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Entry version 146 (18 Sep 2019)
Sequence version 2 (16 May 2006)
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Protein

Stromal membrane-associated protein 1

Gene

SMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stromal membrane-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19651 SMAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611372 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYB5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
60682

Open Targets

More...
OpenTargetsi
ENSG00000112305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134893764

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYB5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97190718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002358381 – 467Stromal membrane-associated protein 1Add BLAST467

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYB5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYB5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYB5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYB5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYB5

PeptideAtlas

More...
PeptideAtlasi
Q8IYB5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYB5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71145 [Q8IYB5-1]
71146 [Q8IYB5-2]
71147 [Q8IYB5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112305 Expressed in 238 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYB5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYB5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030574

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARF6.

Interacts with clathrin heavy chains via the clathrin box-like motif (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P864804EBI-12061577,EBI-12754095

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121956, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYB5, 16 interactors

Molecular INTeraction database

More...
MINTi
Q8IYB5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359484

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYB5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IYB5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 136Arf-GAPPROSITE-ProRule annotationAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi218 – 222Interaction with clathrin heavy chainsBy similarity5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0703 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155884

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYB5

KEGG Orthology (KO)

More...
KOi
K12486

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNGWSGM

Database of Orthologous Groups

More...
OrthoDBi
1097163at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYB5

TreeFam database of animal gene trees

More...
TreeFami
TF313876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412 ArfGap, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105 ArfGap, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115 ARFGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYB5-1) [UniParc]FASTAAdd to basket
Also known as: SMAP1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV
60 70 80 90 100
FICIRCAGIH RNLGVHISRV KSVNLDQWTA EQIQCMQDMG NTKARLLYEA
110 120 130 140 150
NLPENFRRPQ TDQAVEFFIR DKYEKKKYYD KNAIAITNIS SSDAPLQPLV
160 170 180 190 200
SSPSLQAAVD KNKLEKEKEK KKEEKKREKE PEKPAKPLTA EKLQKKDQQL
210 220 230 240 250
EPKKSTSPKK AAEPTVDLLG LDGPAVAPVT NGNTTVPPLN DDLDIFGPMI
260 270 280 290 300
SNPLPATVMP PAQGTPSAPA AATLSTVTSG DLDLFTEQTT KSEEVAKKQL
310 320 330 340 350
SKDSILSLYG TGTIQQQSTP GVFMGPTNIP FTSQAPAAFQ GFPSMGVPVP
360 370 380 390 400
AAPGLIGNVM GQSPSMMVGM PMPNGFMGNA QTGVMPLPQN VVGPQGGMVG
410 420 430 440 450
QMGAPQSKFG LPQAQQPQWS LSQMNQQMAG MSISSATPTA GFGQPSSTTA
460
GWSGSSSGQT LSTQLWK
Length:467
Mass (Da):50,386
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75935CB6F9F99DA9
GO
Isoform 2 (identifier: Q8IYB5-2) [UniParc]FASTAAdd to basket
Also known as: SMAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.

Show »
Length:440
Mass (Da):47,609
Checksum:iB7D7AE5387DB9E25
GO
Isoform 3 (identifier: Q8IYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.
     424-467: MNQQMAGMSI...GQTLSTQLWK → IMQKGDAVLQ...ESADGWHEYQ

Show »
Length:436
Mass (Da):47,862
Checksum:iB4C4E780E6BEDCED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1X9A0A087X1X9_HUMAN
Stromal membrane-associated protein...
SMAP1
457Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5G0H0Y5G0_HUMAN
Stromal membrane-associated protein...
SMAP1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6I8Q5T6I8_HUMAN
Stromal membrane-associated protein...
SMAP1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08672 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394P → H in AAH36123 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048326212A → V1 PublicationCorresponds to variant dbSNP:rs2273566Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018502139 – 165Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_018503424 – 467MNQQM…TQLWK → IMQKGDAVLQHSISAIYWPM TRWLKCPLVDESADGWHEYQ in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY055003 mRNA Translation: AAL14714.1
AY055004 mRNA Translation: AAL14715.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14716.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14717.1
AK023221 mRNA Translation: BAB14473.1
AF442495 mRNA Translation: AAP97320.1
AK222711 mRNA Translation: BAD96431.1
AL354943 Genomic DNA No translation available.
AL591049 Genomic DNA No translation available.
AL121961 Genomic DNA No translation available.
BC008672 mRNA Translation: AAH08672.1 Sequence problems.
BC028074 mRNA Translation: AAH28074.1
BC036123 mRNA Translation: AAH36123.1
AL833906 mRNA Translation: CAD38762.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43478.1 [Q8IYB5-1]
CCDS4973.1 [Q8IYB5-2]
CCDS64459.1 [Q8IYB5-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001037770.1, NM_001044305.2 [Q8IYB5-1]
NP_001268368.1, NM_001281439.1 [Q8IYB5-3]
NP_001268369.1, NM_001281440.1
NP_068759.2, NM_021940.4 [Q8IYB5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316999; ENSP00000313382; ENSG00000112305 [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305 [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305 [Q8IYB5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60682

UCSC genome browser

More...
UCSCi
uc003pfr.5 human [Q8IYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055003 mRNA Translation: AAL14714.1
AY055004 mRNA Translation: AAL14715.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14716.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14717.1
AK023221 mRNA Translation: BAB14473.1
AF442495 mRNA Translation: AAP97320.1
AK222711 mRNA Translation: BAD96431.1
AL354943 Genomic DNA No translation available.
AL591049 Genomic DNA No translation available.
AL121961 Genomic DNA No translation available.
BC008672 mRNA Translation: AAH08672.1 Sequence problems.
BC028074 mRNA Translation: AAH28074.1
BC036123 mRNA Translation: AAH36123.1
AL833906 mRNA Translation: CAD38762.1
CCDSiCCDS43478.1 [Q8IYB5-1]
CCDS4973.1 [Q8IYB5-2]
CCDS64459.1 [Q8IYB5-3]
RefSeqiNP_001037770.1, NM_001044305.2 [Q8IYB5-1]
NP_001268368.1, NM_001281439.1 [Q8IYB5-3]
NP_001268369.1, NM_001281440.1
NP_068759.2, NM_021940.4 [Q8IYB5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRRNMR-A9-136[»]
SMRiQ8IYB5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121956, 14 interactors
IntActiQ8IYB5, 16 interactors
MINTiQ8IYB5
STRINGi9606.ENSP00000359484

PTM databases

iPTMnetiQ8IYB5
PhosphoSitePlusiQ8IYB5

Polymorphism and mutation databases

BioMutaiSMAP1
DMDMi97190718

Proteomic databases

EPDiQ8IYB5
jPOSTiQ8IYB5
MassIVEiQ8IYB5
MaxQBiQ8IYB5
PaxDbiQ8IYB5
PeptideAtlasiQ8IYB5
PRIDEiQ8IYB5
ProteomicsDBi71145 [Q8IYB5-1]
71146 [Q8IYB5-2]
71147 [Q8IYB5-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
60682

Genome annotation databases

EnsembliENST00000316999; ENSP00000313382; ENSG00000112305 [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305 [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305 [Q8IYB5-1]
GeneIDi60682
KEGGihsa:60682
UCSCiuc003pfr.5 human [Q8IYB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
60682
DisGeNETi60682

GeneCards: human genes, protein and diseases

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GeneCardsi
SMAP1
HGNCiHGNC:19651 SMAP1
HPAiHPA030574
MIMi611372 gene
neXtProtiNX_Q8IYB5
OpenTargetsiENSG00000112305
PharmGKBiPA134893764

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000155884
InParanoidiQ8IYB5
KOiK12486
OMAiNNGWSGM
OrthoDBi1097163at2759
PhylomeDBiQ8IYB5
TreeFamiTF313876

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SMAP1 human
EvolutionaryTraceiQ8IYB5

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SMAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
60682
PharosiQ8IYB5

Protein Ontology

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PROi
PR:Q8IYB5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112305 Expressed in 238 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8IYB5 baseline and differential
GenevisibleiQ8IYB5 HS

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYB5
Secondary accession number(s): Q53H70
, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 18, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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