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Entry version 101 (02 Jun 2021)
Sequence version 3 (04 Dec 2007)
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Protein

Putative coiled-coil domain-containing protein 144C

Gene

CCDC144CP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Could be the product of a pseudogene.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative coiled-coil domain-containing protein 144C
Alternative name(s):
Coiled-coil domain-containing protein 144C pseudogene
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC144CP
Synonyms:CCDC144C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29073, CCDC144CP

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYA2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYA2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HGNC:29073

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416239

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122811 – 1237Putative coiled-coil domain-containing protein 144CAdd BLAST1237

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYA2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYA2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYA2

PeptideAtlas

More...
PeptideAtlasi
Q8IYA2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71131

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYA2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IYA2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni120 – 181DisorderedSequence analysisAdd BLAST62
Regioni403 – 435DisorderedSequence analysisAdd BLAST33
Regioni479 – 519DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili440 – 595Sequence analysisAdd BLAST156
Coiled coili636 – 939Sequence analysisAdd BLAST304
Coiled coili965 – 1042Sequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi121 – 153Polar residuesSequence analysisAdd BLAST33
Compositional biasi403 – 422Polar residuesSequence analysisAdd BLAST20
Compositional biasi488 – 507Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC144 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYA2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSEHVEG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYA2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040118, C144A/B/C
IPR039497, CC144C-like_CC_dom
IPR021885, DUF3496

The PANTHER Classification System

More...
PANTHERi
PTHR22245, PTHR22245, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14915, CCDC144C, 1 hit
PF12001, DUF3496, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSWGGEKRG GAEGSPKPAV YATRKTGSVR SQEDQWYLGY PGDQWSSGFS
60 70 80 90 100
YSWWKNSVGS ESKHGEGALD QPQHDVRLED LGELHRAARS GDVPGVEHVL
110 120 130 140 150
VPGDTGVDKR DRKKSIQQLV PEYKEKQTPE SLPQNNNPDW HPTNLTLSDE
160 170 180 190 200
TCQRSKNLKV DDKCPSVSPS MPENQSATKE LGQMNLTERE KMDTGVKTSQ
210 220 230 240 250
EPEMAKDCDR EDIPIYPVLP HVQKSEEMRI EQGKLEWKNQ LKLVINELKQ
260 270 280 290 300
RFGEIYEKYK IPACPEEEPL LDNSTRGTDV KDIPFNLTNN IPGCEEEDAS
310 320 330 340 350
EISVSVVFET FPEQKEPSLK NIIHSYYHPY SGSQEHVCQS SSKLHLHENK
360 370 380 390 400
LDCDNDNKPG IGHIFSTDKN FHNDASTKKA RNPEVVTVEM KEDQEFDLQM
410 420 430 440 450
TKNMNQNSDS GSTNNYKSLK PKLENLSSLP PDSDRTSEVY LHEELQQDMQ
460 470 480 490 500
KFKNEVNTLE EEFLALKKEN VQLHKEVEEE MEKHRSNSTE LSGTLTDGTT
510 520 530 540 550
VGNDDDGLNQ QIPRKENGEH DRLALKQENE EKRNADMLYN KDSEQLRIKE
560 570 580 590 600
EECGKVVETK QQLKWNLRRL VKELRTVVQE RNDAQKQLSE EQDARILQDQ
610 620 630 640 650
ILTSKQKELE MAQKKRNPEI SHRHQKEKDL FHENCMLQEE IALLRLEIDT
660 670 680 690 700
IKNQNKQKEK KYFEDIEVVK EKNDNLQKII KRNEETLTET ILQYSGQLNN
710 720 730 740 750
LTAENKMLNS ELENGKENQE RLEIEMESYR CRLAAAVHDC DQSQTARDLK
760 770 780 790 800
LDFQRTRQEW VRLHDKMKVD MSGLQAKNEI LSEKLSNAES KINSLQIQLH
810 820 830 840 850
NTRDALGRES LILERVQRDL SQTQCQKKET EQMYQSKLKK YIAKQESVEE
860 870 880 890 900
RLSQLQSENM LLRQQLDDVH KKANSQEKTI STIQDQFHSA AKNLQAESEK
910 920 930 940 950
QILSLQEKNK ELMDEYNHLK ERMDQCEKEK AGRKIDLTEA QETVPSRCLH
960 970 980 990 1000
LDAENEVLQL QQTLFSMKAI QKQCETLQKN KKQLKQEVVN LKSYMERNML
1010 1020 1030 1040 1050
ERGEAEWHKL LIEERARKEI EEKLNEAILT LQKQAAVSHE QLAQLREDNT
1060 1070 1080 1090 1100
TSIKTQMELT VIDLESEISR IKTSQADFNK TKLERYKELY LEEVKVRESL
1110 1120 1130 1140 1150
SNELSRTNEM IAEVSTQLTV EKEQTRSRSL FTAYATRPVL ESPCVGNLND
1160 1170 1180 1190 1200
SEGLNRKHIP RKKRSALKDM ESYLLKMQQK LQNDLTAEVA GSSQTGLHRI
1210 1220 1230
PQCSSFSSSS LHLLLCSICQ PFFLILQLLL NMNLDPI
Length:1,237
Mass (Da):143,112
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE18417A167348457
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008088 Genomic DNA No translation available.
AC015818 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008088 Genomic DNA No translation available.
AC015818 Genomic DNA No translation available.

3D structure databases

SMRiQ8IYA2
ModBaseiSearch...

PTM databases

iPTMnetiQ8IYA2
PhosphoSitePlusiQ8IYA2

Genetic variation databases

BioMutaiHGNC:29073
DMDMi162416239

Proteomic databases

jPOSTiQ8IYA2
MassIVEiQ8IYA2
MaxQBiQ8IYA2
PeptideAtlasiQ8IYA2
PRIDEiQ8IYA2
ProteomicsDBi71131

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC144CP
HGNCiHGNC:29073, CCDC144CP
neXtProtiNX_Q8IYA2

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

InParanoidiQ8IYA2
OMAiDSEHVEG
PhylomeDBiQ8IYA2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC144CP, human
PharosiQ8IYA2, Tdark

Protein Ontology

More...
PROi
PR:Q8IYA2
RNActiQ8IYA2, protein

Family and domain databases

InterProiView protein in InterPro
IPR040118, C144A/B/C
IPR039497, CC144C-like_CC_dom
IPR021885, DUF3496
PANTHERiPTHR22245, PTHR22245, 2 hits
PfamiView protein in Pfam
PF14915, CCDC144C, 1 hit
PF12001, DUF3496, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC144C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYA2
Secondary accession number(s): B7WNP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 2, 2021
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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