Interactor of HORMAD1 protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• DNA recombination Source: UniProtKB-KW
• meiotic DNA double-strand break formation Source: UniProtKB
• oogenesis Source: UniProtKB
• regulation of homologous chromosome segregation Source: UniProtKB
• spermatogenesis Source: UniProtKB
• synapsis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE 
        60         70         80         90        100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG 
       110        120        130        140        150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSETLYNFVS NVRESILRLQ 
       160        170        180        190        200
TSVEKSEDHL SSRSQSILDS LETVAKTLQE TIQAQNDLVF EAVQDKGNME 
       210        220        230        240        250
QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV 
       260        270        280        290        300
PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ 
       310        320        330        340        350
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD 
       360        370        380        390        400
KVVQTNCKNW AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF 
       410        420        430        440        450
STSIKNACQK YQAQSMFLCD PREHLVIKQK DGTVEMRGKD KKQQPRKAHR 
       460        470        480        490        500
AHRGRLIASK QKQIPIQTCK FNSKYQSPQP AISVPQSPFL GQQEPRAQPL 
       510        520        530        540        550
HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS 
       560        570        580        590 
SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF       

        10         20         30         40         50
MARVDAKAKE APRASEGCQH AVTSQRNKKS SNWNNNQNDY SSLSDSQFLF 
        60         70         80         90        100
GSQFCPENSE TLSAPLDFGA HLRHSKQSQQ NYLEGEPSIF TKYQTKPQFE 
       110        120        130        140        150
EKKKRAKDKC DSETLYNFVS NVRESILRLQ TSVEKSEDHL SSRSQSILDS 
       160        170        180        190        200
LETVAKTLQE TIQAQNDLVF EAVQDKGNME QAILEMKKRF EARQGEFIEM 
       210        220        230        240        250
KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV PSVLAELKRL ISVPPVKDSA 
       260        270        280        290        300
SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ ALPAAWNPGM GSLQPGEFDV 
       310        320        330        340        350
WGEGAKNDDL QEEAALPAFG SHERNRHVKD KVVQTNCKNW AVTKTGAKNH 
       360        370        380        390        400
GSSVPGHKIP SDRDLVSQGA SQLTSLEINF STSIKNACQK YQAQSMFLCD 
       410        420        430        440        450
PREHLVIKQK DGTVEMRGKD KKQQPRKAHR AHRGRLIASK QKQIPIQTCK 
       460        470        480        490        500
FNSKYQSPQP AISVPQSPFL GQQEPRAQPL HLQCPRSPRK PVCPILGGTV 
       510        520        530        540        550
MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS SQGDHQMSWF SDLNLGCSET 
       560        570 
PLCKEAGKNL LYDLGFDSSD DDGF                             

        10         20         30         40         50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE 
        60         70         80         90        100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG 
       110        120        130        140        150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSCRRLWKSL RTISVQEANL 
       160        170        180        190        200
FWILWRLWPR HVSASCLRYQ QRALVNDEHE LSDPSLVSSG EVPHRVSDER 

MGI                                                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations