit
    PF18147 Suv3_C_1, 1 hit
    PF18114 Suv3_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00490 HELICc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51194 HELICASE_CTER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q8IYB8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSFSRALLWA RLPAGRQAGH RAAICSALRP HFGPFPGVLG QVSVLATASS
    60 70 80 90 100
    SASGGSKIPN TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKVLDKF
    110 120 130 140 150
    YKRKEIQKLG ADYGLDARLF HQAFISFRNY IMQSHSLDVD IHIVLNDICF
    160 170 180 190 200
    GAAHADDLFP FFLRHAKQIF PVLDCKDDLR KISDLRIPPN WYPDARAMQR
    210 220 230 240 250
    KIIFHSGPTN SGKTYHAIQK YFSAKSGVYC GPLKLLAHEI FEKSNAAGVP
    260 270 280 290 300
    CDLVTGEERV TVQPNGKQAS HVSCTVEMCS VTTPYEVAVI DEIQMIRDPA
    310 320 330 340 350
    RGWAWTRALL GLCAEEVHLC GEPAAIDLVM ELMYTTGEEV EVRDYKRLTP
    360 370 380 390 400
    ISVLDHALES LDNLRPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP
    410 420 430 440 450
    PGTKLAQAKK FNDPNDPCKI LVATDAIGMG LNLSIRRIIF YSLIKPSINE
    460 470 480 490 500
    KGERELEPIT TSQALQIAGR AGRFSSRFKE GEVTTMNHED LSLLKEILKR
    510 520 530 540 550
    PVDPIRAAGL HPTAEQIEMF AYHLPDATLS NLIDIFVDFS QVDGQYFVCN
    560 570 580 590 600
    MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN
    610 620 630 640 650
    EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVLDLYLW LSYRFMDMFP
    660 670 680 690 700
    DASLIRDLQK ELDGIIQDGV HNITKLIKMS ETHKLLNLEG FPSGSQSRLS
    710 720 730 740 750
    GTLKSQARRT RGTKALGSKA TEPPSPDAGE LSLASRLVQQ GLLTPDMLKQ
    760 770 780
    LEKEWMTQQT EHNKEKTESG THPKGTRRKK KEPDSD
    Length:786
    Mass (Da):87,991
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD3BC8EC64C23E42
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B1AR60B1AR60_HUMAN
    ATP-dependent RNA helicase SUPV3L1,...
    SUPV3L1
    263Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti234 – 235KL → TS in AAB97370 (PubMed:10453991).Curated2
    Sequence conflicti254V → E in AAB97370 (PubMed:10453991).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0612142S → F. Corresponds to variant dbSNP:rs33998366Ensembl.1
    Natural variantiVAR_03707630P → T. Corresponds to variant dbSNP:rs34596380Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF042169 mRNA Translation: AAB97370.1
    AK290416 mRNA Translation: BAF83105.1
    AL596223 Genomic DNA No translation available.
    CH471083 Genomic DNA Translation: EAW54314.1
    BC036112 mRNA Translation: AAH36112.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS7287.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001288612.1, NM_001301683.1
    NP_003162.2, NM_003171.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000359655; ENSP00000352678; ENSG00000156502

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    6832

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6832

    UCSC genome browser

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    UCSCi
    uc001jpe.2 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF042169 mRNA Translation: AAB97370.1
    AK290416 mRNA Translation: BAF83105.1
    AL596223 Genomic DNA No translation available.
    CH471083 Genomic DNA Translation: EAW54314.1
    BC036112 mRNA Translation: AAH36112.1
    CCDSiCCDS7287.1
    RefSeqiNP_001288612.1, NM_001301683.1
    NP_003162.2, NM_003171.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3RC3X-ray2.08A47-722[»]
    3RC8X-ray2.90A47-722[»]
    SMRiQ8IYB8
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi112699, 32 interactors
    IntActiQ8IYB8, 24 interactors
    MINTiQ8IYB8
    STRINGi9606.ENSP00000352678

    Chemistry databases

    ChEMBLiCHEMBL3642

    PTM databases

    iPTMnetiQ8IYB8
    PhosphoSitePlusiQ8IYB8
    SwissPalmiQ8IYB8

    Polymorphism and mutation databases

    BioMutaiSUPV3L1
    DMDMi74759699

    Proteomic databases

    EPDiQ8IYB8
    jPOSTiQ8IYB8
    MassIVEiQ8IYB8
    MaxQBiQ8IYB8
    PaxDbiQ8IYB8
    PeptideAtlasiQ8IYB8
    PRIDEiQ8IYB8
    ProteomicsDBi71153

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    6832
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000359655; ENSP00000352678; ENSG00000156502
    GeneIDi6832
    KEGGihsa:6832
    UCSCiuc001jpe.2 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6832
    DisGeNETi6832

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SUPV3L1
    HGNCiHGNC:11471 SUPV3L1
    HPAiHPA038380
    HPA038405
    MIMi605122 gene
    neXtProtiNX_Q8IYB8
    OpenTargetsiENSG00000156502
    PharmGKBiPA36257

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0953 Eukaryota
    ENOG410XSEY LUCA
    GeneTreeiENSGT00390000003100
    HOGENOMiHOG000175283
    InParanoidiQ8IYB8
    KOiK17675
    OMAiADMIQHI
    OrthoDBi1106167at2759
    PhylomeDBiQ8IYB8
    TreeFamiTF106432

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SUPV3L1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SUPV3L1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6832

    Pharos

    More...
    Pharosi
    Q8IYB8

    Protein Ontology

    More...
    PROi
    PR:Q8IYB8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000156502 Expressed in 223 organ(s), highest expression level in lower esophagus muscularis layer
    ExpressionAtlasiQ8IYB8 baseline and differential
    GenevisibleiQ8IYB8 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR001650 Helicase_C
    IPR027417 P-loop_NTPase
    IPR022192 SUV3_C
    IPR041082 Suv3_C_1
    IPR041453 Suv3_N
    PfamiView protein in Pfam
    PF00271 Helicase_C, 1 hit
    PF12513 SUV3_C, 1 hit
    PF18147 Suv3_C_1, 1 hit
    PF18114 Suv3_N, 1 hit
    SMARTiView protein in SMART
    SM00490 HELICc, 1 hit
    SUPFAMiSSF52540 SSF52540, 2 hits
    PROSITEiView protein in PROSITE
    PS51194 HELICASE_CTER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUV3_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYB8
    Secondary accession number(s): A8K301, O43630
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2003
    Last modified: September 18, 2019
    This is version 154 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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