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Protein

Serine/threonine-protein kinase NIM1

Gene

NIM1K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Activity regulationi

Activated by phosphorylation at Thr-229, probably by autophosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103ATPPROSITE-ProRule annotationBy similarity1
Active sitei196Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 88ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IY84

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase NIM1 (EC:2.7.11.1)
Alternative name(s):
NIM1 serine/threonine-protein kinase
Gene namesi
Name:NIM1K
Synonyms:NIM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177453.7
HGNCiHGNC:28646 NIM1K
neXtProtiNX_Q8IY84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi229T → A: Loss of autophosphorylation and kinase activity. 1 Publication1
Mutagenesisi229T → E: Constitutively active. 1 Publication1

Organism-specific databases

DisGeNETi167359
OpenTargetsiENSG00000177453

Chemistry databases

ChEMBLiCHEMBL3542
GuidetoPHARMACOLOGYi2291

Polymorphism and mutation databases

BioMutaiNIM1
DMDMi74759697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476661 – 436Serine/threonine-protein kinase NIM1Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IY84
PeptideAtlasiQ8IY84
PRIDEiQ8IY84
ProteomicsDBi71124

PTM databases

iPTMnetiQ8IY84
PhosphoSitePlusiQ8IY84

Expressioni

Gene expression databases

BgeeiENSG00000177453 Expressed in 115 organ(s), highest expression level in middle temporal gyrus
GenevisibleiQ8IY84 HS

Organism-specific databases

HPAiHPA007695

Interactioni

Protein-protein interaction databases

BioGridi127945, 1 interactor
IntActiQ8IY84, 1 interactor
STRINGi9606.ENSP00000313572

Chemistry databases

BindingDBiQ8IY84

Structurei

3D structure databases

ProteinModelPortaliQ8IY84
SMRiQ8IY84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000233016
HOVERGENiHBG082029
InParanoidiQ8IY84
KOiK16310
OMAiGITEEHI
OrthoDBiEOG091G07AG
PhylomeDBiQ8IY84

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IY84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAVYMNGGG LVNPHYARWD RRDSVESGCQ TESSKEGEEG QPRQLTPFEK
60 70 80 90 100
LTQDMSQDEK VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV
110 120 130 140 150
AIKILDKTKL DQKTQRLLSR EISSMEKLHH PNIIRLYEVV ETLSKLHLVM
160 170 180 190 200
EYAGGGELFG KISTEGKLSE PESKLIFSQI VSAVKHMHEN QIIHRDLKAE
210 220 230 240 250
NVFYTSNTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE LFRDEHYIGI
260 270 280 290 300
YVDIWALGVL LYFMVTGTMP FRAETVAKLK KSILEGTYSV PPHVSEPCHR
310 320 330 340 350
LIRGVLQQIP TERYGIDCIM NDEWMQGVPY PTPLEPFQLD PKHLSETSTL
360 370 380 390 400
KEEENEVKST LEHLGITEEH IRNNQGRDAR SSITGVYRII LHRVQRKKAL
410 420 430
ESVPVMMLPD PKERDLKKGS RVYRGIRHTS KFCSIL
Length:436
Mass (Da):49,606
Last modified:March 1, 2003 - v1
Checksum:iC183F11F54E3B87C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04094521R → W1 PublicationCorresponds to variant dbSNP:rs55664335Ensembl.1
Natural variantiVAR_04094664E → Q1 PublicationCorresponds to variant dbSNP:rs55663207Ensembl.1
Natural variantiVAR_040947260L → I1 PublicationCorresponds to variant dbSNP:rs35659008Ensembl.1
Natural variantiVAR_040948320M → I1 PublicationCorresponds to variant dbSNP:rs55770078Ensembl.1
Natural variantiVAR_040949333P → S in a lung neuroendocrine carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs866026698Ensembl.1
Natural variantiVAR_040950411P → T in a lung large cell carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122985 mRNA Translation: BAG53833.1
AC106800 Genomic DNA No translation available.
AC114947 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW56053.1
BC036422 mRNA Translation: AAH36422.1
CCDSiCCDS3943.1
RefSeqiNP_699192.1, NM_153361.3
XP_006714513.1, XM_006714450.1
UniGeneiHs.25845

Genome annotation databases

EnsembliENST00000326035; ENSP00000313572; ENSG00000177453
ENST00000512796; ENSP00000420849; ENSG00000177453
GeneIDi167359
KEGGihsa:167359
UCSCiuc003jno.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122985 mRNA Translation: BAG53833.1
AC106800 Genomic DNA No translation available.
AC114947 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW56053.1
BC036422 mRNA Translation: AAH36422.1
CCDSiCCDS3943.1
RefSeqiNP_699192.1, NM_153361.3
XP_006714513.1, XM_006714450.1
UniGeneiHs.25845

3D structure databases

ProteinModelPortaliQ8IY84
SMRiQ8IY84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127945, 1 interactor
IntActiQ8IY84, 1 interactor
STRINGi9606.ENSP00000313572

Chemistry databases

BindingDBiQ8IY84
ChEMBLiCHEMBL3542
GuidetoPHARMACOLOGYi2291

PTM databases

iPTMnetiQ8IY84
PhosphoSitePlusiQ8IY84

Polymorphism and mutation databases

BioMutaiNIM1
DMDMi74759697

Proteomic databases

PaxDbiQ8IY84
PeptideAtlasiQ8IY84
PRIDEiQ8IY84
ProteomicsDBi71124

Protocols and materials databases

DNASUi167359
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326035; ENSP00000313572; ENSG00000177453
ENST00000512796; ENSP00000420849; ENSG00000177453
GeneIDi167359
KEGGihsa:167359
UCSCiuc003jno.5 human

Organism-specific databases

CTDi167359
DisGeNETi167359
EuPathDBiHostDB:ENSG00000177453.7
GeneCardsiNIM1K
HGNCiHGNC:28646 NIM1K
HPAiHPA007695
neXtProtiNX_Q8IY84
OpenTargetsiENSG00000177453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000233016
HOVERGENiHBG082029
InParanoidiQ8IY84
KOiK16310
OMAiGITEEHI
OrthoDBiEOG091G07AG
PhylomeDBiQ8IY84

Enzyme and pathway databases

SignaLinkiQ8IY84

Miscellaneous databases

GenomeRNAii167359
PROiPR:Q8IY84

Gene expression databases

BgeeiENSG00000177453 Expressed in 115 organ(s), highest expression level in middle temporal gyrus
GenevisibleiQ8IY84 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY84
Secondary accession number(s): B3KVM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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