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Entry version 145 (13 Feb 2019)
Sequence version 3 (02 Sep 2008)
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Protein

Structure-specific endonuclease subunit SLX4

Gene

SLX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310 Fanconi Anemia Pathway

SIGNOR Signaling Network Open Resource

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SIGNORi
Q8IY92

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structure-specific endonuclease subunit SLX4
Alternative name(s):
BTB/POZ domain-containing protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLX4
Synonyms:BTBD12, KIAA1784, KIAA1987
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188827.10

Human Gene Nomenclature Database

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HGNCi
HGNC:23845 SLX4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613278 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8IY92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi anemia complementation group P (FANCP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some individuals affected by Fanconi anemia of complementation group P have skeletal anomalies.
See also OMIM:613951

Keywords - Diseasei

Fanconi anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
84464

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SLX4

MalaCards human disease database

More...
MalaCardsi
SLX4
MIMi613951 phenotype

Open Targets

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OpenTargetsi
ENSG00000188827

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
84 Fanconi anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134983583

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLX4

Domain mapping of disease mutations (DMDM)

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DMDMi
205371796

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001862191 – 1834Structure-specific endonuclease subunit SLX4Add BLAST1834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki970Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1070PhosphoserineCombined sources1
Cross-linki1081Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1121PhosphoserineBy similarity1
Modified residuei1135PhosphoserineBy similarity1
Cross-linki1169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1464PhosphoserineBy similarity1
Modified residuei1469PhosphoserineCombined sources1
Cross-linki1575Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1610PhosphoserineBy similarity1
Cross-linki1657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IY92

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IY92

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IY92

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IY92

PeptideAtlas

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PeptideAtlasi
Q8IY92

PRoteomics IDEntifications database

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PRIDEi
Q8IY92

ProteomicsDB human proteome resource

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ProteomicsDBi
71127
71128 [Q8IY92-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IY92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IY92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188827 Expressed in 119 organ(s), highest expression level in cerebellar vermis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IY92 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA049421
HPA066238

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SLX1A/GIYD1. Interacts with ERCC4; catalytic subunit of the ERCC4-ERCC1 endonuclease. Interacts with MUS81; catalytic subunit of the MUS81-EME1 endonuclease. Interacts with MSH2; component of the MSH2-MSH3 mismatch repair complex. Interacts with TERF2-TERF2IP. Interacts with PLK1 and SLX4IP.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124097, 52 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-484 SLX4-TERF2 complex

Protein interaction database and analysis system

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IntActi
Q8IY92, 164 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000294008

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11834
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M7CX-ray2.05C/D1014-1025[»]
4UYIX-ray1.86A668-796[»]
4ZOUX-ray2.15A669-787[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IY92

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IY92

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini691 – 764BTBPROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 669Interaction with SLX4IP, ERCC4 and MSH21 PublicationAdd BLAST669
Regioni684 – 1834Interaction with PLK1 and TERF2-TERF2IP1 PublicationAdd BLAST1151
Regioni1328 – 1648Interaction with MUS81Add BLAST321
Regioni1632 – 1834Interaction with SLX1Add BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili801 – 870Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi520 – 523Poly-Pro4
Compositional biasi796 – 856Glu-richAdd BLAST61
Compositional biasi1710 – 1721Poly-SerAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLX4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFPH Eukaryota
ENOG410XPS5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000095273

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IY92

KEGG Orthology (KO)

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KOi
K10484

Identification of Orthologs from Complete Genome Data

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OMAi
CESRAEN

Database of Orthologous Groups

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OrthoDBi
288384at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IY92

TreeFam database of animal gene trees

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TreeFami
TF106446

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR018574 Structure-sp_endonuc_su_Slx4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF09494 Slx4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IY92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT GQMMDESDED
60 70 80 90 100
FKELCASFFQ RVKKHGIKEV SGERKTQKAA SNGTQIRSKL KRTKQTATKT
110 120 130 140 150
KTLQGPAEKK PPSGSQAPRT KKQRVTKWQA SEPAHSVNGE GGVLASAPDP
160 170 180 190 200
PVLRETAQNT QTGNQQEPSP NLSREKTREN VPNSDSQPPP SCLTTAVPSP
210 220 230 240 250
SKPRTAQLVL QRMQQFKRAD PERLRHASEE CSLEAAREEN VPKDPQEEMM
260 270 280 290 300
AGNVYGLGPP APESDAAVAL TLQQEFARVG ASAHDDSLEE KGLFFCQICQ
310 320 330 340 350
KNLSAMNVTR REQHVNRCLD EAEKTLRPSV PQIPECPICG KPFLTLKSRT
360 370 380 390 400
SHLKQCAVKM EVGPQLLLQA VRLQTAQPEG SSSPPMFSFS DHSRGLKRRG
410 420 430 440 450
PTSKKEPRKR RKVDEAPSED LLVAMALSRS EMEPGAAVPA LRLESAFSER
460 470 480 490 500
IRPEAENKSR KKKPPVSPPL LLVQDSETTG RQIEDRVALL LSEEVELSST
510 520 530 540 550
PPLPASRILK EGWERAGQCP PPPERKQSFL WEGSALTGAW AMEDFYTARL
560 570 580 590 600
VPPLVPQRPA QGLMQEPVPP LVPPEHSELS ERRSPALHGT PTAGCGSRGP
610 620 630 640 650
SPSASQREHQ ALQDLVDLAR EGLSASPWPG SGGLAGSEGT AGLDVVPGGL
660 670 680 690 700
PLTGFVVPSQ DKHPDRGGRT LLSLGLLVAD FGAMVNNPHL SDVQFQTDSG
710 720 730 740 750
EVLYAHKFVL YARCPLLIQY VNNEGFSAVE DGVLTQRVLL GDVSTEAART
760 770 780 790 800
FLHYLYTADT GLPPGLSSEL SSLAHRFGVS ELVHLCEQVP IATDSEGKPW
810 820 830 840 850
EEKEAENCES RAENFQELLR SMWADEEEEA ETLLKSKDHE EDQENVNEAE
860 870 880 890 900
MEEIYEFAAT QRKLLQEERA AGAGEDADWL EGGSPVSGQL LAGVQVQKQW
910 920 930 940 950
DKVEEMEPLE PGRDEAATTW EKMGQCALPP PQGQHSGARG AEAPEQEAPE
960 970 980 990 1000
EALGHSSCSS PSRDCQAERK EGSLPHSDDA GDYEQLFSST QGEISEPSQI
1010 1020 1030 1040 1050
TSEPEEQSGA VRERGLEVSH RLAPWQASPP HPCRFLLGPP QGGSPRGSHH
1060 1070 1080 1090 1100
TSGSSLSTPR SRGGTSQVGS PTLLSPAVPS KQKRDRSILT LSKEPGHQKG
1110 1120 1130 1140 1150
KERRSVLECR NKGVLMFPEK SPSIDLTQSN PDHSSSRSQK SSSKLNEEDE
1160 1170 1180 1190 1200
VILLLDSDEE LELEQTKMKS ISSDPLEEKK ALEISPRSCE LFSIIDVDAD
1210 1220 1230 1240 1250
QEPSQSPPRS EAVLQQEDEG ALPENRGSLG RRGAPWLFCD RESSPSEAST
1260 1270 1280 1290 1300
TDTSWLVPAT PLASRSRDCS SQTQISSLRS GLAVQAVTQH TPRASVGNRE
1310 1320 1330 1340 1350
GNEVAQKFSV IRPQTPPPQT PSSCLTPVSP GTSDGRRQGH RSPSRPHPGG
1360 1370 1380 1390 1400
HPHSSPLAPH PISGDRAHFS RRFLKHSPPG PSFLNQTPAG EVVEVGDSDD
1410 1420 1430 1440 1450
EQEVASHQAN RSPPLDSDPP IPIDDCCWHM EPLSPIPIDH WNLERTGPLS
1460 1470 1480 1490 1500
TSSPSRRMNE AADSRDCRSP GLLDTTPIRG SCTTQRKLQE KSSGAGSLGN
1510 1520 1530 1540 1550
SRPSFLNSAL WDVWDGEEQR PPETPPPAQM PSAGGAQKPE GLETPKGANR
1560 1570 1580 1590 1600
KKNLPPKVPI TPMPQYSIME TPVLKKELDR FGVRPLPKRQ MVLKLKEIFQ
1610 1620 1630 1640 1650
YTHQTLDSDS EDESQSSQPL LQAPHCQTLA SQTYKPSRAG VHAQQEATTG
1660 1670 1680 1690 1700
PGAHRPKGPA KTKGPRHQRK HHESITPPSR SPTKEAPPGL NDDAQIPASQ
1710 1720 1730 1740 1750
ESVATSVDGS DSSLSSQSSS SCEFGAAFES AGEEEGEGEV SASQAAVQAA
1760 1770 1780 1790 1800
DTDEALRCYI RSKPALYQKV LLYQPFELRE LQAELRQNGL RVSSRRLLDF
1810 1820 1830
LDTHCITFTT AATRREKLQG RRRQPRGKKK VERN
Length:1,834
Mass (Da):200,012
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9131E88628DB15D5
GO
Isoform 2 (identifier: Q8IY92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     313-316: QHVN → MFSF

Show »
Length:1,522
Mass (Da):165,903
Checksum:iA3C234F1E746C5FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06898238L → F1 PublicationCorresponds to variant dbSNP:rs141167501EnsemblClinVar.1
Natural variantiVAR_068983141G → W1 PublicationCorresponds to variant dbSNP:rs137976282EnsemblClinVar.1
Natural variantiVAR_068984197V → A1 PublicationCorresponds to variant dbSNP:rs147826749EnsemblClinVar.1
Natural variantiVAR_068985204R → C1 PublicationCorresponds to variant dbSNP:rs79842542EnsemblClinVar.1
Natural variantiVAR_068986237R → Q1 PublicationCorresponds to variant dbSNP:rs138615800EnsemblClinVar.1
Natural variantiVAR_068987284H → R1 Publication1
Natural variantiVAR_068988378P → T Polymorphism; does not modify the functional properties of the protein. 1 Publication1
Natural variantiVAR_068989385P → T1 PublicationCorresponds to variant dbSNP:rs115694169EnsemblClinVar.1
Natural variantiVAR_068990386M → V1 PublicationCorresponds to variant dbSNP:rs113490934EnsemblClinVar.1
Natural variantiVAR_068991424A → V1 PublicationCorresponds to variant dbSNP:rs551823420EnsemblClinVar.1
Natural variantiVAR_068992457N → K1 PublicationCorresponds to variant dbSNP:rs74319927EnsemblClinVar.1
Natural variantiVAR_068993458K → E1 PublicationCorresponds to variant dbSNP:rs149126845EnsemblClinVar.1
Natural variantiVAR_068994505A → T1 Publication1
Natural variantiVAR_068995506S → N1 PublicationCorresponds to variant dbSNP:rs765859186Ensembl.1
Natural variantiVAR_068996568V → M1 PublicationCorresponds to variant dbSNP:rs371825444Ensembl.1
Natural variantiVAR_068997579L → P1 PublicationCorresponds to variant dbSNP:rs772504776Ensembl.1
Natural variantiVAR_068998671L → S2 PublicationsCorresponds to variant dbSNP:rs77985244EnsemblClinVar.1
Natural variantiVAR_068999787E → K Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs140600202EnsemblClinVar.1
Natural variantiVAR_069000870A → V1 PublicationCorresponds to variant dbSNP:rs149584080EnsemblClinVar.1
Natural variantiVAR_069001894V → G1 PublicationCorresponds to variant dbSNP:rs145137472EnsemblClinVar.1
Natural variantiVAR_069002929P → L1 PublicationCorresponds to variant dbSNP:rs117707719EnsemblClinVar.1
Natural variantiVAR_069003942E → Q1 PublicationCorresponds to variant dbSNP:rs114014006EnsemblClinVar.1
Natural variantiVAR_069004952A → M Requires 2 nucleotide substitutions. 2 PublicationsCorresponds to variant dbSNP:rs863224277EnsemblClinVar.1
Natural variantiVAR_069005975P → L1 PublicationCorresponds to variant dbSNP:rs114472821EnsemblClinVar.1
Natural variantiVAR_0690061007Q → K1 PublicationCorresponds to variant dbSNP:rs138798067Ensembl.1
Natural variantiVAR_0690071060R → W1 PublicationCorresponds to variant dbSNP:rs144273492EnsemblClinVar.1
Natural variantiVAR_0193261122P → L2 PublicationsCorresponds to variant dbSNP:rs714181EnsemblClinVar.1
Natural variantiVAR_0690081123S → Y1 PublicationCorresponds to variant dbSNP:rs144647122EnsemblClinVar.1
Natural variantiVAR_0197291221A → V2 PublicationsCorresponds to variant dbSNP:rs3827530EnsemblClinVar.1
Natural variantiVAR_0193271271S → F1 PublicationCorresponds to variant dbSNP:rs3810813EnsemblClinVar.1
Natural variantiVAR_0690091286A → V1 PublicationCorresponds to variant dbSNP:rs149011965EnsemblClinVar.1
Natural variantiVAR_0690101287V → G1 Publication1
Natural variantiVAR_0690111342S → G1 PublicationCorresponds to variant dbSNP:rs140051968EnsemblClinVar.1
Natural variantiVAR_0463371367A → T. Corresponds to variant dbSNP:rs17136464EnsemblClinVar.1
Natural variantiVAR_0690121421I → F1 PublicationCorresponds to variant dbSNP:rs141567438EnsemblClinVar.1
Natural variantiVAR_0690131476T → S1 PublicationCorresponds to variant dbSNP:rs372321470EnsemblClinVar.1
Natural variantiVAR_0690141550R → W Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs77021998EnsemblClinVar.1
Natural variantiVAR_0463381677P → S. Corresponds to variant dbSNP:rs7196345EnsemblClinVar.1
Natural variantiVAR_0690151694A → V1 PublicationCorresponds to variant dbSNP:rs761226343Ensembl.1
Natural variantiVAR_0690161814R → C1 PublicationCorresponds to variant dbSNP:rs767720336Ensembl.1
Natural variantiVAR_0690171834N → S Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs111738042EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352951 – 312Missing in isoform 2. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_035296313 – 316QHVN → MFSF in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006111 Genomic DNA No translation available.
AB075867 mRNA Translation: BAB85573.1
AB058687 mRNA Translation: BAB47413.1
AL442083 mRNA Translation: CAH10659.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10506.2 [Q8IY92-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115820.2, NM_032444.3 [Q8IY92-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.143681

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294008; ENSP00000294008; ENSG00000188827 [Q8IY92-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84464

UCSC genome browser

More...
UCSCi
uc002cvp.3 human [Q8IY92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SLX4 structure-specific endonuclease subunit homolog (S.cerevisiae) (SLX4)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006111 Genomic DNA No translation available.
AB075867 mRNA Translation: BAB85573.1
AB058687 mRNA Translation: BAB47413.1
AL442083 mRNA Translation: CAH10659.1
CCDSiCCDS10506.2 [Q8IY92-1]
RefSeqiNP_115820.2, NM_032444.3 [Q8IY92-1]
UniGeneiHs.143681

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M7CX-ray2.05C/D1014-1025[»]
4UYIX-ray1.86A668-796[»]
4ZOUX-ray2.15A669-787[»]
ProteinModelPortaliQ8IY92
SMRiQ8IY92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124097, 52 interactors
ComplexPortaliCPX-484 SLX4-TERF2 complex
IntActiQ8IY92, 164 interactors
STRINGi9606.ENSP00000294008

PTM databases

iPTMnetiQ8IY92
PhosphoSitePlusiQ8IY92

Polymorphism and mutation databases

BioMutaiSLX4
DMDMi205371796

Proteomic databases

EPDiQ8IY92
jPOSTiQ8IY92
MaxQBiQ8IY92
PaxDbiQ8IY92
PeptideAtlasiQ8IY92
PRIDEiQ8IY92
ProteomicsDBi71127
71128 [Q8IY92-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294008; ENSP00000294008; ENSG00000188827 [Q8IY92-1]
GeneIDi84464
KEGGihsa:84464
UCSCiuc002cvp.3 human [Q8IY92-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84464
DisGeNETi84464
EuPathDBiHostDB:ENSG00000188827.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLX4
GeneReviewsiSLX4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202244
HGNCiHGNC:23845 SLX4
HPAiHPA049421
HPA066238
MalaCardsiSLX4
MIMi613278 gene
613951 phenotype
neXtProtiNX_Q8IY92
OpenTargetsiENSG00000188827
Orphaneti84 Fanconi anemia
PharmGKBiPA134983583

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFPH Eukaryota
ENOG410XPS5 LUCA
GeneTreeiENSGT00390000014091
HOGENOMiHOG000095273
InParanoidiQ8IY92
KOiK10484
OMAiCESRAEN
OrthoDBi288384at2759
PhylomeDBiQ8IY92
TreeFamiTF106446

Enzyme and pathway databases

ReactomeiR-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiQ8IY92

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLX4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84464

Protein Ontology

More...
PROi
PR:Q8IY92

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188827 Expressed in 119 organ(s), highest expression level in cerebellar vermis
GenevisibleiQ8IY92 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR018574 Structure-sp_endonuc_su_Slx4
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF09494 Slx4, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY92
Secondary accession number(s): Q69YT8, Q8TF15, Q96JP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 2, 2008
Last modified: February 13, 2019
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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