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Entry version 173 (16 Oct 2019)
Sequence version 2 (06 Dec 2005)
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Protein

Serine/arginine repetitive matrix protein 1

Gene

SRRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 1
Alternative name(s):
SR-related nuclear matrix protein of 160 kDa
Short name:
SRm160
Ser/Arg-related nuclear matrix protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRRM1
Synonyms:SRM160
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16638 SRRM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605975 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYB3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20K → A: Strongly reduces DNA and RNA-binding. 1 Publication1
Mutagenesisi22K → A: Strongly reduces DNA and RNA-binding. 1 Publication1
Mutagenesisi23K → A: Strongly reduces DNA and RNA-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10250

Open Targets

More...
OpenTargetsi
ENSG00000133226

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYB3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRRM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83305833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763261 – 904Serine/arginine repetitive matrix protein 1Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei7CitrullineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei140N6-acetyllysineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei234PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei241PhosphothreonineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei260PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1 Publication1
Modified residuei391PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1 Publication1
Modified residuei402PhosphoserineCombined sources1
Modified residuei406PhosphothreonineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Cross-linki447Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei450PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Cross-linki459Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei463PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei478PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei549PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei555PhosphothreonineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei572PhosphothreonineCombined sources1
Modified residuei574PhosphothreonineCombined sources1
Modified residuei581PhosphothreonineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei596PhosphotyrosineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei605PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei614PhosphothreonineCombined sources1
Modified residuei616PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei695PhosphoserineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei718PhosphothreonineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei752PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei778PhosphothreonineBy similarity1
Modified residuei781PhosphoserineCombined sources1
Modified residuei791PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei802PhosphoserineCombined sources1
Cross-linki869Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei872PhosphothreonineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724). Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724).1 Publication
Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYB3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYB3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IYB3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYB3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYB3

PeptideAtlas

More...
PeptideAtlasi
Q8IYB3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYB3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71140 [Q8IYB3-1]
71141 [Q8IYB3-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8IYB3

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYB3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYB3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IYB3

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q8IYB3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133226 Expressed in 235 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IYB3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IYB3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049941
HPA058612

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome C complex.

Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2.

Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10.

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4.

Interacts with BAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115544, 185 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8IYB3

Protein interaction database and analysis system

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IntActi
Q8IYB3, 41 interactors

Molecular INTeraction database

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MINTi
Q8IYB3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326261

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1904
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IYB3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IYB3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 126PWIPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 156Necessary for mRNA 3'-end cleavage and cytoplasmic accumulationAdd BLAST156
Regioni1 – 151Necessary for DNA and RNA-bindingAdd BLAST151
Regioni300 – 688Necessary for speckles and matrix localizationAdd BLAST389

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 726Arg-richAdd BLAST564
Compositional biasi210 – 417Pro-richAdd BLAST208
Compositional biasi278 – 756Ser-richAdd BLAST479
Compositional biasi550 – 799Pro-richAdd BLAST250
Compositional biasi809 – 835Lys-richAdd BLAST27
Compositional biasi836 – 865Ala-richAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2146 Eukaryota
ENOG4111IMU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231139

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IYB3

KEGG Orthology (KO)

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KOi
K13171

Database of Orthologous Groups

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OrthoDBi
1210775at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYB3

TreeFam database of animal gene trees

More...
TreeFami
TF318972

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002483 PWI_dom
IPR036483 PWI_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01480 PWI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00311 PWI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101233 SSF101233, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51025 PWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP
60 70 80 90 100
WITKRVTEIL GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE
110 120 130 140 150
FMGELWPLLL SAQENIAGIP SAFLELKKEE IKQRQIEQEK LASMKKQDED
160 170 180 190 200
KDKRDKEEKE SSREKRERSR SPRRRKSRSP SPRRRSSPVR RERKRSHSRS
210 220 230 240 250
PRHRTKSRSP SPAPEKKEKT PELPEPSVKV KEPSVQEATS TSDILKVPKP
260 270 280 290 300
EPIPEPKEPS PEKNSKKEKE KEKTRPRSRS RSKSRSRTRS RSPSHTRPRR
310 320 330 340 350
RHRSRSRSYS PRRRPSPRRR PSPRRRTPPR RMPPPPRHRR SRSPVRRRRR
360 370 380 390 400
SSASLSGSSS SSSSSRSRSP PKKPPKRTSS PPRKTRRLSP SASPPRRRHR
410 420 430 440 450
PSPPATPPPK TRHSPTPQQS NRTRKSRVSV SPGRTSGKVT KHKGTEKRES
460 470 480 490 500
PSPAPKPRKV ELSESEEDKG GKMAAADSVQ QRRQYRRQNQ QSSSDSGSSS
510 520 530 540 550
SSEDERPKRS HVKNGEVGRR RRHSPSRSAS PSPRKRQKET SPRGRRRRSP
560 570 580 590 600
SPPPTRRRRS PSPAPPPRRR RTPTPPPRRR TPSPPPRRRS PSPRRYSPPI
610 620 630 640 650
QRRYSPSPPP KRRTASPPPP PKRRASPSPP PKRRVSHSPP PKQRSSPVTK
660 670 680 690 700
RRSPSLSSKH RKGSSPSRST REARSPQPNK RHSPSPRPRA PQTSSSPPPV
710 720 730 740 750
RRGASSSPQR RQSPSPSTRP IRRVSRTPEP KKIKKAASPS PQSVRRVSSS
760 770 780 790 800
RSVSGSPEPA AKKPPAPPSP VQSQSPSTNW SPAVPVKKAK SPTPSPSPPR
810 820 830 840 850
NSDQEGGGKK KKKKKDKKHK KDKKHKKHKK HKKEKAVAAA AAAAVTPAAI
860 870 880 890 900
AAATTTLAQE EPVAAPEPKK ETESEAEDNL DDLEKHLREK ALRSMRKAQV

SPQS
Length:904
Mass (Da):102,335
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27D4D2A48EDBFED3
GO
Isoform 2 (identifier: Q8IYB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-308: RSRS → DKM
     407-407: Missing.

Show »
Length:902
Mass (Da):102,126
Checksum:i0211C6D93260EF32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9Z1X7A9Z1X7_HUMAN
Serine/arginine repetitive matrix p...
SRRM1
913Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCT1E9PCT1_HUMAN
Serine/arginine repetitive matrix p...
SRRM1
820Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R088M0R088_HUMAN
Serine/arginine repetitive matrix p...
SRRM1
681Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1E7M0R1E7_HUMAN
Serine/arginine repetitive matrix p...
SRRM1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXG5M0QXG5_HUMAN
Serine/arginine repetitive matrix p...
SRRM1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC09321 differs from that shown. Reason: Frameshift.Curated
The sequence AAP97290 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti269K → Q (PubMed:9531537).Curated1
Sequence conflicti269K → Q (Ref. 2) Curated1
Sequence conflicti275R → Q in AAH36187 (PubMed:15489334).Curated1
Sequence conflicti413H → D (PubMed:9531537).Curated1
Sequence conflicti413H → D (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024065170R → H1 PublicationCorresponds to variant dbSNP:rs17857102Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016522305 – 308RSRS → DKM in isoform 2. 2 Publications4
Alternative sequenceiVSP_016523407Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF048977 mRNA Translation: AAC09321.1 Frameshift.
AF419855 mRNA Translation: AAP97290.1 Frameshift.
AL445648 Genomic DNA No translation available.
AL445686 Genomic DNA No translation available.
BC036187 mRNA Translation: AAH36187.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS255.1 [Q8IYB3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001290377.1, NM_001303448.1
NP_001290378.1, NM_001303449.1
NP_005830.2, NM_005839.3 [Q8IYB3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323848; ENSP00000326261; ENSG00000133226 [Q8IYB3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10250

UCSC genome browser

More...
UCSCi
uc001bjm.4 human [Q8IYB3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048977 mRNA Translation: AAC09321.1 Frameshift.
AF419855 mRNA Translation: AAP97290.1 Frameshift.
AL445648 Genomic DNA No translation available.
AL445686 Genomic DNA No translation available.
BC036187 mRNA Translation: AAH36187.1
CCDSiCCDS255.1 [Q8IYB3-1]
RefSeqiNP_001290377.1, NM_001303448.1
NP_001290378.1, NM_001303449.1
NP_005830.2, NM_005839.3 [Q8IYB3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MP1NMR-A27-134[»]
6FF4electron microscopy16.00Y1-904[»]
6FF7electron microscopy4.50Y1-904[»]
SMRiQ8IYB3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115544, 185 interactors
CORUMiQ8IYB3
IntActiQ8IYB3, 41 interactors
MINTiQ8IYB3
STRINGi9606.ENSP00000326261

Protein family/group databases

TCDBi3.A.18.1.1 the nuclear mrna exporter (mrna-e) family

PTM databases

CarbonylDBiQ8IYB3
iPTMnetiQ8IYB3
PhosphoSitePlusiQ8IYB3
SwissPalmiQ8IYB3

Polymorphism and mutation databases

BioMutaiSRRM1
DMDMi83305833

Proteomic databases

EPDiQ8IYB3
jPOSTiQ8IYB3
MassIVEiQ8IYB3
MaxQBiQ8IYB3
PaxDbiQ8IYB3
PeptideAtlasiQ8IYB3
PRIDEiQ8IYB3
ProteomicsDBi71140 [Q8IYB3-1]
71141 [Q8IYB3-2]

Genome annotation databases

EnsembliENST00000323848; ENSP00000326261; ENSG00000133226 [Q8IYB3-1]
GeneIDi10250
KEGGihsa:10250
UCSCiuc001bjm.4 human [Q8IYB3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10250
DisGeNETi10250

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRRM1
HGNCiHGNC:16638 SRRM1
HPAiHPA049941
HPA058612
MIMi605975 gene
neXtProtiNX_Q8IYB3
OpenTargetsiENSG00000133226
PharmGKBiPA38177

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2146 Eukaryota
ENOG4111IMU LUCA
GeneTreeiENSGT00730000111080
HOGENOMiHOG000231139
InParanoidiQ8IYB3
KOiK13171
OrthoDBi1210775at2759
PhylomeDBiQ8IYB3
TreeFamiTF318972

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SRRM1 human
EvolutionaryTraceiQ8IYB3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SRRM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10250
PharosiQ8IYB3
PMAP-CutDBiQ8IYB3

Protein Ontology

More...
PROi
PR:Q8IYB3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133226 Expressed in 235 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiQ8IYB3 baseline and differential
GenevisibleiQ8IYB3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
PfamiView protein in Pfam
PF01480 PWI, 1 hit
SMARTiView protein in SMART
SM00311 PWI, 1 hit
SUPFAMiSSF101233 SSF101233, 1 hit
PROSITEiView protein in PROSITE
PS51025 PWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRRM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYB3
Secondary accession number(s): O60585, Q5VVN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 16, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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