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Entry version 113 (16 Oct 2019)
Sequence version 4 (02 Nov 2010)
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Protein

Cytoskeleton-associated protein 2-like

Gene

CKAP2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoskeleton-associated protein 2-like
Alternative name(s):
Radial fiber and mitotic spindle protein
Short name:
Radmis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CKAP2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26877 CKAP2L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616174 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYA6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Filippi syndrome (FLPIS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by microcephaly, pre- and postnatal growth failure, syndactyly, and distinctive facial features, including a broad nasal bridge and underdeveloped alae nasi. Some affected individuals have intellectual disability, seizures, undescended testicles in males, and teeth and hair abnormalities.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi198K → R: Abrogates sumoylation. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
150468

MalaCards human disease database

More...
MalaCardsi
CKAP2L
MIMi272440 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169607

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3255 Filippi syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596448

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYA6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CKAP2L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003243351 – 745Cytoskeleton-associated protein 2-likeAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei204Phosphotyrosine1 Publication1
Modified residuei742PhosphothreonineCombined sources1
Modified residuei745PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IYA6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IYA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYA6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYA6

PeptideAtlas

More...
PeptideAtlasi
Q8IYA6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
25385
71132 [Q8IYA6-1]
71133 [Q8IYA6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is cell-cycle dependent. Undetectable in interphase and prophase, strong expression at the spindle pole throughout metaphase to telophase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169607 Expressed in 80 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYA6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYA6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039407
HPA040057
HPA070737

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127298, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYA6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305204

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi185 – 187KEN boxBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CKAP2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGXX Eukaryota
ENOG4111T8P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063691

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111753

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYA6

KEGG Orthology (KO)

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KOi
K16769

Identification of Orthologs from Complete Genome Data

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OMAi
KAKNNCP

Database of Orthologous Groups

More...
OrthoDBi
417608at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYA6

TreeFam database of animal gene trees

More...
TreeFami
TF333003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029197 CKAP2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15297 CKAP2_C, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IYA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGPGPTAAA AVEERQRKLQ EYLAAKGKLK SQNTKPYLKS KNNCQNQPPS
60 70 80 90 100
KSTIRPKNDV TNHVVLPVKP KRSISIKLQP RPPNTAGSQK PKLEPPKLLG
110 120 130 140 150
KRLTSECVSS NPYSKPSSKS FQQCEAGSST TGELSRKPVG SLNIEQLKTT
160 170 180 190 200
KQQLTDQGNG KCIDFMNNIH VENESLDNFL KETNKENLLD ILTEPERKPD
210 220 230 240 250
PKLYTRSKPK TDSYNQTKNS LVPKQALGKS SVNSAVLKDR VNKQFVGETQ
260 270 280 290 300
SRTFPVKSQQ LSRGADLARP GVKPSRTVPS HFIRTLSKVQ SSKKPVVKNI
310 320 330 340 350
KDIKVNRSQY ERPNETKIRS YPVTEQRVKH TKPRTYPSLL QGEYNNRHPN
360 370 380 390 400
IKQDQKSSQV CIPQTSCVLQ KSKAISQRPN LTVGRFNSAI PSTPSIRPNG
410 420 430 440 450
TSGNKHNNNG FQQKAQTLDS KLKKAVPQNH FLNKTAPKTQ ADVTTVNGTQ
460 470 480 490 500
TNPNIKKKAT AEDRRKQLEE WQKSKGKTYK RPPMELKTKR KVIKEMNISF
510 520 530 540 550
WKSIEKEEEE KKAQLELSSK INNTLTECLN LIEGGVPSNE ILNILSSIPE
560 570 580 590 600
AEKFAKFWIC KAKLLASKGT FDVIGLYEEA IKNGATPIQE LRKVVLNILQ
610 620 630 640 650
DSNRTTEGIT SDSLVAETSI TSVEELAKKM ESVKSCLSPK EREQVTATPR
660 670 680 690 700
IAKAEQHNYP GIKLQIGPIP RINGMPEVQD MKFITPVRRS SRIERAVSRY
710 720 730 740
PEMLQEHDLV VASLDELLEV EETKCFIFRR NEALPVTLGF QTPES
Length:745
Mass (Da):83,587
Last modified:November 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46FE794CD9EBADD9
GO
Isoform 2 (identifier: Q8IYA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-411: Missing.
     412-412: Q → M

Note: No experimental confirmation available.
Show »
Length:334
Mass (Da):37,806
Checksum:i303A71394E91CA62
GO
Isoform 3 (identifier: Q8IYA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):65,611
Checksum:i904AA6C1F0C1D27F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBE0F8WBE0_HUMAN
Cytoskeleton-associated protein 2-l...
CKAP2L
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX93053 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti375I → A in BAH14612 (PubMed:14702039).Curated1
Sequence conflicti531L → P in BAC05202 (PubMed:14702039).Curated1
Sequence conflicti615V → A in BAF85219 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03973519L → F. Corresponds to variant dbSNP:rs36093393Ensembl.1
Natural variantiVAR_03973626K → R. Corresponds to variant dbSNP:rs35593767EnsemblClinVar.1
Natural variantiVAR_03973762N → S1 PublicationCorresponds to variant dbSNP:rs17042344Ensembl.1
Natural variantiVAR_039738104T → I. Corresponds to variant dbSNP:rs13007595Ensembl.1
Natural variantiVAR_039739263R → S1 PublicationCorresponds to variant dbSNP:rs17042341Ensembl.1
Natural variantiVAR_039740375I → V2 PublicationsCorresponds to variant dbSNP:rs6731822Ensembl.1
Natural variantiVAR_039741379P → A. Corresponds to variant dbSNP:rs2676126Ensembl.1
Natural variantiVAR_039742519S → G. Corresponds to variant dbSNP:rs36046436Ensembl.1
Natural variantiVAR_039743614L → S. Corresponds to variant dbSNP:rs3811040Ensembl.1
Natural variantiVAR_039744706E → D. Corresponds to variant dbSNP:rs3811039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0322191 – 411Missing in isoform 2. 1 PublicationAdd BLAST411
Alternative sequenceiVSP_0537171 – 165Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_032220412Q → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK097948 mRNA Translation: BAC05202.1
AK292530 mRNA Translation: BAF85219.1
AK302875 mRNA Translation: BAG64055.1
AK316241 mRNA Translation: BAH14612.1
AC079922 Genomic DNA Translation: AAY14923.1
AC112235 Genomic DNA Translation: AAX93053.1 Sequence problems.
BC036217 mRNA Translation: AAH36217.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2100.1 [Q8IYA6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001291290.1, NM_001304361.1 [Q8IYA6-3]
NP_689728.3, NM_152515.4 [Q8IYA6-1]
XP_011508968.1, XM_011510666.2 [Q8IYA6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302450; ENSP00000305204; ENSG00000169607 [Q8IYA6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150468

UCSC genome browser

More...
UCSCi
uc002tie.3 human [Q8IYA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097948 mRNA Translation: BAC05202.1
AK292530 mRNA Translation: BAF85219.1
AK302875 mRNA Translation: BAG64055.1
AK316241 mRNA Translation: BAH14612.1
AC079922 Genomic DNA Translation: AAY14923.1
AC112235 Genomic DNA Translation: AAX93053.1 Sequence problems.
BC036217 mRNA Translation: AAH36217.1
CCDSiCCDS2100.1 [Q8IYA6-1]
RefSeqiNP_001291290.1, NM_001304361.1 [Q8IYA6-3]
NP_689728.3, NM_152515.4 [Q8IYA6-1]
XP_011508968.1, XM_011510666.2 [Q8IYA6-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127298, 5 interactors
IntActiQ8IYA6, 3 interactors
STRINGi9606.ENSP00000305204

PTM databases

iPTMnetiQ8IYA6
PhosphoSitePlusiQ8IYA6

Polymorphism and mutation databases

BioMutaiCKAP2L
DMDMi311033474

Proteomic databases

EPDiQ8IYA6
jPOSTiQ8IYA6
MassIVEiQ8IYA6
MaxQBiQ8IYA6
PaxDbiQ8IYA6
PeptideAtlasiQ8IYA6
PRIDEiQ8IYA6
ProteomicsDBi25385
71132 [Q8IYA6-1]
71133 [Q8IYA6-2]

Genome annotation databases

EnsembliENST00000302450; ENSP00000305204; ENSG00000169607 [Q8IYA6-1]
GeneIDi150468
KEGGihsa:150468
UCSCiuc002tie.3 human [Q8IYA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
150468
DisGeNETi150468

GeneCards: human genes, protein and diseases

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GeneCardsi
CKAP2L
HGNCiHGNC:26877 CKAP2L
HPAiHPA039407
HPA040057
HPA070737
MalaCardsiCKAP2L
MIMi272440 phenotype
616174 gene
neXtProtiNX_Q8IYA6
OpenTargetsiENSG00000169607
Orphaneti3255 Filippi syndrome
PharmGKBiPA144596448

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGXX Eukaryota
ENOG4111T8P LUCA
GeneTreeiENSGT00530000063691
HOGENOMiHOG000111753
InParanoidiQ8IYA6
KOiK16769
OMAiKAKNNCP
OrthoDBi417608at2759
PhylomeDBiQ8IYA6
TreeFamiTF333003

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CKAP2L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
150468
PharosiQ8IYA6

Protein Ontology

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PROi
PR:Q8IYA6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169607 Expressed in 80 organ(s), highest expression level in testis
ExpressionAtlasiQ8IYA6 baseline and differential
GenevisibleiQ8IYA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR029197 CKAP2_C
PfamiView protein in Pfam
PF15297 CKAP2_C, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKP2L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYA6
Secondary accession number(s): A8K915
, B4DZE3, B7ZAC6, F5H0M5, Q53QF8, Q53RS8, Q8N1J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 113 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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