Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Stromal membrane-associated protein 1

Gene

SMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal membrane-associated protein 1
Gene namesi
Name:SMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112305.14
HGNCiHGNC:19651 SMAP1
MIMi611372 gene
neXtProtiNX_Q8IYB5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi60682
OpenTargetsiENSG00000112305
PharmGKBiPA134893764

Polymorphism and mutation databases

BioMutaiSMAP1
DMDMi97190718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358381 – 467Stromal membrane-associated protein 1Add BLAST467

Proteomic databases

EPDiQ8IYB5
MaxQBiQ8IYB5
PaxDbiQ8IYB5
PeptideAtlasiQ8IYB5
PRIDEiQ8IYB5
ProteomicsDBi71145
71146 [Q8IYB5-2]
71147 [Q8IYB5-3]

PTM databases

iPTMnetiQ8IYB5
PhosphoSitePlusiQ8IYB5

Expressioni

Tissue specificityi

Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach.1 Publication

Gene expression databases

BgeeiENSG00000112305 Expressed in 238 organ(s), highest expression level in frontal cortex
CleanExiHS_SMAP1
ExpressionAtlasiQ8IYB5 baseline and differential
GenevisibleiQ8IYB5 HS

Organism-specific databases

HPAiHPA030574

Interactioni

Subunit structurei

Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRR20DP864804EBI-12061577,EBI-12754095

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121956, 9 interactors
IntActiQ8IYB5, 14 interactors
MINTiQ8IYB5
STRINGi9606.ENSP00000359484

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IYB5
SMRiQ8IYB5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IYB5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 136Arf-GAPPROSITE-ProRule annotationAdd BLAST119

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 222Interaction with clathrin heavy chainsBy similarity5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 56C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00900000140892
HOVERGENiHBG055260
InParanoidiQ8IYB5
KOiK12486
OMAiNNGWSGM
OrthoDBiEOG091G0E7F
PhylomeDBiQ8IYB5
TreeFamiTF313876

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYB5-1) [UniParc]FASTAAdd to basket
Also known as: SMAP1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV
60 70 80 90 100
FICIRCAGIH RNLGVHISRV KSVNLDQWTA EQIQCMQDMG NTKARLLYEA
110 120 130 140 150
NLPENFRRPQ TDQAVEFFIR DKYEKKKYYD KNAIAITNIS SSDAPLQPLV
160 170 180 190 200
SSPSLQAAVD KNKLEKEKEK KKEEKKREKE PEKPAKPLTA EKLQKKDQQL
210 220 230 240 250
EPKKSTSPKK AAEPTVDLLG LDGPAVAPVT NGNTTVPPLN DDLDIFGPMI
260 270 280 290 300
SNPLPATVMP PAQGTPSAPA AATLSTVTSG DLDLFTEQTT KSEEVAKKQL
310 320 330 340 350
SKDSILSLYG TGTIQQQSTP GVFMGPTNIP FTSQAPAAFQ GFPSMGVPVP
360 370 380 390 400
AAPGLIGNVM GQSPSMMVGM PMPNGFMGNA QTGVMPLPQN VVGPQGGMVG
410 420 430 440 450
QMGAPQSKFG LPQAQQPQWS LSQMNQQMAG MSISSATPTA GFGQPSSTTA
460
GWSGSSSGQT LSTQLWK
Length:467
Mass (Da):50,386
Last modified:May 16, 2006 - v2
Checksum:i75935CB6F9F99DA9
GO
Isoform 2 (identifier: Q8IYB5-2) [UniParc]FASTAAdd to basket
Also known as: SMAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.

Show »
Length:440
Mass (Da):47,609
Checksum:iB7D7AE5387DB9E25
GO
Isoform 3 (identifier: Q8IYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.
     424-467: MNQQMAGMSI...GQTLSTQLWK → IMQKGDAVLQ...ESADGWHEYQ

Show »
Length:436
Mass (Da):47,862
Checksum:iB4C4E780E6BEDCED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1X9A0A087X1X9_HUMAN
Stromal membrane-associated protein...
SMAP1
457Annotation score:
H0Y5G0H0Y5G0_HUMAN
Stromal membrane-associated protein...
SMAP1
125Annotation score:
Q5T6I8Q5T6I8_HUMAN
Stromal membrane-associated protein...
SMAP1
62Annotation score:

Sequence cautioni

The sequence AAH08672 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394P → H in AAH36123 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048326212A → V1 PublicationCorresponds to variant dbSNP:rs2273566Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018502139 – 165Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_018503424 – 467MNQQM…TQLWK → IMQKGDAVLQHSISAIYWPM TRWLKCPLVDESADGWHEYQ in isoform 3. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055003 mRNA Translation: AAL14714.1
AY055004 mRNA Translation: AAL14715.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14716.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14717.1
AK023221 mRNA Translation: BAB14473.1
AF442495 mRNA Translation: AAP97320.1
AK222711 mRNA Translation: BAD96431.1
AL354943 Genomic DNA No translation available.
AL591049 Genomic DNA No translation available.
AL121961 Genomic DNA No translation available.
BC008672 mRNA Translation: AAH08672.1 Sequence problems.
BC028074 mRNA Translation: AAH28074.1
BC036123 mRNA Translation: AAH36123.1
AL833906 mRNA Translation: CAD38762.1
CCDSiCCDS43478.1 [Q8IYB5-1]
CCDS4973.1 [Q8IYB5-2]
CCDS64459.1 [Q8IYB5-3]
RefSeqiNP_001037770.1, NM_001044305.2 [Q8IYB5-1]
NP_001268368.1, NM_001281439.1 [Q8IYB5-3]
NP_001268369.1, NM_001281440.1
NP_068759.2, NM_021940.4 [Q8IYB5-2]
UniGeneiHs.485717

Genome annotation databases

EnsembliENST00000316999; ENSP00000313382; ENSG00000112305 [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305 [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305 [Q8IYB5-1]
GeneIDi60682
KEGGihsa:60682
UCSCiuc003pfr.5 human [Q8IYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055003 mRNA Translation: AAL14714.1
AY055004 mRNA Translation: AAL14715.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14716.1
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA Translation: AAL14717.1
AK023221 mRNA Translation: BAB14473.1
AF442495 mRNA Translation: AAP97320.1
AK222711 mRNA Translation: BAD96431.1
AL354943 Genomic DNA No translation available.
AL591049 Genomic DNA No translation available.
AL121961 Genomic DNA No translation available.
BC008672 mRNA Translation: AAH08672.1 Sequence problems.
BC028074 mRNA Translation: AAH28074.1
BC036123 mRNA Translation: AAH36123.1
AL833906 mRNA Translation: CAD38762.1
CCDSiCCDS43478.1 [Q8IYB5-1]
CCDS4973.1 [Q8IYB5-2]
CCDS64459.1 [Q8IYB5-3]
RefSeqiNP_001037770.1, NM_001044305.2 [Q8IYB5-1]
NP_001268368.1, NM_001281439.1 [Q8IYB5-3]
NP_001268369.1, NM_001281440.1
NP_068759.2, NM_021940.4 [Q8IYB5-2]
UniGeneiHs.485717

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRRNMR-A9-136[»]
ProteinModelPortaliQ8IYB5
SMRiQ8IYB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121956, 9 interactors
IntActiQ8IYB5, 14 interactors
MINTiQ8IYB5
STRINGi9606.ENSP00000359484

PTM databases

iPTMnetiQ8IYB5
PhosphoSitePlusiQ8IYB5

Polymorphism and mutation databases

BioMutaiSMAP1
DMDMi97190718

Proteomic databases

EPDiQ8IYB5
MaxQBiQ8IYB5
PaxDbiQ8IYB5
PeptideAtlasiQ8IYB5
PRIDEiQ8IYB5
ProteomicsDBi71145
71146 [Q8IYB5-2]
71147 [Q8IYB5-3]

Protocols and materials databases

DNASUi60682
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316999; ENSP00000313382; ENSG00000112305 [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305 [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305 [Q8IYB5-1]
GeneIDi60682
KEGGihsa:60682
UCSCiuc003pfr.5 human [Q8IYB5-1]

Organism-specific databases

CTDi60682
DisGeNETi60682
EuPathDBiHostDB:ENSG00000112305.14
GeneCardsiSMAP1
HGNCiHGNC:19651 SMAP1
HPAiHPA030574
MIMi611372 gene
neXtProtiNX_Q8IYB5
OpenTargetsiENSG00000112305
PharmGKBiPA134893764
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0703 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00900000140892
HOVERGENiHBG055260
InParanoidiQ8IYB5
KOiK12486
OMAiNNGWSGM
OrthoDBiEOG091G0E7F
PhylomeDBiQ8IYB5
TreeFamiTF313876

Miscellaneous databases

ChiTaRSiSMAP1 human
EvolutionaryTraceiQ8IYB5
GeneWikiiSMAP1
GenomeRNAii60682
PROiPR:Q8IYB5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112305 Expressed in 238 organ(s), highest expression level in frontal cortex
CleanExiHS_SMAP1
ExpressionAtlasiQ8IYB5 baseline and differential
GenevisibleiQ8IYB5 HS

Family and domain databases

Gene3Di3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SUPFAMiSSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMAP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB5
Secondary accession number(s): Q53H70
, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again