UniProtKB - Q8IYA8 (IHO1_HUMAN)
Protein
Interactor of HORMAD1 protein 1
Gene
IHO1
Organism
Homo sapiens (Human)
Status
Functioni
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.By similarity
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- homologous chromosome pairing at meiosis Source: UniProtKB
- meiotic DNA double-strand break formation Source: UniProtKB
- oogenesis Source: UniProtKB
- regulation of homologous chromosome segregation Source: UniProtKB
- spermatogenesis Source: UniProtKB
Keywordsi
Biological process | Differentiation, DNA recombination, Meiosis, Oogenesis, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q8IYA8 |
Names & Taxonomyi
Protein namesi | Recommended name: Interactor of HORMAD1 protein 11 PublicationAlternative name(s): Cancer/testis antigen 74 Short name: CT74 Coiled-coil domain-containing protein 36Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27945, IHO1 |
neXtProti | NX_Q8IYA8 |
VEuPathDBi | HostDB:ENSG00000173421.16 |
Subcellular locationi
Other locations
- Chromosome By similarity
Note: Specifically localizes to unsynapsed chromosomal regions during meiosis.By similarity
Nucleus
- condensed nuclear chromosome Source: UniProtKB
Keywords - Cellular componenti
ChromosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 339834 |
OpenTargetsi | ENSG00000173421 |
PharmGKBi | PA142672191 |
Miscellaneous databases
Pharosi | Q8IYA8, Tdark |
Genetic variation databases
BioMutai | CCDC36 |
DMDMi | 313104087 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000302875 | 1 – 594 | Interactor of HORMAD1 protein 1Add BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 588 | PhosphoserineBy similarity | 1 | |
Modified residuei | 589 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q8IYA8 |
PaxDbi | Q8IYA8 |
PeptideAtlasi | Q8IYA8 |
PRIDEi | Q8IYA8 |
ProteomicsDBi | 71135 [Q8IYA8-1] 71136 [Q8IYA8-2] 71137 [Q8IYA8-3] |
PTM databases
iPTMneti | Q8IYA8 |
PhosphoSitePlusi | Q8IYA8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173421, Expressed in testis and 115 other tissues |
Genevisiblei | Q8IYA8, HS |
Organism-specific databases
HPAi | ENSG00000173421, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with HORMAD1 (PubMed:27723721).
Interacts with REC114 (By similarity). Part of the MCD recombinosome complex, at least composed of IHO1, REC114 and MEI4 (By similarity).
Interacts with ANKRD31 (By similarity).
By similarity1 PublicationBinary interactionsi
Q8IYA8
Protein-protein interaction databases
BioGRIDi | 130947, 91 interactors |
IntActi | Q8IYA8, 81 interactors |
MINTi | Q8IYA8 |
STRINGi | 9606.ENSP00000391788 |
Miscellaneous databases
RNActi | Q8IYA8, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 109 – 135 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 165 – 189 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 219 – 245 | Sequence analysisAdd BLAST | 27 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S0PR, Eukaryota |
GeneTreei | ENSGT00390000012418 |
HOGENOMi | CLU_034910_0_0_1 |
InParanoidi | Q8IYA8 |
OMAi | EFIEMKS |
OrthoDBi | 974040at2759 |
PhylomeDBi | Q8IYA8 |
TreeFami | TF337135 |
Family and domain databases
InterProi | View protein in InterPro IPR031529, IHO1 |
PANTHERi | PTHR35662, PTHR35662, 1 hit |
Pfami | View protein in Pfam PF15771, IHO1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IYA8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE
60 70 80 90 100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG
110 120 130 140 150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSETLYNFVS NVRESILRLQ
160 170 180 190 200
TSVEKSEDHL SSRSQSILDS LETVAKTLQE TIQAQNDLVF EAVQDKGNME
210 220 230 240 250
QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV
260 270 280 290 300
PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
310 320 330 340 350
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD
360 370 380 390 400
KVVQTNCKNW AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF
410 420 430 440 450
STSIKNACQK YQAQSMFLCD PREHLVIKQK DGTVEMRGKD KKQQPRKAHR
460 470 480 490 500
AHRGRLIASK QKQIPIQTCK FNSKYQSPQP AISVPQSPFL GQQEPRAQPL
510 520 530 540 550
HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS
560 570 580 590
SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF
Sequence cautioni
The sequence AAH36202 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035002 | 440 | D → E. Corresponds to variant dbSNP:rs13068038Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027987 | 1 – 19 | MNFNV…PSGSG → MARVDAKAKEAPRASEGCQH AVTSQR in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_027988 | 91 – 117 | Missing in isoform 2. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_027989 | 133 – 203 | ETLYN…MEQAI → CRRLWKSLRTISVQEANLFW ILWRLWPRHVSASCLRYQQR ALVNDEHELSDPSLVSSGEV PHRVSDERMGI in isoform 3. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_027990 | 204 – 594 | Missing in isoform 3. 1 PublicationAdd BLAST | 391 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121247 Genomic DNA No translation available. AC135506 Genomic DNA No translation available. BC015057 mRNA No translation available. BC036202 mRNA Translation: AAH36202.1 Different initiation. AK058049 mRNA Translation: BAB71640.1 |
CCDSi | CCDS33755.2 [Q8IYA8-1] |
RefSeqi | NP_001128669.1, NM_001135197.1 [Q8IYA8-1] NP_835467.2, NM_178173.3 [Q8IYA8-1] XP_006713187.1, XM_006713124.3 [Q8IYA8-1] XP_011531974.1, XM_011533672.2 [Q8IYA8-1] XP_011531975.1, XM_011533673.2 [Q8IYA8-1] |
Genome annotation databases
Ensembli | ENST00000296449; ENSP00000296449; ENSG00000173421 [Q8IYA8-1] ENST00000366429; ENSP00000403700; ENSG00000173421 [Q8IYA8-3] ENST00000438782; ENSP00000391788; ENSG00000173421 [Q8IYA8-1] ENST00000452691; ENSP00000407837; ENSG00000173421 [Q8IYA8-1] |
GeneIDi | 339834 |
KEGGi | hsa:339834 |
UCSCi | uc003cwk.3, human [Q8IYA8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121247 Genomic DNA No translation available. AC135506 Genomic DNA No translation available. BC015057 mRNA No translation available. BC036202 mRNA Translation: AAH36202.1 Different initiation. AK058049 mRNA Translation: BAB71640.1 |
CCDSi | CCDS33755.2 [Q8IYA8-1] |
RefSeqi | NP_001128669.1, NM_001135197.1 [Q8IYA8-1] NP_835467.2, NM_178173.3 [Q8IYA8-1] XP_006713187.1, XM_006713124.3 [Q8IYA8-1] XP_011531974.1, XM_011533672.2 [Q8IYA8-1] XP_011531975.1, XM_011533673.2 [Q8IYA8-1] |
3D structure databases
SMRi | Q8IYA8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130947, 91 interactors |
IntActi | Q8IYA8, 81 interactors |
MINTi | Q8IYA8 |
STRINGi | 9606.ENSP00000391788 |
PTM databases
iPTMneti | Q8IYA8 |
PhosphoSitePlusi | Q8IYA8 |
Genetic variation databases
BioMutai | CCDC36 |
DMDMi | 313104087 |
Proteomic databases
MassIVEi | Q8IYA8 |
PaxDbi | Q8IYA8 |
PeptideAtlasi | Q8IYA8 |
PRIDEi | Q8IYA8 |
ProteomicsDBi | 71135 [Q8IYA8-1] 71136 [Q8IYA8-2] 71137 [Q8IYA8-3] |
Protocols and materials databases
Antibodypediai | 48985, 177 antibodies |
DNASUi | 339834 |
Genome annotation databases
Ensembli | ENST00000296449; ENSP00000296449; ENSG00000173421 [Q8IYA8-1] ENST00000366429; ENSP00000403700; ENSG00000173421 [Q8IYA8-3] ENST00000438782; ENSP00000391788; ENSG00000173421 [Q8IYA8-1] ENST00000452691; ENSP00000407837; ENSG00000173421 [Q8IYA8-1] |
GeneIDi | 339834 |
KEGGi | hsa:339834 |
UCSCi | uc003cwk.3, human [Q8IYA8-1] |
Organism-specific databases
CTDi | 339834 |
DisGeNETi | 339834 |
GeneCardsi | IHO1 |
HGNCi | HGNC:27945, IHO1 |
HPAi | ENSG00000173421, Tissue enriched (testis) |
neXtProti | NX_Q8IYA8 |
OpenTargetsi | ENSG00000173421 |
PharmGKBi | PA142672191 |
VEuPathDBi | HostDB:ENSG00000173421.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0PR, Eukaryota |
GeneTreei | ENSGT00390000012418 |
HOGENOMi | CLU_034910_0_0_1 |
InParanoidi | Q8IYA8 |
OMAi | EFIEMKS |
OrthoDBi | 974040at2759 |
PhylomeDBi | Q8IYA8 |
TreeFami | TF337135 |
Enzyme and pathway databases
PathwayCommonsi | Q8IYA8 |
Miscellaneous databases
BioGRID-ORCSi | 339834, 34 hits in 882 CRISPR screens |
ChiTaRSi | CCDC36, human |
GenomeRNAii | 339834 |
Pharosi | Q8IYA8, Tdark |
PROi | PR:Q8IYA8 |
RNActi | Q8IYA8, protein |
Gene expression databases
Bgeei | ENSG00000173421, Expressed in testis and 115 other tissues |
Genevisiblei | Q8IYA8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031529, IHO1 |
PANTHERi | PTHR35662, PTHR35662, 1 hit |
Pfami | View protein in Pfam PF15771, IHO1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IHO1_HUMAN | |
Accessioni | Q8IYA8Primary (citable) accession number: Q8IYA8 Secondary accession number(s): C9JJL0, Q05DG9, Q96LP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports