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Protein

Structure-specific endonuclease subunit SLX4

Gene

SLX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

ReactomeiR-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiQ8IY92

Names & Taxonomyi

Protein namesi
Recommended name:
Structure-specific endonuclease subunit SLX4
Alternative name(s):
BTB/POZ domain-containing protein 12
Gene namesi
Name:SLX4
Synonyms:BTBD12, KIAA1784, KIAA1987
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000188827.10
HGNCiHGNC:23845 SLX4
MIMi613278 gene
neXtProtiNX_Q8IY92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Fanconi anemia complementation group P (FANCP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some individuals affected by Fanconi anemia of complementation group P have skeletal anomalies.
See also OMIM:613951

Keywords - Diseasei

Fanconi anemia

Organism-specific databases

DisGeNETi84464
GeneReviewsiSLX4
MalaCardsiSLX4
MIMi613951 phenotype
OpenTargetsiENSG00000188827
Orphaneti84 Fanconi anemia
PharmGKBiPA134983583

Polymorphism and mutation databases

BioMutaiSLX4
DMDMi205371796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862191 – 1834Structure-specific endonuclease subunit SLX4Add BLAST1834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei169PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki347Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki835Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki970Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1070PhosphoserineCombined sources1
Cross-linki1081Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1121PhosphoserineBy similarity1
Modified residuei1135PhosphoserineBy similarity1
Cross-linki1169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1464PhosphoserineBy similarity1
Modified residuei1469PhosphoserineCombined sources1
Cross-linki1575Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1610PhosphoserineBy similarity1
Cross-linki1657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IY92
MaxQBiQ8IY92
PaxDbiQ8IY92
PeptideAtlasiQ8IY92
PRIDEiQ8IY92
ProteomicsDBi71127
71128 [Q8IY92-2]

PTM databases

iPTMnetiQ8IY92
PhosphoSitePlusiQ8IY92

Expressioni

Gene expression databases

BgeeiENSG00000188827 Expressed in 119 organ(s), highest expression level in cerebellar vermis
CleanExiHS_BTBD12
GenevisibleiQ8IY92 HS

Organism-specific databases

HPAiHPA049421
HPA066238

Interactioni

Subunit structurei

Forms a heterodimer with SLX1A/GIYD1. Interacts with ERCC4; catalytic subunit of the ERCC4-ERCC1 endonuclease. Interacts with MUS81; catalytic subunit of the MUS81-EME1 endonuclease. Interacts with MSH2; component of the MSH2-MSH3 mismatch repair complex. Interacts with TERF2-TERF2IP. Interacts with PLK1 and SLX4IP.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi124097, 49 interactors
ComplexPortaliCPX-484 SLX4-TERF2 complex
IntActiQ8IY92, 164 interactors
STRINGi9606.ENSP00000294008

Structurei

Secondary structure

11834
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IY92
SMRiQ8IY92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini691 – 764BTBPROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 669Interaction with SLX4IP, ERCC4 and MSH21 PublicationAdd BLAST669
Regioni684 – 1834Interaction with PLK1 and TERF2-TERF2IP1 PublicationAdd BLAST1151
Regioni1328 – 1648Interaction with MUS81Add BLAST321
Regioni1632 – 1834Interaction with SLX1Add BLAST203

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili801 – 870Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi520 – 523Poly-Pro4
Compositional biasi796 – 856Glu-richAdd BLAST61
Compositional biasi1710 – 1721Poly-SerAdd BLAST12

Sequence similaritiesi

Belongs to the SLX4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFPH Eukaryota
ENOG410XPS5 LUCA
GeneTreeiENSGT00390000014091
HOGENOMiHOG000095273
InParanoidiQ8IY92
KOiK10484
OMAiHKFVLYA
OrthoDBiEOG091G10TA
PhylomeDBiQ8IY92
TreeFamiTF106446

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR018574 Structure-sp_endonuc_su_Slx4
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF09494 Slx4, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IY92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT GQMMDESDED
60 70 80 90 100
FKELCASFFQ RVKKHGIKEV SGERKTQKAA SNGTQIRSKL KRTKQTATKT
110 120 130 140 150
KTLQGPAEKK PPSGSQAPRT KKQRVTKWQA SEPAHSVNGE GGVLASAPDP
160 170 180 190 200
PVLRETAQNT QTGNQQEPSP NLSREKTREN VPNSDSQPPP SCLTTAVPSP
210 220 230 240 250
SKPRTAQLVL QRMQQFKRAD PERLRHASEE CSLEAAREEN VPKDPQEEMM
260 270 280 290 300
AGNVYGLGPP APESDAAVAL TLQQEFARVG ASAHDDSLEE KGLFFCQICQ
310 320 330 340 350
KNLSAMNVTR REQHVNRCLD EAEKTLRPSV PQIPECPICG KPFLTLKSRT
360 370 380 390 400
SHLKQCAVKM EVGPQLLLQA VRLQTAQPEG SSSPPMFSFS DHSRGLKRRG
410 420 430 440 450
PTSKKEPRKR RKVDEAPSED LLVAMALSRS EMEPGAAVPA LRLESAFSER
460 470 480 490 500
IRPEAENKSR KKKPPVSPPL LLVQDSETTG RQIEDRVALL LSEEVELSST
510 520 530 540 550
PPLPASRILK EGWERAGQCP PPPERKQSFL WEGSALTGAW AMEDFYTARL
560 570 580 590 600
VPPLVPQRPA QGLMQEPVPP LVPPEHSELS ERRSPALHGT PTAGCGSRGP
610 620 630 640 650
SPSASQREHQ ALQDLVDLAR EGLSASPWPG SGGLAGSEGT AGLDVVPGGL
660 670 680 690 700
PLTGFVVPSQ DKHPDRGGRT LLSLGLLVAD FGAMVNNPHL SDVQFQTDSG
710 720 730 740 750
EVLYAHKFVL YARCPLLIQY VNNEGFSAVE DGVLTQRVLL GDVSTEAART
760 770 780 790 800
FLHYLYTADT GLPPGLSSEL SSLAHRFGVS ELVHLCEQVP IATDSEGKPW
810 820 830 840 850
EEKEAENCES RAENFQELLR SMWADEEEEA ETLLKSKDHE EDQENVNEAE
860 870 880 890 900
MEEIYEFAAT QRKLLQEERA AGAGEDADWL EGGSPVSGQL LAGVQVQKQW
910 920 930 940 950
DKVEEMEPLE PGRDEAATTW EKMGQCALPP PQGQHSGARG AEAPEQEAPE
960 970 980 990 1000
EALGHSSCSS PSRDCQAERK EGSLPHSDDA GDYEQLFSST QGEISEPSQI
1010 1020 1030 1040 1050
TSEPEEQSGA VRERGLEVSH RLAPWQASPP HPCRFLLGPP QGGSPRGSHH
1060 1070 1080 1090 1100
TSGSSLSTPR SRGGTSQVGS PTLLSPAVPS KQKRDRSILT LSKEPGHQKG
1110 1120 1130 1140 1150
KERRSVLECR NKGVLMFPEK SPSIDLTQSN PDHSSSRSQK SSSKLNEEDE
1160 1170 1180 1190 1200
VILLLDSDEE LELEQTKMKS ISSDPLEEKK ALEISPRSCE LFSIIDVDAD
1210 1220 1230 1240 1250
QEPSQSPPRS EAVLQQEDEG ALPENRGSLG RRGAPWLFCD RESSPSEAST
1260 1270 1280 1290 1300
TDTSWLVPAT PLASRSRDCS SQTQISSLRS GLAVQAVTQH TPRASVGNRE
1310 1320 1330 1340 1350
GNEVAQKFSV IRPQTPPPQT PSSCLTPVSP GTSDGRRQGH RSPSRPHPGG
1360 1370 1380 1390 1400
HPHSSPLAPH PISGDRAHFS RRFLKHSPPG PSFLNQTPAG EVVEVGDSDD
1410 1420 1430 1440 1450
EQEVASHQAN RSPPLDSDPP IPIDDCCWHM EPLSPIPIDH WNLERTGPLS
1460 1470 1480 1490 1500
TSSPSRRMNE AADSRDCRSP GLLDTTPIRG SCTTQRKLQE KSSGAGSLGN
1510 1520 1530 1540 1550
SRPSFLNSAL WDVWDGEEQR PPETPPPAQM PSAGGAQKPE GLETPKGANR
1560 1570 1580 1590 1600
KKNLPPKVPI TPMPQYSIME TPVLKKELDR FGVRPLPKRQ MVLKLKEIFQ
1610 1620 1630 1640 1650
YTHQTLDSDS EDESQSSQPL LQAPHCQTLA SQTYKPSRAG VHAQQEATTG
1660 1670 1680 1690 1700
PGAHRPKGPA KTKGPRHQRK HHESITPPSR SPTKEAPPGL NDDAQIPASQ
1710 1720 1730 1740 1750
ESVATSVDGS DSSLSSQSSS SCEFGAAFES AGEEEGEGEV SASQAAVQAA
1760 1770 1780 1790 1800
DTDEALRCYI RSKPALYQKV LLYQPFELRE LQAELRQNGL RVSSRRLLDF
1810 1820 1830
LDTHCITFTT AATRREKLQG RRRQPRGKKK VERN
Length:1,834
Mass (Da):200,012
Last modified:September 2, 2008 - v3
Checksum:i9131E88628DB15D5
GO
Isoform 2 (identifier: Q8IY92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     313-316: QHVN → MFSF

Show »
Length:1,522
Mass (Da):165,903
Checksum:iA3C234F1E746C5FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06898238L → F1 PublicationCorresponds to variant dbSNP:rs141167501EnsemblClinVar.1
Natural variantiVAR_068983141G → W1 PublicationCorresponds to variant dbSNP:rs137976282EnsemblClinVar.1
Natural variantiVAR_068984197V → A1 PublicationCorresponds to variant dbSNP:rs147826749EnsemblClinVar.1
Natural variantiVAR_068985204R → C1 PublicationCorresponds to variant dbSNP:rs79842542EnsemblClinVar.1
Natural variantiVAR_068986237R → Q1 PublicationCorresponds to variant dbSNP:rs138615800EnsemblClinVar.1
Natural variantiVAR_068987284H → R1 Publication1
Natural variantiVAR_068988378P → T Polymorphism; does not modify the functional properties of the protein. 1 Publication1
Natural variantiVAR_068989385P → T1 PublicationCorresponds to variant dbSNP:rs115694169EnsemblClinVar.1
Natural variantiVAR_068990386M → V1 PublicationCorresponds to variant dbSNP:rs113490934EnsemblClinVar.1
Natural variantiVAR_068991424A → V1 PublicationCorresponds to variant dbSNP:rs551823420EnsemblClinVar.1
Natural variantiVAR_068992457N → K1 PublicationCorresponds to variant dbSNP:rs74319927EnsemblClinVar.1
Natural variantiVAR_068993458K → E1 PublicationCorresponds to variant dbSNP:rs149126845EnsemblClinVar.1
Natural variantiVAR_068994505A → T1 Publication1
Natural variantiVAR_068995506S → N1 Publication1
Natural variantiVAR_068996568V → M1 PublicationCorresponds to variant dbSNP:rs371825444Ensembl.1
Natural variantiVAR_068997579L → P1 PublicationCorresponds to variant dbSNP:rs772504776Ensembl.1
Natural variantiVAR_068998671L → S2 PublicationsCorresponds to variant dbSNP:rs77985244EnsemblClinVar.1
Natural variantiVAR_068999787E → K Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs140600202EnsemblClinVar.1
Natural variantiVAR_069000870A → V1 PublicationCorresponds to variant dbSNP:rs149584080EnsemblClinVar.1
Natural variantiVAR_069001894V → G1 PublicationCorresponds to variant dbSNP:rs145137472EnsemblClinVar.1
Natural variantiVAR_069002929P → L1 PublicationCorresponds to variant dbSNP:rs117707719EnsemblClinVar.1
Natural variantiVAR_069003942E → Q1 PublicationCorresponds to variant dbSNP:rs114014006EnsemblClinVar.1
Natural variantiVAR_069004952A → M Requires 2 nucleotide substitutions. 2 PublicationsCorresponds to variant dbSNP:rs863224277EnsemblClinVar.1
Natural variantiVAR_069005975P → L1 PublicationCorresponds to variant dbSNP:rs114472821EnsemblClinVar.1
Natural variantiVAR_0690061007Q → K1 PublicationCorresponds to variant dbSNP:rs138798067Ensembl.1
Natural variantiVAR_0690071060R → W1 PublicationCorresponds to variant dbSNP:rs144273492EnsemblClinVar.1
Natural variantiVAR_0193261122P → L2 PublicationsCorresponds to variant dbSNP:rs714181EnsemblClinVar.1
Natural variantiVAR_0690081123S → Y1 PublicationCorresponds to variant dbSNP:rs144647122EnsemblClinVar.1
Natural variantiVAR_0197291221A → V2 PublicationsCorresponds to variant dbSNP:rs3827530EnsemblClinVar.1
Natural variantiVAR_0193271271S → F1 PublicationCorresponds to variant dbSNP:rs3810813EnsemblClinVar.1
Natural variantiVAR_0690091286A → V1 PublicationCorresponds to variant dbSNP:rs149011965EnsemblClinVar.1
Natural variantiVAR_0690101287V → G1 Publication1
Natural variantiVAR_0690111342S → G1 PublicationCorresponds to variant dbSNP:rs140051968EnsemblClinVar.1
Natural variantiVAR_0463371367A → T. Corresponds to variant dbSNP:rs17136464EnsemblClinVar.1
Natural variantiVAR_0690121421I → F1 PublicationCorresponds to variant dbSNP:rs141567438EnsemblClinVar.1
Natural variantiVAR_0690131476T → S1 PublicationCorresponds to variant dbSNP:rs372321470EnsemblClinVar.1
Natural variantiVAR_0690141550R → W Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs77021998EnsemblClinVar.1
Natural variantiVAR_0463381677P → S. Corresponds to variant dbSNP:rs7196345EnsemblClinVar.1
Natural variantiVAR_0690151694A → V1 PublicationCorresponds to variant dbSNP:rs761226343Ensembl.1
Natural variantiVAR_0690161814R → C1 PublicationCorresponds to variant dbSNP:rs767720336Ensembl.1
Natural variantiVAR_0690171834N → S Polymorphism; does not modify the functional properties of the protein. 1 PublicationCorresponds to variant dbSNP:rs111738042EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0352951 – 312Missing in isoform 2. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_035296313 – 316QHVN → MFSF in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006111 Genomic DNA No translation available.
AB075867 mRNA Translation: BAB85573.1
AB058687 mRNA Translation: BAB47413.1
AL442083 mRNA Translation: CAH10659.1
CCDSiCCDS10506.2 [Q8IY92-1]
RefSeqiNP_115820.2, NM_032444.3 [Q8IY92-1]
UniGeneiHs.143681

Genome annotation databases

EnsembliENST00000294008; ENSP00000294008; ENSG00000188827 [Q8IY92-1]
GeneIDi84464
KEGGihsa:84464
UCSCiuc002cvp.3 human [Q8IY92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006111 Genomic DNA No translation available.
AB075867 mRNA Translation: BAB85573.1
AB058687 mRNA Translation: BAB47413.1
AL442083 mRNA Translation: CAH10659.1
CCDSiCCDS10506.2 [Q8IY92-1]
RefSeqiNP_115820.2, NM_032444.3 [Q8IY92-1]
UniGeneiHs.143681

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M7CX-ray2.05C/D1014-1025[»]
4UYIX-ray1.86A668-796[»]
4ZOUX-ray2.15A669-787[»]
ProteinModelPortaliQ8IY92
SMRiQ8IY92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124097, 49 interactors
ComplexPortaliCPX-484 SLX4-TERF2 complex
IntActiQ8IY92, 164 interactors
STRINGi9606.ENSP00000294008

PTM databases

iPTMnetiQ8IY92
PhosphoSitePlusiQ8IY92

Polymorphism and mutation databases

BioMutaiSLX4
DMDMi205371796

Proteomic databases

EPDiQ8IY92
MaxQBiQ8IY92
PaxDbiQ8IY92
PeptideAtlasiQ8IY92
PRIDEiQ8IY92
ProteomicsDBi71127
71128 [Q8IY92-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294008; ENSP00000294008; ENSG00000188827 [Q8IY92-1]
GeneIDi84464
KEGGihsa:84464
UCSCiuc002cvp.3 human [Q8IY92-1]

Organism-specific databases

CTDi84464
DisGeNETi84464
EuPathDBiHostDB:ENSG00000188827.10
GeneCardsiSLX4
GeneReviewsiSLX4
H-InvDBiHIX0202244
HGNCiHGNC:23845 SLX4
HPAiHPA049421
HPA066238
MalaCardsiSLX4
MIMi613278 gene
613951 phenotype
neXtProtiNX_Q8IY92
OpenTargetsiENSG00000188827
Orphaneti84 Fanconi anemia
PharmGKBiPA134983583
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFPH Eukaryota
ENOG410XPS5 LUCA
GeneTreeiENSGT00390000014091
HOGENOMiHOG000095273
InParanoidiQ8IY92
KOiK10484
OMAiHKFVLYA
OrthoDBiEOG091G10TA
PhylomeDBiQ8IY92
TreeFamiTF106446

Enzyme and pathway databases

ReactomeiR-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiQ8IY92

Miscellaneous databases

ChiTaRSiSLX4 human
GeneWikiiSLX4
GenomeRNAii84464
PROiPR:Q8IY92
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188827 Expressed in 119 organ(s), highest expression level in cerebellar vermis
CleanExiHS_BTBD12
GenevisibleiQ8IY92 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR018574 Structure-sp_endonuc_su_Slx4
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF09494 Slx4, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLX4_HUMAN
AccessioniPrimary (citable) accession number: Q8IY92
Secondary accession number(s): Q69YT8, Q8TF15, Q96JP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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