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Entry version 138 (02 Jun 2021)
Sequence version 3 (28 Nov 2006)
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Protein

Protein MB21D2

Gene

MB21D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IYB1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MB21D2
Alternative name(s):
Mab-21 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MB21D2
Synonyms:C3orf59
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30438, MB21D2

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8IYB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000180611.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151963

Open Targets

More...
OpenTargetsi
ENSG00000180611

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485335

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYB1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MB21D2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002393031 – 491Protein MB21D2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei435PhosphothreonineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYB1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYB1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYB1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYB1

PeptideAtlas

More...
PeptideAtlasi
Q8IYB1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYB1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71139

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180611, Expressed in forebrain and 220 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYB1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000180611, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127413, 46 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYB1, 29 interactors

Molecular INTeraction database

More...
MINTi
Q8IYB1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376246

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYB1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni431 – 452DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi431 – 446Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3963, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041150_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYB1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RHDQREY

Database of Orthologous Groups

More...
OrthoDBi
418799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYB1

TreeFam database of animal gene trees

More...
TreeFami
TF329089

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024810, Mab-21_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03281, Mab-21, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01265, Mab-21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMAAPTANK AASLGCNNKP AFPELDFRSG ARVEELNKLI QEFTKHDQRE
60 70 80 90 100
YDDQRALEIH TAKDFIFSML GMVQKLDQKL PVANEYLLLS GGVREGVVDL
110 120 130 140 150
DLDELNVYAR GTDYDMDFTL LVPALKLHDR NQPVTLDMRH SALCHSWLSL
160 170 180 190 200
RLFDEGTISK WKDCCTIVDH INGATNYFFS PTKVADWFYD SISIVLSEIQ
210 220 230 240 250
KKPQRGMPKV EKVEKNGTII SIILGVGSSR MLYDIVPVVS FKGWPAVAQS
260 270 280 290 300
WLMENHFWDG KITEEEVISG FYLVPACSYK GKKDNEWRLS FARSEVQLKK
310 320 330 340 350
CISSSLMQAY QACKAIIIKL LSRPKAISPY HLRSMMLWAC DRLPANYLAQ
360 370 380 390 400
EDYAAHFLLG LIDDLQHCLV NKMCPNYFIP QCNMLEHLSE ETVMLHARKL
410 420 430 440 450
SSVRSDPAEH LRTAIEHVKA ANRLTLELQR RGSTTSIPSP QSDGGDPNQP
460 470 480 490
DDRLAKKLQQ LVTENPGKSI SVFINPDDVT RPHFRIDDKF F
Length:491
Mass (Da):55,800
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7AF79038FE3D4534
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13123 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH45582 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC090025 Genomic DNA No translation available.
AC117416 Genomic DNA No translation available.
BC013123 mRNA Translation: AAH13123.1 Different initiation.
BC036194 mRNA Translation: AAH36194.3
BC045582 mRNA Translation: AAH45582.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3302.2

NCBI Reference Sequences

More...
RefSeqi
NP_848591.2, NM_178496.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392452; ENSP00000376246; ENSG00000180611

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
151963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151963

UCSC genome browser

More...
UCSCi
uc011bsp.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090025 Genomic DNA No translation available.
AC117416 Genomic DNA No translation available.
BC013123 mRNA Translation: AAH13123.1 Different initiation.
BC036194 mRNA Translation: AAH36194.3
BC045582 mRNA Translation: AAH45582.1 Different initiation.
CCDSiCCDS3302.2
RefSeqiNP_848591.2, NM_178496.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127413, 46 interactors
IntActiQ8IYB1, 29 interactors
MINTiQ8IYB1
STRINGi9606.ENSP00000376246

PTM databases

iPTMnetiQ8IYB1
PhosphoSitePlusiQ8IYB1

Genetic variation databases

BioMutaiMB21D2

Proteomic databases

EPDiQ8IYB1
jPOSTiQ8IYB1
MassIVEiQ8IYB1
MaxQBiQ8IYB1
PaxDbiQ8IYB1
PeptideAtlasiQ8IYB1
PRIDEiQ8IYB1
ProteomicsDBi71139

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46851, 40 antibodies

The DNASU plasmid repository

More...
DNASUi
151963

Genome annotation databases

EnsembliENST00000392452; ENSP00000376246; ENSG00000180611
GeneIDi151963
KEGGihsa:151963
UCSCiuc011bsp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151963
DisGeNETi151963

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MB21D2
HGNCiHGNC:30438, MB21D2
HPAiENSG00000180611, Tissue enhanced (placenta)
neXtProtiNX_Q8IYB1
OpenTargetsiENSG00000180611
PharmGKBiPA143485335
VEuPathDBiHostDB:ENSG00000180611.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3963, Eukaryota
GeneTreeiENSGT01030000234655
HOGENOMiCLU_041150_1_0_1
InParanoidiQ8IYB1
OMAiRHDQREY
OrthoDBi418799at2759
PhylomeDBiQ8IYB1
TreeFamiTF329089

Enzyme and pathway databases

PathwayCommonsiQ8IYB1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
151963, 8 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MB21D2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
151963
PharosiQ8IYB1, Tdark

Protein Ontology

More...
PROi
PR:Q8IYB1
RNActiQ8IYB1, protein

Gene expression databases

BgeeiENSG00000180611, Expressed in forebrain and 220 other tissues
GenevisibleiQ8IYB1, HS

Family and domain databases

InterProiView protein in InterPro
IPR024810, Mab-21_dom
PfamiView protein in Pfam
PF03281, Mab-21, 1 hit
SMARTiView protein in SMART
SM01265, Mab-21, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM21D2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYB1
Secondary accession number(s): Q86VD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 28, 2006
Last modified: June 2, 2021
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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