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Protein

Homeobox protein Mohawk

Gene

MKX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a morphogenetic regulator of cell adhesion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 132Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: HGNC

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Mohawk
Gene namesi
Name:MKX
Synonyms:C10orf48, IRXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000150051.13
HGNCiHGNC:23729 MKX
neXtProtiNX_Q8IYA7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150051
PharmGKBiPA134964449

Polymorphism and mutation databases

BioMutaiMKX
DMDMi296437371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688561 – 352Homeobox protein MohawkAdd BLAST352

Proteomic databases

PaxDbiQ8IYA7
PeptideAtlasiQ8IYA7
PRIDEiQ8IYA7
ProteomicsDBi71134

PTM databases

iPTMnetiQ8IYA7
PhosphoSitePlusiQ8IYA7

Expressioni

Gene expression databases

BgeeiENSG00000150051 Expressed in 138 organ(s), highest expression level in prostate gland
CleanExiHS_MKX
ExpressionAtlasiQ8IYA7 baseline and differential
GenevisibleiQ8IYA7 HS

Organism-specific databases

HPAiHPA006927

Interactioni

Protein-protein interaction databases

BioGridi129453, 9 interactors
IntActiQ8IYA7, 1 interactor
STRINGi9606.ENSP00000364946

Structurei

3D structure databases

ProteinModelPortaliQ8IYA7
SMRiQ8IYA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000290195
HOVERGENiHBG057105
InParanoidiQ8IYA7
OMAiKCDSAAN
OrthoDBiEOG091G09ZM
PhylomeDBiQ8IYA7
TreeFamiTF319371

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IYA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIPDGPP
60 70 80 90 100
LKDNLGLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK
110 120 130 140 150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV
160 170 180 190 200
QGNAERLSVS SDDSCSEDGE NPPRTHMNEG GYNTPVHHPV IKSENSVIKA
210 220 230 240 250
GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT MMGKTRQRNH
260 270 280 290 300
SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGSNKGE SAANRKGPSK
310 320 330 340 350
DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ

QF
Length:352
Mass (Da):39,331
Last modified:May 18, 2010 - v2
Checksum:i6450BDEF5BCCEDE9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKC7H0YKC7_HUMAN
Homeobox protein Mohawk
MKX
290Annotation score:
H0YMU2H0YMU2_HUMAN
Homeobox protein Mohawk
MKX
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11G → S in AAH36207 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03387540R → H. Corresponds to variant dbSNP:rs34439626Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125339 mRNA Translation: BAG54187.1
AC024606 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86052.1
CH471072 Genomic DNA Translation: EAW86053.1
BC036207 mRNA Translation: AAH36207.1
CCDSiCCDS7156.1
RefSeqiNP_001229631.1, NM_001242702.1
NP_775847.2, NM_173576.2
XP_016871594.1, XM_017016105.1
XP_016871595.1, XM_017016106.1
UniGeneiHs.128193

Genome annotation databases

EnsembliENST00000375790; ENSP00000364946; ENSG00000150051
ENST00000419761; ENSP00000400896; ENSG00000150051
GeneIDi283078
KEGGihsa:283078
UCSCiuc001itx.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125339 mRNA Translation: BAG54187.1
AC024606 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86052.1
CH471072 Genomic DNA Translation: EAW86053.1
BC036207 mRNA Translation: AAH36207.1
CCDSiCCDS7156.1
RefSeqiNP_001229631.1, NM_001242702.1
NP_775847.2, NM_173576.2
XP_016871594.1, XM_017016105.1
XP_016871595.1, XM_017016106.1
UniGeneiHs.128193

3D structure databases

ProteinModelPortaliQ8IYA7
SMRiQ8IYA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129453, 9 interactors
IntActiQ8IYA7, 1 interactor
STRINGi9606.ENSP00000364946

PTM databases

iPTMnetiQ8IYA7
PhosphoSitePlusiQ8IYA7

Polymorphism and mutation databases

BioMutaiMKX
DMDMi296437371

Proteomic databases

PaxDbiQ8IYA7
PeptideAtlasiQ8IYA7
PRIDEiQ8IYA7
ProteomicsDBi71134

Protocols and materials databases

DNASUi283078
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375790; ENSP00000364946; ENSG00000150051
ENST00000419761; ENSP00000400896; ENSG00000150051
GeneIDi283078
KEGGihsa:283078
UCSCiuc001itx.5 human

Organism-specific databases

CTDi283078
EuPathDBiHostDB:ENSG00000150051.13
GeneCardsiMKX
HGNCiHGNC:23729 MKX
HPAiHPA006927
neXtProtiNX_Q8IYA7
OpenTargetsiENSG00000150051
PharmGKBiPA134964449
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOGENOMiHOG000290195
HOVERGENiHBG057105
InParanoidiQ8IYA7
OMAiKCDSAAN
OrthoDBiEOG091G09ZM
PhylomeDBiQ8IYA7
TreeFamiTF319371

Miscellaneous databases

ChiTaRSiMKX human
GeneWikiiMKX
GenomeRNAii283078
PROiPR:Q8IYA7

Gene expression databases

BgeeiENSG00000150051 Expressed in 138 organ(s), highest expression level in prostate gland
CleanExiHS_MKX
ExpressionAtlasiQ8IYA7 baseline and differential
GenevisibleiQ8IYA7 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMKX_HUMAN
AccessioniPrimary (citable) accession number: Q8IYA7
Secondary accession number(s): B3KWM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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