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Entry version 119 (08 May 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Interactor of HORMAD1 protein 1

Gene

CCDC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, DNA recombination, Meiosis, Oogenesis, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interactor of HORMAD1 protein 11 Publication
Alternative name(s):
Cancer/testis antigen 74
Short name:
CT74
Coiled-coil domain-containing protein 36Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC36Imported
Synonyms:IHO11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27945 CCDC36

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
339834

Open Targets

More...
OpenTargetsi
ENSG00000173421

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672191

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC36

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104087

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003028751 – 594Interactor of HORMAD1 protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei588PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYA8

PeptideAtlas

More...
PeptideAtlasi
Q8IYA8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYA8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71135
71136 [Q8IYA8-2]
71137 [Q8IYA8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173421 Expressed in 92 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045690
HPA069534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HORMAD1 (PubMed:27723721). Interacts with REC114 (By similarity). Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4 (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130947, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYA8, 77 interactors

Molecular INTeraction database

More...
MINTi
Q8IYA8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IYA8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili109 – 135Sequence analysisAdd BLAST27
Coiled coili165 – 189Sequence analysisAdd BLAST25
Coiled coili219 – 245Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH7Y Eukaryota
ENOG410YHF5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012418

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111410

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYA8

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDKCDSE

Database of Orthologous Groups

More...
OrthoDBi
974040at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYA8

TreeFam database of animal gene trees

More...
TreeFami
TF337135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031529 IHO1

The PANTHER Classification System

More...
PANTHERi
PTHR35662 PTHR35662, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15771 IHO1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IYA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE
60 70 80 90 100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG
110 120 130 140 150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSETLYNFVS NVRESILRLQ
160 170 180 190 200
TSVEKSEDHL SSRSQSILDS LETVAKTLQE TIQAQNDLVF EAVQDKGNME
210 220 230 240 250
QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV
260 270 280 290 300
PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
310 320 330 340 350
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD
360 370 380 390 400
KVVQTNCKNW AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF
410 420 430 440 450
STSIKNACQK YQAQSMFLCD PREHLVIKQK DGTVEMRGKD KKQQPRKAHR
460 470 480 490 500
AHRGRLIASK QKQIPIQTCK FNSKYQSPQP AISVPQSPFL GQQEPRAQPL
510 520 530 540 550
HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS
560 570 580 590
SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF
Length:594
Mass (Da):66,343
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36E6C739E55DF4B1
GO
Isoform 2 (identifier: Q8IYA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MNFNVWNIKEMLSIPSGSG → MARVDAKAKEAPRASEGCQHAVTSQR
     91-117: Missing.

Note: No experimental confirmation available.
Show »
Length:574
Mass (Da):64,264
Checksum:i9127B48535B0C518
GO
Isoform 3 (identifier: Q8IYA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-203: ETLYNFVSNV...QDKGNMEQAI → CRRLWKSLRT...HRVSDERMGI
     204-594: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,196
Checksum:i39D09FB06217D536
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36202 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035002440D → E. Corresponds to variant dbSNP:rs13068038Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0279871 – 19MNFNV…PSGSG → MARVDAKAKEAPRASEGCQH AVTSQR in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_02798891 – 117Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027989133 – 203ETLYN…MEQAI → CRRLWKSLRTISVQEANLFW ILWRLWPRHVSASCLRYQQR ALVNDEHELSDPSLVSSGEV PHRVSDERMGI in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_027990204 – 594Missing in isoform 3. 1 PublicationAdd BLAST391

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC121247 Genomic DNA No translation available.
AC135506 Genomic DNA No translation available.
BC015057 mRNA No translation available.
BC036202 mRNA Translation: AAH36202.1 Different initiation.
AK058049 mRNA Translation: BAB71640.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33755.2 [Q8IYA8-1]

NCBI Reference Sequences

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RefSeqi
NP_001128669.1, NM_001135197.1 [Q8IYA8-1]
NP_835467.2, NM_178173.3 [Q8IYA8-1]
XP_006713187.1, XM_006713124.3 [Q8IYA8-1]
XP_011531974.1, XM_011533672.2 [Q8IYA8-1]
XP_011531975.1, XM_011533673.2 [Q8IYA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296449; ENSP00000296449; ENSG00000173421 [Q8IYA8-1]
ENST00000366429; ENSP00000403700; ENSG00000173421 [Q8IYA8-3]
ENST00000438782; ENSP00000391788; ENSG00000173421 [Q8IYA8-1]
ENST00000452691; ENSP00000407837; ENSG00000173421 [Q8IYA8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
339834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:339834

UCSC genome browser

More...
UCSCi
uc003cwk.3 human [Q8IYA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121247 Genomic DNA No translation available.
AC135506 Genomic DNA No translation available.
BC015057 mRNA No translation available.
BC036202 mRNA Translation: AAH36202.1 Different initiation.
AK058049 mRNA Translation: BAB71640.1
CCDSiCCDS33755.2 [Q8IYA8-1]
RefSeqiNP_001128669.1, NM_001135197.1 [Q8IYA8-1]
NP_835467.2, NM_178173.3 [Q8IYA8-1]
XP_006713187.1, XM_006713124.3 [Q8IYA8-1]
XP_011531974.1, XM_011533672.2 [Q8IYA8-1]
XP_011531975.1, XM_011533673.2 [Q8IYA8-1]

3D structure databases

SMRiQ8IYA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130947, 62 interactors
IntActiQ8IYA8, 77 interactors
MINTiQ8IYA8
STRINGi9606.ENSP00000391788

PTM databases

iPTMnetiQ8IYA8
PhosphoSitePlusiQ8IYA8

Polymorphism and mutation databases

BioMutaiCCDC36
DMDMi313104087

Proteomic databases

PaxDbiQ8IYA8
PeptideAtlasiQ8IYA8
PRIDEiQ8IYA8
ProteomicsDBi71135
71136 [Q8IYA8-2]
71137 [Q8IYA8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
339834
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296449; ENSP00000296449; ENSG00000173421 [Q8IYA8-1]
ENST00000366429; ENSP00000403700; ENSG00000173421 [Q8IYA8-3]
ENST00000438782; ENSP00000391788; ENSG00000173421 [Q8IYA8-1]
ENST00000452691; ENSP00000407837; ENSG00000173421 [Q8IYA8-1]
GeneIDi339834
KEGGihsa:339834
UCSCiuc003cwk.3 human [Q8IYA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
339834
DisGeNETi339834

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC36

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0017873
HGNCiHGNC:27945 CCDC36
HPAiHPA045690
HPA069534
neXtProtiNX_Q8IYA8
OpenTargetsiENSG00000173421
PharmGKBiPA142672191

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH7Y Eukaryota
ENOG410YHF5 LUCA
GeneTreeiENSGT00390000012418
HOGENOMiHOG000111410
InParanoidiQ8IYA8
OMAiKDKCDSE
OrthoDBi974040at2759
PhylomeDBiQ8IYA8
TreeFamiTF337135

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC36 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
339834

Protein Ontology

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PROi
PR:Q8IYA8

Gene expression databases

BgeeiENSG00000173421 Expressed in 92 organ(s), highest expression level in testis
GenevisibleiQ8IYA8 HS

Family and domain databases

InterProiView protein in InterPro
IPR031529 IHO1
PANTHERiPTHR35662 PTHR35662, 1 hit
PfamiView protein in Pfam
PF15771 IHO1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIHO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYA8
Secondary accession number(s): C9JJL0, Q05DG9, Q96LP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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